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Extending the neurocircuitry of behavioural inhibition:a role for the bed nucleus of the stria terminalis in risk for anxiety disorders

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General Psychiatry 2019年第6期32卷 309-315页

作者： jacqueline Clauss Child and Adolescent Psychiatry Massachusetts General HospitalBostonMassachusettsUSA Child and Adolescent Psychiatry McLean HospitalBelmontMassachusettsUSA

Behavioural inhibition is a biologically based risk factor for anxiety *** with behavioural inhibition are shy,cautious and avoidant of new *** research on behavioural inhibition has focused on the amygdala as an underlying neural substrate and has identified differences in amygdala function and volume;however,amygdala findings have yet to lead to meaningful interventions for prevention or treatment of anxiety *** bed nucleus of the stria terminalis(BNST)is a prime candidate to be a neural substrate of behavioural inhibition,given current evidence of BNST function and development in human research and animal *** with behavioural inhibition have an increased startle response to safety cues and an increased cortisol response to social evaluative situations,both of which are mediated by the *** rodents,activation of the BNST underlies contextual fear responses and responses to uncertain and sustained ***-human primates with anxious temperament(the macaque equivalent of behavioural inhibition)have increased BNST activity to ambiguous social situations,and activity of the BNST in anxious temperament is significantly ***,the BNST is sexually dimorphic and continues to develop into adulthood,paralleling the development of anxiety disorders in ***,these findings suggest that further investigation of the BNST in behavioural inhibition is necessary and may lead to new avenues for the prevention and treatment of anxiety disorders.

关键词： behaviour prevention finding

Gene expression arrays as a tool to unravel mechanisms of normal tissue radiation injury and prediction of response

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World Journal of Gastroenterology 2007年第19期13卷 2669-2674页

作者： jacqueline JCM Kruse Fiona A Stewart The Netherlands Cancer Institute Division of Experimental Therapy (H6) Plesmanlaan 121 1066 CX Amsterdam The Netherlands

Over the past 5 years there has been a rapid increase in the use of microarray technology in the field of cancer research, The majority of studies use microarray analysis of tumor biopsies for profiling of molecular characteristics in an attempt to produce robust classifiers for prognosis. There are now several published gene sets that have been shown to predict for aggressive forms of breast cancer, where patients are most likely to benefit from adjuvant chemotherapy and tumors most likely to develop distant metastases, or be resistant to treatment. The number of publications relating to the use of microarrays for analysis of normal tissue damage, after cancer treatment or genotoxic exposure, is much more limited. A PublVled literature search was conducted using the following keywords and combination of terms： radiation, normal tissue, microarray, gene expression profiling, prediction. With respect to normal tissue radiation injury, microarrays have been used in three ways：（1） to generate gene signatures to identify sensitive and resistant populations （prognosis）; （2） to identify sets of biomarker genes for estimating radiation exposure, either accidental or as a result of terrorist attack （diagnosis）; （3） to identify genes and pathways involved in tissue response to injury （mechanistic）. In this article we will review all （relevant） papers that covered our literature search criteria on microarray technology as it has been applied to normal tissue radiation biology and discuss how successful this has been in defining predisposition markers for radiation sensitivity or how it has helped us to unravel molecular mechanisms leading to acute and late tissue toxicity. We also discuss some of the problems and limitations in application and interpretation of such data.

关键词： Radiation Normal tissue response Microarrays Gene expression Limitations

Epigenetics:Potentials and Challenges in Crop Breeding

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Molecular Plant 2019年第10期12卷 1309-1311页

作者： Soodeh Tirnaz jacqueline Batley School of Biological Sciences University of Western AustraliaPerthWAAustralia

The rapidly increasing global crop demand due to world population growth and changes in diet,combined with the challenges imposed on crop production due to global climate change are highlighting the urgency for improving both crop yield and *** can provide novel directions to drive plant breeding strategies and is rapidly gaining its place among modern crop breeding *** we discuss the necessity of including epigenetic diversity in crop breeding programs,as visualized in Figure 1.

关键词： breeding Figure directions

Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer cell line

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Frontiers of Chemical Science and Engineering 2013年第4期7卷 482-489页

作者： jacqueline CONCHA Caroline WEINSTEIN Maria Elvira ZUNIGA Department of Biochemistry Pharmacy School Universidad de Valparaiso Gran Bretafia 1093 Playa Ancha Valparaiso Chile School of Biochemistry Engineering Pontificia Universidad Catolica de Valparaiso General Cruz 34 Valparaiso Chile Creas Conicyt-Regional Gore Region de Valparaiso R12C1001 Blanco 1623 of 1402 Valparaiso Chile

In the last years, sugar beet pectins have been the subject of several investigations involving extraction methodologies, chemical composition and functional properties. The structure of pectins, which depends on the extraction method, is decisive in their capacity to induce apoptosis on several cancer cell lines like colon, prostate and breast. In this work, sugar beet pectin extraction was performed in the following steps： lipid extraction with hexane, removal of soluble complex carbohydrates and proteins, and enzymatic treatment with amyloglucosidase, protease, and pectinase. The enzymatic treatment was carried out with Rohapect DA6L under the following conditions： 50℃, pH 4.0, 2% enzyme/substrate （E/S） ratio, 15 h, and a solid to liquid ratio of 1 ： 10. The pectic extract showed a degree of polymerization （DP） profile of 55.8% with DP≥7; 4.9% with DP6; 5.8% between DP2 and DP6 ; 4.7% with DP2; and 28.8% with DP1. The pectic extract was examined for its antiproliferative activity on the MCF-7 breast cancer cell line. At a concentration range of 12.5-25 mg/mL the pectic extract killed 80.6% of the cells, exhibiting a higher antiproliferative activity than 4-hydroxytamoxifen （4- OHT）, a classical anticancer drug, which killed 56.5% of the cells.

关键词： pectic extracts antiproliferative activity,breast cancer enzymatic treatment

Magnetic and superconducting phase diagrams and transition temperatures predicted using text mining and machine learning

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npj Computational Materials 2020年第1期6卷 1521-1529页

作者： Callum J.Court jacqueline M.Cole Cavendish Laboratory Department of PhysicsUniversity of CambridgeJ.J.Thomson AvenueCambridge CB30HEUK ISIS Neutron and Muon Source STFC Rutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcotOxfordshire OX110QXUK Argonne National Laboratory 9700 South Cass AvenueArgonneIL 60439USA Department of Chemical Engineering and Biotechnology University of CambridgeWest Cambridge SitePhilippa Fawcett DriveCambridge CB30FSUK

Predicting the properties of materials prior to their synthesis is of great importance in materials *** and superconducting materials exhibit a number of unique properties that make them useful in a wide variety of applications,including solid oxide fuel cells,solid-state refrigerants,photon detectors and metrology *** all these applications,phase transitions play an important role in determining the feasibility of the materials in ***,we present a pipeline for fully integrating data extracted from the scientific literature into machine-learning tools for property prediction and materials *** advanced natural language processing(NLP)and machine-learning techniques,we successfully reconstruct the phase diagrams of well-known magnetic and superconducting compounds,and demonstrate that it is possible to predict the phase-transition temperatures of compounds not present in the *** provide the tool as an online open-source platform,forming the basis for further research into magnetic and superconducting materials discovery for potential device applications.

关键词： phase transition superconducting

Development of new classes of plasmon active nano-structures and their application in bio-sensing and energy guiding

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Frontiers of physics 2014年第5期9卷 652-664页

作者： Ondrej Stranik jacqueline Jatschka Andrea Csaki Wolfgang Fritzsche Leibniz Institute of Photonic Technology Jena 07745 Germany

Metal nanostructures exhibit special optical resonance modes originating fronl tile subwavelengt.h confinement of conductive electrons in the material. These resonance modes represent a strong research focus due to their application potential in optics and sensing application, in this short review recent achievements of our group in this field are highlighted. A wet-chemistry approach synthesis of advanced metallic nanostruetures will be introduced and their exact positioning and manipulation by electric field is shown. Next. the application of these nanostructures for a detection of small molecules will be described in several examples. Also, it will be shown that inetal nanostruetures can be used for sub-wavelength light focusing and for efficient energy coupling into polymer chains.

关键词： plasmonics sensing nanostructures fabrication energy guiding

Genomic imbalances in esophageal carcinoma cell lines involve Wnt pathway genes

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World Journal of Gastroenterology 2011年第24期17卷 2909-2923页

作者： jacqueline Brown Hannelie Bothma Robin Veale Pascale Willem National Health Laboratory Services and University of the Witwatersrand School of Molecular and Cell Biology University of the Witwatersrand

AIM： To identify molecular markers shared across South African esophageal squamous cell carcinoma （ESCC） cell lines using o/togenetics, fluorescence in situ hybridization （FISH） and single nucleotide polymorphism （SNP） array copy number analysis. METHODS： We used conventional cytogenetics, FISH, and multicolor FISH to characterize the chromosomal rearrangements of five ESCC cell lines established in South Africa. The whole genome copy number profile was established from 250K SNP arrays, and data was analyzed with the CNAT 4.0 and GISTIC software. tions involved the following chromosomal regions and genes： 11q13.3 （CCND1, FGF3, FGF4, FGF19, MYEOV）, 8q24.21（C-MYC, FAM84B）, 11q22.1-q22.3 （B[RC2, BIRC3）, 5p15.2 （CTNND2）, 3qll.2-q12.2 （MINA） and 18p11.32 （TYMS, YES1）. The significant deletions included 1p31.2-p31.1 （CTH, GADD45a, DIRAS3）, 2q22.1 （LRPIB）, 3p12.1-p14.2 （FHIT）, 4q22.1-q32.1 （CASP6, SMAD1）, 8p23.2-q11.1 （BNIP3L） and 18q21.1-q21.2 （SMAD4, DCC）. The 3p11.2 translocation breakpoint was shared across four cell lines, supporting a role for genes involved at this site, in particular, the EPHA3 gene which has previously been reported to be deleted in ***： The finding that a significant number of genes that were amplified （FGF3, FGF4, FGF19, CCND1 and C-MYC） or deleted （SFRP2 gene） are involved in the Wnt and fibroblast growth factor signaling pathways, suggests that these pathways may be activated in these cell lines.

关键词： Esophagus Cancer Single nucleotide polymorphism arrays Fluorescent in situ hybridization

In vivo and in vitro use of plasma membrane DNA in the detection and follow-up of systemic lupus erythematosus

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Journal of Molecular Cell Biology 2011年第3期3卷 200-201页

作者： jacqueline Keyhani Ezzatollah Keyhani Genevieve Servais Jean Duchateau Laboratory for Life Sciences 19979 TehranIran Immunology Department University Hospital BrugmannU.L.B.BrusselsBelgium

Dear Editor,Systemic lupus erythematosus(SLE)is a chronic inflammatory autoimmune disease in which the immune system attacks the patient’s tissues,resulting in inflammation and damage(Tan et al.,1982).SLE is associated with the presence of abnormally elevated titers of a variety of antibodies,including antibodies to doublestranded(ds)DNA,in the serum(Egner,2000).

关键词： lupus erythematosus damage vivo

Parametric instability of a liquid metal sessile drop under the action of low-frequency alternating magnetic fields

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Journal of Hydrodynamics 2013年第2期25卷 300-308页

作者：雷作胜郭加宏 FAUTRELLE Yves ERNST Roland ETAY jacqueline 任忠鸣 Shanghai Key Laboratory of Modern Metallurgy and Materials Processing Shanghai University SIMAP-EPM Laboratory Grenoble Institute of Technology/CNRS UMR 5266 France Shanghai Institute of Applied Mathematics and Mechanics Shanghai University SIMAP-EPM Laboratory Grenoble Institute of Technology/CNRS UMR 5266France

A 2-D mathematical model is developed in order to simulate a parametric electromagnetic instability oscillation process of a liquid metal droplet under the action of low frequency magnetic field. The Arbitrary Lagrangian-Eulerian （ALE） method and weak form constraint boundary condition are introduced in this model for implementation of the surface tension and electromagnetic force on liquid droplet free surface. The results of the numerical calculations indicate the appearance of various regimes of oscillation. It is found that according to the magnetic field frequency various types of oscillation modes may be found. The oscillation is originated from an instability phenomenon. The stability diagram of liquid metal droplet in the parameter space of magnetic frequency and magnetic flux density is determined numerically. The diagram is very similar to that found in the so-called parametric instability.

关键词： sessile drop parametric instability low-frequency alternating magnetic fields numerical simulation