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Extending the neurocircuitry of behavioural inhibition:a role for the bed nucleus of the stria terminalis in risk for anxiety disorders

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General Psychiatry 2019年第6期32卷 309-315页

作者： jacqueline Clauss Child and Adolescent Psychiatry Massachusetts General HospitalBostonMassachusettsUSA Child and Adolescent Psychiatry McLean HospitalBelmontMassachusettsUSA

Behavioural inhibition is a biologically based risk factor for anxiety *** with behavioural inhibition are shy,cautious and avoidant of new *** research on behavioural inhibition has focused on the amygdala as an underlying neural substrate and has identified differences in amygdala function and volume;however,amygdala findings have yet to lead to meaningful interventions for prevention or treatment of anxiety *** bed nucleus of the stria terminalis(BNST)is a prime candidate to be a neural substrate of behavioural inhibition,given current evidence of BNST function and development in human research and animal *** with behavioural inhibition have an increased startle response to safety cues and an increased cortisol response to social evaluative situations,both of which are mediated by the *** rodents,activation of the BNST underlies contextual fear responses and responses to uncertain and sustained ***-human primates with anxious temperament(the macaque equivalent of behavioural inhibition)have increased BNST activity to ambiguous social situations,and activity of the BNST in anxious temperament is significantly ***,the BNST is sexually dimorphic and continues to develop into adulthood,paralleling the development of anxiety disorders in ***,these findings suggest that further investigation of the BNST in behavioural inhibition is necessary and may lead to new avenues for the prevention and treatment of anxiety disorders.

关键词： behaviour prevention finding

Role of nitric oxide in cerebral ischemia/reperfusion injury:A biomolecular overview

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World Journal of Clinical Cases 2025年第10期13卷 9-13页

作者： Roberto Anaya-Prado Abraham I Canseco-Villegas Roberto Anaya-Fernández Michelle Marie Anaya-Fernandez Miguel A Guerrero-Palomera Citlalli Guerrero-Palomera Ivan F Garcia-Ramirez Daniel Gonzalez-Martinez Consuelo Cecilia Azcona-Ramírez Claudia Garcia-Perez Airim L Lizarraga-Valencia Aranza Hernandez-Zepeda jacqueline F Palomares-Covarrubias Jorge HA Blackaller-Medina jacqueline Soto-Hintze Mayra C Velarde-Castillo Dayri A Cruz-Melendrez Department of Research&Department of Surgery School of Medicine and Health SciencesTecnologico de MonterreyCorporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Direction of Research and Education Corporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Department of Research School of Medicine and Health SciencesTecnologico de MonterreyZapopan 45116JaliscoMexico Division of Research and Education Corporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Division of Research School of MedicineUniversity of GuadalajaraGuadalajara 44340JaliscoMexico Division of Research School of MedicineAutonomous University of GuadalajaraZapopan 45116JaliscoMexico Research&Education Corporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Division of Research Corporate Hospitals Puerta de HierroZapopan 45116JaliscoMexico Research School of MedicineUNIVA UniversityZapopan 45116JaliscoMexico

Nitric oxide(NO)is a gaseous molecule produced by 3 different NO synthase(NOS)isoforms:Neural/brain NOS(nNOS/bNOS,type 1),endothelial NOS(eNOS,type 3)and inducible NOS(type 2).Type 1 and 3 NOS are constitutively *** can serve different purposes:As a vasoactive molecule,as a neurotransmitter or as an *** plays a key role in cerebral ischemia/reperfusion injury(CIRI).Hypoxic episodes simulate the production of oxygen free radicals,leading to mitochondrial and phospholipid *** reperfusion,increased levels of oxygen trigger oxide synthases;whose products are associated with neuronal damage by promoting lipid peroxidation,nitrosylation and *** pathways in CIRI can be altered by *** effects are observed with eNOS *** nNOS interplay is prone to endothelial inflammation,oxidative stress and ***,nNOS appears to be *** interaction between NO and other free radicals develops peroxynitrite;which is a cytotoxic *** plays a main role in the likelihood of hemorrhagic events by tissue plasminogen activator(t-PA).Peroxynitrite scavengers are currently being studied as potential targets to prevent hemorrhagic transformation in CIRI.

关键词： Nitric oxide Cerebral ischemia/reperfusion injury Nitric oxide synthase Reactive nitrogen species Nitrosylation

Epigenetics:Potentials and Challenges in Crop Breeding

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Molecular Plant 2019年第10期12卷 1309-1311页

作者： Soodeh Tirnaz jacqueline Batley School of Biological Sciences University of Western AustraliaPerthWAAustralia

The rapidly increasing global crop demand due to world population growth and changes in diet,combined with the challenges imposed on crop production due to global climate change are highlighting the urgency for improving both crop yield and *** can provide novel directions to drive plant breeding strategies and is rapidly gaining its place among modern crop breeding *** we discuss the necessity of including epigenetic diversity in crop breeding programs,as visualized in Figure 1.

关键词： breeding Figure directions

Magnetic and superconducting phase diagrams and transition temperatures predicted using text mining and machine learning

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npj Computational Materials 2020年第1期6卷 1521-1529页

作者： Callum J.Court jacqueline M.Cole Cavendish Laboratory Department of PhysicsUniversity of CambridgeJ.J.Thomson AvenueCambridge CB30HEUK ISIS Neutron and Muon Source STFC Rutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcotOxfordshire OX110QXUK Argonne National Laboratory 9700 South Cass AvenueArgonneIL 60439USA Department of Chemical Engineering and Biotechnology University of CambridgeWest Cambridge SitePhilippa Fawcett DriveCambridge CB30FSUK

Predicting the properties of materials prior to their synthesis is of great importance in materials *** and superconducting materials exhibit a number of unique properties that make them useful in a wide variety of applications,including solid oxide fuel cells,solid-state refrigerants,photon detectors and metrology *** all these applications,phase transitions play an important role in determining the feasibility of the materials in ***,we present a pipeline for fully integrating data extracted from the scientific literature into machine-learning tools for property prediction and materials *** advanced natural language processing(NLP)and machine-learning techniques,we successfully reconstruct the phase diagrams of well-known magnetic and superconducting compounds,and demonstrate that it is possible to predict the phase-transition temperatures of compounds not present in the *** provide the tool as an online open-source platform,forming the basis for further research into magnetic and superconducting materials discovery for potential device applications.

关键词： phase transition superconducting

Development of new classes of plasmon active nano-structures and their application in bio-sensing and energy guiding

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Frontiers of physics 2014年第5期9卷 652-664页

作者： Ondrej Stranik jacqueline Jatschka Andrea Csaki Wolfgang Fritzsche Leibniz Institute of Photonic Technology Jena 07745 Germany

Metal nanostructures exhibit special optical resonance modes originating fronl tile subwavelengt.h confinement of conductive electrons in the material. These resonance modes represent a strong research focus due to their application potential in optics and sensing application, in this short review recent achievements of our group in this field are highlighted. A wet-chemistry approach synthesis of advanced metallic nanostruetures will be introduced and their exact positioning and manipulation by electric field is shown. Next. the application of these nanostructures for a detection of small molecules will be described in several examples. Also, it will be shown that inetal nanostruetures can be used for sub-wavelength light focusing and for efficient energy coupling into polymer chains.

关键词： plasmonics sensing nanostructures fabrication energy guiding

In vivo and in vitro use of plasma membrane DNA in the detection and follow-up of systemic lupus erythematosus

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Journal of Molecular Cell Biology 2011年第3期3卷 200-201页

作者： jacqueline Keyhani Ezzatollah Keyhani Genevieve Servais Jean Duchateau Laboratory for Life Sciences 19979 TehranIran Immunology Department University Hospital BrugmannU.L.B.BrusselsBelgium

Dear Editor,Systemic lupus erythematosus(SLE)is a chronic inflammatory autoimmune disease in which the immune system attacks the patient’s tissues,resulting in inflammation and damage(Tan et al.,1982).SLE is associated with the presence of abnormally elevated titers of a variety of antibodies,including antibodies to doublestranded(ds)DNA,in the serum(Egner,2000).

关键词： lupus erythematosus damage vivo

Parametric instability of a liquid metal sessile drop under the action of low-frequency alternating magnetic fields

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Journal of Hydrodynamics 2013年第2期25卷 300-308页

作者：雷作胜郭加宏 FAUTRELLE Yves ERNST Roland ETAY jacqueline 任忠鸣 Shanghai Key Laboratory of Modern Metallurgy and Materials Processing Shanghai University SIMAP-EPM Laboratory Grenoble Institute of Technology/CNRS UMR 5266 France Shanghai Institute of Applied Mathematics and Mechanics Shanghai University SIMAP-EPM Laboratory Grenoble Institute of Technology/CNRS UMR 5266France

A 2-D mathematical model is developed in order to simulate a parametric electromagnetic instability oscillation process of a liquid metal droplet under the action of low frequency magnetic field. The Arbitrary Lagrangian-Eulerian （ALE） method and weak form constraint boundary condition are introduced in this model for implementation of the surface tension and electromagnetic force on liquid droplet free surface. The results of the numerical calculations indicate the appearance of various regimes of oscillation. It is found that according to the magnetic field frequency various types of oscillation modes may be found. The oscillation is originated from an instability phenomenon. The stability diagram of liquid metal droplet in the parameter space of magnetic frequency and magnetic flux density is determined numerically. The diagram is very similar to that found in the so-called parametric instability.

关键词： sessile drop parametric instability low-frequency alternating magnetic fields numerical simulation

The Use of the Past to Shape the Present:Shifting Depictions of the Ancient World in Twentieth-Century American Cinema

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Fudan Journal of the Humanities and Social Sciences 2019年第1期12卷 61-78页

作者： jacqueline E.Jay History Department Eastern Kentucky UniversityKeith 323521 Lancaster Ave.RichmondKY 40475USA

The ancient film epic has its roots at the very dawn of cinema as a form of popular art and entertainment,with a number of early silent films drawing their plots from ancient Biblical and Classical sources,and the genre remains relevant in the early twenty-first *** film epics thus provide a useful lens through which to trace evolutions in film history and in western culture more *** paper analyzes seven American films spanning the early twentieth century to the early twenty-first century(Intolerance,Quo Vadis,The Egyptian,The Ten Com?***,Gladiator,300),identifying specific ways each film mirrors or challenges the time period in which it was produced.

关键词： Film history Ancient history Ancient film epic Intolerance D.W.Griffith Quo Vadis The Egyptian The Ten Commandments Cecil B.DeMille-Spartacus Stanley Kubrick Gladiator 300

Paraspinal strength and electromyographic fatigue in patients with sub-acute back pain and controls:Reliability,clinical applicability and between-group differences

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World Journal of Orthopedics 2021年第11期12卷 816-832页

作者： George A Koumantakis jacqueline A Oldham Laboratory of Advanced Physiotherapy(LAdPhys) Physiotherapy DepartmentUniversity of West Attica(UNIWA)Athens 12243AttikiGreece Faculty of Biology Medicine and HealthThe University of ManchesterManchester M17DNLancsUnited Kingdom

BACKGROUND Paraspinal muscle strength and fatigue are considered important in low back pain(LBP)prevention and *** reliability of paraspinal strength and electromyographic(EMG)-fatigue parameters has not been universally ***,the discriminative validity of these parameters requires further exploration,under the threat of potentially poor reliability of the methods *** To investigate the reliability and discriminative validity of paraspinal strength and EMG-related fatigue in subjects with recurrent LBP and healthy *** Test-retest measurements were performed in 26 healthy and 66 LBP volunteers,for *** isometric maximal and mean strength were determined with a maximum voluntary isometric contraction(MVIC)protocol,performed in a custom-made *** the fatigue test,participants performed a 60% MIVC level continuous isometric contraction of the paraspinals,in conjunction with EMG analysis from 4 muscle sites of the lumbar *** median frequency(IMF),the median frequency slope(MFslope),as well as the root mean square(RMS)slope EMG parameters were used as fatigue *** were analysed with repeated measures ANOVA for test-retest *** reliability,the intraclass correlation coefficient(ICC3,1),standard error of the measurement(SEM)and the smallest detectable difference(SDD)were ***-related differences for fatigue measures were analysed with a Multivariate Analysis of Covariance,with age,weight and strength as *** Isometric strength presented statistically significant between-day differences(P<0.01),however these did not exceed 10%(healthy:7.2%/LBP-patients:9.7%)and ICC reliability values were excellent,yet test-retest error was increased for the patient group(healthy:ICC3,1:0.92-0.96,SEM:5.72-5.94 Hz,SDD:18.51%-18.57%/LBP-patients:ICC3,1:0.91-0.96,SEM:6.49-6.96,SDD:30.75%-31.61%).For the frequency data,IMF reliability was excellent(healthy:ICC3,1:0

关键词： Low back pain Power spectral analysis Surface electromyography Multifidus Reliability