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Asian Journal of Andrology 2024年第1期26卷 20-24页

作者： John Shung-Lai Leung Wai-kit Ma Brian Sze-Ho Ho Stacia Tsun-Tsun Chun Rong Na Yongle Zhan Chi-Yuen Ng Chi-Ho ip Ada Tsui-Lin Ng Yiu-Chung Lam Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina Division of Urology Department of SurgeryPrincess Margaret HospitalHongKongChina

We aim to evaluate prostate health index as an additional risk-stratification tool in patients with prostate Imaging Reporting and Data System score 3 lesions on multiparametric magnetic resonance *** with biochemical or clinical suspicion of having prostate cancer who underwent multiparametric magnetic resonance imaging in two tertiary centers(Queen Mary Hospital and princess Margaret Hospital,Hong kong,China)between January 2017 and June 2022 were ***-magnetic resonance imaging fusion biopsies were performed after prostate health index *** who only had prostate Imaging Reporting and Data System score 3 lesions were further stratified into four prostate health index risk groups and the cancer detection rates were *** of the 747 patients,47.3%had prostate Imaging Reporting and Data System score 3 lesions *** detection rate of clinically significant prostate cancer in this group was 15.0%.The cancer detection rates of clinically significant prostate cancer had statistically significant differences:5.3%in prostate health indexprostate health index 25.0-34.9,17.9%in prostate health index 35.0-54.9,and 52.6%in prostate health index≥55.0(ppatients,26.9%could have avoided a biopsy with a prostate health indexpense of a 5.3%risk of missing clinically significant prostate *** health index could be used as an additional risk stratification tool for patients with prostate Imaging Reporting and Data System score 3 *** could be avoided in patients with low prostate health index,with a small risk of missing clinically significant prostate cancer.

关键词： biopsy fusion biopsy magnetic resonance imaging prostate cancer prostate health index

Clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMIR study

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Journal of Geriatric Cardiology 2024年第7期21卷 723-732页

作者： Francisco Marín Manuel Anguita Sánchez Iñaki Lekuona Marcelo Sanmartín Fernán-dez Vivencio Barrios Carlos perez Muñoz Juan Cosín-Sales Alejandro ipérez Cabeza Vanesa Roldán Schilling Carles Rafols priu Esteban Orenes-piñero María Asunción Es-teve-pastor Department of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usansolo BizkaiaSpain Department of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of Cardiology Hospital Arnau de VilanovaValenciaSpain Department of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and Molecular Biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial fibrillation(AF),taking rivaroxaban in clinical *** Observational and non-interventional study that included AF adults recruited from 79 Spanish centers,anticoagulated with rivaroxaban ≥ 6 months before being *** were analyzed according to age(≥ 80 vs.patients,453(31.6%) were octogenarians at *** to younger patients,octogenarians had more comorbidities,higher CHA2DS2-VASc(4.5 ± 1.3 vs.3.0 ± 1.4;p p prescribed in 83.4% of patients,but more frequently in the younger population(71.1% vs.89.1%;p = 0.039).After a mean follow-up of 2.2 ± 0.6 years,annual rates of stroke + systemic embolism + transient ischemic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03% and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar compared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with MACE,and higher HAS-BLED score with major *** In clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately prescribed in the majority of octogenarians.

关键词： patients atrial bleeding

LOCAL MEDIAN ESTIMATION OF VARIANCE FUNCTION

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Acta Mathematica Scientia 2004年第1期24卷 28-38页

作者：杨瑛 W.C.ip Y.k.kwan p.Y.k.kwan School of Mathematical Sciences Peking University Beijing 100871 China Department of Applied Mathematics The Hong Kong Polgytechnic University Hung Hom Kowloon Hongkong China

This paper considers local median estimation in fixed design regression problems. The proposed method is employed to estimate the median function and the variance function of a heteroscedastic regression model. Strong convergence rates of the proposed estimators are obtained. Simulation results are given to show the performance of the proposed methods.

关键词： Heteroscedasticity nonparametric median regression strong convergence rate variance function local median estimation

AN OSCILLATION CRITERIA FOR SECOND ORDERFUNCTIONAL EQUATIONS

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Acta Mathematica Scientia 2002年第1期22卷 56-62页

作者：申建华 ip. Stavroulakis Department of Mathematics Hunan Normal University Changsha 410081 China Department of Mathematics University of Ioannina 451 10 Ioannina Greece

This paper is concerned with the oscillation of second order linear functional equations of the form x(g(t)) = p(t)x(t) + Q(t)X(g(2)(t)), Where p, Q, g : [t(0), infinity) --> R+ = [0, infinity) are given real valued functions such that g(t) not equivalent to t, lim(t-->infinity) g(t) = infinity. It is proved here that when 0 less than or equal to m := lim inf(t-->infinity) Q(t)p(g(t)) less than or equal to 1/4 all solutions of this equation oscillate if the condition lim(t-->infinity) sup Q(t)p(g(t)) > (1 + root1 -4m/2)(2) (*) is satisfied. It should be emphasized that the condition (*) can not be improved in some sense.

关键词： oscillation nonoscillation functional equations

Generalized time-dependent generator coordinate method for induced fission dynamics

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Frontiers of physics 2024年第4期19卷 1-12页

作者： B.Li D.Vretenar T.Nikšić J.Zhao p.W.Zhao J.Meng State key Laboratory of Nuclear physics and Technology School of PhysicsPeking UniversityBeijing 100871China physics Department Faculty of ScienceUniversity of Zagreb10000 ZagrebCroatia Center for Circuits and Systems Peng Cheng LaboratoryShenzhen 518055China

The generalized time-dependent generator coordinate method(TD-GCM)is extended to include pairing *** correlated GCM nuclear wave function is expressed in terms of time-dependent generator states and weight *** particle–hole channel of the effective interaction is determined by a Hamiltonian derived from an energy density functional,while pairing is treated dynamically in the standard BCS approximation with time-dependent pairing tensor and single-particle occupation *** the inclusion of pairing correlations,various time-dependent phenomena in open-shell nuclei can be described more *** model is applied to the description of saddle-to-scission dynamics of induced *** generalized TD-GCM charge yields and total kinetic energy distribution for the fission of 240pu,are compared to those obtained using the standard time-dependent density functional theory(TD-DFT)approach,and with available data.

关键词： nuclear density functional theory generator coordinate method fission dynamics

Ferroelectricity Induced by Oxygen Vacancies in Rhombohedral ZrO_(2) Thin Films

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Energy & Environmental Materials 2024年第1期7卷 229-237页

作者： Veniero Lenzi José p.B.Silva Břetislav Šmíd Vladimir Matoín Cosmin M.Istrate Corneliu Ghica Judith L.MacManus-Driscoll Luís Marques physics Center of Minho and porto Universities(CF-UM-Up) University of MinhoCampus de Gualtar 4710-057Braga Portugal Laboratory of physics for Materials and Emergent Technologies LapMETUniversity of Minho4710-057Braga Portugal Department of Surface and plasma Science Faculty of Mathematics and PhysicsCharles UniversityV Holešovičkách 218000Prague 8 Czech Republic National Institute of Materials physics 105 bis Atomistilor 077125Magurele Romania Department of Materials Science and Metallurgy 27 Charles Babbage Rd.Cambridge CB3 OFSUK

Rhombohedral phase Hf_(x)Zr_(1.x)O_(2)(HZO,x from 0 to 1)films are promising for achieving robust ferroelectric polarization without the need for an initial wake-up pre-cycling,as is normally the case for the more commonly studied orthorhombic ***,a large spontaneous polarization observed in rhombohedral films is not fully understood,and there are also large discrepancies between experimental and theoretical *** this work,in rhombohedral ZrO_(2)thin films,we show that oxygen vacancies are not only a key factor for stabilizing the phase,but they are also a source of ferroelectric polarization in the *** is shown experimentally through the investigation of the structural properties,chemical composition and the ferroelectric properties of the films before and after an annealing at moderate temperature(400℃)in an oxygen environment to reduce the V_(o)concentration *** experimental work is supported by density functional theory(DFT)calculations which show that the rhombohedral phase is the most stable one in highly oxygen defective ZrO_(2)*** DFT calculations also show that V_(o)contribute to the ferroelectric *** findings reveal the importance of V_(o)for stabilizing rhombohedral ZrO_(2)thin films with superior ferroelectric properties.

关键词： charged defects ferroelectric polarization rhombohedral phase stability zirconia

The presence of D-Alanine in phascolosoma Arcuatum (Sipuncula)

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中山大学学报论丛 1995年第3期15卷 211-213页

作者： W.T.Ong W.p.Low Y.k.ip DepartmentofZoology NationalUniversityofSingaporeDepartmentofZoologyNationalUniversityofSingaporeDepartmentofZoologyNationalUniversityofSingapore

***[1].Inphascolosomaarcuatum,***hods,[2]onlyapproximatelyhalfthetotalamountofalaninedeterminedusing

关键词： ADH Sipuncula The presence of D-Alanine in phascolosoma Arcuatum

Risk of ischaemic and haemorrhagic stroke in Chinese undergoing percutaneous coronary intervention treated with potent p2Y12 inhibitor versus clopidogrel

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Stroke & Vascular Neurology 2022年第4期7卷 310-318,I0015-I0019页

作者： Andrew kei-Yan Ng pauline Yeung Ng April ip kui kai Lau Chung-Wah Siu Cardiac Medical Unit Grantham HospitalHong KongHong Kong Department of Adult Intensive Care Queen Mary HospitalHong KongHong Kong Department of Medicine The University of Hong KongHong KongHong Kong The State key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong KongHong Kong

Background Stroke after acute coronary syndrome(ACS)can be *** is uncertain whether the risks of ischaemic stroke or intracranial haemorrhage(ICH)are associated with different choices of p2Y12 inhibitors(potent p2Y12 inhibitors such as ticagrelor and prasugrel vs clopidogrel).Even though East Asians are known to have different thrombotic and haemorrhagic profiles from Caucasians,data on Chinese patients are *** This was a retrospective cohort study conducting in Chinese patients with ACS who underwent first-ever percutaneous coronary intervention from 14 hospitals in Hong kong between 2010 and *** primary efficacy endpoint was ischaemic *** secondary efficacy endpoint was a composite outcome of thrombotic events including all-cause mortality,non-fatal myocardial infarction and ischaemic *** primary safety endpoint was *** secondary safety endpoint was a composite of major bleeding *** After adjustment of baseline characteristics by 1:1 propensity score matching,a total of 6220 patients(3110 on each group)were *** with clopidogrel,potent p2Y12 inhibitors were associated with a lower risk of ischaemic stroke(HR 0.57;95%CI 0.37 to 0.87;p=0.008)and a lower risk of thrombotic events(HR 0.77;95%CI 0.66 to 0.90;p=0.001).potent p2Y12 inhibitor was associated with similar risk of ICH(HR 0.65;95%CI 0.34 to 1.25,p=0.20)and major bleeding(HR 0.83;95%CI 0.68 to 1.01,p=0.069).Conclusions potent p2Y12 inhibitors were associated with a lower adjusted risk of ischaemic stroke and thrombotic events,compared with *** risks of ICH and major bleeding were similar.

关键词： p2Y12 coronary haemorrhagic

Health correlates, addictive behaviors, and peer victimization among adolescents in China

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World Journal of pediatrics 2018年第5期14卷 454-460页

作者： Qi-Qi Chen Meng-Tong Chen Yu-Hong Zhu ko Ling Chan patrick ip Department of Applied Social Sciences The Hong Kong Polytechnic UniversityHung HomHong KongChina Department of Social Work Renmin University of ChinaHaidianBeijingChina Department of pediatrics and Adolescent Medicine The University of Hong KongPokfulamHong KongChina

Background peer victimization has been recognized as a common social problem affecting children and adolescents in all parts of the world. This study aims to examine the prevalence of different types of peer victimization and to evaluate the associations between peer victimization and health correlates. Methods Using a large population sample of 18,341 adolescents aged 15–17 years from 6 cities in China, this study esti-mated the prevalence of different types of peer victimization, addictive behaviors, and health-related variables with self-administrated questionnaires. A three-phase logistical regression analysis was conducted to investigate the associations between peer victimization and addictive behaviors as well as health-related factors among adolescents. Results A total of 42.9% of the surveyed Chinese adolescents have been bullied by peers, with boys reporting higher rate on overt victimization (36.9%) and girls on relational forms (33.9%). School environment (34.7%) was the most frequent scene of peer violence, followed by neighborhood, family, and internet. Addictive behaviors except substance abuse were found related to higher possibility of peer victimization (aOR 1.21–1.73, ppeer victimization was significantly associated with more depressive symptoms, post-traumatic stress disorder symptoms, and suicide ideation and deliberate self-harm (aOR 1.05–2.27, ppoorer self-esteem and health-related quality of life (aOR 0.95–0.97, ppossible explanations of the associations found in this study are discussed and implications for future services are raised.

关键词： Addictive behavior Adolescent Health peer victimization