检索结果-南通市图书馆

Respiratory Mechanics, Respiratory Muscle Strength, Control of Ventilation and Gas Exchange in patients with Autoimmune Liver Disease

在线全文

学校读者我要写书评

暂无评论

Open Journal of Respiratory Diseases 2024年第2期14卷 25-38页

作者： Ahmet Baydur jacob Korula Divisions of pulmonary Critical Care and Sleep Medicine Los Angeles USA Keck School of Medicine University of Southern California Los Angeles California USA Liver Diseases Rancho Los Amigos National Rehabilitation Center Downey California USA

Objectives: To assess respiratory elastance and resistive properties in patients with autoimmune liver disorders using the passive relaxation expiration technique and compare findings to a group of patients with non-autoimmune liver disease and control subjects. These findings were then related to control of ventilation and gas exchange. A secondary objective was to assess respiratory muscle strength and gas exchange and their relation to respiratory mechanics. Methods: Measurements included respiratory elastance and resistance using the passive relaxation method. pulmonary function, gas exchange and control of ventilation were assessed using standard methods. Results: a) Compared to control subjects, Ers in patients with liver disease was on average 50% greater than in controls;b) mean respiratory resistance, expressed as the respiratory constants, K1 and K2 in the Rohrer relationship, pao/V’ = K1 + K2V’, was not different from control resistance;c) mean maximal inspiratory and maximal expiratory pressures averaged 36% and 55% of their respective control values;d) inspiratory occlusion pressure in 0.1 sec (p0.1) was increased and negatively associated with FVC;and e) increases in p0.1, mean inspiratory flow (Vt/Ti) and presence of respiratory alkalosis confirmed the increase in ventilatory drive. Despite inspiratory muscle weakness in patients, p0.1/pimax averaged 5-fold higher than in control subjects. Conclusions: Despite inspiratory muscle weakness and a V’E similar to that in normal subjects, central drive is increased in patients with chronic liver disease. The increase in ventilatory drive is related to smaller lung volumes and weakly associated with increase in respiratory elastance. Findings confirm that p0.1 is a reliable measure of central drive and is an approach that can be used in the evaluation of control of ventilation in patients with chronic liver dis

关键词： Autoimmune Liver Disease Control of Ventilation Occlusion pressure passive Relaxation Method primary Biliary Cirrhosis Respiratory Elastance Respiratory Resistance

In vivo measurement of NADH fluorescence lifetime in skeletal muscle via -ber-coupled time-correlated single photon counting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2024年第1期17卷 121-134页

作者： Kathryn M.priest jacob V.Schluns Nathania Nischal Colton L.Gattis Jeffrey C.Wolchok Timothy J.Muldoon Department of Biomedical Engineering University of Arkansas FayettevilleARUSA

Nicotinamide adenine dinucleotide(NADH)is a cofactor that serves to shuttle electrons during metabolic processes such as glycolysis,the tricarboxylic acid cycle,and oxidative phosphorylation(OXpHOS).NADH is autofluorescent,and itsfluorescence lifetime can be used to infer metabolic dynamics in living ***-coupled time-correlated single photon counting(TCSpC)equipped with an implantable needle probe can be used to measure NADH lifetime in vivo,enabling investigation of changing metabolic demand during muscle contraction or tissue *** study illustrates a proof of concept for point-based,minimally-invasive NADHfluorescence lifetime measurement in *** muscle loss(VML)injuries were created in the left tibialis anterior(TA)muscle of male Sprague Dawley *** lifetime measurements were collected before,during,and after a 30 s tetanic contraction in the injured and uninjured TA muscles,which was subsequently-t to a biexponential decay model to yield a metric of NADH utilization(cytoplasmic vs protein-bound NADH,the A11/A22 ratio).On average,this ratio was higher during and after contraction in uninjured muscle compared to muscle at rest,suggesting higher levels of free NADH in contracting and recovering muscle,indicating increased rates of *** injured muscle,this ratio was higher than uninjured muscle overall but decreased over time,which is consistent with current knowledge of inflammatory response to injury,suggesting tissue regeneration has *** data suggest that-ber-coupled TCSpC has the potential to measure changes in NADH binding in vivo in a minimally invasive manner that requires further investigation.

关键词： Glycolysis oxidative phosphorylation energy metabolism volumetric muscle loss

Neonatal Direct Rigid Laryngoscopy and Bronchoscopy: A Near Miss

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Anesthesiology 2024年第4期14卷 126-130页

作者： Dennis E. Feierman Mark Kronenfeld jacob Sutton Gil Zoizner Evan p. Salant Department of Anesthesiology Maimonides Medical Center New York USA Rutgers Robert Wood Johnson University Hospital New Brunswick USA Meir Hospital Clalit Health Services Kefar Sava Israel

Airway management is a skill necessary for healthcare providers who manage patients. Intubation is a skill that both anesthesiologists and intensivists use daily. We present a case of a neonate that developed significant worsening stridor after a successful intubation for a hernia repair. After 4 intubation attempts, with easy visualization of the vocal cords and unsuccessful placement of the endotracheal tube, the patient was emergently brought to the operating room for evaluation.

关键词： Neonate Direct Laryngoscopy Intubation

Creation and validation of a novel low-cost dry lab for early resident training and assessment of robotic prostatectomy technical proficiency

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Urology 2024年第2期18卷 133-138页

作者： Kevin Kunitsky Abhishek Venkataramana Katherine E.Fero Jorge Ballon jacob Komberg Robert Reiter Wayne Brisbane Institute of Urologic Oncology Department of UrologyDavid Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA Charles E.Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFLUSA

purpose:To evaluate the preliminary validity and acceptability of a low-cost low-fidelity robotic surgery dry lab for training and assessing residents’technical proficiency with key robotic radical prostatectomy *** and methods:Three standardized inanimate tasks were created to simulate the radical prostatectomy steps of posterior dissection,neurovascular bundle release,and urethrovesical *** trainees and faculty at a single institution completed and evaluated each dry lab *** validity was evaluated by comparing task completion times and Global Evaluative Assessment of Robotic Skills scores across four participant cohorts:medical students(n=5),junior residents(n=5),senior residents(n=5),and attending surgeons(n=7).Content validity,face validity,and acceptabilitywere evaluated through a posttask survey using a 5-point Likert ***:There was a significant difference in the individual and composite task completion times and Global Evaluative Assessment of Robotic Skills scores across all participant cohorts(all pptability for use in residency ***,model realism,compared with human tissue,was poorly *** dry lab production cost was less than US$***:This low-cost procedure-specific dry lab demonstrated evidence of content validity,construct validity,and acceptability for simulating key robotic prostatectomy technical steps and can be used to augment robot-assisted laparoscopic prostatectomy surgical training.

关键词： Robotic surgery education Radical prostatectomy Simulation Dry laboratory Validation

Exploring a New Lifetime Distribution for Modelling the Waiting Time of Bank Customers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Applied Mathematics and physics 2024年第1期12卷 194-209页

作者： Simon A. Ogumeyo jacob C. Ehiwario Festus C. Opone Department of Mathematics Delta State University of Science and Technology Ozoro Nigeria Department of Statistics University of Delta Agbor Nigeria Department of Statistics Delta State University of Science and Technology Ozoro Nigeria

The fitting of lifetime distribution in real-life data has been studied in various fields of research. With the theory of evolution still applicable, more complex data from real-world scenarios will continue to emerge. Despite this, many researchers have made commendable efforts to develop new lifetime distributions that can fit this complex data. In this paper, we utilized the KM-transformation technique to increase the flexibility of the power Lindley distribution, resulting in the Kavya-Manoharan power Lindley (KMpL) distribution. We study the mathematical treatments of the KMpL distribution in detail and adapt the widely used method of maximum likelihood to estimate the unknown parameters of the KMpL distribution. We carry out a Monte Carlo simulation study to investigate the performance of the Maximum Likelihood Estimates (MLEs) of the parameters of the KMpL distribution. To demonstrate the effectiveness of the KMpL distribution for data fitting, we use a real dataset comprising the waiting time of 100 bank customers. We compare the KMpL distribution with other models that are extensions of the power Lindley distribution. Based on some statistical model selection criteria, the summary results of the analysis were in favor of the KMpL distribution. We further investigate the density fit and probability-probability (p-p) plots to validate the superiority of the KMpL distribution over the competing distributions for fitting the waiting time dataset.

关键词： KM-Transformation power Lindley Distribution Data Fitting Moments Quantiles

A randomized controlled trial of promoting physical Activity in Regional and Remote Cancer Survivors(ppARCS)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第1期13卷 81-89页

作者： Sarah J.Hardcastle Chloe Maxwell-Smith Vinicius Cavalheri Terry Boyle Marta Leyton Román Cameron platell Michael Levitt Christobel Saunders Frank Sardelic Sophie Nightingale jacob McCormick Craig Lynch paul A.Cohen Max Bulsara Dana Hince Sport and physical Activity Research Centre Sheffield Hallam UniversitySheffieldS102BPUK Institute for Health Research The University of Notre DameFremantleWA 6959Australia Curtin School of population Health Curtin UniversityPerthWA 6845Australia Curtin School of Allied Health Curtin UniversityPerthWA 6845Australia Allied Health South Metropolitan Health ServiceMurdochWA 6150Australia Australian Centre for precision Health University of South AustraliaAdelaideSA 5001Australia Department of Didactics of Musical Plastic and Body ExpressionUniversity of ExtremaduraCaceres 10071Spain St.John of God Subiaco Hospital PerthWA 6008Australia Department of Surgery University of MelbourneMelbourneVIC 3010Australia Tamara private Hospital TamworthNSW 2340Australia peter MacCallum Cancer Centre MelbourneVIC 3000Australia College of Health and Medicine Australian National UniversityCanberraACT 2600Australia Division of Obstetrics and Gynaecology Medical SchoolUniversity of Western AustraliaPerthWA 6009Australia

Background:physical activity(pA)is important for cancer *** of remotely delivered interventions are needed to assist in reaching under-served non-metropolitan cancer *** objective of this study was to ascertain whether wearable technology,coupled with health coaching was effective in increasing pA in breast and colorectal cancer survivors living in regional and remote areas in ***:Cancer survivors from 5 states were randomized to intervention and control *** participants were given a Fitbit Charge 2TMand received up to 6 telephone health coaching *** participants received pA print *** assessments at baseline and 12 weeks measured moderate-to-vigorous pA(MVpA),light pA,and sedentary ***:Eighty-seven participants were recruited(age=63±11 years;74(85%)female).There was a significant net improvement in MVpA of 49.8 min/week,favoring the intervention group(95%confidence interval(95%CI):13.6-86.1,p=0.007).There was also a net increase in MVpA bouts of 39.5 min/week(95%CI:11.9-67.1,p=0.005),favoring the intervention *** groups improved light pA and sedentary behavior,but there were no between-group ***:This’s the first study to demonstrate that,when compared to standard practice(i.e.,pA education),a wearable technology intervention coupled with distance-based health coaching,improves MVpA in non-metropolitan cancer *** results display promise for the use of scalable interventions using smart wearable technology in conjunction with phone-based health coaching to foster increased pA in geographically disadvantaged cancer survivors.

关键词： Behavior change Exercise Health disparities Oncology Wearable technology

Analysis of the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension

在线全文

学校读者我要写书评

暂无评论

Chronic Diseases and Translational Medicine 2024年第2期10卷 102-117页

作者： Nicholas R.powell Tyler Shugg jacob Leighty Matthew Martin Rolf p.Kreutz Michael T.Eadon Dongbing Lai Tao Lu Todd C.Skaar Division of Clinical pharmacology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Department of pharmacology and Toxicology School of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Cardiology School of MedicineKrannert Institute of CardiologyIndiana UniversityIndianapolisIndianaUSA Division of Nephrology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Medical and Molecular Genetics School of MedicineIndiana UniversityIndianapolisIndianaUSA

Background Hypertension(HTN)involves genetic variability in the renin-angiotensin system and influences antihypertensive *** previously reported that angiotensinogen(AGT)messenger RNA(mRNA)is endogenously bound by miR-122-5p and rs699 A>G decreases reporter mRNA in the microRNA functional-assay *** AGT promoter variant rs5051 C>T is in linkage disequilibrium(LD)with rs699 A>G and increases AGT *** independent effect of these variants is understudied due to their LD therefore we aimed to test the hypothesis that increased AGT by rs5051 C>T counterbalances AGT decreased by rs699 A>G,and when these variants occur independently,it translates to HTN-related *** We used in silico,in vitro,in vivo,and retrospective models to test this *** In silico,rs699 A>G is predicted to increase miR-122-5p binding affinity by 3%.Mir-eCLIp results show rs699 is 40–45 nucleotides from the strongest microRNA-binding site in the AGT ***,rs699 A>G increases AGT mRNA in an AGT-plasmid-cDNA HepG2 expression ***-Tissue Expression(GTEx)and UK Biobank analyses demonstrate liver AGT expression and HTN phenotypes are not different when rs699 A>G occurs independently from rs5051 C>***,GTEx and the in vitro experiments suggest rs699 A>G confers cell-type-specific effects on AGT mRNA abundance,and suggest paracrine renal renin-angiotensin-system perturbations could mediate the rs699 A>G associations with *** We found that rs5051 C>T and rs699 A>G significantly associate with systolic blood pressure in Black participants in the UK Biobank,demonstrating a fourfold larger effect than in White *** studies are warranted to determine if altered antihypertensive response in Black individuals might be due to rs5051 C>T or rs699 A>*** like this will help clinicians move beyond the use of race as a surrogate for genotype.

关键词： angiotensinogen genetic and genomic medicine hypertension rs699

Effect of post-thermal annealing on the structural and optical properties of ZnO thin films prepared from a polymer precursor

在线全文

学校读者我要写书评

暂无评论

Chinese physics B 2012年第7期21卷 551-558页

作者： Jijoy.p.Mathew George Varghese jacob Mathew Thin Film Research Laboratory Department of PhysicsSt.Berchmans CollegeChanganasseryKerala 686101India Department of physics Calicut UniversityThenjippalamKeralaIndia

ZnO thin films were synthesised by a new method which uses polyvinyl alcohol （pVA） as the polymer precursor. The films are annealed at different temperatures and for different annealing times. The structural parameters, like grain size, lattice constants, optical band gap, and Urbach energy, depend on the annealing temperature and time. All the films possess tensile strain, which relaxes as the annealing temperature and time increase. The photoluminescence （pL） spectra contain only ultraviolet （UV） peaks at low temperature, but as the annealing temperature and time increase, we observe peaks at the blue and green regions with a variation in the intensities of these peaks with annealing temperature and time.

关键词： stress, band gap, Urbach energy photoluminescence

Influences of at-sea fishery monitoring on science, management, and fleet dynamics

在线全文

学校读者我要写书评

暂无评论

Aquaculture and Fisheries 2020年第3期5卷 107-112页

作者： jacob p.Kritzer Environmental Defense Fund 18 Tremont StreetBostonMA02108USA

Fisheries are complex systems comprised of scientific,management,fishing fleet,and ecological *** the composition,behavior,and functions of these sub-systems vary considerably,a review of case studies,research,and theory illustrates that one positive and pervasive influence across all can be at-sea monitoring of fishing activity and ***-sea monitoring provides reliable and high-resolution data on spatial and temporal patterns in effort and total catch,and the taxonomic and life stage composition of catch,thereby improving the science underlying management *** decisions can draw upon a wider range of approaches,such as rights-based management and finer scale spatial,temporal,and catch restrictions,that require the greater oversight facilitated by *** science and implementation can in turn increase confidence in management among the fishing fleet,bolstered by the knowledge that other fishers are equally accountable for their *** series of positive outcomes represent a self-reinforcing virtuous cycle in the ***,breakdowns in science,management,and fishing behavior can create an‘accountability cascade’of blame,distrust,and ***,effective at-sea monitoring,in combination with other reforms,can move fisheries away from overexploitation and toward *** to this transformation is a growing toolkit of technological innovations that increasingly make at-sea monitoring more feasible in fleets spanning diverse ecological,economic,political,and operational gradients.

关键词： Monitoring Accountability Uncertainty Incentives Compliance