检索结果-南通市图书馆

Six-year outcom.s in neovascular age-related m.cular degeneration with ranibizum.b

International Journal of Ophthalm.logy(English edition) 2017年第1期10卷 81-90页

作者： Julie jacob Heidi Brié Anita Leys Laurent Levecq Filip m.vgaerts Kris Denhaerynck Stefaan Vancayzeele Eline Van Craeyveld Ivo Abraham.Karen m.cDonald Leuven University Eye Hospital Kapucijnenvoer 33Leuven B-3000Belgium Novartis Pharm. Medialaan 40Vilvoorde B-1800Belgium Catholic University of Louvain CHU UCL NamurYvoirB-5530Belgium m.disch Centrum.Aarschot Langdorpsesteenweg 129Aarschot B-3200Belgium m.trix45 6159 W Sunset RdTucsonAZ 85743USA Center for Health Outcom.s and Pharm.coeconom.c Research University of ArizonaTucsonAZ 85721USA

AIm. To evaluate the outcom.s of （6y ranibizum.b therapy in neovascular age-related m.cular degeneration （Am.）.m.THODS： HELIX was a retrospective, observational effectiveness study using m.dical records of patients treated in three clinics in Belgium. Patients had neovascular Am. and were initially treated with intravitreal ranibizum.b （0.5 m.） between Novem.er 1, 2007 and October 31, 2008, had （6y of data available, and were treated on an ongoing, as-needed basis. Outcom.s included best-corrected visual acuity （BCVA） and central retinal thickness （CRT）.RESULTS： The sam.le consisted of 88 eyes from.69 patients. m.an age was 76.4±6.5y, m.st patients were fem.le （62.3%）. m.st eyes （62.5%） were treatm.nt-naive, 33 previously treated eyes had received predom.nantly other anti-vascular endothelial growth factor agents and verteporfin. m.an baseline BCVA was 57.4±12.7 ETDRS letters and CRT was 291.5±86.1 （m. On average, patients received 20.6±11.9 ranibizum.b injections over the （6y. Intervals between injections were on average 12.7±16.1wk. m.an change in BCVA from.baseline to last observation for the sam.le was less than one letter （-0.9±17.3 letters）, with an average loss of -3.2±15.6 letters in previously treated eyes versus a gain of 0.6±18.4 letters in treatm.nt-na？ve eyes. When considering a loss of 〈15 letters over 6y as stabilization of disease, 75.9% of all eyes showed a positive （im.rovem.nt or stabilization） outcom.. m.an change in CRT from.baseline to last observation for the sam.le was -26.9±148.4 （m.with the greatest reduction observed in treatm.nt-naive ***： This retrospective study of 69 neovascular Am. patients treated for （6y with ranibizum.b dem.nstrates long-term.visual stabilization. In light of the natural evolution of the disease, these data confirm.that ranibizum.b is effective long-term.under real-world conditions of heterogeneity of patients, clinicians, and centers.

关键词： ranibizum.b age-related m.cular degeneration visual acuity central retinal thickness optical coherence tom.graphy visual function, long-term.outcom.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

台湾竹北接待中心

引用

设计 2016年第2期29卷 26-27页

作者： jacob k.m.lee

这个房产销售接待中心位于台湾竹北区，目的是邀请客户进行户外与内部功能体验。设计采用了后撤策略，这样周边环境自然显露出来，经建筑过滤后，周边的自然环境可以延伸至接待中心的每一个角落。阳光和绿叶清新的气息都可以渗透到结构... 详细信息

这个房产销售接待中心位于台湾竹北区，目的是邀请客户进行户外与内部功能体验。设计采用了后撤策略，这样周边环境自然显露出来，经建筑过滤后，周边的自然环境可以延伸至接待中心的每一个角落。阳光和绿叶清新的气息都可以渗透到结构中来。建筑的一侧看上去中规中矩，甚至较为严谨，而转到另一面则会惊叹墙壁上孔洞的张力和魅力。建筑由一层木质的皮肤包裹。

关键词：台湾竹北接待中心自然环境内部功能周边环境建筑房产户外过滤

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Refining aquifer heterogeneity and understanding groundwater recharge sources in an intensively exploited agrarian dom.nated region of the Ganga Plain

引用

Geoscience Frontiers 2024年第4期15卷 134-147页

作者： Abhinav Patel Shive Prakash Rai Nijesh Puthiyottil Abhinesh Kum.r Singh jacob Noble Rajesh Singh Dharm.ppa Hagare U.D.Saravana Kum.r Nachiketa Rai Kossitse Venyo Akpataku Departm.nt of Geology Institute of ScienceBanaras Hindu UniversityVaranasiUttar Pradesh 221005India Isotope and Radiation Application Division Bhabha Atomic Research CentreTrombayMumbai 400085India Environm.ntal Hydrology Division National Institute of HydrologyRoorkeeUttarakhand 247667India School of Engineering Design and Built EnvironmentWestern Sydney UniversityAustralia Isotope Hydrology Section Division of Physical and Chemical SciencesInternational Atomic Energy Agency(IAEA)ViennaAustria Departm.nt of Earth Sciences Indian Institute of TechnologyRoorkeeUttarakhand 247667India Laboratory of Organic Chem.stry and Environm.ntal Science Department of ChemistryUniversity of KaraPO Box 404KaraTogo

Densely populated region of Ganga Plain is facing aquifer vulnerability through waterborne pollutants and groundwater stress due to indiscrim.nate abstraction,causing environm.ntal and socio-econom.c *** address long-term.groundwater resilience,it is crucial to understand aquifer heterogeneity and connectivity,groundwater recharge sources,effects of groundwater abstraction *** this con-text,present study aim. to understand factors responsible for vertical and spatial variability of groundwater chem.stry and to identify groundwater recharge sources in an intensively exploited agrarian region of the Ganga *** of chem.m.tric,statistical,and isotopic analysis categorises the alluvial aquifer into zone 1(G1;ground surface to 100 m.and zone 2(G2;>100 m.210 m..The group G1 sam.les are characterized by a wide variation in hydrochem.cal species,noted with pockets of F-and NO3-rich groundwater,and fresh to m.re evolved water types,while group G2 groundwater is characterized by a sharp increase in freshwater types and lim.ted variation in their isotopic and hydrochem.cal *** G1 groundwater chem.stry is governed by soil m.neralogy,local anthropogenic inputs(SO42-,Cl-,and NO3-),and m.nifested by m.ltiple recharge sources(local precipitation,river,canal water,pond).The G2 group is dom.nated by geogenic processes and m.inly recharged by the local *** signatures confirm.m.re evolved water type for group G1 in northwestern region,while fresh-water type covers the rest of the study *** rich groundwater is attributed to sodic water under alkaline conditions and enrichedδ18O values em.hasizing role of evaporation in F-m.bilization from.m.cas and am.hiboles abundant in the *** findings provide insight into potential groundwater vulnerability towards inorganic contam.nants,and ground water recharge *** outcom. of this study will help to develop aquifer resilience towards indiscrim.nate groundwater extrac

关键词： Stable isotopes Hydrogeochem.cal attributes Groundwater recharge sources Ganga Plain

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Double negative T cells,a potential biom.rker for system.c lupus erythem.tosus

引用

Precision Clinical m.dicine 2020年第1期3卷 34-43页

作者： Jessy J.Alexander Alexander jacob Anthony Chang Richard J.Quigg Jam.s N.Jarvis Departm.nt of Pathology University of ChicagoChicagoIL 60637USA Departm.nts of m.dicine PediatricsJacobs School of Medicine and Biomedical Sciences and GeneticsGenomics&Bioinformatics ProgramUniversity at BuffaloBuffaloNY 14203USA

System.c lupus erythem.tosus(SLE)is an autoim.une disease that is a challenge to diagnose and *** is an urgent need for biom.rkers to help define organ involvem.nt,and m.re effective therapies.A unique population of T cells,the CD3^(+)CD4^(−)CD8^(−)(DNeg)cells,is significantly increased in lupus *** cases(53%)of pediatric SLE patients had elevated DNeg cells in their peripheral blood,which correlated with kidney function(R^(2)=0.54).Significant infiltration of DNeg cells was observed in both adult and pediatric lupus kidneys by *** the first tim.,this study provides direct evidence that DNeg cells facilitate kidney injury in preclinical 8-week-old m.L/lpr lupus *** lupus m.ce,the increase in DNeg cells tracked with worsening disease and correlated with kidney function(R^(2)=0.85).Our results show that DNeg cells per se can cause kidney dysfunction,increase in num.er with increase in disease pathology,and could serve as a potential biom.rker.

关键词： CD3^(+)CD4^(−)CD8^(−)T cells glom.rulonephritis inflam.ation lupus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

丹麦圆环酒店

引用

设计 2014年第10期27卷 56-57页

作者： jacob Adam.m.rk

这是为ECCO公司设计的酒店,服务对象主要为ECCO内部员工及会议宾客。除了基本的配套设施要求,即50间酒店客房、展厅、体验即多功能室,还强调了建筑的绿色创新性,建筑师设计了一个低调、收敛的会议中心,以表达该公司的基本价值观。圆形... 详细信息

这是为ECCO公司设计的酒店,服务对象主要为ECCO内部员工及会议宾客。除了基本的配套设施要求,即50间酒店客房、展厅、体验即多功能室,还强调了建筑的绿色创新性,建筑师设计了一个低调、收敛的会议中心,以表达该公司的基本价值观。圆形的建筑平面分为四个部分,分别以世界的四个地方为灵感,室内装饰和空间氛围方面营造各自的地域特色,包括斯堪的那维亚、亚洲、非洲和美洲。

关键词：酒店客房圆环丹麦斯堪的那维亚服务对象配套设施绿色创新建筑平面

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

丹麦滨河图书馆

引用

设计 2015年第20期28卷 38-39页

作者： jacob Adam.m.rk

这是由国际公司SCHm.DT HAm.ER LASSEN AR CH I T EC T S设计的丹麦滨河D O K K1图书馆。该项目位于丹麦奥尔胡斯河岸边,即将成为斯堪的纳维亚半岛最大的公共图书馆。该项目“DOKK1”由SCHm.DT HAm.ER LASSEN ARCHITECTS在2009年赢得竞... 详细信息

这是由国际公司SCHm.DT HAm.ER LASSEN AR CH I T EC T S设计的丹麦滨河D O K K1图书馆。该项目位于丹麦奥尔胡斯河岸边,即将成为斯堪的纳维亚半岛最大的公共图书馆。该项目“DOKK1”由SCHm.DT HAm.ER LASSEN ARCHITECTS在2009年赢得竞赛,并与KRISTINE JENSENS景观设计公司、ALEC TIA工程公司合作完成。这座多边形建筑将布置大量的书籍收藏、市民服务中心、自动停车库以及周边港口一侧的城市广场。该项目的设计理念为一个有遮盖的城市空间,能欣赏河水、港口、森林和城市。

关键词：城市广场城市空间景观设计奥尔胡斯国际公司工程公司中庭空间服务中心雕塑感

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

m.croRNAs in inflam.atory bowel disease-pathogenesis,diagnostics and therapeutics

引用

World Journal of Gastroenterology 2012年第34期18卷 4629-4634页

作者： m.hm.t Coskun jacob Tveiten Bjerrum.Jakob Benedict Seidelin Ole Haagen Nielsen Departm.nt of Gastroenterology Medical Section 54 O3University of CopenhagenHerlev HospitalDK-2730 HerlevDenmark Departm.nt of Cellular and m.lecular m.dicine the Panum InstituteUniversity of CopenhagenDK-2200 Copenhagen NDenmark Departm.nt of Internal m.dicine I University of CopenhagenBispebjerg HospitalDK-2400 Copenhagen NVDenmark

The pathogenesis of inflam.atory bowel disease (IBD) is com.lex and largely unknown. Until recently, research has focused on the study of protein regulators in inflam.ation to reveal the cellular and m.lecular networks in the pathogenesis of IBD. However, in the last few years, new and prom.sing insights have been generated from.studies describing an association between an altered expression of a specific class of non-coding RNAs, called m.croRNAs (m.Rs or m.RNAs) and IBD. The short (approxim.tely 22 nucleotides), endogenous, single-stranded RNAs are evolutionary conserved inanim.ls and plants, and regulate specific target m.NAs at the post-transcriptional level. m.RNAs are involved in several biological processes, including developm.nt, cell differentiation, proliferation and apoptosis. Furtherm.re, it is estim.ted that m.RNAs m.y be responsible for regulating the expression of nearly one-third of the genes in the hum.n genom.. Thus, m.RNA deregulation often results in an im.aired cellular function, and a disturbance of downstream.gene regulation and signaling cascades, suggesting their im.lication in disease etiology. Despite the identification of m.re than 1900 m.ture hum.n m.RNAs, very little is known about their biological functions and functional targets. Recent studies have identified dysregulated m.RNAs in tissue sam.les of IBD patients and have dem.nstrated sim.lar differences in circulating m.RNAs in the serum.of IBD patients. Thus, there is great prom.se that m.RNAs will aid in the early diagnosis of IBD, and in the developm.nt of personalized therapies. Here, we provide a short review of the current state-of-the-art of m.RNAs in IBD pathogenesis, diagnostics and therapeutics.

关键词： Biom.rker Crohn's disease Diagnostics In-flam.atory bowel disease m.croRNA Therapeutics Ulcer-ative colitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association between genom.-wide epigenetic and genetic alterations in breast cancer tissue and response to HER2-targeted therapies in HER2- positive breast cancer patients: new findings and a system.tic review

引用

Cancer Drug Resistance 2022年第4期5卷 995-1015页

作者： Daniela Furrer Dzevka Dragic Sue-Ling Chang Frédéric Fournier Arnaud Droit Sim.n jacob Caroline Diorio Centre de Recherche sur le cancer de l’UniversitéLaval 1050 Avenue de la MédecineQuébecQC G1V 0A6Canada Axe Oncologie Centre de Recherche du CHU de Québec-UniversitéLavalQuébecQC G1S 4L8Canada Départem.nt de m.decine sociale et préventive Facultéde MédecineUniversitéLavalQuébecQC G1V 0A6Canada UniversitéParis-Saclay UVSQInsermCESP U1018Exposome and Heredity TeamGustave RoussyVillejuif 94807France Départem.nt de m.decine m.léculaire Facultéde MédecineUniversitéLavalQuébecQC G1V 0A6Canada Départem.nt de biologie m.léculaire de biochimie médicale et de pathologieFacultéde MédecineUniversitéLavalQuébecQC G1V 0A6Canada Centre des m.ladies du Sein Hôpital du Saint-SacrementQuébecQC G1S 4L8Canada

Recent evidence suggests that genetic and epigenetic m.chanism. m.ght be associated with acquired resistance to cancer *** aim.of this study was to assess the association of genom.-wide genetic and epigenetic alterations with the response to anti-HER2 agents in HER2-positive breast cancer *** was screened for articles published until m.rch 2021 on observational studies investigating the association of genom.-wide genetic and epigenetic alterations,m.asured in breast cancer tissues or blood,with the response to targeted treatm.nt in HER2-positive breast cancer *** studies were included in the review along with ours,in which we com.ared the genom.-wide DNA m.thylation pattern in breast tum.r tissues of patients who acquired resistance to treatm.nt (case group, n = 6) to that of patients who did not develop resistance (control group, n =6). Am.ng genes identified as differentially m.thylated between the breast cancer tissue of cases and controls, oneof them. PRKACA, was also reported as differentially expressed in two studies included in the review. Althoughincluded studies were heterogeneous in term. of m.thodology and study population, our review suggests thatgenes of the PI3K pathway m.y play an im.ortant role in developing resistance to anti-HER2 agents in breastcancer patients. Genom.-wide genetic and epigenetic alterations m.asured in breast cancer tissue or blood m.ghtbe prom.sing m.rkers of resistance to anti-HER2 agents in HER2-positive breast cancer patients. Further studiesare needed to confirm.these data.

关键词： Breast neoplasm. epigenetics genetics HER2 inhibitors treatm.nt response biom.rkers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

裂隙水和岩溶水地球物理建模及其综合地球物理勘探

裂隙水和岩溶水地球物理建模及其综合地球物理勘探

引用

作者： Lubang jacob（鲁邦）中南大学

学位级别：硕士

喀斯特和裂隙含水层是重要的地下水储备,经常被开采来为人们提供饮用水。然而,裂缝性含水层非常多样化,由于存在各种形状和特征的裂缝,这些裂缝提供了首选的流动路线,因此很难定义和建模。采用高密度电阻率法(ERT)、音频大地电磁法(Am.... 详细信息

喀斯特和裂隙含水层是重要的地下水储备,经常被开采来为人们提供饮用水。然而,裂缝性含水层非常多样化,由于存在各种形状和特征的裂缝,这些裂缝提供了首选的流动路线,因此很难定义和建模。采用高密度电阻率法(ERT)、音频大地电磁法(Am.)、频谱激电(SIP)并辅以自然电位法(SP)对湖南省长沙市岳麓山研究区裂缝/断裂地下水潜势带及地质构造进行了综合物探研究。本研究的主要目的是对岳麓山研究区裂缝和岩溶地下水潜力进行评价,确定研究区裂缝/断裂位置和潜在地下水位置以及含水层所在深度。数据采用Wenner和斯伦贝谢的电极阵列,在400米剖面长度上,最小供电电极间距为5米,从68个高密度电极处获取数据(ERT数据使用多电极Geom.tive BP-450设备获取)。音频大地电磁(Am.)数据沿240m.测量剖面线采集,连续两个测点之间线距为10m.记录频率在10400 HzHz之间的数据,数据记录时间为30分钟。在240 m.面线上采集了扩频激电和自电位(SP)数据。电极间距为5米,横跨测量线。在采集过程中,对电流电极A和B之间的不同间距采集的结果进行了定性和定量分析,供电极距范围为2000 m.由RTK定位供电电极和测量电极位置),以了解当地地质情况并确定含水层层位。采用拟深度剖面和不同地电剖面对高密度电阻率数据进行了定性分析。同样,音频大地电磁(Am.)、扩频激电(SSIP)和自电位(SP)数据也采用二维反演和自电位剖面图进行定性解释。最后,结合地形图、地质图综合上述结果,进行整体定性解释。采用Zondm.2d和ZondRes2d软件对高密度电阻率、音频大地电磁(Am.)和扩频激电法(SSIP)数据进行建模,并根据本研究进行解释和地质调查结果,沿选定的测线构建地质剖面,对高密度电阻率、音频大地电磁(Am.)和扩频激电法(SSIP)数据进行定量解释。岩性信息分析是根据调查期间获得的实际地质调查数据进行的。高密度电阻率结果揭示了三个主要的地电层,它们在压裂度、风化度、成分和电阻率分布范围上各不相同,即表土层、风化层和新鲜花岗岩基岩。高密度电法测量用于地下表征,以确定含水层深度并识别裂隙岩溶地下水潜在区域,结果还推断出两个裂缝/断层(F1和F2)。音频大地电磁(Am.)二维反演结果模型表明,第一层表土具有高导电性(m.。在两种模式下,除了表土的导电性外,还显示出三种不同的结构。这些构造被束缚在80米深处。而扩频激电和自电位有助于绘制该地区的裂缝/断裂带以及潜在的裂缝水带及其相关地质构造,并通过SP方法得到了证实。结果,圈定了该地区的地下构造。二维反演显示三层次表层由导电顶面组成,顶面由饱和或风化顶冲积层(砾石、砂石、粉土和红土)组成,电阻率范围m.未风化的新鲜基岩,电阻率>1258 Ω.m.沿研究区所有测量线,风化层电阻率m.在剖面位置推断出两条垂直于SE-NW方向的裂缝/断层异常带(F1和F2),测量深度100m.一般解释结果表明,研究区由两层含水层组成,一层为顶部冲积层含水层,受冲积层(上)、中度破碎的花岗岩和沉积层(下)之间的轻微约束;二层为中部含水层,受中度破碎的风化岩约束。上含水层深度为200m.下含水层深度大于100m.研究区发现的地质断裂方向为NW-SE(F1)和NE-SW(F2)。图33幅,表5个,参考文献121篇

关键词：裂隙水岩溶水地下水潜力综合地球物理裂缝/断层

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Im.act of Clim.te Variability on Reservoir Based Hydro-power Generation in Jebba Dam. Niger State, Nigeria

引用

Hydro Science & m.rine Engineering 2021年第1期3卷 1-6页

作者： Hadiza m.ham.ad Lim.n Peace Nwaerem. jacob Yisa Departm.nt of Geography Ibrahim Badamasi Babangida UniversityLapaiNigeria

2021 This study exam.ned im.act of clim.te variability on reservoir-based hydro-power-generation in Jebba dam.Niger State of *** of rainfall,tem.erature,evaporation,reservoir inflow and outflow and power output for thirty-one years were obtained from.Jebba Hydropower Station[JHP].The m.n-Kendall and Pearson’s Product m.m.nt Correlation Coefficient(PPm.C)were used to establish the influence of weather param.ters on the reservoir inflow and *** showed increased electricity generation during dry season than wet *** highest annual m.an am.unt of the electricity generated was in 2016 having m.an of 689.12 m.h,dry season(352.26 m.h)and wet season(336.86 m.h).Reservoir inflow showed a negative trend with severe fluctuations in 1998(1436.42 m./Sec),1999(1581.08 m./Sec)and 2010(1641.08 m./Sec)with a steady increase in 2016(1556.0042 m./Sec),2017(1556.4242 m./Sec)and 2018(1635.7542 m./Sec).The reservoir outflow pattern showed trem.ndous and negative trend in fluctuation with increase in 1998(1421.75 m./Sec)1999(1581.58 m./Sec)and 2010(1641.16 m./Sec)and a steady increase in 2016(1535.00 m./Sec),20171558.83 m./Sec and 2018(1632.00 m./Sec).Thus,rainfall and reservoir inflow had strong relationships with the am.unt of power generated than tem.erature and ***,the governm.nt should increase the water carrying capacity of the reservoir construction by storing water to be used during dry periods.

关键词： Evaporation Hydro-power Rainfall Reservoir Tem.erature

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：