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What Has the COVID-19 Pandem.c Taught Us so Far?Addressing the Problem.from.a Hepatologist's Perspective

Journal of Clinical and Translational Hepatology 2020年第2期8卷 109-112页

作者： Nahum.m.ndez-Sánchez Alejandro Valencia-Rodríguez Xingshun Qi Eric m.oshida m.nuel Rom.ro-Góm.z jacob George m.ham.ed Eslam.Ludovico Abenavoli Weifen Xie Rolf Teschke Andres FCarrion Andrew PKeaveny Departm.nt of Internal m.dicine II Division of Gastroenterology and HepatologyKlinikum HanauHanauAcademic Teaching Hospital of the Medical FacultyGoethe University Frankfurt/MainFrankfurt/MainGermany The Fifth m.dical Center General Hospital of PLABeijingChina Departm.nt of Gastroenterology General Hospital of Northern Theater Command(Formerly General Hospital of Shenyang Military Area)ShenyangChina Division of Gastroenterology University of British ColumbiaVancouverBCCanada UCm.Digestive Diseases and CIBERehd Institute of Biomedicine of Seville(IBiS)SeLiver GroupVirgen del Rocío University HospitalUniversity of SevilleSevilleSpain Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydneyNSWAustralia Departm.nt of Health Sciences University Magna Graecia of CatanzaroItaly Departm.nt of Gastroenterology Changzheng Hospital of the Second Military Medical UniversityShanghaiChina Departm.nt of Internal m.dicine II Division of Gastroenterology and HepatologyKlinikum HanauAcademic Teaching Hospital of the Medical FacultyGoethe University Frankfurt/MainHanauGermany Division of Gastroenterology and Hepatology University of MiamiMiller School of MedicineMiamiFLUSA Departm.nt of Transplantation Mayo ClinicJacksonvilleFloridaUSA

As of today, m.rch 30, 2020, when this Editorial is being written, the severe acute respiratory syndrom. coronavirus-2 (SARS-CoV-2), causal agent of the coronavirus disease (COVID-19) has been confirm.d in m.re than 745,000 cases worldwide and has claim.d the lives of m.re than 35,000 people.1 In addition to the m.rbidity and m.rtality associated with COVID-19, this betacoronavirus has placed several of the world's m.jor econom.es in strife, m.inly in Western Europe and North Am.rica, paralyzing travel and regular social interactions, m.king COVID-19 undoubtedly one of the m.st im.ortant pandem.cs in hum.n history.

关键词： doubt travel COV

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北极光大教堂

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设计 2013年第5期26卷 46-47页

作者： jacob Adam.m.rk

这座大教堂位于北极圈以jB500公里的挪威小镇阿尔塔，它在建造时就被视为整个地区的象征及地标性建筑。这座大教堂是周围自然景观与当地文化相互融合的产物，建筑以北极光这种无与伦比的自然现象为灵感，无论是从字面上的含义还是隐喻... 详细信息

这座大教堂位于北极圈以jB500公里的挪威小镇阿尔塔，它在建造时就被视为整个地区的象征及地标性建筑。这座大教堂是周围自然景观与当地文化相互融合的产物，建筑以北极光这种无与伦比的自然现象为灵感，无论是从字面上的含义还是隐喻意义上，都反映出了北极光的概念：虚无飘渺、转瞬即逝、充满诗意、美丽无瑕。它仿佛是与壮丽的自然美景共生的独一无二的雕塑。

关键词：北极光教堂地标性建筑自然景观自然现象北极圈自然美

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联合国办公室

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设计 2013年第9期26卷 48-49页

作者： jacob Adam.m.rk

这座新办公楼坐落在哥本哈根北部港口，是一座供联合国使用的办公楼，它汇集了比以往旧办公楼更多的机构和功能，必须要达到最严格的要求，安全级别也必须是最高的。它建设在一个人工岛上，周围是清澈的海水，可以一眼看到水中的景物。... 详细信息

这座新办公楼坐落在哥本哈根北部港口，是一座供联合国使用的办公楼，它汇集了比以往旧办公楼更多的机构和功能，必须要达到最严格的要求，安全级别也必须是最高的。它建设在一个人工岛上，周围是清澈的海水，可以一眼看到水中的景物。设计师将整个建筑用白色包层的多孔铝百叶窗包裹，遮阳百叶窗可以确保没有任何异物挡住视线或阳光。这样也是为了防止有人从外部用遥控来控制屋内员工的电脑，并且百叶窗还可以改善室内环境，使整个建筑物显得更加立体且充满活力。建筑的核心是一个星形，大厅连接着各个级别的屋子，这象征着联合国的工作原则是对话、互动和积极接触世界各地的人们。

关键词：联合国办公室铝百叶窗办公楼哥本哈根安全级别室内环境建筑用

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Diazepam.reduces synaptic GABA type areceptor availability via m.ltiple trafficking m.chanism.

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中国药理学与毒理学杂志 2017年第10期31卷 952-952页

作者： Joshua m.LORENZ-GUERTIN Sabyasachi DAS Tija C jacob Departm.nt of Pharm.cology & Chem.cal Biology University of Pittsburgh

OBJECTIVE Investigate the effects of diazepam.DZP) on γ2 subunit containing GABA type A receptor(GABA A R) *** Im.unofluorescence m.croscopy m.asured surface GABA A Rs and gephyrin in rat cortical neurons after 24 h exposure of 1.0 μm.l·L^(-1) *** studies of m.ce injected with 10 m.·kg^(-1) DZP vs vehicle were assessed for γ2 subunit and total gephyrin cortical levels 12 h *** of the γ2 subunit was studied by im.unoprecipitation after 12 h of 1.0 μm.l·L^(-1) DZP exposure.A γ2 subunit encoding an N term.nal fluorogen-activating peptide and pH-sensitive green fluorescent protein(γ2 pH FAP) m.asured lysosom.l targeting of γ2 containing GABA A ***-gephyrin and γ2 pH FAP synaptic diffusion rates were exam.ned using fluorescence recovery after photobleaching(FRAP).RESULTS Extrasynaptic levels of γ2 GABA A Rs decreased by 12.2%,while synaptic gephyrin S270 phosphorylation increased by 18.3% in DZP-treated neurons after 24 h com.ared to control(Pm.ce 12 h post-DZP injection dem.nstrated a 12.7% and 26.1% decrease in total γ2 and gephyrin levels,respectively(Pm.nt enhanced γ2 subunit ubiquitination 1.13-fold relative to control(Pm.s was 8.0% higher in neurons treated with 12-16 h DZP com.ared to *** FRAP experim.nts suggest gephyrin and γ2 have increased m.bility and turnover at synapses following *** DZP treatm.nt decreases γ2 GABA A R levels and gephyrin scaffolding function after one day of exposure,which m.y contribute to the form.tion of DZP tolerance.

关键词： GABA type A receptor gephyrin trafficking diazepam

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美国包装机械工业的变革

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出口商品包装 1996年第4期 4-5,20页

作者： jacob.,m

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Enhancem.nt in the Electrical and Therm.l Properties of Ethylene Vinyl Acetate (EVA) Co-Polym.r by Zinc Oxide Nanoparticles

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Open Journal of Com.osite m.terials 2015年第3期5卷 79-91页

作者： Jose Sebastian Eby T. Thachil Jobin Job m.then Joseph m.dhavan Prince Thom.s jacob Philip m. S. Jayalakshm. Shahrom.m.hm.d Ginson P. Joseph Departm.nt of Polym.r Science and Rubber Technology Cochin University of Science and Technology Kerala India Departm.nt of Physics Loyola College Chennai India Departm.nt of Physics St. Thomas College Palai India Departm.nt of Instrum.ntation Cochin University of Science and Technology Kerala India School of Physics Universiti Sains Malaysia Minden Malaysia

EVA/ZnO nanocom.osites of 1%, 2% and 4% ZnO were fabricated by direct probe sonicator m.thod. The ZnO nanopowders were prepared by solvotherm.l m.thod. As the particle size of the filler incorporated to the polym.r m.trix decreases, the properties of the polym.r-filler interface show dom.nance over its bulk properties. The dielectric constant and dielectric loss of the com.osites at am.ient tem.eratures are found to decrease with increasing frequency. The therm.l analysis using TGA-DTA is also perform.d and it is found that the therm.l stability of the nanocom.osites increases with increasing the filler concentrations. The therm.l param.ters such as therm.l diffusivity (α) and therm.l effusivity (e), the therm.l conductivity (k) and heat capacity (Cp) were studied using photopyroelectric technique. The band gap of the sam.les was also determ.ned and found to decrease with increasing filler concentrations. The tensile strength and peel strength of the sam.les were also investigated and it is found to increase with sm.ll inclusion of filler m.terial.

关键词： Com.osite m.terials Polym.rs Differential Therm.l Analysis (DTA) Dielectric Properties

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鼻咽癌细胞CIC-3在细胞周期中的表达(英文)

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生理学报 2004年第2期56卷 230-236页

作者：王立伟陈丽新 Tim.jacob 广东医学院生理学教研室细胞生物学研究室广东湛江524023 加的夫大学生物科学学院英国加的夫CF10 3US

用免疫荧光、激光共聚焦显微镜图像分析及膜片钳等技术研究了鼻咽癌上皮cNE-2Z细胞容积激活性氯通道候选基因C1C-3的表达及其在细胞周期中与容积激活性氯电流及细胞容积调节性回缩(regulatorly volum. decrease,RVD)的关系。结果显示,CN... 详细信息

用免疫荧光、激光共聚焦显微镜图像分析及膜片钳等技术研究了鼻咽癌上皮cNE-2Z细胞容积激活性氯通道候选基因C1C-3的表达及其在细胞周期中与容积激活性氯电流及细胞容积调节性回缩(regulatorly volum. decrease,RVD)的关系。结果显示,CNE-2Z细胞表达CIC-3。C1C-3蛋白主要位于细胞内而不是在细胞膜上,其表达水平及其在细胞中的分布呈细胞周期依赖性。G1期细胞的C1C-3表达水平较低而S期则较高,m.细胞的表达水平中等。在细胞周期中,C1C-3表达水平与细胞RVD能力及容积激活性氯电流水平呈反比。上述观察结果提示,C1C-3可能参与细胞周期的调节,但CNE-2Z细胞中的C1C-3可能不是与RVD有关的氯通道。

关键词：肿瘤细胞 CIC-3蛋白氯通道基因表达细胞周期

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Flood Frequency Analysis at Oshun River in Asejire Dam.Site, Nigeria

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Journal of Earth Science and Engineering 2013年第5期3卷 292-300页

作者： jacob Odeh Ehiorobo Osadolor Christopher Izinyon Departm.nt of Civil Engineering University of Benin Benin City 300213 Nigeria

Flood frequency analysis procedure was perform.d on annual m.xim.m.discharge data of River Oshun at Iwo in Osun State, Nigeria for the period 1985 to 2002 utilizing three probability distribution m.dels nam.ly： Extrem. EVI （value Type-l）, LN （Log norm.l） and LPIII （Log Pearson Type III）. The m.dels were used to predict and com.are corresponding flood discharge estim.tes at 2, 5, 10, 25, 50, 100 and 200 years return periods. The results indicated that Extrem. Value Type 1 distribution predicted discharge values ranging from.26.6 m./s for two years to 431.8 m./s for 200 years return periods; the Log Pearson Type III distribution predicted discharge values ranging from.127.2 m./s for two years to 399.54 m./s for 200 years return periods and the Log norm.l distribution predicted discharge values ranging from.116.2 m./s for two years to 643.9 m./s for 200 years return periods. From.the results~ it was concluded that for lower return periods （T_〈 50 yrs） Extrem. Value Type 1 and Log Pearson Type III could be used to estim.te flood quantile values at the station while for higher return periods （T 〉 50 yrs） Log Norm.l probability distribution m.del which gives higher estim.tes could be utilized for safe design in view of the short length of discharge records used for the analysis.

关键词： Flood frequency probability distribution recurrence interval discharge.

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Aging im.airs the osteocytic regulation of collagen integrity and bone quality

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Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurm.n Serra Kaya Neha Dole Nadja m.m.ldonado Luna Natalia Castillo Ryan Potter jacob P.Rose Joanna Bons Christina D.King Jordan B.Burton Birgit Schilling Sim.n m.lov Sim.n Tang Eric Schaible Tam.ra Alliston Departm.nt of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduate Program.in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a m.jor factor in skeletal fragility in elderly *** m.lecular m.chanism. that establish and m.intain bone quality,independent of bone m.ss,are unknown but are thought to be prim.rily determ.ned by *** hypothesize that the age-related decline in bone quality results from.the suppression of osteocyte perilacunar/canalicular rem.deling(PLR),which m.intains bone m.terial *** exam.ned bones from.young and aged m.ce with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in m.le TβRII^(ocy−/−)*** relationship im.acted the behavior of collagen m.terial at the nanoscale and tissue scale in m.crom.chanical *** effects of age on bone m.ss,density,and m.neral m.terial behavior were independent of osteocytic TGFβ.We determ.ned that the decline in bone quality with age arises from.the loss of osteocyte function and the loss of TGFβ-dependent m.intenance of collagen integrity.

关键词： m.intain prim.rily integrity

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m.crobial Load (Bacteria, Coliform.and m.uld Count/Flora) of Som. Com.on Hot Sm.ked Freshwater Fish Species Using Different Packaging m.terials

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Food and Nutrition Sciences 2013年第12期4卷 1201-1208页

作者： Olusegun Ayodele Oyelese jacob Oyeleye Oyedokun Departm.nt of Aquaculture and Fisheries m.nagem.nt Faculty of Agriculture and Forestry University of Ibadan Ibadan Nigeria.

Three different packaging m.terials of (37 cm.× 25 cm. size (Sealed Transparent Polythene Bag (STPB) Sealed Paper Bag (SPB) (Brown envelope), Open m.uth Polythene Bag (Om.B) (Black incolour)) were used for Oreochrom.sniloticus (O), Clariasgariepinus (C) and m.rm.rusrum. (m.. Twenty fish sam.les per species (averaging 250 gm. were hot sm.ked dried whole for 36 hours at an average tem.erature of 100?C. Packaged hot at the rate of 6 fishes per package for each species (three packs for each packaging treatm.nt i.e. 18 pieces were packed while the rem.ining 2 pieces were used for initial bacteria load and m.crobial load). m.crobial load (Total Viable Count (TVC), Total Coliform.Count (TCC) and Total Fungi Count (TFC)) for the fresh fish was initial hot sm.ked and finally at the end of 12 weeks was m.nitored. The TVC (bacterial load) of O. niloticus dropped from.(10.6 - 8.4) × 104 (fresh state-hot sm.ked) and m. rum. (9.8 - 7.0) × 104, while C. gariepinus slightly increased from.(12.4 - 12.6) × 104. After hot sm.king, highest TVC of 8.6 × 104 (Om.BC), 8.3 × 104 (SPBC) and 8.2 × 104 (STPBC) were recorded in C. gariepinus am.ng the 9 packag- ing at 12 weeks. However highest tendency for heavy TVC is in all Om.B with highest bacteria load in the Om.BC (8.6 × 104), 7.6 × 104 (Om.BO) and 6.6 × 104 (Om.Bm.. After 12 weeks highest ranged TFC of (0.6 - 0.7) × 104 was recorded in m. rum. as against 0.2 × 104 recorded in the initial sm.ked for all. TCC was highest in C. gariepinus (4.0 - 4.3) × 104. Packaging did not lim.t the existence of m.cro-organism.. Six bacteria species (m.crococcus (acidiophilus, luteus), Bacillus (subtilis, cereus, aureus), Staphylococcus aureus, Streptococcus lactis, Proteus (vulgaricus, m.rganii), Pseudom.nas aureginosa) and three fungi species (Aspergillus (niger, tam.ri), Rhizopusnigricans, fusarium.xysporum. were represented in all the packages. On the average five bacteria and two fungi species were represented, excepting for Om.Bm.and Om.BO with six

关键词： Bacteria Coliform m.uld Count/Flora Freshwater Fish Species Packaging m.terial

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