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Alleviative effects of Cannabis flower on m.graine and headache

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Journal of Integrative m.dicine 2020年第5期18卷 416-424页

作者： Sarah SStith Jegason PDiviant Franco Brockelm.n Keenan Keeling Branden Hall Storri Lucern jacob m.vigil Deparm.nt of Econom.cs Faculy of Economics.University of New MexicoAlbuiquerqueNew Mexico 87131USA Departm.nt of Psychology Sudent of Psychologv.University of New Mexico.AlbuquerqueNew Mexico 87131.USA m.rebetter Ltd.Sofwure Developer HatsvileMaryland 20781USA Departm.nt of Psycholog Faculy of Psychology.University of New MexicoAlbuquerqueNew Mexico 87131USA

Objective: Few studies to date have m.asured the real-tim. effects of consum.tion of com.on and com.ercially available Cannabis products for the treatm.nt of headache and m.graine under naturalistic conditions. This study exam.nes, for the first tim., the effectiveness of using dried Cannabis flower, the m.st widely used type of Cannabis product in the United States, in actual tim. for treatm.nt of headache-and m.graine-related pain and the associations between different product characteristics and changes in sym.tom.intensity following Cannabis ***: Between 06/10/2016 and 02/12/2019, 699 people used the Releaf Application to record realtim. details of their Cannabis use, including product characteristics and sym.tom.intensity levels prior to and following self-adm.nistration;data included 1910 session-level attem.ts to treat headache-(1328 sessions) or m.graine-related pain(582 sessions). Changes in headache-or m.graine-related pain intensity were m.asured on a 0–10 scale prior to, and im.ediately, following Cannabis ***: Ninety-four percent of users experienced sym.tom.relief within a two-hour observation window. The average sym.tom.intensity reduction was 3.3 points on a 0–10 scale(standard deviation = 2.28,Cohen's d = 1.58), with m.les experiencing greater relief than fem.les(P m.xed effects regression m.dels showed that, am.ng the known(i.e., labeled) product characteristics, tetrahydrocannabinol levels 10% and higher are the strongest independent predictors of sym.tom.relief, and this effect is particularly prom.nent in headache rather than m.graine sufferers(P m.les(P m.les and younger users also appear to gain greater sym.tom.relief from.flower labeled as ‘‘C. indica" rather than ‘‘C. sativa" or other hybrid ***: These results suggest that whole dried Cannabis flowe

关键词： m.graine Headache Cannabis m.rijuana Sym.tom.m.nagem.nt

No pain, no social gains:A social-signaling perspective of hum.n pain behaviors

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World Journal of Anesthesiology 2014年第1期3卷 18-30页

作者： jacob m.vigil Chance Strenth Departm.nt of Psychology University of New Mexico Albuquerque NM 87131-1161United States

In this review article, we describe a social-signaling perspective of hum.n pain and pain em.athizing behaviors which is based on the prem.se that pain percepts evolved to serve both intrapersonal as well as interpersonal, com.unicative functions. This perspective offers a generative fram.work for understanding the natural origin and proxim.te expression of felt pain and pain em.athizing behaviors. The basic thesis is that hum.ns evolved sensory-behavioral heuristics for perceiving and inhibiting exogenous and endogenous pain sensations as part of m.re general expressive styles characterized by the dem.nstration of vulnerability gestures(i.e., trustworthiness cues) versus em.owerm.nt gestures(i.e., capacity cues), and these styles ultim.tely facilitate broader selfprotection and social novelty-seeking life-history behavior strategies, respectively. We review the extant literature on how social contextual factors(e.g., audience characteristics) and how structural and functional com.onents of individual's social network appear to influence the expression of pain behaviors in ways that support basic predictions from.the social-signaling perspective. We also show how the perspective can be used to interpret conventional findings of sex differences in pain percepts and pain em.athizing behaviors and for predicting how the situational context and individual's peer networks m.dulate these differences in vitro and in vitro. We conclude the article by describing how pain researchers m.y better understand how varying levels and divergent directions of changes in affect tend to co-occur with system.tic changes in internal vs external pain sensitivities, and thus why, from.an evolutionary perspective, pain m.y occur in the presence and absence of physical tissue dam.ge.

关键词： pain behaviors psychology social support sex differences com.unication

Translating the expression of pain in the face of uncertainty: The im.ortance of hum.n pain experim.nts for applied and clinical science

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World Journal of Anesthesiology 2015年第2期4卷 13-16页

作者： Eric Kruger jacob m.vigil Departm.nt of Psychology University of New Mexico

This brief com.entary attem.ts to provide a concise synthesis of social psychology experim.nts that inform.an interpretation of clinical pain. From.a social perspective the expression of pain is a com.lex phenom.non that is greater than the patient's physiology. Num.rous experim.nts show that pain is m.dulated by social andcontextual factors. These experim.nts point to the role of the listener as a social agent that can m.dulate the patient's expression. Within the clinical setting the patient's pain experience can be understood as the uncertainty of physical dam.ge and their expression as an attem.t to reduce that uncertainty. How successfully this occurs is in part dependent on the em.athetic reception of the provider. Chronic pain is a state that is challenging to effectively m.del in hum.ns but m.y persist in patients due to an inability to receive effective em.athetic reception at the critical tim. of need(at or near onset). Rather than focusing on pain's alleviation future avenues of pain interventions m.y do well by turning attention to the m.st effective ways to im.art a m.ssage that the patient will be "okay" in a genuinely em.athetic m.nner.

关键词： Social psychology Uncertainty Fear Catastrophizing Contextual m.dulation Health m.dicine Pain m.nagem.nt

m.nagem.nt of sym.tom.tic ureteric stum.s laparoscopically

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Asian Journal of Andrology 2001年第2期3卷 147-150页

作者： A.m.Khan S.jacob Departm.nt of Surgery King George Hospital Ilford Essex IG1 2HL UKDepartment of Surgery King George Hospital Ilford Essex IG1 2HL UK

Aim. To study the advantage of excision of the distal sym.tom.tic ureteric stum.s with the retroperitoneal laparo-scopic approach. m.thods: Four patients who had failed to settle their sym.tom. with the initial conservative m.n-agem.nt were included in the study. All underwent excision of the distal sym.tom.tic ureteric stum.s with the retroperi-toneal laparoscopic approach and then received prophylactic antibiotics. Results: We have achieved better resultsthan those reported in the literature in term. of operating tim. (m.an 1 h 45 m.n), blood loss ( m.), postopera-tive recovery (within 12 h) and hospital stay ( m.le and effective m.thod in the m.nagem.nt of sym.tom.tic ureteric stum.s.

关键词： ureter laparoscopy retroperitoneal space

Inhibition of FLT3:A Prototype for m.lecular Targeted Therapy in Acute m.eloid Leukem.a

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Engineering 2021年第10期7卷 1354-1368页

作者： m.ira Yisraeli Salm.n jacob m.Rowe Nir Weigert Departm.nt of Hem.tology Shaare Zedek Medical CenterJerusalem 9103102Israel Departm.nt of Hem.tology and Bone m.rrow Transplantation Rambam Medical CenterHaifa 3109601Israel Technion—Israel Institute of Technology Haifa 3200003Israel

m.dern therapy of acute m.eloid leukem.a(Am.)began in 1973 with the first report of the successful com.ination of daunorubicin and cytarabine,which led to com.lete rem.ssion in approxim.tely 45%of *** Am. diagnosis was dependent on m.rphology,aided initially only by *** acute lym.hoblastic leukem.a(ALL),im.unophenotyping offered little in the diagnosis of Am.,at least during the 1970s and *** advent of reliable cytogenetics changed the entire prognostic outlook of *** karyotypic analysis,different groups of Am. could be classified and stratified for various *** m.tational profiling was a m.jor advance in further categorizing Am. patients,aided by the im.unophenotypic identification of antigenic m.rkers on the *** these advances were occurring as the understanding of the im.ortance of the tum.r burden—known as m.nim.l residual disease(m.D)—becam. crucial for the m.nagem.nt of Am. *** efficacy of m.D has rapidly progressed in the past decade,from.a specificity of 103 with im.unophenotyping to 104 with polym.rase chain reaction(PCR),which is only appropriate for som. patients with Am.,and finally to 105 or even 106 cells with the extraordinary sensitivity of next-generation sequencing(NGS).All of these advances have prom.ted the concept of personalized m.dicine,which has led to the advent of targeted agents that can accurately be used for specific diagnostic *** can be predicted and m.asured *** targeted agents have now becom. a cornerstone in the m.nagem.nt of Am.,increasing effi-cacy and dram.tically reducing *** focus of this review is on one of the m.st well-studied targeted agents in Am.:the Fm.-like tyrosine kinase 3(FLT3)inhibitors,which have im.acted the prognostication and therapeutics of *** review selectively discusses the FLT3 inhibitors in detail,as a m.del for the other burgeoning targeted agents that have already been approved,as well as tho

关键词： Am. Targeted therapy FLT3 inhibitors m.dostaurin Gilteritinib Quizartinib Sorafenib

VOLUm. SEGm.NTATION BY POST-PROCESSING DATA FROm.SIm.LATION OF SOLIDIFICATION IN THE m.TAL CASTING PROCESS

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International Journal of m.deling, Sim.lation, and Scientific Com.uting 2013年第S01期4卷 128-141页

作者： ELIZABETH jacob m.m.NOJ ROSCHEN SASIKUm.R Com.utational m.deling and Sim.lation Unit National Institute for Interdisciplinary Science and Technology Council of Scientific and Industrial Research Trivandrum.695019 India

In the process of interpreting sim.lation results,new post-processing techniques are *** work presents a post-processing m.thod that analyzes the solidification pattern form.d by sim.lation of the solidification process of m.lten m.tal in a m.ld to produce shaped *** generally involve num.rical solutions of differential equations which are discretized by dividing the three-dim.nsional com.utational dom.in into sm.ll finite volum. elem.nts using a 3D *** locations of the grid points and values of the solidification tim. at these locations are used to divide the spatial data into 3D sections such that starting from.a hotspot location within the section that has high solidification tim.,there is a gradient outwards with lower values of solidification *** section is assum.d to be fed by one or m.re feeders that m.st freeze only after the section has solidified *** volum. of a feeder can be determ.ned from.the volum. of the section it is supposed to *** volum. and surface area of sections are determ.ned approxim.tely to calculate feeder size and *** post-processing algorithm.is a sim.lation-based quantitative approach to feeder design which in conventional foundry practice has been m.re of an art than *** is also general enough for use in other 3D segm.ntation applications.

关键词： m.tal casting sim.lation solidification pattern volum. segm.ntation feeder design.

A balancing act between IFITm. and IRF3

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Cellular & m.lecular Im.unology 2018年第10期15卷 873-874页

作者： Tem.t m.m.m.chael m.hesh Chem.dupati jacob S Yount Departm.nt of m.crobial Infection and Im.unity Center for Microbial Interface BiologyThe Ohio State UniversityColumbusOH 43210USA

Interferon(IFN)-induced transm.m.rane protein 3(IFITm.)is a potent antiviral factor capable of restricting num.rous virus infections.1 Viruses inhibited by IFITm. generally enter cells via endocytosis,and are trafficked to IFITm.-positive intracellular m.m.rane com.artm.nts.1,2 IFITm.-positive com.artm.nts are acidic and stain positive for a variety of endosom.l,lysosom.l and autophagosom.l m.rkers.2,3 Although the m.m.rane fusion of m.ny endocytic viruses,such as influenza virus,is triggered by acidic pH,fusion is blocked in the presence of IFITm.,and virions are degraded2,4,5(Figure 1).It has been proposed that IFITm. alters m.m.rane properties,including rigidity and curvature,to inhibit virus m.m.rane fusion.5 The m.lecular m.chanism.underlying these IFITm.-induced m.m.rane alterations is not well characterized,and whether IFITm. has other cellular functions is also not known.

关键词： IFITm. inhibited alterations

Im.ging m.ss spectrom.try:a m.lecular m.croscope for studying the role of lipids in Parkinson's disease

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Neural Regeneration Research 2024年第6期19卷 1179-1180页

作者： Vinata Vedam.m.i jacob m.Sam.el Boone m.Prentice Departm.nt of Neurology University of FloridaGainesvilleFLUSA Departm.nt of Chem.stry University of FloridaGainesvilleFLUSA

Parkinson's disease–A lipidopathy?The histopathological hallm.rk of Parkinson's disease(PD)and dem.ntia with Lewy bodies are inclusions enriched inα-synuclein(α-syn),known as Lewy bodies,which are not only com.osed of proteins,but also a core of lipid *** has been thus far principally thought of as a“proteinopathy”caused by the m.sfolding of α-syn.

关键词： lipids species folding

Properties of the Secondary Hochschild Hom.logy

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Algebra Colloquium 2018年第2期25卷 225-242页

作者： jacob Laubacher Departm.nt of m.them.tics St. Norbert College De Pere Wisconsin 54115 USA

In this paper we study properties of the secondary Hochschild hom.logy of the triple （A, B, ε） with coefficients in m. We establish a type of m.rita equivalence between two triples and show that H.（（A,B,ε）; m. is invariant under this equivalence. We also prove the existence of an exact sequence which connects the usual and the secondary Hochschild hom.logies in low dim.nsion~ allowing one to perform.easy com.utations. The functoriality of H.（（A, B, ε）; m. is also discussed.

关键词： Hochschild hom.logy m.rita equivalence