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Targeting sepsis through inflammation and oxidative metabolism

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World Journal of Critical Care Medicine 2025年第1期14卷 69-81页

作者： Salena jacob Sanjana Ann jacob Joby Thoppil Halmos College of Arts and Sciences Nova Southeastern UniversityFort LauderdaleFL 33328United States Dell School of Medicine University of Texas at Austin Medical SchoolAustinTX 78712United States Emergency Medicine UT Southwestern Medical CenterDallasTX 75390United States

Infection is a public health problem and represents a spectrum of disease that can result in sepsis and septic *** is characterized by a dysregulated immune response to *** shock is the most severe form of sepsis which leads to distributive shock and high mortality *** have been significant advances in sepsis management mainly focusing on early identification and ***,complicating matters is the lack of reliable diagnostic tools and the poor specificity and sensitivity of existing scoring tools i.e.,systemic inflammatory response syndrome criteria,sequential organ failure assessment(SOFA),or quick *** limitations have underscored the modest progress in reducing sepsis-related *** review will focus on novel therapeutics such as oxidative stress targets,cytokine modulation,endothelial cell modulation,etc.,that are being conceptualized for the management of sepsis and septic shock.

关键词： Sepsis Inflammation Oxidative Metabolism Infection Reactive oxygen species

Sulfurized-polyacrylonitrile in lithium-sulfur batteries:Interactions between undercoordinated carbons and polymer structure under low lithiation

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Journal of Energy Chemistry 2022年第3期31卷 587-596,I0016页

作者： Samuel Bertolini Timo jacob Institute of Electrochemistry Ulm UniversityAlbert-Einstein-Allee 4789081 UlmGermany Helmholtz-Institute Ulm(HIU) Electrochemical Energy StorageHelmholtzstr.1189081 UlmGermany Karlsruhe Institute of Technology(KIT) P.O.Box 364076021 KarlsruheGermany

Lithium-sulfur battery(LSB)represents an important candidate to be used in energy storage applications,due to its high specific ***-polyacrylonitrile(SPAN)is a candidate as a host material in LSB to replace graphite,due to its ability to chemisorb polysulfides(PSs).The sulfur chains attached to the polymer can reversibly form Li2S,and SPAN indicates to have a good cyclability and better performance than graphite,thus,SPAN acts partially as an active and also as a host *** this study,we investigated the capacity of the solvent or the SPAN to lose a hydrogen atom from the backbone,to predict possible anodic reactions between solvent and host *** simulation suggests that the photophilic salts may preferentially react with the solvent,and possibly building a cathode electrolyte interphase(CEI).We observed that an undercoordinated carbon(C_(uc))can be thermodynamically created,due to *** Cuccan react with the solvent on the polymer backbone through different mechanisms,however,the simulations indicated that the reaction should be affected by the interaction between the solvent and C_(uc),according to SPAN’s ***,C_(uc)reacts with long sulfur chains attached to SPAN,capturing sulfur and forming a C-S bond.A sulfur chain from one SPAN can connect to another polymer backbone,however,this process is affected by lithiation and ***,this work also investigates the formation of interconnected SPAN structures and the multiple C_(uc)effects.

关键词： Density functional theory Ab initio molecular dynamics Lithium-sulfur batteries Sulfurized-polyacrylonitrile

Mixed mode properties of CNT reinforced composites using Arcan test rig

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Frontiers of Structural and Civil Engineering 2015年第4期9卷 397-404页

作者： jacob MUTHU DST-NRF Centre of Excellence in Strong Materials and RP/Composite Facility School of Mechanical Industrial and AeronauticalEngineering University of the Witwatersrand Johannesburg South Africa

Composite materials reinforced with carbon nanotubes were mechanical tested using Arcan test rig under Mode-I, Mode-II and mixed mode loading conditions to obtain their fracture properties. The butterfly composite specimens were fabricated with 0.02, 0.05 and 0.1 wt % CNTs. The polyester/CNT composite was fabricated using VRTM (Vacuum Resin Transfer Molding) where the CNTs were first functionalised to reach an optimum properties. Arcan test rig was designed and fabricated to work with the Shimadzu testing machine. The results show that the functionalised CNTs have improved the fracture behavior by acting as bridge between the cracked face. In addition, the fracture properties were not improved for the higher weight fraction of 0.1 wt% CNTs.

关键词： CNT composites Arcan test rig stress intensity factor

The Mathematical Theory of Multifocal Lenses(Dedicated to Professor Haim Brezis on the occasion of his 70th birthday)

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Chinese Annals of Mathematics,Series B 2017年第2期38卷 647-660页

作者： jacob RUBINSTEIN department of mathematics TechnionHaifa 32000Israel

This paper presents the fundamental optical concepts of designing multifocal ophthalmic lenses and the mathematical methods associated with them. In particular, it is shown that the design methodology is heavily based on differential geometric ideas such as Willmore surfaces. A key role is played by Hamilton's eikonal functions. It is shown that these functions capture all the information on the local blur and distortion created by the lenses. Along the way, formulas for computing the eikonal functions are derived. Finally,the author lists a few intriguing mathematical problems and novel concepts in optics as future projects.

关键词： Optical design, Differential geometry, Eikonal functions,Multifocal lenses

Distributed media cooperation for enhanced video communication

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 773-783页

作者： CHAKARESKI jacob Ecole Polytechnique Fédérale de Lausanne

The author designed two algorithms for distributed cooperation among multiple video streams sharing common communication resources. The algorithms take advantage of an optimization framework that characterizes video packets such that joint resource allocation can be implemented not only over the packets of a single stream, but also across packets of different streams. The first algorithm enables collaboration among multiple video senders in an 802.11 CSMA/CA wireless network such that their joint performance is maximized. Via the algorithm, the users cooperatively establish transmission priorities based on the assigned characterizations of their video packets. The second technique allows for low-complexity joint bandwidth adaptation of multiple video streams at intermediate network nodes in the Internet in order to maximize the overall network performance. The author analyzes the advantages of the proposed algorithms over conventional solutions employed in such scenarios. It is shown that depending on system parameters such as available network data rate the proposed techniques can provide substantial gains in end-to-end performance.

关键词： Media cooperation, Distributed video streaming, Wireless networks, Resource allocation, Rate-quality optimization

Hydration lubrication

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Friction 2013年第1期1卷 1-23页

作者： jacob KLEIN Department of Materials&Interfaces Weizmann Institute of ScienceRehovot76100Israel

The hydration lubrication paradigm,whereby hydration layers are both strongly held by the charges they surround,and so can support large pressures without being squeezed out,and at the same time remain very rapidly relaxing and so have a fluid response to shear,provides a framework for understanding,controlling,and designing very efficient boundary lubrication systems in aqueous and biological *** review discusses the properties of confined water,which-unlike organic solvents-retains its fluidity down to molecularly thin *** then describes lubrication by hydrated ions trapped between charged surfaces,and by other hydrated boundary species including charged and zwitterionic polymer brushes,surfactant monolayers,liposomes,and biological macromolecules implicated in synovial joint ***,challenges and prospects for future development of this new boundary lubrication approach are considered.

关键词： hydration lubrication biolubrication boundary lubrication liposomes polymer brushes hydration repulsion hydration layers

Properties of the Secondary Hochschild Homology

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Algebra Colloquium 2018年第2期25卷 225-242页

作者： jacob Laubacher Department of Mathematics St. Norbert College De Pere Wisconsin 54115 USA

In this paper we study properties of the secondary Hochschild homology of the triple （A, B, ε） with coefficients in M. We establish a type of Morita equivalence between two triples and show that H.（（A,B,ε）; M） is invariant under this equivalence. We also prove the existence of an exact sequence which connects the usual and the secondary Hochschild homologies in low dimension~ allowing one to perform easy computations. The functoriality of H.（（A, B, ε）; M） is also discussed.

关键词： Hochschild homology Morita equivalence

Symmetry breaking in thermal photonics

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Light(Science & Applications) 2022年第12期11卷 2835-2836页

作者： Xueji Wang Zubin jacob Birck Nanotechnology Center Elmore Family School of Electrical and Computer EngineeringPurdue UniversityWest LafayetteIN 47907USA

Engineering symmetries in nanostructures and metasurfaces provides a new paradigm to control incoherent heat radiation for applications in energy conversion,thermal sources,infrared imaging,and radiative cooling.

关键词： thermal breaking radiative

Response of small rodents to manipulations of vegetation height in agro-ecosystems

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Integrative Zoology 2008年第1期3卷 3-10页

作者： Jens jacob Federal Research Centre for Cultivated Plants-Julius Kuehn Institute Vertebrate ResearchMünsterGermany

Some small mammal populations require human interference to conserve rare or threatened species or to minimizeadverse effects in plant production. Without a thorough understanding about how small rodents behave in theirenvironment and consideration of how they react to management efforts, management will not be optimal. Socialbehavior, spatial and temporal activity patterns, predator avoidance and other behavioral responses can affect pestrodent management. Some of these behavioral patterns and their causes have been well studied. However, theirimpact on pest rodent management, especially for novel management approaches, is not always clear. Habitatmanipulation occurs necessarily through land use and intentionally to reduce shelter and food availability and toincrease predation pressure on rodents. Rodents often respond to decreased vegetation height with reducedmovements and increased risk sensitivity in their feeding behavior. This seems to result mainly from an elevatedperceived predation risk. Behavioral responses may lessen the efficacy of the management because the desiredeffects of predators might be mediated. It remains largely unknown to what extent such responses can compensateat the population level for the expected consequences of habitat manipulation and how population size and cropdamage are affected. It is advantageous to understand how target and non-target species react to habitatmanipulation to maximize the management effects by appropriate techniques, timing and spatial scale withoutcausing unwanted effects at the system level.

关键词： behavior crop protection pest rodent population dynamics vegetation height