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Alleviative effects of Cannabis flower on migraine and headache

Journal of Integrative medicine 2020年第5期18卷 416-424页

作者： Sarah SStith Jegason PDiviant Franco Brockelman Keenan Keeling Branden Hall Storri Lucern jacob m.vigil Deparment of Economics Faculy of Economics.University of New MexicoAlbuiquerqueNew Mexico 87131USA Department of Psychology Sudent of Psychologv.University of New Mexico.AlbuquerqueNew Mexico 87131.USA morebetter Ltd.Sofwure Developer HatsvileMaryland 20781USA Department of Psycholog Faculy of Psychology.University of New MexicoAlbuquerqueNew Mexico 87131USA

Objective: Few studies to date have measured the real-time effects of consumption of common and commercially available Cannabis products for the treatment of headache and migraine under naturalistic conditions. This study examines, for the first time, the effectiveness of using dried Cannabis flower, the most widely used type of Cannabis product in the United States, in actual time for treatment of headache-and migraine-related pain and the associations between different product characteristics and changes in symptom intensity following Cannabis ***: Between 06/10/2016 and 02/12/2019, 699 people used the Releaf Application to record realtime details of their Cannabis use, including product characteristics and symptom intensity levels prior to and following self-administration;data included 1910 session-level attempts to treat headache-(1328 sessions) or migraine-related pain(582 sessions). Changes in headache-or migraine-related pain intensity were measured on a 0–10 scale prior to, and immediately, following Cannabis ***: Ninety-four percent of users experienced symptom relief within a two-hour observation window. The average symptom intensity reduction was 3.3 points on a 0–10 scale(standard deviation = 2.28,Cohen's d = 1.58), with males experiencing greater relief than females(P mixed effects regression models showed that, among the known(i.e., labeled) product characteristics, tetrahydrocannabinol levels 10% and higher are the strongest independent predictors of symptom relief, and this effect is particularly prominent in headache rather than migraine sufferers(P males(P males and younger users also appear to gain greater symptom relief from flower labeled as ‘‘C. indica" rather than ‘‘C. sativa" or other hybrid ***: These results suggest that whole dried Cannabis flowe

关键词： migraine Headache Cannabis marijuana Symptom management

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No pain, no social gains:A social-signaling perspective of human pain behaviors

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World Journal of Anesthesiology 2014年第1期3卷 18-30页

作者： jacob m vigil Chance Strenth Department of Psychology University of New Mexico Albuquerque NM 87131-1161United States

In this review article, we describe a social-signaling perspective of human pain and pain empathizing behaviors which is based on the premise that pain percepts evolved to serve both intrapersonal as well as interpersonal, communicative functions. This perspective offers a generative framework for understanding the natural origin and proximate expression of felt pain and pain empathizing behaviors. The basic thesis is that humans evolved sensory-behavioral heuristics for perceiving and inhibiting exogenous and endogenous pain sensations as part of more general expressive styles characterized by the demonstration of vulnerability gestures(i.e., trustworthiness cues) versus empowerment gestures(i.e., capacity cues), and these styles ultimately facilitate broader selfprotection and social novelty-seeking life-history behavior strategies, respectively. We review the extant literature on how social contextual factors(e.g., audience characteristics) and how structural and functional components of individual's social network appear to influence the expression of pain behaviors in ways that support basic predictions from the social-signaling perspective. We also show how the perspective can be used to interpret conventional findings of sex differences in pain percepts and pain empathizing behaviors and for predicting how the situational context and individual's peer networks modulate these differences in vitro and in vitro. We conclude the article by describing how pain researchers may better understand how varying levels and divergent directions of changes in affect tend to co-occur with systematic changes in internal vs external pain sensitivities, and thus why, from an evolutionary perspective, pain may occur in the presence and absence of physical tissue damage.

关键词： pain behaviors psychology social support sex differences communication

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Translating the expression of pain in the face of uncertainty: The importance of human pain experiments for applied and clinical science

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World Journal of Anesthesiology 2015年第2期4卷 13-16页

作者： Eric Kruger jacob m vigil Department of Psychology University of New Mexico

This brief commentary attempts to provide a concise synthesis of social psychology experiments that inform an interpretation of clinical pain. From a social perspective the expression of pain is a complex phenomenon that is greater than the patient's physiology. Numerous experiments show that pain is modulated by social andcontextual factors. These experiments point to the role of the listener as a social agent that can modulate the patient's expression. Within the clinical setting the patient's pain experience can be understood as the uncertainty of physical damage and their expression as an attempt to reduce that uncertainty. How successfully this occurs is in part dependent on the empathetic reception of the provider. Chronic pain is a state that is challenging to effectively model in humans but may persist in patients due to an inability to receive effective empathetic reception at the critical time of need(at or near onset). Rather than focusing on pain's alleviation future avenues of pain interventions may do well by turning attention to the most effective ways to impart a message that the patient will be "okay" in a genuinely empathetic manner.

关键词： Social psychology Uncertainty Fear Catastrophizing Contextual modulation Health medicine Pain management

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低收入女性的生活史特质与繁衍策略的关系(英文)

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心理学报 2007年第3期39卷 469-480页

作者： Jennifer Byrd-Craven David C. Geary jacob m. vigil mary K. Hoard University of missouri-Columbia University of missouri–Columbia

本研究探讨了单一性伙伴(n = 222)、两个以上性伙伴(n = 145)与无性伙伴(n = 106)三组低收入女性的长期配偶偏好、人生阅历、生活史特质与个人特征的关系。研究结果显示三组女性的配偶偏好趋于一致,繁衍策略的组别差异与人生阅历和所处... 详细信息

本研究探讨了单一性伙伴(n = 222)、两个以上性伙伴(n = 145)与无性伙伴(n = 106)三组低收入女性的长期配偶偏好、人生阅历、生活史特质与个人特征的关系。研究结果显示三组女性的配偶偏好趋于一致,繁衍策略的组别差异与人生阅历和所处环境具有较高相关,三组女性并不偏好特定类型的配偶。路径分析显示首次生育年龄直接预测配偶数量,受教育水平和初次性交时间对配偶数量与首次生育年龄之间的关系具有显著调节作用;女儿与父亲相处的时间可以预测初次性交年龄。研究结果显示父亲投资影响青少年性行为发展的时间表,人类繁衍的长期进化是性行为变化的根源。

关键词：生活史配偶选择父亲投资繁衍策略

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management of symptomatic ureteric stumps laparoscopically

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Asian Journal of Andrology 2001年第2期3卷 147-150页

作者： A.m.Khan S.jacob Department of Surgery King George Hospital Ilford Essex IG1 2HL UKDepartment of Surgery King George Hospital Ilford Essex IG1 2HL UK

Aim: To study the advantage of excision of the distal symptomatic ureteric stumps with the retroperitoneal laparo-scopic approach. methods: Four patients who had failed to settle their symptoms with the initial conservative man-agement were included in the study. All underwent excision of the distal symptomatic ureteric stumps with the retroperi-toneal laparoscopic approach and then received prophylactic antibiotics. Results: We have achieved better resultsthan those reported in the literature in terms of operating time (mean 1 h 45 min), blood loss ( mL), postopera-tive recovery (within 12 h) and hospital stay ( mple and effective method in the management of symptomatic ureteric stumps.

关键词： ureter laparoscopy retroperitoneal space

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The microglial P2Y_(6)receptor as a therapeutic target for neurodegenerative diseases

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Translational Neurodegeneration 2024年第1期13卷 377-387页

作者： jacob m.Dundee Guy C.Brown Department of Biochemistry University of CambridgeCambridgeUK

Neurodegenerative diseases are associated with chronic neuroinflammation in the brain,which can result in microglial phagocytosis of live synapses and neurons that may contribute to cognitive deficits and neuronal *** microglial P2Y_(6) receptor(P2Y_(6)R)is a G-protein coupled receptor,which stimulates microglial phagocytosis when activated by extracellular uridine diphosphate,released by stressed *** or inhibition of P2Y_(6)R can prevent neu-ronal loss in mouse models of Alzheimer’s disease(AD),Parkinson’s disease,epilepsy,neuroinflammation and aging,and prevent cognitive deficits in models of AD,epilepsy and *** review summarises the known roles of P2Y_(6)R in the physiology and pathology of the brain,and its potential as a therapeutic target to prevent neurodegeneration and other brain pathologies.

关键词： Alzheimer’s disease Parkinson’s disease Neurodegeneration Neuroinflammation P2Y_(6)receptor Drug development microglia

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Inhibition of FLT3:A Prototype for molecular Targeted Therapy in Acute myeloid Leukemia

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Engineering 2021年第10期7卷 1354-1368页

作者： meira Yisraeli Salman jacob m.Rowe Nir Weigert Department of Hematology Shaare Zedek Medical CenterJerusalem 9103102Israel Department of Hematology and Bone marrow Transplantation Rambam Medical CenterHaifa 3109601Israel Technion—Israel Institute of Technology Haifa 3200003Israel

modern therapy of acute myeloid leukemia(AmL)began in 1973 with the first report of the successful combination of daunorubicin and cytarabine,which led to complete remission in approximately 45%of *** AmL diagnosis was dependent on morphology,aided initially only by *** acute lymphoblastic leukemia(ALL),immunophenotyping offered little in the diagnosis of AmL,at least during the 1970s and *** advent of reliable cytogenetics changed the entire prognostic outlook of *** karyotypic analysis,different groups of AmL could be classified and stratified for various *** mutational profiling was a major advance in further categorizing AmL patients,aided by the immunophenotypic identification of antigenic markers on the *** these advances were occurring as the understanding of the importance of the tumor burden—known as minimal residual disease(mRD)—became crucial for the management of AmL *** efficacy of mRD has rapidly progressed in the past decade,from a specificity of 103 with immunophenotyping to 104 with polymerase chain reaction(PCR),which is only appropriate for some patients with AmL,and finally to 105 or even 106 cells with the extraordinary sensitivity of next-generation sequencing(NGS).All of these advances have promoted the concept of personalized medicine,which has led to the advent of targeted agents that can accurately be used for specific diagnostic *** can be predicted and measured *** targeted agents have now become a cornerstone in the management of AmL,increasing effi-cacy and dramatically reducing *** focus of this review is on one of the most well-studied targeted agents in AmL:the FmS-like tyrosine kinase 3(FLT3)inhibitors,which have impacted the prognostication and therapeutics of *** review selectively discusses the FLT3 inhibitors in detail,as a model for the other burgeoning targeted agents that have already been approved,as well as tho

关键词： AmL Targeted therapy FLT3 inhibitors midostaurin Gilteritinib Quizartinib Sorafenib

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VOLUmE SEGmENTATION BY POST-PROCESSING DATA FROm SImULATION OF SOLIDIFICATION IN THE mETAL CASTING PROCESS

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International Journal of modeling, Simulation, and Scientific Computing 2013年第S01期4卷 128-141页

作者： ELIZABETH jacob m.mANOJ ROSCHEN SASIKUmAR Computational modeling and Simulation Unit National Institute for Interdisciplinary Science and Technology Council of Scientific and Industrial Research Trivandrum–695019 India

In the process of interpreting simulation results,new post-processing techniques are *** work presents a post-processing method that analyzes the solidification pattern formed by simulation of the solidification process of molten metal in a mold to produce shaped *** generally involve numerical solutions of differential equations which are discretized by dividing the three-dimensional computational domain into small finite volume elements using a 3D *** locations of the grid points and values of the solidification time at these locations are used to divide the spatial data into 3D sections such that starting from a hotspot location within the section that has high solidification time,there is a gradient outwards with lower values of solidification *** section is assumed to be fed by one or more feeders that must freeze only after the section has solidified *** volume of a feeder can be determined from the volume of the section it is supposed to *** volume and surface area of sections are determined approximately to calculate feeder size and *** post-processing algorithm is a simulation-based quantitative approach to feeder design which in conventional foundry practice has been more of an art than *** is also general enough for use in other 3D segmentation applications.

关键词： metal casting simulation solidification pattern volume segmentation feeder design.

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A balancing act between IFITm3 and IRF3

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Cellular & molecular Immunology 2018年第10期15卷 873-874页

作者： Temet m mcmichael mahesh Chemudupati jacob S Yount Department of microbial Infection and Immunity Center for Microbial Interface BiologyThe Ohio State UniversityColumbusOH 43210USA

Interferon(IFN)-induced transmembrane protein 3(IFITm3)is a potent antiviral factor capable of restricting numerous virus infections.1 Viruses inhibited by IFITm3 generally enter cells via endocytosis,and are trafficked to IFITm3-positive intracellular membrane compartments.1,2 IFITm3-positive compartments are acidic and stain positive for a variety of endosomal,lysosomal and autophagosomal markers.2,3 Although the membrane fusion of many endocytic viruses,such as influenza virus,is triggered by acidic pH,fusion is blocked in the presence of IFITm3,and virions are degraded2,4,5(Figure 1).It has been proposed that IFITm3 alters membrane properties,including rigidity and curvature,to inhibit virus membrane fusion.5 The molecular mechanism underlying these IFITm3-induced membrane alterations is not well characterized,and whether IFITm3 has other cellular functions is also not known.

关键词： IFITm3 inhibited alterations

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Imaging mass spectrometry:a molecular microscope for studying the role of lipids in Parkinson's disease

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Neural Regeneration Research 2024年第6期19卷 1179-1180页

作者： Vinata Vedam-mai jacob m.Samuel Boone m.Prentice Department of Neurology University of FloridaGainesvilleFLUSA Department of Chemistry University of FloridaGainesvilleFLUSA

Parkinson's disease–A lipidopathy?The histopathological hallmark of Parkinson's disease(PD)and dementia with Lewy bodies are inclusions enriched inα-synuclein(α-syn),known as Lewy bodies,which are not only composed of proteins,but also a core of lipid *** has been thus far principally thought of as a“proteinopathy”caused by the misfolding of α-syn.

关键词： lipids species folding

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