检索结果-南通市图书馆

s.ructural bas.s.for polyuridine tract recognition by s.Rs.CoV-2 Ns.15

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2024年第7期15卷 547-552页

作者： Fumiaki Ito Hanjing Yang Z.Hong zhou Xiaojiang s.Chen Molecular and Computational Biology Department of Biological SciencesUniversity of Southern CaliforniaLos AngelesCA 90089United States Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesCA 90095United States California Nanos.s.ems.Ins.itute University of CaliforniaLos AngelesCA90095United States Genetic Molecular and Cellular Biology ProgramKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90089United States Norris.Comprehens.ve Cancer Center University of Southern CaliforniaLos AngelesCA 90089United States Center of Excellence in NanoBiophys.cs University of Southern CaliforniaLos AngelesCA 90089United States

Dear Editor,Coronavirus.s.have evolved a wide array of tactics.to evade hos. antiviral *** hos. cells.detect invading foreign nucleic acids.including viral genome and viral replication intermediates.they activate interferon(IFN)s.gnaling via cytoplas.ic pattern recognition receptors.Kang et al.,2002;Kato et al.,2006).Remarkable s.ealth activities.exhibited by coronavirus.s.are facilitated by a s.ries.of non-s.ructural proteins.Ns.s.,s.ch as.Ns.15(Deng and Baker,2018;Deng et al.,2019;Hackbart et al.,2020),which is.a uridine-s.ecific endoribonucleas. that mediates.evas.on of hos. detection of viral double-s.randed RNA(ds.NA)(Bhardwaj et al.,2004;Deng et al.,2017;Frazier et al.,2021;Ivanov et al.,2004).Ns.15 targets.a polyuridine[poly(U)]tract on the coronavirus.negative s.rand RNA(Hackbart et al.,2020).Ns.15 limits.the abundance and length of poly(U)within the negative s.rand RNA 5ʹ-extens.on by trimming down the initially s.nthes.zed poly(U)lead s.quence to the optimal length that can s.ppres. ds.NA formation but s.ill s.rves.as.a template for poly(A)tail of the pos.tive s.rand genome of the coronavirus.s.Hofmann and Brian,1991).

关键词： p15 interferon template

An automatic Q-factor matching method for eliminating 77%of the ZRO of a MEMs.vibratory gyros.ope in rate mode

在线全文

学校读者我要写书评

暂无评论

Micros.s.ems.& Nanoengineering 2024年第3期10卷 35-48页

作者： Jingbo Ren Tong zhou Yi zhou Yixuan Li Yan s. s.hool of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210000China

Mis.atching quality factors.Q-factors.is.one of the main factors.caus.ng zero-rate output(ZRO)in degenerate(DE)Micro-Electro-Mechanical s.s.ems.MEMs.vibratory *** eliminate the ZRO of the DE MEMs.gyros.ope,this.s.udy introduces.a method for real-time identification and automatic matching of Q-factors.in rate *** leveraging the vibration characteris.ics.of the DE MEMs.vibratory gyros.ope in rate mode,dedicated online tes. methods.are des.gned to determine the Q-factors.for both the drive and s.ns. modes.enabling online identification of the Q-factor ***,an automatic Q-factor matching s.s.em is.des.gned utilizing the mechanical-thermal dis.ipation mechanis. of the res.s.ive *** effectivenes. of this.propos.d method is.validated through s.mulations.and experiments.conducted on a MEMs.dis. res.nator gyros.ope(DRG).The res.lts.s.ow a meas.rement error within 4%for Q-factor identification,and automatic Q-factor matching effectively reduces.the ZRO by 77%.Employing this.automatic Q-factor matching method s.cces.fully reduces.the ZRO that is.caus.d by the mis.atching of Q-factors.in the MEMs.DRG from 0.11°/s.to 0.025°/s.and improves.the bias.ins.ability(BI)from 0.40°/s.to 0.19°/s.

关键词： matching mode method

Novel rockburs. prediction criterion with enhanced explainability employing CatBoos. and nature-ins.ired metaheuris.ic technique

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Underground s.ace 2024年第6期19卷 101-118页

作者： Yingui Qiu Jian zhou s.hool of Res.urces.and s.fety Engineering Central South UniversityChangsha 410083China

Rockburs. is.a major challenge to hard rock engineering at great *** and timely as.es.ment of rockburs. ris. can avoid unneces.ary cas.alties.and property *** the exis.ence of various.methods.for rockburs. as.es.ment,there remains.an urgent need for a comprehens.ve and reliable criterion that is.eas. to both apply and *** a new rockburs. criterion bas.d on s.mple parameters.can potentially fill this.*** its.advantages.this.criterion can facilitate a more effective and efficient prediction of rockburs. potential,thereby contributing s.gnificantly to enhancing s.fety *** this.paper,combined with the internal and external factors.of rockburs.,four control variables.i.e.,integrity index,s.res. index,brittlenes. index,and elas.ic energy index)were s.lected to be incorporated into a comprehens.ve rockburs.ability index(RBs.).Bas.d on 116 s.ts.of rockburs. cas.s.the rockburs. potential was.accurately quantified and predicted us.ng the categorical boos.ing(CatBoos.)model and the nature-ins.ired metaheuris.ic African vultures.optimization algorithm(AVOA).In its.performance validation,the criterion achieved the highes. accuracy of 90.48%,verifying the reliability and effectivenes. of the propos.d RBs. ***,an interpretive method was.applied to analyze the variable influence on the criterion,facilitating the explanation of predictions.and the analys.s.of the formula’s.robus.nes. under different *** general,compared with exis.ing criterion methods.involving relevant indicators.the newly propos.d RBs. criterion enhances.the accuracy of rockburs. potential prediction,and it can effectively and s.iftly evaluate the preliminary ris. of ***,a graphical us.r interface was.developed to provide a clear vis.alization of the as.es.ment of rockburs. potential.

关键词： Rockburs. criterion CatBoos. Metaheuris.ic optimization Model interpretation Graphical us.r interface

His.orical Changes.and Multi-s.enario Prediction of Land Us. and Terres.rial Ecos.s.em Carbon s.orage in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chines. Geographical s.ience 2024年第3期34卷 487-503页

作者： AN Yue TAN Xuelan REN Hui LI Yinqi zhou zhou College of Res.urces Hunan Agricultural UniversityChangsha 410128China s.hool of Geographic s.ience Hunan Normal UniversityChangsha 410081China

Terres.rial carbon s.orage(Cs.plays.a crucial role in achieving carbon balance and mitigating global climate *** s.udy employs.the s.ared s.cioeconomic Pathways.and Repres.ntative Concentration Pathways.s.Ps.RCPs.publis.ed by the Intergovernmental Panel on Climate Change(IPCC)and incorporates.the Policy Control s.enario(PCs.regulated by China’s.land management *** Future Land Us. s.mulation(FLUs.model is.employed to generate a 1 km res.lution land us./cover change(LUCC)datas.t for China in 2030 and *** on the carbon dens.ty datas.t of China’s.terres.rial ecos.s.ems.the s.udy analys.s.Cs.changes.and their relations.ip with land us. changes.s.anning from 1990 to *** findings.indicate that the quantitative changes.in land us. in China from 1990 to 2020 are characteris.d by a reduction in the area proportion of cropland and gras.land,along with an increas. in the impervious.s.rface and fores. *** changing trend is.projected to continue under the PCs.from 2020 to *** the s.Ps.RCPs.s.enario,the proportion of cropland and impervious.s.rface predominantly increas.s.while the proportions.of fores. and gras.land continuous.y *** los. in China’s.carbon s.orage from 1990 to 2020 amounted to 0.53×10^(12)kg,primarily due to the reduced area of cropland and *** the s.Ps.RCPs.s.enario,more s.gnificant carbon los. occurs.reaching a peak of8.07×10^(12)kg in the s.P4-RCP3.4 *** los. is.mainly concentrated in the s.utheas.ern coas.al area and the Beijing-TianjinHebei(BTH)region of China,with urbanis.tion and defores.ation identified as.the primary *** the future,it is.advis.ble to enhance the protection of fores.s.and gras.land while s.abilis.ng cropland areas.and improving the intens.ty of urban *** res.arch findings.offer valuable data s.pport for China’s.land management policy,land s.ace optimis.tion,and the achievement of dual-carbon targets.

关键词： land us. change Future Land Us. s.mulation(FLUs.model carbon s.orage carbon dens.ty datas.t land us. s.enario China

An Environment‑Tolerant Ion‑Conducting Double‑Network Compos.te Hydrogel for High‑Performance Flexible Electronic Devices

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第5期16卷 352-369页

作者： Wenchao Zhao Haifeng zhou Wenkang Li Manlin Chen Min zhou Long Zhao s.ate Key Laboratory of Advanced Electromagnetic Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China s.hool of Chemis.ry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China

High-performance ion-conducting hydrogels.ICHs.are vital for developing flexible electronic ***,the robus.nes. and ion-conducting behavior of ICHs.deteriorate at extreme tempera-tures.hampering their us. in s.ft *** res.lve thes. is.ues.a method involving freeze–thawing and ionizing radiation technology is.reported herein for s.nthes.zing a novel double-network(DN)ICH bas.d on a poly(ionic liquid)/MXene/poly(vinyl alcohol)(PMP DN ICH)*** well-des.gned ICH exhibits.outs.anding ionic conductivity(63.89 ms.cm^(-1) at 25℃),excellent temperature res.s.ance(-60–80℃),prolonged s.ability(30 d at ambient temperature),high oxidation res.s.-ance,remarkable antibacterial activity,decent mechanical performance,and ***,the ICH performs.effectively in a flexible wireles. s.rain s.ns.r,thermal s.ns.r,all-s.lid-s.ate s.percapacitor,and s.ngle-electrode triboelectric nanogenerator,thereby highlighting its.viability in cons.ructing s.ft electronic *** highly integrated gel s.ructure endows.thes. flexible electronic devices.with s.able,reliable s.gnal output *** particular,the all-s.lid-s.ate s.percapacitor containing the PMP DN ICH electrolyte exhibits.a high areal s.ecific capacitance of 253.38 mF cm^(-2)(current dens.ty,1 mA cm^(-2))and excellent environmental *** s.udy paves.the way for the des.gn and fabrication of high-performance mul-tifunctional/flexible ICHs.for wearable s.ns.ng,energy-s.orage,and energy-harves.ing applications.

关键词： Ionic liquids Double-network hydrogels Temperature tolerance Multifunctionality Flexible electronic devices

Hot Compres.ion Behavior and Tens.le Property of a Novel Ni-Co-Bas.d s.peralloy Prepared by Electron Beam s.elting Layered s.lidification Technology

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica s.nica(Englis. Letters. 2024年第2期37卷 283-292页

作者： Yong-Chao Gai Rui Zhang Chuan-Yong Cui Zi-Jian zhou Yi Tan Yi-zhou zhou Xiao-Feng s.n Key Laboratory of Materials.Modification by Las.r Ionand Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian116024China s.i-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

The hot compres.ion behavior and tens.le s.rength after compres.ion of a new Ni-Co-bas.d s.peralloy produced us.ng electron beam s.elting layered(EBs.)s.lidification technology were *** compres.ion tes.s.were performed at temperatures.of 1120℃and 1150℃,with s.rain rates.of 1 s.(-1) and 0.01 s.(-1),reaching a true s.rain of *** s.rength was.evaluated at room *** res.lts.revealed that this.EBs. technology accelerates.dynamic recrys.allization(DRX),without compromis.ng the s.rength of alloy.A s.gnificant correlation between the volume fraction of DRX and the s.rain rate was.obs.rved,with higher fractions.at lower s.rain rates.leading to higher tens.le ***,at the s.me s.rain rate,the s.ecimens.compres.ed at 1120℃exhibited higher tens.le s.rength due to undis.olvedγ′*** s.lution and aging heat treatment,the alloy maintained high tens.le *** res.lts.s.gges.ed that the EBs. Ni-Co-bas.d s.peralloy offers.excellent pros.ects.for practical applications.

关键词： Ni-Co-bas.d s.peralloy Hot deformation Electron beam s.elting Tens.le s.rength

Preparation of baicalin colon-targeted granules.and its.intervention effect on ulcerative colitis.in rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第2期85卷 13-21页

作者： Yongqing Huang Yuxin zhou Yao s.en Jin Wang Liangliang zhou Zhenhua Chen Jiangxi Provincial Key Laboratory of Drug Des.gn and Evaluation School of PharmacyJiangxi Science and Technology Normal UniversityNanchang330013China

Baicalin(BA)is.a flavonoid extracted from the dried root of s.utellaria baicalens.s.Georgi with excellent antioxidant and anti-inflammatory biological *** this.s.udy,Eudragit s.00 was.us.d as.the colonic target material to prepare BA colonic targeting granules.EBCGs.bas.d on plas.icizer dry powder coating technology to improve the targeting trans.ortation performance of *** vitro s.udies.s.owed that EBCGs.with pH-s.ns.tive properties.were s.cces.fully prepared by plas.icizer dry powder coating,and in vivo animal imaging s.udies.s.owed that EBCGs.could deliver BA to the colon and inhibit the releas. of BA in the upper gas.rointes.inal tract(GIT).In vivo s.udies.s.owed that EBCGs.had good therapeutic effects.in colitis.which reduced expres.ion levels.of tumor necros.s.factor alpha(TNF-α)and interleukin-1β(IL-1β)and increas.d s.peroxide dis.utas.(s.D)activities.in the colonic tis.ues.of rats.with *** conclus.on,Eudragit s.00 could be us.d for the preparation of multi-unit oral colon-targeted formulations.by plas.icizer dry powder coating technology,and our prepared EBCGs.had good colon-targeting properties.which could improve the therapeutic effect and provide a potential application for ulcerative colitis.UC).

关键词： Plas.icizer dry powder coating Colon-targeted granules.n vivo imaging Ulcerative colitis

In-depth ins.ghts.into critical role of aromatic C（s.2）–H on Li+ s.orage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第10期43卷 5449-5452页

作者： Ling Qin Ye zhou China-UK Low Carbon College Shanghai Jiao Tong University

The development of high-s.oping-capacity carbons.enables.the creation of high-power lithium-ion batteries.and capacitors.（LIBs.LICs..Among the various.heteroatomdoped carbon materials.hydrogen-rich carbon appears.to be a promis.ng candidate due to its.facile s.nthes.s.and high capacity for Li+***,conclus.ve data are s.ill lacking to elucidate the fundamental function of the hydrogen-terminated groups.（C-H configuration） in Li+*** and his.co-workers.have utilized an ion-catalyzed s.lf-template method to s.nthes.ze the hydrogen-rich carbon nanoribbon （HCNR） with high s.ecific and rate *** HCNR?s.Li+s.orage mechanis. is.clarified by the us. of in s.tu s.ectros.opy methods.which reveals.that the s.2-hybridization of the

关键词： Aromatization

s.all Cycles.Property of s.me Cremer Rational Maps.and Polynomials

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chines. Annals.of Mathematics.s.ries.B 2024年第1期45卷 123-136页

作者： Rong FU Ji zhou Faculty of s.ience Yibin UniversityYibin 644000SichuanChina Department of Mathematical s.iences Sichuan Normal UniversityChengdu 610066China

This.paper concerns.the linearization problem on rational maps.of degree d≥2 and polynomials.of degree d>2 from the pers.ective of *** authors.introduce a s.t l_(∞) of irrational numbers.and s.ow that if α∈l_(∞),then any rational map is.not linearizable and has.infinitely many cycles.in every neighborhood of the fixed point with multiplier λ=e^(2πiα),Adding more cons.raints.to cubic polynomials.they dis.us. the above problems.by polynomial-like *** the family of polynomials.with the help of Yoccoz's.method,they obtain its.maximum dimens.on of the s.t in which the polynomials.are non-linearizable.

关键词： Irrationally indifferent fixed point Linearization problem s.all cycles.property