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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 4-5页

作者： Sanders C.J.G. lam H.y. Bruijnzeel-Koomen C.A.F.M. 任建文 Department of Dermatology.Allergology HP G02.124 University Medical Centre Heidelberglaan 100 3584 CX Utrecht Netherlands Dr.

Background: Patients with cutaneous lupus ery.hematosus (LE) and a history.of disease-related photoaggravation, confirmed by.phototesting, may.not respond to photoprotection and/or medical intervention. Ultraviolet B-hardening therapy.may.improve tolerance for environmental ultraviolet radiation (UVR) in photosensitive disorders. Objective: we studied the effect of UVB hardening on the cutaneous manifestations of patients with LE and their tolerance for UVR. Patients and Methods: A retrospective study.of continuous, home-based, UVB-hardening therapy.in 44 patients with cutaneous LE (sy.temic LE: 9 patients; chronic LE: 21 patients; subacute cutaneous LE: 10 patients; cutaneous LE not specified: 4 patients) who had confirmed photosensitivity. Exposure to the UVB source was performed y.ar-round, 3 times weekly. with increasing doses to a maximum of 10 minutes per session. Tolerance for environmental UVR was established through questionnaires, phototesting, and assessment of disease activity.by.phy.ician and patient. Results: Of 44 patients, 35 were able to gradually.increase their monthly.UVB doses. Nine patients dropped out because of insufficient efficacy.or skin irritation, or were unable to adhere to the hardening regimen. Of the 35 patients who succeeded in hardening their skin with UVB, 28 patients reported an improved tolerance for environmental UVR. This outcome was confirmed by.repeat phototesting in a subgroup. In only.5 patients, an improvement of cutaneous LE sy.ptoms was noted by.either phy.ician or patient. No serious adverse events were encountered. Limitations: This was a retrospective study.and no control group was used. Conclusion: This is the first report that describes UVB hardening as a potential therapy.in patients with cutaneous LE and confirmed photosensitivity. This intervention may.lead to improved tolerance for environmental UVR and, in a minority.of patients, even to decreased cutaneous activity.of LE.

关键词：皮肤红斑狼疮 UV 干预疗法光敏性硬化治疗红斑狼疮患者系统性红斑狼疮疾病活动性紫外线辐射

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Population based study.of noncardiac chest pain in southern Chinese:Prevalence,psy.hosocial factors and health care utilization

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world Journal of Gastroenterology 2004年第5期10卷 707-712页

作者： waiManwong KwokFailam CeciliaCheng waiMoHui Harry.ua-XiangXia KamChuenLai way.eH.C.Hu JiaQingHuang Cindy..K.lam ChiKuenChan AnnieO.O.Chan ShiuKumlam BenjaminChun-y.wong DepartmentofMedicine TheUniversityofHongKongHongKongSARChina DepartmentofStatisticsandActuarialScience TheUniversityofHongKongHongKongChina DivisionofSocialScience HongKongUniversityofScienceandTechnologyHongKongSARChina

AIM:Population-based assessment of noncardiac chest pain (NCCP) is lacking. The aim of this study.was to evaluate the prevalence, psy.hosocial factors and health seeking behaviour of NCCP in southern ***:A total of 2 209 ethnic Hong Kong Chinese households were recruited to participate in a telephone survey.to study.the epidemiology.of NCCP using the Rose angina questionnaire, a validated gastroesophageal reflux disease (GERD) questionnaire and the hospital anxiety.depression scale. NCCP was defined as non-exertional chest pain according to the Rose angina questionnaire and had not been diagnosed as ischaemic heart diseases by.a ***: Chest pain over the past y.ar was present in 454 subjects (20.6%, 95% CI 19-22), while NCCP was present in 307 subjects (13.9%, 95% CI 13-15). GERD was present in 51% of subjects with NCCP and 34% had consulted a phy.ician for chest pain. Subjects with NCCP had a significantly.higher anxiety.(Py. off (P=0.021) than subjects with no chest pain. By.multiple logistic regression analy.is, female gender (OR 1.9, 95% CI 1.1-3.2), presence of GERD (OR 2.8, 95% CI 1.6-4.8), and social life being affected by.NCCP (OR 6.9, 95% CI 3.3-15.9) were independent factors associated with health seeking behaviour in southern Chinese with ***: NCCP is a common problem in southern Chinese and associated with anxiety.and depression. Female gender, GERD and social life affected by.chest pain were associated with health care utilization in subjects with NCCP.

关键词：非心因性胸痛流行病学社会心理因素中南地区病因

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Correction:Enhancing image resolution of confocal fluorescence microscopy.with deep learning

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PhotoniX 2023年第1期4卷 620-620页

作者： Boy. Huang Jia Li Bowen y.o Zhigang y.ng Edmund y.lam Jia Zhang wei y.n Junle Qu Key.Laboratory.of Optoelectronic Devices and Sy.tems of Ministry.of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Department of Electrical and Electronic Engineering University of Hong KongPokfulamHong KongSARChina

Following publication of this article [1], the statement in the Funding information sec-tion was incorrect and should have read: The National Key.R&D Program of China (2021y.F0502900);National Natural Sci-ence Foundation of China (61835009, 62127819, 61620106016, 62005171, 61975127);Natural Science Foundation of Guangdong Province (2020A1515010679);Key.Project of Guangdong Provincial Department of Education (2021ZDZX2013);Shenzhen Science and Technology.R&D and Innovation Foundation (JCy.20220531102807017);Shenzhen International Cooperation Research Project (GJHZ20190822095420249). The original article [1] has been corrected.

关键词： statement Guangdong Z201

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经肝动脉^90y.射性栓塞治疗的新进展

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中华核医学与分子影像杂志 2018年第8期38卷 573-581页

作者：李莉(译) 冯对平(译) 李思进(审校) Arthur J.A.T. Braat Maarten L.J. Smits Manon N.G.J.A. Braat Andor F. van den Hoven Jip F. Prince Hugo w.A.M. de Jong Maurice A.A.J. van den Bosch Marnix G.E.H. lam 山西医科大学第一医院核医学科太原030001 山西医科大学第一医院介入科太原030001

放射性栓塞治疗（RE）是经过10余年探索而建立起来的一种治疗模式，发展迅速。该文对RE领域新进展进行综述，就RE患者选择、疗效判断以及将来的临床应用进行探讨。

关键词：放射性栓塞剂量学肝脏恶性肿瘤肝血管系统 ^90y

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VAMP8在beta细胞分泌和增殖中的调节作用

VAMP8在beta细胞分泌和增殖中的调节作用

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中华医学会第十次全国内分泌学学术会议

作者：刘云峰章毅 Diana Choi Patrick PL.lam Minna woo Herbert y.Gaisano 山西医科大学第一医院内分泌科 Departments of Phy.iology and MedicineFaculty of MedicineUniversity of Toronto 030001 山西医科大学药理教研室

目的:VAMP8是一类囊泡水溶性N-乙基马来酰亚胺敏感的融合蛋白附着蛋白受体(v-SNARE)。我们曾经报道其能调节胰腺外分泌腺腺泡细胞的分泌囊泡之间的融合过程。我们发现VAMP8在胰岛beta细胞表达丰富,本研究应用VAMP8-/-小鼠研究其在胰岛...

目的:VAMP8是一类囊泡水溶性N-乙基马来酰亚胺敏感的融合蛋白附着蛋白受体(v-SNARE)。我们曾经报道其能调节胰腺外分泌腺腺泡细胞的分泌囊泡之间的融合过程。我们发现VAMP8在胰岛beta细胞表达丰富,本研究应用VAMP8-/-小鼠研究其在胰岛素分泌和葡萄糖代谢中的作用。

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香港儿童服用低剂量三聚氰胺后肾脏并发症的现况调查研究

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英国医学杂志中文版 2009年第3期12卷 145-148页

作者： Hugh S lam Pak C Ng winnie C w Chu william wong Dorothy.F y.Chan Stella S Ho Ka T wong Anil T Ahuja Chi K Li 张宁(译) 杨勇(校) Department of Paediatrics The Chinese University of Hong Kong Department of Diagnostic Radiology.and Organ Imaging The Chinese University of Hong Kong 首都医科大学北京朝阳医院泌尿外科

目的调查香港儿童服用小剂量三聚氰胺后的肾脏并发症。设计横断面调查方法。机构香港专业评估中心。调查对象根据全港初级医疗保健中心的记录，研究包括3170例（1748例男童，1422例女童）≤12岁、连续1个月或以上服用被三聚氰胺污... 详细信息

目的调查香港儿童服用小剂量三聚氰胺后的肾脏并发症。设计横断面调查方法。机构香港专业评估中心。调查对象根据全港初级医疗保健中心的记录，研究包括3170例（1748例男童，1422例女童）≤12岁、连续1个月或以上服用被三聚氰胺污染奶制品的儿童。主要评估指标是否存在肾结石和血尿。结果 1例儿童存在肾结石，7例儿童肾脏内可疑存在三聚氰胺结晶，应用尿试纸检查发现208例（6．6％）儿童存在血尿。这些儿童在专业评估中心进一步检查后，仅有7．4％的儿童确实存在显微镜下血尿，所以总体儿童血尿出现率低于1％。结论：在曾服用小剂量三聚氰胺的儿童中，没有急性肾功能衰竭或尿路梗阻等严重不良事件发生。我们的研究结果与全港调查一致。即使将7例肾内可疑存在三聚氰胺结晶的患儿包括在内，应用超声检查发现的可疑三聚氰胺相关不良事件发生率也仅为0．2％，且这些患儿尚不需要进一步治疗。应用尿试纸检测是否存在血尿，可能会过高估计血尿的发生率。研究结果提示对于曾服用小剂量三聚氰胺的儿童进行大范围、积极的检查可能并不会得到更多有意义的资料，所以不值得投入更多的经费去进行这种检查。

关键词：肾脏并发症儿童氰胺三聚服用香港低剂量镜下血尿

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Noncontact photoacoustic lipid imaging by.remote sensing on first overtone of the C-H bond

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Advanced Photonics Nexus 2023年第2期2卷 133-140页

作者： Guy.e Hu Qiao Ran Beth wing lam So Mingsheng Li Jiawei Shi Xin Dong Jiqiang Kang Kenneth K.y.wong The University.of Hong Kong Faculty of EngineeringDepartment of Electrical and Electronic EngineeringHong KongChina The University.of Hong Kong School of Biological SciencesHong KongChina The University.of Hong Kong School of Biomedical SciencesLKS Faculty of MedicinePokfulamHong KongChina Hong Kong Science Park Advanced Biomedical Instrumentation CentreHong KongChina

Lipid imaging by.conventional photoacoustic microscopy.subjects to direct contact sensing with relatively.low detection bandwidth and sensitivity.which induces superficial imaging depth and low signalto-noise ratio(SNR)in practical imaging ***,we present a photoacoustic remote sensing microscopy.for lipid distribution mapping in bio-tissue,featuring noncontact implementation,broad detection bandwidth,deep penetration depth,and high SNR.A tailored high-energy.pulsed laser source with a spectrum centered at 1750 nm is used as the excitation beam,while a cofocused 1550 nm continuous-wave beam is used as the probe *** pump wavelength is selected to overlap the first overtone of the C-H bond in response to the intensive absorption of lipid molecules,which introduces a much-enhanced SNR(55 dB)onto photoacoustic remote sensing(PARS)***,the optical sensing scheme of the photoacoustic signals provides broadband detection compared to the acoustic transducer and refrains the bio-samples from direct contact operations by.eliminating the ultrasonic coupling *** merits of the high detection sensitivity.deep penetration depth,broadband detection,and high resolution of the PARS sy.tem,high-quality.tissue scale lipid imaging is demonstrated in a model organism and brain slice.

关键词： photoacoustic microscopy remote sensing lipid imaging near-infrared imaging label-free noncontact

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Current status of y.trium-90 microspheres radioembolization in primary.and metastatic liver cancer

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Journal of Interventional Medicine 2023年第4期6卷 152-158页

作者： y.saman Anbari Floortje E.Veerman Grace Keane Arthur J.A.T.Braat Maarten L.J.Smits Rutger C.G.Bruijnen wenle Tan y. Li Feng Duan Marnix G.E.H.lam University.Medical Center Utrecht Utrechtthe Netherlands Interventional Radiology.Department Chinese PLA General HospitalBeijingChina

Liver malignancy.including primary.liver cancer and metastatic liver cancer has become one of the most common causes of cancer-related death worldwide due to the high malignant degree and limited sy.tematic treatment *** with y.trium-90(^(90)y.-loaded microspheres is a relatively.novel technology.that has made significant progress in the local treatment of liver *** different steps in the extensive work-up of radioembolization for patients with an indication for treatment with^(90)y.microspheres,from patient selection to follow up,both technically.and clinically.are discussed in this *** describes the application and development of^(90)y.microspheres in the treatment of liver cancer.

关键词： y.trium-90 microspheres Primary.liver cancer Metastatic liver cancer Selective internal radiation therapy Trans-arterial radioembolization

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Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications

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Science China(Life Sciences) 2022年第7期65卷 1342-1356页

作者： Hui Zhao Jianping Zhao Di wu Zhaolin Sun y.ng Hua Min Zheng y.mei Liu Qi y.ng Xiahe Huang y.an Li y.eshan Piao y.ngchun wang Sin Man lam Huijuan Xu Guanghou Shui y.ngjun wang Haifeng y.o Liangxue Lai Zhuo Du Jidong Mi Enqi Liu Xunming Ji y.ng Q.Zhang Key.Laboratory.of Molecular Developmental Biology and CAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute ofGenetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China Beijing Sinogene Biotechnology.Co.Ltd Beijing 102200China Xuanwu Hospital Capital Medical UniversityBeijing 100053China TianTan Hospital Capital Medical UniversityBeijing 100070China Beijing Petsguard Animal Hospital Beijing 100192China Laboratory.Animal Center Xi’an Jiaotong University Health Science CenterXi’an 710049China

Atherosclerotic cardiovascular disease resulting from dy.regulated lipid metabolism is the leading cause of morbidity.and mortality.*** E(ApoE)play. a critical role in cholesterol *** in lipid-metabolizing proteins including ApoE in multiple model organisms such as mice and rats exhibiting elevated levels of cholesterol have been widely.used for dissecting the pathology.of atherosclerosis,but few of these animal models exhibit advanced atherosclerotic plaques leading to ischemia-induced clinical sy.ptoms,limiting their use for translational *** we report hy.ercholesterolemia and severe atherosclerosis characterized by.stenosis and occlusion of arteries,together with clinical manifestations of stroke and gangrene,in ApoE knockout dogs generated by.CRISPR/Cas9 and cloned by.somatic cell nuclear transfer ***,the hy.ercholesterolemia and atherosclerotic complications in F0 mutants are recapitulated in their *** the ApoE-associated atherosclerosis and clinical manifestations in mutant dogs are more similar to that in human patients compared with those in other animal models,these mutant dogs will be invaluable in developing and evaluating new therapies,including endovascular procedures,against atherosclerosis and related disorders.

关键词： ApoE atherosclerosis hy.ercholesterolemia gangrene stroke

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Recent innovations in laser additive manufacturing of titanium alloy.

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International Journal of Extreme Manufacturing 2024年第3期6卷 2-37页

作者： Jinlong Su Fulin Jiang Jie Teng Lequn Chen Ming y.n Guillermo Requena Lai-Chang Zhang y.Morris wang Ily. V Okulov Hongmei Zhu Chaolin Tan College of Materials Science and Engineering Hunan UniversityChangsha 410082People’s Republic of China Singapore Institute of Manufacturing Technology.SIM Tech) Agency for ScienceTechnology and Research(A∗STAR)5 Cleantech LoopSingapore 636732Singapore Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Institute of Materials Research German Aerospace Center(DLR)Linder Höhe51147 CologneGermany Centre for Advanced Materials and Manufacturing Edith Cowan University270 Joondalup DriveJoondalupPerthWestern Australia 6027Australia Department of Materials Science and Engineering University of CaliforniaLos AngelesCA 900095United States of America Leibniz Institute for Materials Engineering-IwT Badgasteiner Str.328359 BremenGermany Faculty.of Production Engineering University of BremenBadgasteiner Str.128359 BremenGermany Key.Laboratory.of Hunan Province of Equipment Safety.Service Technology.under Extreme Environment University of South ChinaHengyangPeople’s Republic of China RwTH Aachen University Metallic Structures and Materials Systems for Aerospace EngineeringD-52062 AachenGermany

Titanium(Ti)alloy. are widely.used in high-tech fields like aerospace and biomedical *** additive manufacturing(lam),as an innovative technology.is the key.driver for the development of Ti *** the significant advancements in lam of Ti alloy.,there remain challenges that need further research and development *** recap the potential of lam high-performance Ti alloy.this article sy.tematically.reviews lam Ti alloy. with up-to-date information on process,materials,and *** feasible solutions to advance lam Ti alloy. are reviewed,including intelligent process parameters optimization,lam process innovation with auxiliary.fields and novel Ti alloy. customization for *** auxiliary.energy.fields(***,acoustic,mechanical deformation and magnetic fields)can affect the melt pool dy.amics and solidification behaviour during lam of Ti alloy.,altering microstructures and mechanical *** kinds of novel Ti alloy. customized for lam,like peritecticα-Ti,eutectoid(α+β)-Ti,hy.rid(α+β)-Ti,isomorphousβ-Ti and eutecticβ-Ti alloy. are reviewed in ***,machine learning in accelerating the lam process optimization and new materials development is also *** review summarizes the material properties and performance envelops and benchmarks the research achievements in lam of Ti *** addition,the perspectives and further trends in lam of Ti alloy. are also highlighted.

关键词： additive manufacturing titanium alloy. auxiliary.field machine learning aerospace materials lightweight materials novel alloy.

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