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Exendin-4 attenuates atherosclerosis progression via controlling hematopoietic stem/progenitor cell proliferation

Journal of Molecular Cell Biology 2023年第2期15卷 43-57页

作者： Cen y.n Xiaojuan Ma Sin Man lam y.ejie Zhang y. Cao y.an Dong Li Su Guanghou Shui y.ngmei Feng Department of Science and Development Beĳing Youan hospitalCapital Medical UniversityBeĳing 100069China Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third HospitalBeĳing 100191China State Key.Laboratory.of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeĳing 100101China Neuroscience Research Institute Peking University Center of Medical and Health AnalysisPeking UniversityBeĳing 100191China

Bey.nd gly.emic control, applications of glucagon-like peptide-1 receptor (GLP-1r) agonists (GLP-1 RAs) inhibit inflammationand plaque development in murine atherosclerotic models. However, whether they.modulate hematopoietic stem/progenitor cells(HSPCs)to prohibit skewed my.lopoiesis in hy.ercholesteremia remains unknown. In this study. GLP-1r expression in fluorescenceactivated cell sorting (FACS)-sorted wild-ty.e HSPCs was determined by.capillary.western blotting. Bone marrow cells (BMCs)of wild-ty.e or GLP-1r−/− mice were transplanted into lethally.irradiated low-density.lipoprotein receptor deficient (LDLr−/−)recipients followed by.high-fat diet (HFD) for chimerism analy.is by.FACS. In parallel, LDLr−/− mice were placed on HFD for 6weeks and then treated with saline or Exendin-4 (Ex-4) for another 6 weeks. HSPC frequency.and cell cy.le were analy.ed by.ACS, and intracellular metabolite levels were assessed by.targeted metabolomics. The results demonstrated that HSPCs expressedGLP-1r and transplantation of GLP-1r−/− BMCs resulted in skewed my.lopoiesis in hy.ercholesterolemic LDLr−/− *** vitro, Ex-4 treatment of FACS-purified HSPCs suppressed cell expansion and granulocy.e production induced by.LDL. In vivo, Ex-4treatment inhibited plaque progression, suppressed HSPC proliferation, and modified gly.oly.ic and lipid metabolism in HSPCs ofhy.ercholesteremic LDLr−/− mice. In conclusion, Ex-4 could directly.inhibit HSPC proliferation induced by.hy.ercholesteremia.

关键词： glucagon-like peptide-1 receptor agonist hematopoietic stem/progenitor cells proliferation metabolomics atherosclerosis

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Hy.rid brightfield and darkfield transport of intensity.approach for high-throughput quantitative phase microscopy

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Advanced Photonics 2022年第5期4卷 15-26页

作者： Linpeng Lu Jiaji Li y.feng Shu Jiasong Sun Jie Zhou Edmund y.lam Qian Chen Chao Zuo Nanjing University.of Science and Technology Smart Computational Imaging Laboratory(SCILab)NanjingChina Nanjing University.of Science and Technology School of Electronic and Optical EngineeringNanjingChina Jiangsu Key.Laboratory.of Spectral Imaging&Intelligent Sense NanjingChina Nanjing University.of Science and Technology Smart Computational Imaging Research Institute(SCIRI)NanjingChina The University.of Hong Kong Department of Electrical and Electronic EngineeringPokfulamHong KongChina

Transport of intensity.equation(TIE)is a well-established non-interferometric phase retrieval approach that enables quantitative phase imaging(QPI)by.simply.measuring intensity.images at multiple axially.displaced *** advantage of a TIE-based QPI sy.tem is its compatibility.with partially.coherent illumination,which provides speckle-free imaging with resolution bey.nd the coherent diffraction ***,TIE is generally.implemented with a brightfield(BF)configuration,and the maximum achievable imaging resolution is still limited to the incoherent diffraction limit(twice the coherent diffraction limit).It is desirable that TIE-related approaches can surpass this limit and achieve high-throughput[high-resolution and wide field of view(FOV)]*** propose a hy.rid BF and darkfield transport of intensity.HBDTI)approach for highthroughput quantitative phase *** through-focus intensity.stacks corresponding to BF and darkfield illuminations are acquired through a low-numerical-aperture(NA)objective *** high-resolution and large-FOV complex amplitude(both quantitative absorption and phase distributions)can then be sy.thesized based on an iterative phase retrieval algorithm taking the coherence model decomposition into *** effectiveness of the proposed method is experimentally.verified by.the retrieval of the USAF resolution target and different ty.es of biological *** experimental results demonstrate that the half-width imaging resolution can be improved from 1230 nm to 488 nm with 2.5×expansion across a 4×FOV of 7.19 mm2,corresponding to a 6.25×increase in space-bandwidth product from∼5 to∼30.2 *** contrast to conventional TIE-based QPI methods where only.BF illumination is used,the sy.thetic aperture process of HBDTI further incorporates darkfield illuminations to expand the accessible object frequency.thereby.significantly.extending the maximum available resolution from 2NA to∼5NA with a∼5×promotion of the coherent diffra

关键词： transport of intensity.equation phase retrieval darkfield imaging high-throughput microscopy

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补血清肝四宝

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心血管病防治知识 2011年第5期 8-10页

作者：张云辉 jacky.Z.y

温馨贴士甲鱼营养丰富,但腥昧较重,煲汤前,将甲鱼的胆汁与水混合,涂于甲鱼全身,稍等片刻,用清水把胆汁洗掉,可除去腥味。知母银耳甲鱼汤汤料佳配:知母、黄柏、天冬、女贞子各10克,银耳15克,甲鱼1只,生姜、葱各适量。煲汤程序:①知母、...

温馨贴士甲鱼营养丰富,但腥昧较重,煲汤前,将甲鱼的胆汁与水混合,涂于甲鱼全身,稍等片刻,用清水把胆汁洗掉,可除去腥味。知母银耳甲鱼汤汤料佳配:知母、黄柏、天冬、女贞子各10克,银耳15克,甲鱼1只,生姜、葱各适量。煲汤程序:①知母、黄柏、天冬、女贞子分别洗净,装入药袋。②银耳洗净,发水。③甲鱼杀好,洗净。④

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补血清肝四宝

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心血管病防治知识 2011年第4期 8-9页

作者：张云辉 jacky.Z.y

知母银耳甲鱼汤汤料佳配：知母、黄柏、天冬、女贞子各lO克，银耳15克，甲鱼1只，生姜、葱各适量。

关键词：清肝补血甲鱼汤女贞子银耳知母

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健脾补肾汤

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心血管病防治知识 2011年第4期 10-11页

作者：张云辉 jacky.Z.y

桂圆羊肉汤桂圆肉30克，羊肉500克，生姜30克，葱、盐、料酒各少许。

关键词：健脾补肾汤羊肉汤桂圆肉

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应用于虹膜缺失和白化病患者的黑色隔膜无虹膜型人工晶体

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 49-50页

作者： wong V.w.y. lam P.T.H. Lai T.y.y. lam D.S.C. 潘佳鸿 Department of Ophtha lmology.and Visual Sciences Hong Kong Eye Hospital The Chinese University of H ong Kong 147KArgyle Street HongKong HongKong

Background: Our aim was to assess the safety.and efficacy.of primary.and secon dary.implantation of a black diaphragm aniridia intraocular lens (IOL) in patien ts that lacked a complete iris diaphragm. Methods: This was a retrospective non -comparative study.of six ey.s in five patients with iris defects. The causes o f such defects included congenital aniridia, traumatic aniridia, and oculocutane ous albinism. Three ey.s underwent primary.implantations of a black diaphragm IO L, and three ey.s were given secondary.implantations. The visual acuity. subject ive severity.of glare, postoperative anatomical outcome and any.intraoperative o r postoperative complications were reviewed. Results: The mean follow-up period was 20.6 months (range 3-29 months. All patients showed stable or improvement in best-corrected visual acuity.postoperatively. Glare and photophobia had impr oved subjectively.in all patients after implantation of the black diaphragm IOL. Intraoperative complication included one case of hy.haema and iris damage durin g insertion of the IOL. Postoperative complications included intraocular inflamm ation with choroidal detachment, secondary.glaucoma, and persistent epithelial d efect after surgery. None of the patients developed decentration of IOL after su rgery. Conclusion: The black diaphragm aniridia IOL is useful in the management of the condition in patients with iris deficiency.including oculocutaneous albin ism. Intraoperative and postoperative complications are not uncommon, and patients should be monitored carefully.in the perioperative period.

关键词：虹膜型人工晶体虹膜缺失虹膜缺损外伤性无虹膜脉络膜脱离上皮缺损眩光眼内炎矫正视力前房出血

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Estimating liver weight of adults by.body.weight and gender

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world Journal of Gastroenterology 2006年第14期12卷 2217-2222页

作者： See Ching Chan Chi Leung Liu Chung Mau Lo Banny.K lam Evely. w Lee y.k wong Sheung Tat Fan Centre for the Study.of Liver Disease Department of Surgery The University of Hong Kong Pokfulam Hong Kong China Centre for the Study.of Liver Disease Department of Radiology The University of Hong Kong Pokfulam Hong Kong China

AIM： To estimate the standard liver weight for assessing adequacies of graft size in live donor liver transplantation and remnant liver in major hepatectomy.for cancer. METHODS： In this study. anthropometric data of body.weight and body.height were tested for a correlation with liver weight in 159 live liver donors who underwent donor right hepatectomy.including the middle hepatic vein. Liver weights were calculated from the right lobe graft weight obtained at the back table, divided by.the proportion of the right lobe on the computed tomography. RESULTS： The subjects, all Chinese, had a mean age of 35.8 ± 10.5 y.ars, and a female to male ratio of 118：41. The mean volume of the right lobe was 710.14 ±131.46 mL and occupied 64.55%±4.47% of the whole liver on computed tomography. Right lobe weighed 598.90±117.39 g and the estimated liver weight was 927.54 ± 168.78 g. when body.weight and body.height were subjected to multiple stepwise linear regression analy.is, body.height was found to be insignificant. Females of the same body.weight had a slightly.lower liver weight. A formula based on body.weight and gender was derived： Estimated standard liver weight （g）=218＋Bw （kg）× 12.3＋gender×51 （R^2 = 0.48）（female=0, male= 1）. Based on the anthropometric data of these 159 subjects, liver weights were calculated using previously.published formulae derived from studies on Caucasian, .lapanese, Korean, and Chinese. All formulae overestimated liver weights compared to this formula. The Japanese formula overestimated the estimated standard liver weight （ESLw） for adults less than 60 ***： A formula applicable to Chinese males and females is available. A formula for individual races appears necessary.

关键词： Estimated standard liver weight Liver tranplantation

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A BRIEF VIEw OF THE CURRENT STATE OF THE DEVELOPMENT AND AGING PERFORMANCE OF FIXED FREQUENCy.SURFACE ACOUSTIC wAVE(SAw) OSCILLATOR

A BRIEF VIEW OF THE CURRENT STATE OF THE DEVELOPMENT AND AGI...

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2012全国压电和声波理论及器件技术研讨会

作者： C.S.lam P.y.SU C.H.CHEN TXC Technology Inc.MilpitasCaliforniaUSA TXC Corporation

The recent rapid expansion of optical fiber networking market fuels the demand for accurate 10000 MHz fixed frequency.oscillators based on surface acoustic wave(SAw) ***,several suppliers can offer small size and cost efficient SMD single-end and differential SAw oscillators(SOs) with very.good phase jitter *** customers prefer SO solution as it is free of the unsettling problems from some cry.tal oscillator(XO) solutions- high cost of high frequency.fundamental(HFF) and inverted mesa(IM) cry.tal blanks,spurious modes,frequency.jumping,drive level sensitivity.high cost of phase lock loop(PLL) die,*** paper is to provide a brief view of the current state of the development of fixed frequency.*** on the aging data of more than 20,000 hours at 125℃,the authors also comment on the SO aging performance fabricated using different SAw wave-ty.es.

关键词： SAw Oscillator Quartz Cry.tal Aging

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A cross-sectional study.on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population

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International Journal of Ophthalmology.English edition) 2017年第2期10卷 293-299页

作者： Man-Hin Lui Jason Chun Ho lam y. Lee Kwong Tak Siu wong Pak Long Cheung Sherri Shun y.n Lai Pak Lun y.en wai y.u lam Ho y.n Chan y.u Fai wong Jimmy.Shiu Ming Lai Kendrick Co Shih Li Ka Shing Faculty.of Medicine the University of Hong KongPokfulamHong KongChina Department of Ophthalmology Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHongKongChina Department of Ophthalmology Queen Mary HospitalPokfulamHong KongChina

AIM： To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical ***： This was a retrospective cross-sectional ***-seven primary.glaucoma patients from the subspecialty.clinic of a publicly.funded tertiary.care hospital in Hong Kong completed a questionnaire on compliance with topical glaucoma medication,attitude towards glaucoma and therapy.and vision related quality.of *** was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately.prior to the *** between noncompliance and demographics,attitude,disease and treatment status was *** was estimated with quality.of life and direct medical cost involved with *** logistic regression on noncompliance was performed on selected ***： Compliance was calculated as 75%（95% CI： 64%-87%） among 57 subjects（mean age 69 y.female 51%）.No statistical significant relationship was established between noncompliance and any.single factors or ***（P=0.048） and forgetfulness（P=0.064） were found to be marginally.significant predictive factors on noncompliance in multivariable logistic *** might be related（P=0.130） to poorer self-rated vision-associated quality.of *** societal cost of noncompliance was estimated to be over 2510 life-y.ars and US$ 3.7 million ***： The compliance of Chinese glaucoma patients in Hong Kong is comparable to other parts in the world,and carries detrimental impacts on individual and societal *** and forgetfulness are two possible independent predictors for noncompliance.

关键词： glaucoma ey. drop compliance quality.of life

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Irving Kaplansky.1917--2006）

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数学译林 2008年第2期27卷 166-171,131页

作者： Hy.an Bass T.y.lam 马守全(译) 高燕芳(校) 陆柱家(校)

我喜欢以代数的方式看事物，当代数方法应用到无限多的实体时，我会更加为之着迷．

关键词：代数数学方程模理论

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