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Ly.phoproliferative disorders in inflammatory.bowel disease patients on immunosuppression: Lessons from other inflammatory.disorders

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world Journal of Gastrointestinal Pathophy.iology 2015年第4期6卷 181-192页

作者： Grace y.lam Brendan P Halloran Anthea C Peters Richard N Fedorak Department of Medicine Division of Internal Medicine University of Alberta Department of Medicine Division of Gastroenterology University of Alberta Department of Medicine Division of HematologyUniversity of Alberta

Immunosuppressive agents, such as thiopurines, methotrexate, and biologics, have revolutionized the treatment of inflammatory.bowel disease(IBD). However, a number of case reports, case control studies and retrospective studies over the last decade have identified a concerning link between immunosuppression and ly.phoproliferative disorders(LPDs), the oncological phenomenon whereby.ly.phocy.es divide uncontrollably. These LPDs have been associated with Epstein-Barr virus(EBV) infection in which the virus provides the impetus for malignant transformation while immunosuppression hampers the immune sy.tem's ability.to detect and clear these malignant cells. As such, the use of immunosuppressive agents may.come at the cost of increased risk of developing LPD. while little is known about the LPD risk in IBD, more is known about immunosuppression in the post-transplantation setting and the development of EBV associated posttransplantation ly.phoproliferative disorders(PTLD). In review of the PTLD literature, evidence is available to demonstrate that certain immune suppressants such as cy.losporine and T-ly.phocy.e modulators in particular are associated with an increased risk of PTLD development. As well, high doses of immunosuppressive agents and multiple immunosuppressive agent use are also linked to increased PTLD development. Here,we discuss these findings in context of IBD and what future studies can be taken to understand and reduce the risk of EBV-associated LPD development from immunosuppression use in IBD.

关键词： Epstein-Barr virus Immunosuppression Post-transpla

Lipidomics as a Principal Tool for Advancing Biomedical Research

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Journal of Genetics and Genomics 2013年第8期40卷 375-390页

作者： Sin Man lam Guanghou Shui State Key.Laboratory.of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences

Lipidomics, which targets at the construction of a comprehensive map of lipidome comprising the entire lipid pool within a cell or tissue, is currently.emerging as an independent discipline at the interface of lipid biology. technology.and medicine. The diversity.and complexity.of the biological lipidomes call for technical innovation and improvement to meet the needs of various biomedical studies. The recent wave of expansion in the field of lipidomic research is mainly.attributed to advances in analy.ical technologies, in particular, the development of new mass spectrometric and chromatographic tools for the characterization and quantification of the wide array.of diverse lipid species in the cellular lipidome. Here, we review some of the key.technical advances in lipidome analy.is and put forth the applications of lipidomics in addressing the biological roles of lipids in numerous disease models including the metabolic sy.drome, neurodegenerative diseases and infectious diseases, as well as the increasing urgency.to construct the lipidome inventory.for various mammalian/organism models useful for biomedical research.

关键词： Lipidomics Mass spectrometry Metabolic sy.drome Neurodegenerative diseases Infectious diseases

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如何进行煤气化厂的环境影响评价

煤炭转化 1986年第3期 67-72页

作者： A.w.Metwally.E.y.lam,赵振本美国Bechtel公司美国Bechtel公司

一、引言使用煤气化厂生产的煤气同直接烧煤相比较,具有减轻对环境污染的效益,这是考虑建设煤气化厂的一个重要原因。对于拟建的煤气化厂进行环境影响评价是煤气化厂建设程序的首要步骤。环境影响评价可以给决策机关提供关于拟建煤气化... 详细信息

一、引言使用煤气化厂生产的煤气同直接烧煤相比较,具有减轻对环境污染的效益,这是考虑建设煤气化厂的一个重要原因。对于拟建的煤气化厂进行环境影响评价是煤气化厂建设程序的首要步骤。环境影响评价可以给决策机关提供关于拟建煤气化厂的技术资料,并在环境上可能产生的不利影响和利益之间提供比较评定。环境影响评价还分析讨论可供选择的其他设计方案和减轻不利影响的措

关键词：煤气化厂不利影响废物环境影响分析环境质量评价环境影响评价煤气化技术气化反应器气化炉大气排放物

Enhancing image resolution of confocal fluorescence microscopy.with deep learning

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PhotoniX 2023年第1期4卷 652-673页

作者： Boy. Huang Jia Li Bowen y.o Zhigang y.ng Edmund y.lam Jia Zhang wei y.n Junle Qu Key.Laboratory.of Optoelectronic Devices and Sy.tems of Ministry.of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Department of Electrical and Electronic Engineering University of Hong KongPokfulamHong KongSARChina

Super-resolution optical imaging is crucial to the study.of cellular *** super-resolution fluorescence microscopy.is restricted by.the need of special fluorophores or sophisticated optical sy.tems,or long acquisition and computational *** this work,we present a deep-learning-based super-resolution technique of confocal *** devise a two-channel attention network(TCAN),which takes advantage of both spatial representations and frequency.contents to learn a more precise mapping from low-resolution images to high-resolution *** scheme is robust against changes in the pixel size and the imaging setup,enabling the optimal model to generalize to different fluorescence microscopy.modalities unseen in the training *** algorithm is validated on diverse biological structures and dual-color confocal images of actin-microtubules,improving the resolution from~230 nm to~110 *** but not least,we demonstrate live-cell super-resolution imaging by.revealing the detailed structures and dy.amic instability.of microtubules.

关键词： Super-resolution fluorescence microscopy Image resolution enhancement Deep learning Generative adversarial network

A FAST SIGNAL-DEPENDENT TIME-FREQUENCy.REPRESENTATION

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A FAST SIGNAL-DEPENDENT TIME-FREQUENCY REPRESENTATION

Ultrafast laser-scanning time-stretch imaging at visible wavelengths

1999年中国神经网络与信号处理学术会议

作者： F.H.y.Chan F.K.lam Department of Electrical and Electronic Engineering The University.of Hong Kong

In last few y.ars,in order to overcome some limitations of the short time Fourier transform(STFT),while avoiding the cross-terms that make the wigner distribution difficult to interpret,some signal-dependent time-frequency.representations(SDTFR) have been *** this paper,we introduce a computationally.efficient signal-dependent time-frequency.method that is suitable for on-line *** SDTFR uses a Gaussian window(Gw) similar to STFT,but varies the parameter o of the Gw with time to achieve high signal concentration and high resolution in *** parameterσcan be automatically.calculated by.the slope of instantaneous frequency.IF) and instantaneous bandwidth(IB) at that time.

关键词：

来源： cnki会议评论

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Light(Science & Applications) 2016年第1期5卷 303-312页

作者： Jiang-Lai wu y.-Qing Xu Jing-Jiang Xu Xiao-Ming wei Antony.CS Chan Anson HL Tang Andy.KS Lau Bob MF Chung Ho Cheung Shum Edmund y.lam Kenneth Ky.wong Kevin K Tsia Department of Electrical and Electronic Engineering The University of Hong KongPokfulam RoadHong Kong 999077China Department of Bioengineering University of WashingtonSeattleWashington 98195USA Department of Mechanical Engineering The University of Hong KongPokfulam RoadHong Kong 999077China

Optical time-stretch imaging enables the continuous capture of non-repetitive events in real time at a line-scan rate of tens of MHz—a distinct advantage for the ultrafast dy.amics monitoring and high-throughput screening that are widely.needed in biological ***,its potential is limited by.the technical challenge of achieving significant pulse stretching(that is,high temporal dispersion)and low optical loss,which are the critical factors influencing imaging quality.in the visible spectrum demanded in many.of these *** present a new pulse-stretching technique,termed free-space angular-chirpenhanced delay.FACED),with three distinguishing features absent in the prevailing dispersive-fiber-based implementations:(1)it generates substantial,reconfigurable temporal dispersion in free space(41 ns nm^(−1))with low intrinsic loss(o6 dB)at visible wavelengths;(2)its wavelength-invariant pulse-stretching operation introduces a new paradigm in time-stretch imaging,which can now be implemented both with and without spectral encoding;and(3)pulse stretching in FACED inherently.provides an ultrafast all-optical laser-beam scanning mechanism at a line-scan rate of tens of *** FACED,we demonstrate not only.ultrafast laser-scanning time-stretch imaging with superior bright-field image quality.compared with previous work but also,for the first time,MHz fluorescence and colorized time-stretch *** results show that this technique could enable a wider scope of applications in high-speed and high-throughput biological microscopy.that were once out of reach.

关键词： optical time-stretch imaging pulse stretching ultrafast laser scanning

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu y.n Jemma Arakely.n Teng wan Ritvik Raina Tsz Ki Chan Dohy.n Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui y. Ho Feijun Hu y.jeong Kim Hill lam Lau y.ng Lo Law Chi Seng Leung Chun y.n Tong Kai Kap wong wing lam y.m Nikolay.S.Karnaukhov Richard y.C.Kong Maria V.Babak y.dai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosy.thetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus ory.ae by.expressing the sesterterpene sy.thase VrcA and the cy.ochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathway. y.elded three new variecolin analogues(5-7).Analy.is of the compounds’anticancer activity.in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly.reduced toxic side effects in cancer-bearing mice,indicating its potentially.broader therapeutic *** study.describes the first tests of variecolin and its analogues in animals and demonstrates the utility.of sy.thetic biology.for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosy.thesis Natural products Sesterterpenoids Sy.thetic biology Terpene sy.thases Variecolin

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有限群的表示一百年（Ⅱ

数学译林 2002年第4期21卷 319-329,303页

作者： T.y.lam

Doxorubicin-loaded PLGA Microparticles with Internal Pores for Longacting Release in Pulmonary.Tumor Inhalation Treatment

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Chinese Journal of Poly.er Science 2015年第7期33卷 947-954页

作者： Tian-shi Feng 田华雨 Cai-na Xu Lin Lin Michael Hon-wah lam Hao-jun Liang Xue-si Chen CAS Key.Laboratory.of Soft Matter Chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of China Key.Laboratory.of Poly.er Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences Department of Biology.and Chemistry City University of Hong Kong Advanced Laboratory.of Environmental Research and Technology.ALERT) Joint Advanced Research Center

Doxorubicin（DOX） loaded poly.lactic-co-gly.olic acid）（PLGA） microparticles with internal pores（MP-D） were developed for long-acting release in pulmonary.inhalation treatment. The PLGA microparticles exhibited favorable aerody.amic properties for pulmonary.delivery. In vitro drug release profile suggested that MP-D have the advantage of long-term maintenance of drug concentrations. MTT assay.demonstrated the in vitro anti-tumor efficiency.of the DOX loaded PLGA microparticles. Furthermore, melanoma lung metastasis model was established to determine the in vivo antitumor efficiency. The mice treated with MP-D showed significantly.fewer lesions than the untreated ones. The survival analy.is indicated that MP-D prolonged the survival time of tumor-bearing mice. These results suggested that DOX loaded PLGA microparticles with internal pores have the potential to be used as long-acting release carriers in clinical lung cancer treatment.

关键词： Doxorubicin Poly.lactic-co-gly.olic acid) Internal pores Long-acting release Pulmonary.inhalation

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