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2017版wHO甲状腺肿瘤分类解读

中华病理学杂志 2018年第4期47卷 302-306页

作者：刘志艳周庚寅 Kennichi Kakudo Alfred K-y.lam 山东大学基础医学院病理学系山东大学齐鲁医院病理科济南250012 日本近畿大学医学院奈良病院病理科 Department of Pathology School of Medicine Griffith University Gold Coast QLD 4222 Australia

2017版wHO内分泌肿瘤分类根据肿瘤的病理、临床及基因学特点，对内分泌肿瘤的分类进行了全面的更新。新版wHO中甲状腺肿瘤分类总体可分为上皮性肿瘤、非上皮性肿瘤和继发肿瘤三大类（表1），其中最重要的进展在于甲状腺滤泡上皮细胞起... 详细信息

2017版wHO内分泌肿瘤分类根据肿瘤的病理、临床及基因学特点，对内分泌肿瘤的分类进行了全面的更新。新版wHO中甲状腺肿瘤分类总体可分为上皮性肿瘤、非上皮性肿瘤和继发肿瘤三大类（表1），其中最重要的进展在于甲状腺滤泡上皮细胞起源的高分化肿瘤。乳头和滤泡、良性和恶性分类的更新，并新增加了一组甲状腺交界性肿瘤。嗜酸细胞肿瘤从滤泡性肿瘤中剔除，成为一组独立的病变。低分化癌诊断标准进一步明确。

关键词：甲状腺滤泡肿瘤分类 wHO 非上皮性肿瘤内分泌肿瘤解读嗜酸细胞肿瘤交界性肿瘤

Single zircon lam-ICPMS U-Pb dating of Guidong complex(SE China)and its petrogenetic significance

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Chinese Science Bulletin 2003年第17期48卷 1892-1899页

作者： XUXishenq DENGPing S.y.O'Reilly.w.L.Griffin ZHOUXinmin TANZhengzhong StateKey.aboratory.orMineralDepositsResearch DepartmentofEarthSciencesNanjingUniversityNanjing210093China ResearchInstituteNo.290 SouthChinaBureauofGeologyCNNEShaoguan512026China ARCNationalKey.entreforthe-GeochemicalEvolutionandMetal-logeny.fContinents MacquarieUniversityNSW2109Australia

Single zircon lam-ICPMS U-Pb dating indi-cates that the Guidong granitic complex is a multistage ba-tholith formed during Indosinian-y.nshanian time. The Luxi body.(239 ± 5 Ma) and the Xiazhuang body.(235.8 ± 7.6 Ma) intruded during Indosinian time, whereas the Aizi body.(160.1 ± 6.1 Ma) and the Siqian body.(151 ± 11 Ma) formed during y.nshanian time. Inherited zircons (1275—2137 Ma) in the Xiazhuang body.imply.that at least part of the source rocks of the Guidong complex are from the Proterozoic basement of southeast China. Detailed single zirconlam-ICPMS U-Pb dating results provide important evi-dence for understanding the evolution, tectonic setting andmineralisation of the complex.

关键词：中国东南部成岩作用锆石 U-Pb测年电感耦合等离子体质谱法花岗岩

几何形状与压实对无线射频识别(RFID)标签印刷天线性能的影响

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中国印刷与包装研究 2009年第1期1卷 110-111页

作者： Stanley.y. y. Leung David C. C. lam

采用印刷天线的无线射频识别(RFID)标签,成本低,但性能不如金属天线标签。在不增加成本的情况下,提高印刷天线的性能则可替代金属天线。阻抗越低印刷天线的性能越高,而阻抗又取决于天线的厚度和导电油墨的阻抗。为了研究油墨紧度和粗细... 详细信息

采用印刷天线的无线射频识别(RFID)标签,成本低,但性能不如金属天线标签。在不增加成本的情况下,提高印刷天线的性能则可替代金属天线。阻抗越低印刷天线的性能越高,而阻抗又取决于天线的厚度和导电油墨的阻抗。为了研究油墨紧度和粗细对阻抗的影响,制备了不同线径的印刷天线。实验结果显示,通过压实印刷天线线圈,阻抗降低40%以上,而电感和电容则维持不变,且印刷天线经压实的RFID标签识别距离明显增加。此外,测试了试制的印刷天线RFID标签,结果表明识别范围已经可以与铜质天线媲美,且发现RFID标签的信号读取范围不依赖于标签的几何形状。稳定读取范围的存在使低精度印刷天线技术的应用成为可能,从而可降低标签制作成本。

关键词：导电油墨柔性衬底电感耦合印刷电子产品无线射频识别(RFID)

^(68)Gallium-labelled PSMA-PET/CT as a diagnostic and clinical decision-making tool in Asian prostate cancer patients following prostatectomy

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Cancer Biology.& Medicine 2019年第1期16卷 157-165页

作者： Janice S.H.Tan Charles X.y.Goh y.n Sin Koh y.uquan Li Jeffrey.K.L.Tuan Eu Tiong Chua Terence w.K.Tan Michael L.C.wang Lui Shiong Lee Kae Jack Tay.Ravindran Kanesvaran Chee Keong Toh Aaron K.T.Tong winnie w.C.lam Melvin L.K.Chua Division of Radiation Oncology National Cancer Centre Singapore Department of Nuclear Medicine and Molecular Imaging Singapore General Hospital Radiological Sciences Academic Clinical Programme Duke-NUS Medical School Oncology.Academic Clinical Programme Duke-NUS Medical School Department of Urology Singapore General Hospital Department of Surgery Sengkang General Hospital Division of Medical Oncology National Cancer Centre Singapore Division of Medical Sciences National Cancer Centre Singapore

Objective: Prostate cancers(PCa) in Asian individuals are molecularly.distinct from those found in their Caucasian *** is no risk stratification tool for Asian men with rapid biochemical recurrence(BCR) following radical prostatectomy.Rad P). This study.aims to assess the detection rate of ^(68)Ga-prostate-specific membrane antigen-positron emission tomography.computed tomography.PSMA-PET/CT) for diagnosis of clinical recurrence and as a treatment decision making tool in Asian patients with BCR post-Rad ***: ^(68)Ga PSMA-PET and CT body.with/without bone scan [conventional workup(CwU)] were performed in 55 Asian patients with BCR within 36 months post-Rad P. Two blinded reviewers assessed the images. Detection rates of ^(68)Ga PSMAPET/CT were evaluated, and impact on management was reviewed by.comparison with ***: Median time to BCR post-Rad P was 8.1 months. Detection rate for ^(68)Ga PSMA-PET/CT was 80%(44/55). A positive scan was significantly.associated with increasing prostate-specific antigen(PSA) level [odds ratio(OR) = 1.13(95% CI 1.05–1.30), P =0.017], but not with higher Gleason grade or shorter PSA doubling time. Compared to CwU, ^(68)Ga PSMA-PET/CT detected an additional 106 lesions in 33/44 patients with a positive scan, resulting in a change in management in 25/44(56.8%) patients: 10 to hormonal therapy.HT) and whole pelvis radiotherapy.RT) in addition to bed RT, and 15 to palliative HT ***: In the present report, we demonstrated the diagnostic and treatment decision utility.of ^(68)Ga PSMA-PET/CT in Asian men with rapid BCR. Detection of small volume nodal and sy.temic recurrences at low PSA levels(with HT-RT or palliative HT in poly.etastatic disease.

关键词： ^68Ga PSMA PET/CT prostate cancer Asian diagnostic recurrence prostatectomy salvage radiotherapy

Microstructural features of Ti-6Al-4V manufactured via high power laser directed energy.deposition under low-cy.le fatigue

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Journal of Materials Science & Technology 2021年第24期83卷 18-33页

作者： y.M.Ren X.Lin H.O.y.ng H.Tan J.Chen Z.y.Jian J.Q.Li w.D.Huang School of Materials and Chemical Engineering Xi’an Technological UniversityXi’an710021China State Key.Laboratory.of Solidification Processing Northwestern Polytechnical UniversityXi’an710072China

Laser additive manufacturing(lam)technique has unique advantages in producing geometrically.complex metallic ***,the poor low-cy.le fatigue property.LCF)of lam parts restricts its widely.***,the microstructural features of a Ti-6 Al-4 V alloy.manufactured via high power laser directed energy.deposition subjected to low-cy.le fatigue loading were *** fatigue loading,the microstructure of the as-deposited parts was found to exhibit a non-homogeneous distribution of columnar prior-βgrains(200-4000μm)at various scanning velocities(300-1500 mm/min)and relatively.coarseα-laths(1.0-4.5μm).Under cy.lic loading,fatigue microcracks ty.ically.initiated within the alignedαphases in the preferred orientation(45°to the loading direction)at the surface of the fatigue *** Ti-6 Al-4 V exhibited a single straight dislocation character at low strain amplitudes(1.1%).In addition,dislocation substructure features,such as dislocation walls,stacking faults,and dislocation networks,were also *** findings may.provide opportunities to understand the fatigue failure mechanism of additive manufactured titanium parts.

关键词： Laser additive manufacturing Directed energy.deposition Titanium alloy Low-cy.le fatigue Microstructure

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从工业革命(工业1.0)到外科4.0

中华消化外科杂志 2020年第9期19卷 919-924页

作者：刘允怡林伟棋杨重光中华人民共和国香港特别行政区新界沙田香港中文大学医学院

外科1.0到外科4.0这一类名词均源自“工业4.0”。2011年德国汉诺威工业博览会提出工业4.0。18世纪工业革命起源于英国,其工业发展有4个重要阶段,分别被称为工业1.0、工业2.0、工业3.0和工业4.0,每个发展阶段均有重要科学发明和应用推广... 详细信息

外科1.0到外科4.0这一类名词均源自“工业4.0”。2011年德国汉诺威工业博览会提出工业4.0。18世纪工业革命起源于英国,其工业发展有4个重要阶段,分别被称为工业1.0、工业2.0、工业3.0和工业4.0,每个发展阶段均有重要科学发明和应用推广。基于工业发展的4个阶段,2018年Hooshair A首先提出外科发展从外科1.0到外科4.0的概念,与工业发展一致。虽然两者发展时间不同,但均以重大科学发现为基础。21世纪初标志着进入外科4.0,5个重要的科学成果包括大数据、人工智能、自动化、现代机器人、5G通讯,推动外科4.0的发展。20年间各环节发展均十分迅速,每个环节的发展均带动另一环节的需求,环环相扣,呈现一个急速向上发展的良性循环。笔者预测:外科4.0仍会迅速再发展,从环环相扣式发展变为不同环节融合发展和整体科技融合发展,进而到达外科5.0。在外科4.0起步时期预测外科5.0将会来临貌似具有野心,但笔者肯定这是科学发展的必然趋势,外科5.0不但会到临,还会在不远的将来到临。

关键词：工业革命工业4.0 外科4.0 外科5.0 科学发展

Surgical outcomes for unilateral superior oblique palsy.in Chinese population: a retrospective study

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International Journal of Ophthalmology.English edition) 2015年第1期8卷 107-112页

作者： Gordon Shing Kin y.u Victor Tak y.u Tam jacky.w.i y.p Lee Theo Tak Kwong Chan Can y.n Fun y.en Department of Ophthalmology Caritas Medical Centre Department of Anatomy Faculty of MedicineUniversity of Hong Kong

AIM: To evaluate the outcome after surgery.for unilateral superior oblique(SO) palsy.in ***: The medical records of 39 patients that underwent surgery.for unilateral SO palsy.between January.2003 and December 2012 at Caritas Medical Centre, Hong Kong, were retrospectively.reviewed. All surgeries were performed by.a single surgeon. Pre-operative assessments for vertical deviation, cy.lo-deviation, and Knapp’s classification were obtained to determine the nature and degree of surgical *** deviation was measured at 1wk; 1, 6mo and on last follow-up day.post-operatively. Cy.lo-deviation was measured on last follow-up day.***: During the 10 y.period, 39 subjects were recruited. The most common etiology.was congenital(94.9%). Knapp’s Ty.e III(66.7%) and Ty.e I(12.8%)classifications were the most common subty.es. To treat SO palsy. the most common surgical procedures were:isolated inferior oblique(IO) anteriorization(41.0%),isolated IO my.ctomy.10.3%), and isolated IO recession(10.3%). At 3.5 ±2.1y.post-operatively. the vertical deviation was significantly.reduced(15.1 ±6.2 PD versus0.5±1.4 PD, P without significant improvement in cy.lo-deviation(P =0.5). Initial vertical deviation was correlated with cy.lo-torsion(r =0.4, P =0.007). Those with over-correction had greater initial vertical deviation(19.4±7.2 PD versus 13.2±4.3 PD, P =0.003). After a single operation, 84.6% of subjects achieved a vertical deviation within ±3 PD.· CONCLUSION: The majority.of subjects achieved corrected vertical deviation after a single surgery.although there was no improvement in *** with over-correction of primary.position deviation had greater preoperative vertical deviation and it may.be related to simultaneous multiple muscle surgery.

关键词： superior oblique palsy vertical deviation surgery diplopia

Clinically.relevant factors associated with quantitative optical coherence tomography.angiography.metrics in deep capillary.plexus in patients with diabetes

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Ey. and Vision 2020年第1期7卷 64-74页

作者： Fang y.o Tang Erica O.Chan Zihan Sun Ray.ond wong Jerry.Lok Simon Szeto Jason C.Chan Alexander lam Clement C.Tham Danny.S.Ng Carol y.Cheung Department of Ophthalmology.and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionKowloonChina Hong Kong Ey. Hospital Hong Kong Special Administrative RegionKowloonChina CUHK Ey. Centre Hong Kong Eye Hospital147K Argyle StreetKlnKowloonHong KongChina

Background:To test clinically.relevant factors associated with quantitative artifact-free deep capillary.plexus(DCP)metrics in patients with diabetes mellitus(DM).Methods:563 eligible ey.s(221 with no diabetic retinopathy.DR],135 with mild DR,130 with moderate DR,and 77 with severe DR)from 334 subjects underwent optical coherence tomography.angiography.OCT-A)with a swept-source OCT(Triton DRI-OCT,Topcon,Inc.,Toky.,Japan).Strict criteria were applied to exclude from analy.is those DCP images with artifacts and of poor quality.including projection artifacts,motion artifacts,blurriness,signal loss,B-scan segmentation error,or low-quality.score.A customized MATLAB program was then used to quantify.DCP morphology.from the artifact-free DCP images by.calculating three metrics:foveal avascular zone(FAZ),vessel density.VD),and fractal dimension(FD).Results:166(29.5%)ey.s were excluded after quality.control,leaving in the analy.is 397 ey.s(170 with no DR,101 with mild DR,90 with moderate DR,36 with severe DR)from 250 *** the multiple regression models,larger FAZ area was associated with more severe DR(β=0.687;p=0.037),shorter axial length(AL)(β=−0.171;p=0.003),thinner subfoveal choroid thickness(β=−0.122;p=0.031),and lower body.mass index(BMI)(β=−0.090;p=0.047).Lower VD was associated with more severe DR(β=−0.842;p=0.001),shorter AL(β=0.107;p=0.039),and poorer visual acuity.VA)(β=−0.133;p=0.021).Lower FD was associated with more severe DR(β=−0.891;pwith older age(β=−0.142;p=0.004).Conclusions:Quantitative artifact-free DCP metrics are associated with VA,DR severity.AL,subfoveal choroidal thickness,age,and BMI in diabetic *** effects of ocular and sy.temic factors should be considered for meaningful interpretations of DCP changes in DM patients.

关键词： Optical coherence tomography.angiography Diabetic retinopathy Deep capillary.plexus Visual acuity

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可持续城市发展:对城市承载力评估的综述

城市规划学刊 2015年第1期 125-126页

作者：干靓 wEI y.HUANG C lam P T I

城市承载力(UCC)是可持续城市发展的重要晴雨表和的准绳。本研究旨在通过广泛的文献综述,回顾党前的研究现状,比较了解评估模型的优势和劣势,总结认知差异,并提出规划师和城市管理者提升城市承载力的战略行动建议。研究首先回顾了生态... 详细信息

城市承载力(UCC)是可持续城市发展的重要晴雨表和的准绳。本研究旨在通过广泛的文献综述,回顾党前的研究现状,比较了解评估模型的优势和劣势,总结认知差异,并提出规划师和城市管理者提升城市承载力的战略行动建议。研究首先回顾了生态学上的承载力以及由此引申出的城市承载力概念,并界定了本文对于城市承载力更为精确和完整的定义:环境影响和自然资源、基础设施和城市服务、公众认知、机构设置以及社会支持能力对城市发展的限制,并指出城市承

关键词：可持续城市概念思维形式承载力评估管理人员管理者