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Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy

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World Journal of Gastroenterology 2006年第45期12卷 7271-7277页

作者： José Eymard Medeiros-Filho Isabel Maria Vicente guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U Neumann Fernanda de Mello Malta Luiz Caetano da silva Flair José Carrilho Hepatology Branch Department of Gastroenterology University of So Paulo School of Medicine So Paulo Brazil Viral Immu-nology Laboratory Instituto Butantan So Paulo Brazil Hepatology Branch Department of Gastroenterology University of S?o Paulo School of Medicine So Paulo Brazil Faculty of Life Sciences Bar-Ilan Univer-sity Ramat-Gan Israel Virology Branch Instituto Adolfo Lutz So Paulo Brazil

AIM： TO evaluate the impact of hepatitis C virus （HCV） infection with genotype 1 or 3 and the presence or absence of liver cirrhosis （LC） in the early viral kinetics response to treatment. METHODS： Naive patients （n = 46） treated with interferon-α （IFN-α） and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 （n = 28, 7 with LC） or 3 （n = 18, 5 with LC）. RESULTS： The first phase decline was larger in genotype 3 patients than in genotype 1 patients （1.72 vs 0.95 log IU/mL, P 〈 0.001）. The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients （0.87 vs 0.15 log/wk, P 〈 0.001）. Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2^nd phase slope than non-cirrhotic patients （0.06 vs 0.18 log/wk, P 〈 0,02）. None of genotype 1 cirrhotic patients had a 1^st phase decline larger than 1 log （non-cirrhotic patients： 55%, P 〈 0.02）. A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic patients but the 1^st phase slope decline was not different. Sustained viral response was higher in genotype 3 patients than in genotype 1 patients ,（72% vs 14%, P 〈 0.001） and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients （19% vs 0%）. A second phase decline slower than 0.3 log per week was predictive of non-response in all groups. CONCLUSION： Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1^st phase slope decline in genotype 1 patients.

关键词： Hepatitis C virus Treatment Early kinetics Cirrhosis Genotypes

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Nutritional Characteristics of Brachiaria brizanthaCultivars Subjected to Different Intensities Cutting

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American Journal of Plant Sciences 2014年第13期5卷 1961-1972页

作者： Kátia Aparecida de Pinho Costa Eduardo da Costa Severiano Gustavo André Simon Patrícia Soares Epifanio Alessandro Guerra da silva Raoni Ribeiro guedes Fonseca Costa Charles Barbosa Santos Carlos Ribeiro Rodrigues Goiano Federal Institute Rio Verde Brazil University of Rio Verde Rio Verde Brazil

This study evaluated the nutritional characteristics of Brachiaria brizantha cultivars subjected to three cutting intensities in the course of one year. The experiment was conducted at the University of Rio Verde. The experiment was performed as a randomized 3 × 3 factorial in complete block design with three replications and repeated measures in the time. Three Brachiaria brizantha cultivars (Marandu palisadegrass, Xaraes palisadegrass, and Piata palisadegrass), were tested at three cutting intensities (10, 20, and 30 cm sward height). The evaluations were conducted on the same plots throughout one year and during all four seasons (autumn, winter, spring, and summer). The results showed that the Piata palisadegrass had the best chemical composition compared to the Marandu palisadegrass and Xaraes palisadegrass. The management of Brachiaria brizantha cultivars at the lowest residual height (10 cm) affected the nutritional value of these feed grasses. Seasonality also influenced the nutritional value of these forages.

关键词： Marandu Palisadegrass Piata Palisadegrass Sward Height Xaraes Palisadegrass

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Paclobutrazol on In VitroGrowth and Development of Zygopetalum crinitumOrchid, and on Seedling Acclimatization

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American Journal of Plant Sciences 2018年第5期9卷 1029-1036页

作者： Renata Gimenes Kathia Fernandes Lopes Pivetta Renata Bachin Mazzini-guedes Marcos Vieira Ferraz Suzana Targanski Sajovic Pereira águila silva Santos Ricardo Tadeu de Faria Lívia Caroline Praseres de almeida Sao Paulo State University—UNESP Jaboticabal Brazil Federal University of Paraná—UFPR Jandaia do Sul Brazil State University of Londrina—UEL Londrina Brazil

In vitro cultivation is a technique that allows the production of great amount of plants. However, significant losses may occur during the acclimatization period (ex vitro stage). The objective of this study was to evaluate the effect of paclobutrazol, in the Murashige and Skoog culture medium, on growth, development, and survival of Zygopetalum crinitum plants. The experimental design (both in vitro and ex vitro) was completely randomized with four treatments: three paclobutrazol concentrations (0.5;1.0;and 1.5 mg L-1 active ingredient) and the control (without PBZ). Morphological changes promoted by the paclobutrazol application were observed in the seedlings;however, it did not result in higher seedling survival rates of the Zygopetalum crinitum orchid.

关键词： Growth Regulator Growth Retardant Triazol Orchidaceae

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Recovery of polyphenols from camu-camu(Myrciaria dubia ***)depulping residue by cloud point extraction

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Chinese Journal of Chemical Engineering 2018年第12期26卷 2471-2476页

作者： Carlos Eduardo de Araujo Padilha Juliana Chris silva de Azevedo Francisco Caninde de Sousa Junior Sergio dantas de Oliveira Junior Domingos Fabiano de Santana Souza jackson Araujo de Oliveira Gorete Ribeiro de Macedo Everaldo Silvino dos Santos Laboratory of Biochemical Engineering Chemical Engineering Department Federal University of Rio Grande do Notre(UFRN)NatalRNBrazil Laboratory of Food Bioactive Compounds and dairy Technology Chemical Engineering DepartmentFederal University of Rio Grande do Notre(UFRN)NatalRNBrazil

In this study the potential of cloud point extraction formed by a non-ionic surfactant was used in order to separate polyphenols from industrial residues of camu-camu. The effects of operational conditions of the cloud point extraction(CPE) on the polyphenol recovery and volumetric ratio were investigated. The results showed a maximum recovery of 95.71% that was obtained using 7.0 wt% Triton X-114, native pH(3.25), and 80 wt%polyphenol extract at 30 °C. The use of cloud point extraction was successful to recover the polyphenols from agroindustrial residue since it is a simple as well as of low-cost technique.

关键词： Cloud point extraction Recovery Polyphenols Camu-camu Depulping residue

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Effects of Five Years Adoption of No-Tillage Systems for Vegetables Crops in Soil Organic Matter Contents

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Agricultural Sciences 2018年第1期9卷 117-128页

作者： Carlos E. P. Lima ítalo M. R. guedes Juscimar da silva Flávia A. Alcantara Nuno R. Madeira Agnaldo D. F. Carvalho Mariana R. Fontenelle Embrapa Hortaliç as CNPH Brasília Brazil

Vegetables productions systems are done normally with intense soil tillage causing a strong decline of soil quality. Use of conservation systems can be an alternative to recover this quality. In order to evaluate the effects of such systems on soil organic matter, an experiment has been conducted in randomized blocks design and factorial scheme 3 × 2: three soil management systems (no-tillage;reduced tillage and conventional tillage) and two cover crops (maize single;and intercropping maize with gray velvet bean—Stizolobium niveum);and repeated measures over time. Soil samples were collected before the implementation of the experiment and at the end of each crop cycle until the fifth crop cycle. Carbon associated with humic substances is also determined in 0 - 5 cm, 5 - 10 cm and 10 - 30 cm at the end of the last crop cycle. The SOM content was higher in RT (48.34 g·kg-1) than in the CT (39.48 g·kg-1) at the end of the fifth crop cycle. SOM content in NT (44.92 g·kg-1) was statistically equal to RT and CT, during the same period. In 0 - 5 cm, carbon contents associated to the humic substances present the same behavior of SOM contents in 0 - 10 cm. Probably these results are associated with the capacity of each system to improve superficial contents of SOM stable fractions. It follows that the conservation systems used are alternatives to the cultivation vegetables in order to improve soil organic matter contents.

关键词： No-Tillage Reduced Tillage Soil Conservation Soil Management

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Musculoskeletal Tuberculosis in Dermatomyositis: Association or Coincidence?

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Open Journal of Rheumatology and Autoimmune Diseases 2014年第1期4卷 58-61页

作者： Andressa silva Abreu Geórgea Hermogenes Fernandes Eduardo Ferreira Borba Lissiane Karine Noronha guedes Jéssica Fernandes Ramos Samuel Katsuyuki Shinjo Division of Rheumatology and Infectious Disease Department Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo Sao Paulo Brazil.

Dermatomyositis is a rare idiopathic inflammatory myopathy characterized by proximal muscle weakness associated with typical skin abnormalities and compatible electromyographic finds. Tuberculosis could determine several clinical manifestations but the classic one is the lung presentation. Among the extra pulmonary manifestations of tuberculosis, the musculoskeletal form is rare and it is usually a direct extension of the bone involvement nearby. In the present study, the authors described two dermatomyositis patients and musculoskeletal tuberculosis. In both cases, there was presence of bilateral tenosynovitis, which is considered atypical for further infectious.

关键词： Dermatomyositis Tenosynovitis Tuberculosis

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Corona Detection System on Insulators via Acoustic Emissions

Corona Detection System on Insulators via Acoustic Emissions

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2012 Asian Pacific Conference on Energy,Environment and Sustainable Development(APEESD 2012)

作者： RENNó Marco Ant?nio Martins BONALDI Erik Leandro OLIVEIRA Levy Ely Lacerda silva Jonas guedes Borges LAMBERT-TORRES Germano Transmineira Power Transmission Co. PS Solutions Co.

This paper presents a computational package and equipment with the purpose to detect corona problems of insulators in transmission lines. Low-cost equipment detects presence of corona, via acoustic emissions and stores them in a memory. These data are processed by computer programs. The applicability of this equipment is immediate for any transmission company, because the perfect understanding of the operational capacity of its lines in various operating conditions and climate change allows for a safer operation with improvement of quality of service provided.

关键词： Corona effects Transmission lines Measuring system Signal processing and Acoustic emissions

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Study on the Attack of Molten Silicates on Plasma-Sprayed Thermal Barrier Coatings

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Journal of Minerals and Materials Characterization and Engineering（矿物质和材料特性和工程） 2023年第5期

作者： roberto Fernando Martins Karl Friehe Cecília Chaves guedes e silva Dolores Ribeiro Ricci Lazar Antônio Augusto Couto Carlos roberto Camello Lima

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Biomechanical Analysis of the STS Movement and Impact of an Assistive Device on the Elderly and People with Displacement Difficulties

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Journal of Mechanics Engineering and Automation 2019年第4期9卷 111-119页

作者： Rodrigo Goncalves de Souza Maciel daniel Kioshi Kawasaki Cavalcanti Carlos Eduardo guedes Catunda Fernando Ribeiro da silva Department of Mechanical Engineering Federal Center of Technological Education Celso Suckow da Fonseca(CEFET/RJ)Rio de JaneiroRJ20271-110Brazil

This study presents a biomechanical analysis of the performance of the STS(sit-to-stand)movement applied to elderly and people with difficulty of displacement comparing it with and without an assistive technology device.A biomechanical kinemetry method was used for the movement evaluation.A two-dimensional virtual human model was developed through segmented ergonomic video analysis and the data obtained were numerically simulated to measure the inertial forces and torques of the complete execution of the STS *** device allows a vertical elevation of 0 to 400 mm and an anterior slope of up to 25°.A prototype was used to compare the movement with and without the assistive *** a result,the torques in the lower limbs’joints and the vertical ground reaction forces were reduced by up to 60%and 23%,*** was a reduction of up to 37°in the maximum trunk flexion angle during the *** horizontal displacement of the center of mass was reduced by up to 70%.

关键词： STS biomechanics assistive technologies kinemetry method ergonomics video analysis human model posture

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Transaction-Level Modeling of a Reconfigurable System on Chip for Wireless Sensor Networks

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通讯和计算机（中英文版） 2011年第1期8卷 31-42页

作者： Gilmar silva Beserra Jose Edil Guimaraes de Medeiros Heider Marconi guedes Madureira Juan Fernando Eusse Joao Lucas de Carvalho Carneiro Ricardo Pezzuol Jacobi Jose Camargo da Costa Department of Electrical Engineering University of Brasilia Brasilia DF 70919-970 Brazil

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