检索结果-南通市图书馆

Primary squamous cell carcinoma of pancreas diagnosed by EUS-FNA:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第34期15卷 4343-4345页

作者： Larry Hin Lai Joseph Romagnuolo David Adams jack Yang Institute of Digestive Disease The Chinese University of Hong KongPrince of Wales Hospital Digestive Disease Center Medical University of South Carolina Department of Pathology and Laboratory Medicine Medical University of South Carolina

Squamous cell carcinoma of the pancreas has been sparsely described since the 1940s,and generally has a poor ***,we present a case of primary squamous cell carcinoma of the pancreas with liver metastasis,both confirmed by endoscopic ultrasoundguided fine needle aspiration(EUS-FNA).To the best of our knowledge,this is the first case report in literature utilizing EUS-FNA for a cell-type specific diagnosis of primary pancreatic squamous cell carcinoma with a liver metastasis.

关键词： Computed tomography Cytology Endoscopic ultrasound

Role of the JNK signal transduction pathway in inflammatory bowel disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第2期14卷 200-202页

作者： Praveen K Roy Farzana Rashid jack Bragg Jamal A Ibdah Division of Gastroenterology and Hepatology University of Missouri School of Medicine Columbia Missouri United States

The c-Jun NH2-terminal Kinase (JNK) pathway representsone sub-group of the mitogen-activated protein (MAP)kinases which plays an important role in variousinflammatory diseases states, including inflammatorybowel disease (IBD). Significant progress towardsunderstanding the function of the JNK signaling pathwayhas been achieved during the past few years. Blockadeof the JNK pathway with JNK inhibitors in animal modelsof IBD lead to resolution of intestinal *** data suggest specific JNK inhibitors hold promiseas novel therapies in IBD.

关键词： JNK pathway Inflammatory bowel disease Inflammation

Machine learning algorithms for suicide risk:a premature arms race?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

General Psychiatry 2020年第6期33卷 429-431页

作者： jack C Lennon Department of Psychology Adler UniversityChicagoIllinoisUSA

INTRODUCTION Machine learning(ML)techniques1 are becoming a major area of study in psychiatry,as ML possesses the theoretical capacity to draw conclusions based on a broad range of data once the system has been taught through a process of trial and ***,and arguably most importantly,ML can do so more quickly and accurately than clinicians.2 Several studies have demonstrated accuracy through the use of ML in various populations and geographic locations,further perpetuating the perceived need to incorporate ML into ongoing studies.

关键词： becoming learning conclusions

The Photoshop 7 Wow! Book

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Autonomic Regulation of the Cardiovascular System: Diseases,Treatments, and Novel Approaches

丛书名：电脑平面设计系列

2003年

作者：（美）jack Davis 陈刚等译

本书主要介绍了Photoshop的基础知识、颜色、照片的润饰和增强、合成图像、使用滤镜、绘画、文字和图形的特效、网页和动画的制作等等内容。

ISBN: (纸本)7508315561

本书主要介绍了Photoshop的基础知识、颜色、照片的润饰和增强、合成图像、使用滤镜、绘画、文字和图形的特效、网页和动画的制作等等内容。

关键词：图象处理应用软件

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2019年第1期35卷 1-3页

作者： Zixi jack Cheng Renjun Wang Qing-Hui Chen Burnett School of Biomedical Sciences College of MedicineUniversity of Central FloridaOrlandoFL 32816USA Department of Biotechnology School of Life ScienceJilin Normal UniversitySiping 136000China Department of Kinesiology and Integrative Physiology Michigan Technological UniversityHoughtonMI 49931-1200USA

The autonomic nervous system(ANS)integrates the involuntary physiological activities of visceral organs that are vital for *** particular,the ANS controls heart rate,blood pressure,breathing,gastrointestinal contraction and secretion,and electrolyte and fluid *** studies have focused on understanding the neural mechanisms of autonomic dysfunction or neuropathy in pathophysiological states including hypertension,heart failure.

关键词： In ANS Autonomic Regulation of the Cardiovascular System Diseases,Treatments

Novel susceptibility genes in inflammatory bowel disease

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第13期12卷 1991-1999页

作者： Colin Noble Elaine Nimmo Daniel Gaya Richard K Russell jack Satsangi Gastrointestinal Unit Molecular Medicine Centre University of EdinburghWestern General HospitalEdinburghUnited Kingdom

The inflammatory bowel disease, Crohn's disease and ulcerative colitis, are polygenic disorders with important environmental interactions. To date, the most widely adopted approach to identifying susceptibility genes in complex diseases has involved genome wide linkage studies followed by studies of positional candidate genes in loci of interest. This review encompasses data from studies into novel candidate genes implicated in the pathogenesis of inflammatory bowel disease. Novel techniques to identify candidate genes-genome wide association studies, yeast-two hybrid screening, microarray gene expression studies and proteomic profiling, are also reviewed and their potential role in unravelling the pathogenesis of inflammatory bowel disease are discussed.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Yeast-two hybrid Genomics

Auditory symptoms and autistic spectrum disorder:A scoping review and recommendations for future research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Otology 2022年第4期17卷 239-246页

作者： Sara Timms Sirat Lodhi jack Bruce Emma Stapleton Department of Otolaryngology Manchester Royal InfirmaryManchesterM139WLUK The University of Manchester Medical School Oxford RoadManchesterM139PLUK

Introduction:Auditory symptoms in individuals with Autistic Spectrum Disorder(ASD)are well described within the neurodevelopmental literature,yet there is minimal mention of ASD in Otolaryngology *** is surprising considering the potential clinical and diagnostic implications of this link,and the potential for ASD to present to Otolaryngologists in the form of unexplained auditory *** aims of this literature review were to explore the intersection of auditory symptoms and ASD from the perspective of clinical Otolaryngology,and to outline a clinically focused research agenda based on emerging themes relevant to ***:We searched Pubmed,Embase,Ovid and Cochrane library for studies until November *** authors independently reviewed 227 publications identified.39 were filtered into the final *** PRISMA 2020 guidelines were *** heterogeneity of literature meant that a Systematic Review was not *** studies were therefore classified thematically,forming the basis of the scoping ***:Diagnostic theories for auditory symptoms in ASD include the entire auditory pathway and *** is a growing body of literature on auditory symptoms in ASD,suggesting that a primary diagnosis of ASD should be considered in patients presenting with otherwise unexplained auditory symptoms,and indicating a learning need for Otolaryngologists and audiologists,to whom these patients may ***:We recommend a research agenda focusing on multidisciplinary collaboration,stakeholder engagement,responsible clinical screening,and clarification of pathophysiological mechanisms and terminology.

关键词： Autistic disorder Audiology Otolaryngology Tinnitus Hyperacusis

Lattice distortion releasing local surface strain on high-entropy alloys

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第6期15卷 4775-4779页

作者： Christian M.Clausen jack K.Pedersen Thomas A.A.Batchelor Jan Rossmeisl Department of Chemistry University of Copenhagen2100 KøbenhavnØDenmark

High-entropy alloys(HEAs)have the potential to be a paradigm-shift for rational catalyst discovery but this new type of alloy requires a completely new approach to predict the surface *** addition to the ligand effect perturbing the surface–adsorbate bond,the random configuration of elements in the surface will also induce local strain effects due to the varying radii of neighboring *** modelling of HEA surface reactivity requires an estimate of this effect:To what degree is the adsorption of intermediates on these lattice distorted atomic environments affected by local strain?In this study,more than 3,500 density functional theory(DFT)calculated adsorption energies of*OH and*O adsorbed on the HEAs IrPdPtRhRu and AgAuCuPdPt are statistically analyzed with respect to the lattice constants of the alloys and the surfaces of each individual binding *** is found that the inherent distortion of the lattice structure in HEAs releases the local strain effect on the adsorption energy as the atomic environment surrounding the binding atom(s)settles into a relaxed *** is even observed to be true for clusters of atoms of which the sizes deviate significantly from the atomic environment in which they are *** elucidates an important aspect of binding site interaction with the neighboring atoms and thus constitutes a step towards a more accurate theoretical model of estimating the reactivity of HEA surfaces.

关键词： high-entropy alloys surface reactivity strain effect surface strain electrocatalysis oxygen reduction reaction

Effects of medium chain triglycerides on hepatic fatty acid oxidation in clofibrate-fed newborn piglets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Nutrition 2023年第1期12卷 334-344页

作者： Jinan Zhao Brandon Pike Jin Huang Zhihua Feng jack Odle Xi Lin Laboratory of Developmental Nutrition Department of Animal SciencesNorth Carolina State UniversityRaleighNC 27695USA Zinpro Corporation Eden PrairieMN 55344USA College of Biological Engineering Henan University of TechnologyZhengzhou450001China College of Animal Science and Technology Agricultural University of HebeiBaoding071001China

To investigate whether increasing tricarboxylic acid(TCA)cycle activity and ketogenic capacity would augment fatty acid(FA)oxidation induced by the peroxisome proliferator-activated receptor-alpha(PPARα)agonist clofibrate,suckling newborn piglets(n=54)were assigned to 8 groups following a 2(±clofibrate)×4(glycerol succinate[SUC],triglycerides of 2-methylpentanoic acid[T2M],valeric acid[TC5]and hexanoic acid[TC6])factorial *** group was fed an isocaloric milk formula containing either 0%or 0.35%clofibrate(wt/wt,dry matter basis)with 5%SUC,T2M,TC5 or TC6 for 5 *** 6 pigs served as newborn *** acid oxidation was examined in fresh homogenates of liver collected on d 6 using[1-^(14)C]palmitic acid(1 mM)as a substrate(0.265μCi/μmol).Measurements were performed in the absence or presence of L-carnitine(1 mM)or inhibitors of 3-hydroxy-3-methylglutaryl-CoA synthase(L659699,1.6μM)or acetoacetate-CoA deacylase(iodoacetamide,50μM).Without clofibrate stimulation,^(14)C accumulation in CO_(2) was higher from piglets fed diets containing T2M and TC5 than SUC,but similar to those fed *** clofibrate stimulation,accumulation also was higher in homogenates from piglets fed TC5 than all other dietary *** between clofibrate and carnitine or the inhibitors were observed(P=0.0004)for acid soluble products(ASP).In vitro addition of carnitine increased^(14)C-ASP(P<0.0001)above all other treatments,regardless of clofibrate *** percentage of^(14)C in CO_(2) was higher(P=0.0023)in TC5 than in the control *** these results we suggest that dietary supplementation of anaplerotic and ketogenic FA could impact FA oxidation and modify the metabolism of acetyl-CoA(product ofβ-oxidation)via alteration of TCA cycle activity,but the modification has no significant impact on the hepatic FA oxidative capacity induced by PPARα.In addition,the availability of carnitine is a critical element to maintain FA oxidation during the neonatal perio

关键词： PPARα Clofibrate Newborn piglets Medium chain triglyceride(MCT) Hepatic fatty acid oxidation