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SO_2蒸汽预处理对黑松制取生物乙醇的影响

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农业工程学报 2011年第S1期27卷 194-199页

作者：钟月华 jack n.saddler 肖泽仪沈飞四川大学化学工程学院成都610065 Forest Products Biotechnology Department of Wood ScienceUniversity of British Columbia 四川农业大学资源环境学院成都611130

以加拿大不列颠哥伦比亚省甲虫致死黑松为原料,通过SO2催化蒸汽爆破方式对其进行预处理,并对预处理后的原料进行酶水解和乙醇发酵研究,以考察预处理方式结合酶水解对黑松制取乙醇的影响。结果表明,较低的SO2吸收率和原料含水率(干基)影... 详细信息

以加拿大不列颠哥伦比亚省甲虫致死黑松为原料,通过SO2催化蒸汽爆破方式对其进行预处理,并对预处理后的原料进行酶水解和乙醇发酵研究,以考察预处理方式结合酶水解对黑松制取乙醇的影响。结果表明,较低的SO2吸收率和原料含水率(干基)影响了预处理效果;水洗对预处理后原料的酶水解效率没有显著的影响;当水解底物质量浓度由20mg/mL增加到150mg/mL时,水解率均在42%左右,底物质量浓度的增加纤维素的水解率没有受到显著影响。从发酵结果看,黑松经汽爆预处理后,不进行水洗处理更有利于后续发酵。分步糖化发酵乙醇得率可以达最大乙醇得率的66%,而同步糖化水乙醇得率为55%。由此可见,低浓度SO2催化汽爆预处理低湿度黑松不能得到较好的预处理效果,需进一步优化。

关键词：农业废弃物酶水解发酵生物乙醇 SO2催化汽爆

Transplacental induction of fatty acid oxidation in term fetal pigs by the peroxisome proliferator-activated receptor alpha agonist clofibrate

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Journal of Animal Science and Biotechnology 2016年第3期7卷 341-352页

作者： Xi Lin Sheila Jacobi jack Odle Laboratory of Developmental nutrition Department of Animal SciencesNorth Carolina State University

Background： To induce peroxisomal proliferator-activated receptor α（PPARα） expression and increase milk fat utilization in pigs at birth, the effect of maternal feeding of the PPARα agonist, clofibrate（2-（4-chlorophenoxy）-2-methyl-propanoic acid, ethyl ester）, on fatty acid oxidation was examined at ful-term delivery（0 h） and 24 h after delivery in this *** group of pigs（n = 10） was delivered from pregnant sows fed a commercial diet with or without 0.8% clofibrate for the last 7 d of gestation. Blood samples were col ected from the utero-ovarian artery of the sows and the umbilical cords of the pigs as they were removed from the sows by C-section on day 113 of ***： HPLC analysis identified that clofibric acid was present in the plasma of the clofibrate-fed sow（~4.2 μg/m L）and its offspring（~1.5 μg/m L）. Furthermore, the maternal-fed clofibrate had no impact on the liver weight of the pigs at 0 h and 24 h, but hepatic fatty acid oxidation examined in fresh homogenates showed that clofibrate increased（P 〈 0.01）^14C-accumulation in CO2 and acid soluble products 2.9-fold from [1-^14C]-oleic acid and 1.6-fold from[1-^14C]-lignoceric acid respectively. Correspondingly, clofibrate increased fetal hepatic carnitine palmitoyltransferase（CPT）and acyl-Co A oxidase（ACO） activities by 36% and 42% over controls（P 〈 0.036）. The m RnA abundance of CPT I was 20-fold higher in pigs exposed to clofibrate（P 〈 0.0001） but no differences were detected for ACO and PPARα m RnA between the two ***： These data demonstrate that dietary clofibrate is absorbed by the sow, crosses the placental membrane, and enters fetal circulation to induce hepatic fatty acid oxidation by increasing the CPT and ACO activities of the newborn.

关键词： Clofibrate Fatty acid oxidation Pigs Placenta transfer

Methodological considerations of priming repetitive transcranial magnetic stimulation protocols in clinical populations

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General Psychiatry 2024年第1期37卷 173-176页

作者： jack Jiaqi Zhang Zhongfei Bai Kenneth n K Fong Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong KongChina Shanghai YangZhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Centre) School of MedicineTongji UniversityShanghaiChina

InTRODUCTIOn Repetitive transcranial magnetic stimulation(rTMS)is a neuroplasticity-enhancing technique that modifies brain responsiveness to various therapeutic modalities in clinical psychiatric and neurological applications. Furthermore,its effect can be attributed to long-term potentiation(LTP)or longterm depression(LTD)-like ***,responsiveness to rTMS is largely variable in healthy and pathological brains and is mediated by complex biological *** refers to a higher-order plasticity mechanism in which the direction and magnitude of synaptic plasticity are modified by prior neuronal activity and is believed to be a significant factor leading to the response variability of rTMs.

关键词： stimulation clinical transcranial

SO2蒸汽预处理对花旗松制取生物乙醇的影响

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SO2蒸汽预处理对花旗松制取生物乙醇的影响

Muscadine or amla extracts standardized to ellagic acid content ameliorate glucolipotoxicity associatedβ-cell dysfunction via inhibition of IL-1βand improved insulin secretion

全国农村清洁能源与低碳技术学术研讨会

作者：钟月华 jack n.saddler 肖泽仪沈飞四川大学化学工程学院 Forest Products Biotechnology Department of Wood ScienceUniversity of British ColumbiaVancouver V6T1Z4Canada 四川农业大学资源环境学院

以加拿大不列颠哥伦比亚省甲虫致死花旗松为原料,通过SO催化蒸汽爆破方式对其进行预处理,并对预处理后的原料进行酶水解和乙醇发酵研究,以考察预处理方式结合酶水解对花旗松制取乙醇的影响。结果表明,较低的SO吸收率和原料含水率(干基)... 详细信息

以加拿大不列颠哥伦比亚省甲虫致死花旗松为原料,通过SO催化蒸汽爆破方式对其进行预处理,并对预处理后的原料进行酶水解和乙醇发酵研究,以考察预处理方式结合酶水解对花旗松制取乙醇的影响。结果表明,较低的SO吸收率和原料含水率(干基)影响了预处理效果;水洗对预处理后原料的酶水解效率没有显著的影响;当水解底物质量浓度由20mg/mL增加到150mg/mL时,水解率均在42%左右,底物质量浓度的增加纤维素的水解率没有受到显著影响。从发酵结果看,花旗松经汽爆预处理后,不进行水洗处理更有利于后续发酵。分步糖化发酵乙醇得率可以达最大乙醇得率的66%,而同步糖化水乙醇得率为55%。由此可见,低浓度SO催化汽爆预处理低湿度花旗松不能得到较好的预处理效果,需进一步优化。

关键词：农业废弃物酶水解发酵生物乙醇 SO2催化汽爆

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Food Production, Processing and nutrition 2020年第1期2卷 91-101页

作者： Srikanth Earpina Karen McDonough Millicent Yeboah-Awudzi Kristina J.Cook Sita Aggarwal jack n.Losso Chronic Degenerative Disease Prevention Laboratory School of Nutrition and Food ScienceLouisiana State University AgCenterLouisiana State University SystemBaton RougeLA 70803USA School of Animal Science Louisiana State University AgCenterLouisiana State University SystemBaton RougeLA 70803USA William Hansel Cancer Prevention Pennington Biomedical Research CenterLouisiana State University SystemBaton RougeLA 70808USA Louisiana State University System Baton RougeLA 70803USA

Glucolipotocixity induces IL-1βsecretion which impairs pancreaticβ-cell insulin *** acid and urolithin A have strong anti-inflammatory effect on *** and amla are very good sources of ellagic *** present study examined the effect of ellagic acid,ellagic acid-rich muscadine or amla extract,or urolothin A on inflammation inβcells under glucolipotoxic *** nIT-1βcells were incubated in glucolipotoxic conditions(33.3 mM glucose,250μM palmitic acid or 33.3 mM glucose+250μM palmitic acid with or without ellagic acid,ellagic acid-rich muscadine or amla extracts standardized to its ellagic acid content,or urolithin A).Inflammatory status was evidenced by ELISA analysis of insulin and IL-1β*** acid-rich muscadine or amla extracts dose-dependently stimulated insulin secretion and down-regulated IL-1βbetter than pure ellagic acid,or urolithin *** A did not statistically stimulate insulin secretion and did not inhibit IL-1β.

关键词： Muscadine Amla Ellagic acid nIT-1 pancreaticβ-cells glucose,Palmitic acid Glucolipotoxicity IL-1β Inflammation Inflammasome Insulin secretion

QUAnTIZATIOn AnD TRAInInG OF LOW BIT-WIDTH COnVOLUTIOnAL nEURAL nETWORKS FOR OBJECT DETECTIOn

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Journal of Computational Mathematics 2019年第3期37卷 349-359页

作者： Penghang Yin Shuai Zhang Yingyong Qi jack Xin Department of Mathematics University of CaliforniaLos AngelesCA 90095USA Department of Mathematics University of CaliforniaIrvineCA 92697USA

We presen t LBW-net,an efficient optimization based method for qua nt ization and training of the low bit-width convolutional neural networks(Cnns).Specifically,we quantize the weights to zero or powers of 2 by minimizing the Euclidean distance between full-precision weights and quantized weights during backpropagation(weight learning).We characterize the combinatorial nature of the low bit-width quantization *** 2-bit(ternary)Cnns,the quantization of n weights can be done by an exact formula in O(n log n)*** the bit-width is 3 and above,we further propose a semi-analytical thresholding scheme with a single free parameter for quantization that is computationally *** free parameter is further determined by network retraining and object detection *** LBW-net has several desirable advantages over full-precision Cnns,including considerable memory savings,energy efficiency,and faster *** experiments on PASCAL VOC dataset show that compared with its 32-bit floating-point counterpart,the performance of the 6-bit LBW-net is nearly lossless in the object detection tasks,and can even do better in real world visual scenes,while empirically enjoying more than 4× faster deployment.

关键词： Quantization Low bit width deep neural networks Exact and approximate analytical formulas network training Object detection

Real-time hybrid simulation of structures equipped with viscoelastic-plastic dampers using a user-programmable computational platform

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Earthquake Engineering and Engineering Vibration 2017年第4期16卷 693-711页

作者： jack Wen Wei Guo Ali Ashasi-Sorkhabi Oya Mercan Constantin Christopoulos Kinetica 1235 Bay St.Suite 1004ONM5R 3K4 Department of Civil Engineering University of Waterloo200 University Avenue WWaterlooONN2L 3G1Canada Department of Civil Engineering University of Toronto35 St.George StreetTorontoONM5S 1A4Canada

A user-programmable computational/control platform was developed at the University of Toronto that offers real-time hybrid simulation （RTHS） capabilities. The platform was verified previously using several linear physical substructures. The study presented in this paper is focused on further validating the RTHS platform using a nonlinear viscoelastic-plastic damper that has displacement, frequency and temperature-dependent properties. The validation study includes damper component characterization tests, as well as RTHS of a series of single-degree-of-freedom （SDOF） systems equipped with viscoelastic-plastic dampers that represent different structural designs. From the component characterization tests, it was found that for a wide range of excitation frequencies and friction slip loads, the tracking errors are comparable to the errors in RTHS of linear spring systems. The hybrid SDOF results are compared to an independently validated thermal- mechanical viscoelastic model to further validate the ability for the platform to test nonlinear systems. After the validation, as an application study, nonlinear SDOF hybrid tests were used to develop performance spectra to predict the response of structures equipped with damping systems that are more challenging to model analytically. The use of the experimental performance spectra is illustrated by comparing the predicted response to the hybrid test response of 2DOF systems equipped with viscoelastic-plastic dampers.

关键词： real-time hybrid simulation user-programmable computational/control platform supplemental dampers performance spectra

nanofabricated high turn-density spiral coils for on-chip electromagneto-optical conversion

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Microsystems & nanoengineering 2024年第2期10卷 181-192页

作者： Ilhan Bok Alireza Ashtiani Yash Gokhale jack Phillips Tianxiang Zhu Aviad Hai Department of Biomedical Engineering University of Wisconsin–MadisonMadisonWIUSA Department of Electrical and Computer Engineering University of Wisconsin–MadisonMadisonWIUSA Wisconsin Institute for Translational neuroengineering(WITne) University of Wisconsin–MadisonMadisonWIUSA

Circuit-integrated electromagnets are fundamental building blocks for on-chip signal transduction,modulation,and tunability,with specific applications in environmental and biomedical micromagnetometry.A primary challenge for improving performance is pushing quality limitations while minimizing size and fabrication complexity and retaining spatial *** efforts have exploited highly involved three-dimensional synthesis,advanced insulation,and exotic material ***,we present a rapid nanofabrication process that employs electron beam dose control for high-turn-density diamond-embedded flat spiral coils;these coils achieve efficient on-chip electromagnetic-to-optical signal *** fabrication process relies on fast 12.3 s direct writing on standard poly(methyl methacrylate)as a basis for the metal lift-off *** with 70 micrometer overall diameters and 49–470 nm interturn spacings with corresponding inductances of 12.3–12.8 nH are *** utilize optical micromagnetometry to demonstrate that magnetic field generation at the center of the structure effectively correlates with finite element modeling *** designs based on our process can be integrated with photolithography to broadly enable optical magnetic sensing and spin-based computation.

关键词： utilize retaining high

Effects of medium chain triglycerides on hepatic fatty acid oxidation in clofibrate-fed newborn piglets

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Animal nutrition 2023年第1期12卷 334-344页

作者： Jinan Zhao Brandon Pike Jin Huang Zhihua Feng jack Odle Xi Lin Laboratory of Developmental nutrition Department of Animal SciencesNorth Carolina State UniversityRaleighNC 27695USA Zinpro Corporation Eden PrairieMN 55344USA College of Biological Engineering Henan University of TechnologyZhengzhou450001China College of Animal Science and Technology Agricultural University of HebeiBaoding071001China

To investigate whether increasing tricarboxylic acid(TCA)cycle activity and ketogenic capacity would augment fatty acid(FA)oxidation induced by the peroxisome proliferator-activated receptor-alpha(PPARα)agonist clofibrate,suckling newborn piglets(n=54)were assigned to 8 groups following a 2(±clofibrate)×4(glycerol succinate[SUC],triglycerides of 2-methylpentanoic acid[T2M],valeric acid[TC5]and hexanoic acid[TC6])factorial *** group was fed an isocaloric milk formula containing either 0%or 0.35%clofibrate(wt/wt,dry matter basis)with 5%SUC,T2M,TC5 or TC6 for 5 *** 6 pigs served as newborn *** acid oxidation was examined in fresh homogenates of liver collected on d 6 using[1-^(14)C]palmitic acid(1 mM)as a substrate(0.265μCi/μmol).Measurements were performed in the absence or presence of L-carnitine(1 mM)or inhibitors of 3-hydroxy-3-methylglutaryl-CoA synthase(L659699,1.6μM)or acetoacetate-CoA deacylase(iodoacetamide,50μM).Without clofibrate stimulation,^(14)C accumulation in CO_(2) was higher from piglets fed diets containing T2M and TC5 than SUC,but similar to those fed *** clofibrate stimulation,accumulation also was higher in homogenates from piglets fed TC5 than all other dietary *** between clofibrate and carnitine or the inhibitors were observed(P=0.0004)for acid soluble products(ASP).In vitro addition of carnitine increased^(14)C-ASP(Pnts,regardless of clofibrate *** percentage of^(14)C in CO_(2) was higher(P=0.0023)in TC5 than in the control *** these results we suggest that dietary supplementation of anaplerotic and ketogenic FA could impact FA oxidation and modify the metabolism of acetyl-CoA(product ofβ-oxidation)via alteration of TCA cycle activity,but the modification has no significant impact on the hepatic FA oxidative capacity induced by PPARα.In addition,the availability of carnitine is a critical element to maintain FA oxidation during the neonatal perio

关键词： PPARα Clofibrate newborn piglets Medium chain triglyceride(MCT) Hepatic fatty acid oxidation