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Multi-Segmental Osteocutaneous Free Fibula Flap for Three-Dimensional Post-Traumatic Thumb and Wrist Reconstruction

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Modern Plastic Surgery 2023年第1期13卷 23-31页

作者： jack D. Sudduth Shireen Dogar Narges L. Horriat Marc e. Walker Division of Plastic and Reconstructive Surgery Department of Surgery University of Mississippi Medical Center Jackson MS USA

Thumb reconstruction following a traumatic injury challenge depends on the extent of the injury. Ideally, reconstruction should restore thumb length and position and retain thumb stability, mobility, and strength, while preserving sensation and aesthetics. Achieving these outcomes can be especially challenging in severe cases of soft tissue and bony loss. The authors present a case of a 20-year-old right-hand dominant female involved in a motor vehicle accident who sustained severe crush injuries and burns to her right hand. Her injuries included soft tissue and bony defects extending from the thumb to the distal radius, namely avulsion of the thumb and significant loss of the distal radial and carpal column, resulting in severe wrist instability. We employed a three-segment vascularized osteocutaneous fibula flap to reconstruct the thumb and wrist to restore bony construct, carpal support, and soft tissue coverage. Thumb motion could not be achieved, but this technique offered a sensate, functional post for opposition and the appearance of an anatomic hand. Because of this surgery, the patient was enabled to graduate from college and pursue full-time employment. The authors hope that this report will add to the fund of knowledge and surgeon armamentarium for similar devastating injuries demanding thumb and wrist reconstruction.

关键词： Thumb Reconstruction Wrist Reconstruction Microvascular Reconstruction Free Fibula Flap Thumb Amputation

establishing a treatment protocol for concomitant major burn and trauma patients:a tropical Asian hospital's experience

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Burns & Trauma 2017年第3期5卷 215-217页

作者： Yee Onn Kok Nadia Sim Priya Tiwari Ting Hway Wong Si jack Chong Department of Plastic Reconstructive and Aesthetic Surgery Singapore General Hospital Level 5 Academia Singapore 169865 Singapore Department of Plastic Reconstructive and Aesthetic Surgery Singapore General Hospital Level 5 Academia Singapore 169865 Singapore Yong Loo Lin School of Medicine National University of Singapore 1E Kent Ridge Road Level 11 NUHS Tower Block Singapore 119228 Singapore Division of Plastic Reconstructive and Aesthetic Surgery Department of Surgery National University Health System Level 8 NUHS Tower Block 1E Kent Ridge Road Singapore 119228 Singapore Department of General Surgery Singapore General Hospital Level 5 Academia Singapore 169865 Singapore

Dear editor,Burns and trauma represent two of the most severe injuries that both developing and developed countries face today. Concomitant burn and traumatic injuries are significant in terms of disease burden and co... 详细信息

关键词： Burns Trauma Protocol

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马丁·伊登

Regulation of expression for the RNP-4F Splicing Assembly Factor in the Fruit-Fly <i>Drosophila melanogaster</i>

2016年

作者： jack London[]

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Open Journal of Animal Sciences 2015年第4期5卷 418-428页

作者： Sushmita Ghosh Shelby e. Thomas Lindsey M. Abraham jack C. Vaughn Department of Biology Cell Molecular and Structural Biology Program Miami University Oxford USA

Intron splicing in eukaryotic organisms requires the interactions of five snRNAs and numerous different proteins in the spliceosome. Although the molecular mechanism behind splicing has been well studied, relatively little is known about regulation of expression for these splicing factor proteins. One of these proteins is the evolutionarily-conserved Drosophila RNP-4F splicing assembly factor. This protein is transcribed from a single gene into two developmentally regulated mRNAs that differ in their 5’-UTR structure. In the longer isoform, known to be abundant in the developing fly central nervous system, a conserved retained intron which folds into a stem-loop has been implicated in expression control of the mRNA. Here, we describe construction and utilization of several new rnp-4f gene expression study vectors using a GFP reporter in the ΦC31 system. The results confirm our previous observation that presence of the regulatory stem-loop enhances RNP-4F protein expression. However, in that study, the enhancement factor protein was not identified. We show here that overexpression of the RNP-4F transgene compared to the control results in additional translation, as indicated by the GFP reporter in the fluorescent images. These results are interpreted to show that RNP-4F protein acts back on its own mRNA 5’-UTR regulatory region via a feedback pathway to enhance protein synthesis in the developing fly central nervous system. A model is proposed to explain the molecular mechanism behind rnp-4f gene expression control.

关键词： rnp-4f Gene Gene expression Control ΦC31 Transgenic Vectors UAS-GAL4 System Fluorescence Microscopy

Review of stem cells as promising therapy for perianal disease in inflammatory bowel disease

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World Journal of Transplantation 2018年第4期8卷 97-101页

作者： Francis e Dailey erica P Turse Maliha Naseer jack D Bragg Veysel Tahan Division of Gastroenterology and Hepatology Department of Internal Medicine University of Missouri Health Center Division of Gastroenterology and Hepatology Department of Internal Medicine University of Missouri-Columbia

Those patients with perianal Crohn's disease or ul-cerative colitis experience a difficult to treat disease process with a delayed state and often inability to heal despite current therapies. The approaches currently used to treat these patients with corticosteroids,antibiotics,immunomodulators, anti-tumor necrosis factor-α drug, and surgical repair are limited in their healing ability. This review presents all current literature since emergence in the early 2000s of stem cell therapy for patients with perianal inflammatory bowel disease and analyzes the efficacy, outcomes and safety within these studies.

关键词： Crohn’s disease Stem cells Mesenchymal Perianal disease Fistula Inflammatory bowel disease

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期权新世界

组织多普勒成像技术分析先天性膈疝胎儿心室舒张功能变化

2020年

作者： jack，陈竑廷

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中国医学影像技术 2009年第8期25卷 1423-1425页

作者：曹荔田志云 RYCHIK jack 南京医科大学附属南京妇幼保健院江苏南京210004 美国费城儿童医院心内科费城19104

目的运用组织多普勒成像(DTI)技术分析先天性膈疝(CDH)胎儿心室舒张功能变化。方法采用DTI技术记录22例先天性膈疝胎儿和151名正常胎儿心室心肌的最大运动速度,然后用脉冲多普勒技术记录心室流入道的血流速度峰值。计算舒张早期的最大... 详细信息

目的运用组织多普勒成像(DTI)技术分析先天性膈疝(CDH)胎儿心室舒张功能变化。方法采用DTI技术记录22例先天性膈疝胎儿和151名正常胎儿心室心肌的最大运动速度,然后用脉冲多普勒技术记录心室流入道的血流速度峰值。计算舒张早期的最大血流速度(e)和最大心肌运动速度(ea)之比(e/ea)。结果经过孕周配比后,在舒张早期,与正常胎儿相比,CDH胎儿舒张早期ea值明显降低,而心房的e值与心室心肌的ea值之比(e/ea)未见明显变化。结论CDH胎儿的心室舒张功能无明显改变;e/ea可作为一个定量评价胎儿心室充盈压力的指标。

关键词：组织多普勒成像胎儿超声心动描记术心室舒张膈疝

Chemical and behavioral analysis of the cuticular hydrocarbons from Asian citrus psyllid, Diaphorina citri

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Insect Science 2013年第3期20卷 367-378页

作者： Rajinder S. Mann Russell L. Rouseff jack Smoot Nandikeswara Rao Wendy L. Meyer Stephen L. Lapointe Paul S. Robbins Dong Cha Charles e. Linn Francis X. Webster Siddharth Tiwari Lukasz L. Stelinski entomology and Nematology Department Citrus Research and Education Center University of Florida Flavor and Volatile Analysis Group Citrus Research and Education Center University of Florida Lake Alfred FL 33850 USA National Research Center for Citrus Nagpur Maharashtra India USDA-ARS US Horticultural Research Laboratory Fort Pierce FL 34945 Department of entomology NYS Agricultural Experiment Station Cornell University Geneva NY 14456 Department of Chemistry State University of New York College of Environmental Science and Forestry Syracuse NY 13210 USA

Huanglongbing （HLB） is the most destructive disease of citrus worldwide. The Asian citrus psyllid, Diaphorina citri Kuwayama （Hemiptera： Psyllidae）, is the vector of the phloem-inhabiting bacterium, Candidatus Liberibacter asiaticus, which is presumed to cause HLB in Florida citrus. Laboratory and field studies were conducted to examine the behavioral responses of male and female D. cirri to their cuticular extracts. In olfactometer assays, more male D. citri were attracted to one, five, or 10 female cuticular extract equivalent units than blank controls. The results were confirmed in field studies in which clear or yellow traps baited with 10 female cuticular extract equivalent units attracted proportionately more males than clear traps baited with male cuticular extract or unbaited traps. Analyses of cuticular constituents of male and female D. citri revealed differences between the sexes in chemical composition of their cuticular extracts. Laboratory bioassays with synthetic chemicals identified from cuticular extracts indicated that dodecanoic acid attracted more males than clean air. Traps baited with dodecanoic acid did not increase total catch olD. citri as compared with blank traps at the dosages tested; however, the sex ratio ofpsyllid catch was male biased on traps baited with the highest lure loading dosage tested （10.0 mg）.

关键词： citrus cuticular hydrocarbon dodecanoic acid Huanglongbing semiochemical

Analysis of the nitrification and Ammonia and Nitrite oxidizing Bacteria Stratification in a Filter Reactor

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Analysis of the nitrification and Ammonia and Nitrite oxidiz...