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国外铁道机车与动车 1982年第9期 10-21页

作者： DR.D.h.C.taylor 叶家伟

1982年3月10日～13日,英国里卡多(RICADO)咨询工程师有限公司的专家应邀来铁道部进行了一次技术讲座,并与大连内燃机车研究所等单位进行了技术交流和座谈,本文为里卡多公司的泰勒博士在座谈会上所作的报告摘录。

关键词：柴油机爆发压力烟度压燃发动机油耗率平均有效压力动力装置

Improved nonlinear fluid model in rotating flow

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Applied Mathematics and Mechanics(English Edition) 2012年第11期33卷 1419-1430页

作者： N. AShRAFI h. KARIMI-hAGhIGhI Department of Mechanical and Aerospace Engineering Science and Research Branch Islamic Azad University

The pseudoplastic circular Couette flow （CCF） in annuli is investigated. The viscosity is dependent on the shear rate that directly affects the conservation equations solved by the spectral method in the present study. The pseudoplastic model adopted here is shown to be the suitable representative of nonlinear fluids. Unlike the previous studies, where only the square of the shear ered to ease the numerical manipulations, quadratic power is also taken into account. rate term in the viscosity expression is consid- in the present study, the term containing the The curved streamlines of the CCF can cause the centrifugal instability leading to toroidal vortices, known as the taylor vortices. It is further found that the critical taylor number becomes lower as the pseudoplastic effect increases. The comparison with the existing measurements on the pseudoplastic CCF results in good agreement.

关键词： pseudoplastic circular Couette flow (CCF) toroidal vortex spectralmethod

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Dictyosporiaceae ***.

Fungal Diversity 2016年第5期80卷 457-482页

作者： Saranyaphat Boonmee Melvina J.D’souza Zonglong Luo Umpava Pinruan Kazuaki Tanaka hongyan Su Darbhe J.Bhat Eric h.C.McKenzie E.B.Gareth Jones Joanne E.taylor Alan J.L.Phillips Kazuyuki hirayama Prapassorn D.Eungwanichayapant Kevin D.hyde Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand College of Agriculture and Biology Sciences Dali UniversityDaliYunnan 671003China National Center for Genetic Engineering and Biotechnology National Science and Technology Development AgencyThailand Science Park113 Phahonyothin RoadKlong 1Klong Luang Pathumthani 12120Thailand Formerly Department of BotanyGoa UniversityNo.128/1-JAzad Housing SocietyCurca Goa VelhaIndia Manaaki Whenua Landcare Research Private Bag 92170AucklandNew Zealand Faculty of Sciences Biosystems and Integrative Sciences Institute(BioISI)University of LisbonCampo Grande1749-016 LisbonPortugal Royal Botanic Garden Edinburgh 20A Inverleith RowEdinburgh EH35LRUK Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Faculty of Agriculture and Life Science Hirosaki University3 Bunkyo-choHirosakiAomori 036-8561Japan Apple Experiment Station Aomori Prefectural Agriculture and Forestry Research Center24 FukutamiBotandairaKuroishiAomori 036-0332Japan

Dictyosporiaceae *** introduced to accommodate a holomorphic group of Dothideomycetes that are saprobes on decaying wood and plant debris in terrestrial and freshwater *** sexual morph comprises Dictyosporium meiosporum,***,Gregarithecium curvisporum,Pseudocoleophoma calamagrostidis and *** sexual morphs are characterized by immersed to erumpent,superficial,globose to subglobose,dark brown to black ascomata,bitunicate asci,and septate,hyaline,sheathed *** asexual morphs are hyphomycetous with brown,multi-septate,cheirosporous conidia,produced from holoblastic conidiogenous cells,on micronematous *** analyses of LSU,SSU and TEF1 sequence data place the genera with cheirospores in a monophyletic clade in the order *** analyses based on ITS sequence data show the family to comprise 44 distinct lineages that correspond to ten genera and an undetermined *** new genera Dictyocheirospora,Dictyopalmispora,Jalapriya and Vikalpa,and eight new species Dictyocheirospora bannica,***,***,Dictyopalmispora palmae,Dictyosporium olivaceosporum,***,Jalapriya pulchra,and Vikalpa lignicola,are introduced in the family.

关键词： Cheirosporous conidia KeylPhylogeny Sexual states Sporodochial fungi

非风湿性心房纤颤患者长期抗凝或抗血小板治疗的系统性综述

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英国医学杂志中文版 2002年第1期5卷 16-20页

作者： F C taylor h Cohen S Ebrahim 刘靖 Department of haematology University College London Hospitals Department of Social Medicine CanyngeHall

目的 :比较非风湿性心房纤颤患者长期抗凝(华法令 )或抗血小板治疗 (阿司匹林或吲哚洛芬 )的效益及风险。方法 :对 1 966年～ 1 999年 1 2月间收录在Cochranelibrary,Medline,Embase ,Cinhal及Sigle上的随机对照试验进行汇总分析。计算... 详细信息

目的 :比较非风湿性心房纤颤患者长期抗凝(华法令 )或抗血小板治疗 (阿司匹林或吲哚洛芬 )的效益及风险。方法 :对 1 966年～ 1 999年 1 2月间收录在Cochranelibrary,Medline,Embase ,Cinhal及Sigle上的随机对照试验进行汇总分析。计算比数比及其 95 %的可信区间 ,以评估治疗效果。结果的测量指标 :致命性及非致命性心血管事件减少定义为有益。发生致命性及较严重非致命性出血事件定义为风险。结果 :1 989年以前无临床试验。 1 989年～1 999年间共有 5项随机对照试验发表。抗凝和抗血小板治疗的死亡率无显著差异 (固定效益模型 :卒中死亡的比数比 0 74,95 %可信区间 0 39～1 4 0 ;因血管性原因死亡的比数比 0 86 ,95 %可信区间 0 63～ 1 70 )。非致命性卒中发生率在抗凝组较低 ,两组差异显著性达到临界值 (比数比0 68,95 %可信区间 0 4 6～ 0 99) ;在除外一项设计方法欠科学的试验后 ,比数比为 0 75(95 %可信区间 0 50～ 1 1 3)。随机效益模型显示总致命性和非致命性事件发生率无显著差异 (比数比0 79,95 %可信区间 0 61～ 1 0 2 )。抗凝治疗的较严重出血事件发生率高于抗血小板治疗 (比数比1 4 5 ,95 %可信区间 0 93～ 2 2 7)。一项试验因抗凝治疗优势显著而提前?

关键词：非风湿性心房纤颤抗凝治疗抗血小板治疗随机对照试验

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Effect of Carboxyamidotriazole Orotate, a Modulator of Calcium-Dependent Signaling Pathways, on Advanced Solid Tumors

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Journal of Cancer Therapy 2015年第4期6卷 322-333页

作者： Matthew h. taylor Alan Sandler Walter J. Urba Antonio M. P. Omuro Greg S. Gorman Rashida A. Karmali Knight Cancer Institute Oregon Health and Science University Portland OR USA Genentech San Francisco CA USA Earle A Chiles Research Institute Providence Cancer Center Portland OR USA Memorial Sloan-Kettering Cancer Center New York NY USA Samford University Birmingham AL USA Tactical Therapeutics Inc. New York NY USA

Pre-clinical studies suggest carboxyamidotriazole orotate (CTO) demonstrates anti-tumor activity through modulation of multiple tyrosine kinase signaling pathways and interactions with the tumor microenvironment. We determined the safety and tolerability, pharmacokinetic profile, maximum tolerated dose, and recommended Phase II dose of CTO monotherapy in patients with advanced solid tumors. In this first-in-human Phase I clinical trial, eligible patients with advanced solid tumors were enrolled to receive a once-daily dose of CTO following a standard 3 + 3 Phase I design (starting at 50 mg/m2/day) with dose escalations of 30% - 100%. Dose limiting toxicity (DLT) was defined in the first cycle of treatment. Measurable disease and response were defined by RECIST version 1.1. Forty-four patients were evaluable for safety. CTO-related grade 3 toxicities included diarrhea (2.5%), fatigue (5.0%), lymphopenia (2.5%) and transient creatine phosphokinase (CPK) elevation (2.5%). There were no grade 4 or 5 toxicities. Steady state plasma levels of CAI (CTO metabolite) were achieved by day 12 with a half life estimate of 55 hr. Although no objective response rates were observed, nine patients with rapidly progressive and treatment-refractory tumors achieved stable disease (SD) durable for up to 14 months. The maximum tolerated dose for CTO alone was 427 mg/m2/day. The dose-limiting toxicity was grade 3 fatigue. CTO is orally bioavailable, safe, well tolerated and produces disease stabilization in a broad range of heavily treated refractory tumors. Combination trials of CTO with other antineoplastic agents are ongoing.

关键词： CTO Safety Ca-Dependent Signaling Pathways

Synergistic Antitumor Activity of Vitamins C and K3 on human Bladder Cancer Cell Lines

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Journal of Cancer Therapy 2013年第6期4卷 7-19页

作者： Karen McGuire James M. Jamison Jacques Gilloteaux jack L. Summers Department of Anatomical Sciences St Georges’ University International School of Medicine K B Taylor Scholar’s Programme Newcastle upon Tyne UK. The Apatone Development Center St. Thomas Hospital Summa Health System Akron USA

Exponentially growing cultures of human bladder tumor cells (RT4 and T24) were treated with Vitamin C (VC) alone, Vitamin K3 (VK3) alone, or with a VC:VK3 combination continuously for 5 days or treated with vitamins for 1 h, washed with PBS and then incubated in culture medium for 5 days. Co-administration of the vitamins enhanced the antitumor activity 12- to 24-fold for the RT-4 cells and 6- to 41-fold for the T24 cells. Flow cytometry of RT4 cells exposed to the vitamins revealed a growth arrested population and a population undergoing cell death. Growth arrested cells were blocked near the G0/G1-S-phase interface, while cell death was due to autoschizis. Catalase treatment abrogated both cell cycle arrest and cell death which implicated hydrogen peroxide (h2O2) in these processes. The h2O2 production resulted in a moderate increase in lipid peroxidation and depletion of cell thiol levels. Analysis of cellular ATP levels revealed a transient increase in ATP production for VC and the VC:VK3 combination, but decreased ATP levels following VK3 treatment. Lipid peroxidation, thiol depletion and ATP modulation occurred at a 17-fold lower concentration in the vitamin combination than with either vitamin alone. These results suggested that the increased cytotoxicity of the vitamin combination was due to redox cycling and increased oxidative stress.

关键词： Bladder Carcinoma Vitamin C Vitamin K3

PhOSPhATIC ONCOIDS AND ThE PRESERVATION OF EARLY BRYOZOANS BY BIOIMMURATION IN ThE ARENIG (ORDOVICIAN) OF WALES AND ThE CZECh REPUBLIC

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PHOSPHATIC ONCOIDS AND THE PRESERVATION OF EARLY BRYOZOANS B...

The First Approved “Deuterated” Drug: A Short Review of the Concept

第二届国际古生物学大会

作者： Paul D.taylor Andrej ERNST Department of Palaeontology Natural History Museum London UK

Transgressive basal lag deposits (Garth Grit and Pared-mawr Member, St Tudwal’s Formation) in the Arenig of Wales contain pebbles and cobbles often enveloped by dark-coloured, layered phosphatic accretions. These accretions were regarded as bryozoans by h.P. Lewis (1926), who named them Bolopora undosa, assigning this new genus to the Ceramoporidae (order Cystoporata). The fossils were re-interpreted as

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Pharmacology & Pharmacy 2018年第10期9卷 440-446页

作者： Robert B. Raffa Joseph V. Pergolizzi Robert taylor Neumentum Inc. Palo Alto CA USA Colleges of Pharmacy University of Arizona Tucson AZ USA Temple University School of Pharmacy Philadelphia PA USA NEMA Research Inc. Naples FL USA

The first “deuterated” drug has recently been approved by the U.S. FDA (Food & Drug Administration). A “deuterated” drug is a drug in which the hydrogen atom in one or more of the carbon-hydrogen bonds in its chemical structure is replaced by deuterium (“heavy hydrogen”, a hydrogen isotope that has a neutron, i.e., one neutron instead of the usual no neutrons). A carbon-deuterium (C-D) bond is more stable in the body than a carbon-hydrogen (C-h) bond. If the deuterium is strategically located in a drug’s chemical structure, the extra stability of the bond will be more resistant to metabolic breakdown, and the duration of drug action will be prolonged. We review the general concept of deuterated drugs, historical examples of the classes of application, and the new approval.

关键词： Deuterium Drug Structure Chemical Bonds Drug Metabolism Duration of Action

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妊娠母猪分阶段饲养

国外畜牧学（猪与禽） 2013年第3期33卷 39-41页

作者：傅强 William h.Close Jules A.taylor-Pickard Close咨询公司奥特奇公司

母猪妊娠期中的每一天均是不一样的。每一天都标志着未出生仔猪的生长进一步加快—理论上,每一天都需要一套新的营养方案。通过将妊娠期分为三个阶段,母猪的营养需求能够被更清楚地详细定义:它们需要什么?

关键词：妊娠母猪分阶段饲养营养方案营养需求妊娠期仔猪

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重症监护治疗

重症监护治疗