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Food Bioscience 2022年第3期47卷 197-210页

作者： Rock-Seth Agoua Laurent Bazinet jacinthe thibodeau Eugène Vorobiev Nabil Grimi Sergey Mikhaylin Institute of Nutrition and Functional Foods (INAF) Dairy Research Center (STELA)Food Science DepartmentUniversité LavalQuébecQCCanada Laboratory of Food Sustainability (EcoFoodLab) Food Science DepartmentUniversité LavalQuébecQCCanada Laboratoire de Transformation Alimentaire et Procédés Électro-Membranaires (LTAPEM) Food Science DepartmentUniversité LavalQuébecQCCanada University of Technology of Compiègne Laboratory of Agro-industrial technologiesCompiègneFrance

Chymotryptic hydrolysis of β-lactoglobulin (β-lg) leads to the release of a wide range of biofunctional ***,the proteolysis of native β-lg is limited due to its compact globular structure,thus ending with low yields of *** our previous study showed that eco-efficient High Voltage Electric Treatments (HVET),namely Pulsed Electric Fields (PEF) and Electric Arc (ARC),of β-lg substantially improved its enzymatic hydrolysis,no information regarding the nature of released peptides is available up to ***,the time-dependent release of peptides and the dynamics of this release were discussed in the current *** analysis of the final hydrolysates showed that chymotrypsinolysis of HVET samples released 19% more peptides with higher concentration than the native and preheated ***,1-min HVET were found to be more efficient than 10-min ones as they led to the release of bioactive peptides (even without chymotrypsin) with higher eco-efficiency scores.

关键词： β-lactoglobulin Peptides High-voltage electrical treatments Eco-efficiency Chymotrypsin Hydrolysis.

Tribological behaviour of the green anode paste with a steel plate at 150 ℃

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Friction 2014年第3期2卷 272-286页

作者： Stéphane thibodeau Houshang D.ALAMDARI Donald P.ZIEGLER Mario FAFARD NSERC/Alcoa Industrial Research Chair MACE3 and Aluminium Research Centre−REGAL Laval UniversityQuébecQCG1V 0A6Canada Department of Mining Metallurgical and Materials Engineering1065 avenue de la Médecine Laval UniversityQuebecQCG1V 0A6Canada Alcoa Primary Metals Alcoa Technical Center100 Technical Drive Alcoa CenterPA 15069-0001USA

In order to accurately predict the mechanical behaviour of paste during forming process,the friction law between the carbon paste and the mould wall is an important parameter to be *** paper presents the tribological behaviour of the lubricated paste/steel interface subjected to high stress conditions at the anode forming temperature of 150℃.A method to characterize the tribological behaviour has been developed and an apparatus was *** method is based on the comparison of two successive *** the first experiment,the paste is in contact with the friction *** the second one,a layer of Teflon is placed under the paste in order to excite another parameter thereby allowing the identification of the friction coefficient between the paste and steel *** experiments were performed with a paste under different normal *** static and kinetic friction coefficients of the Teflon/steel,steel/steel and paste/steel interfaces have been *** static and kinetic friction coefficients of the Teflon/steel are respectively 0.17 and *** steel/steel friction coefficients were evaluated twice which gave a static coefficient that varies between 0.22 and *** kinetic coefficient varies between 0.18 and *** static and kinetic paste/steel friction coefficients obtained from both experiments are clearly *** values are 0.15 and 0.13 respectively.

关键词： carbon paste high stresses high temperature friction paste/steel interface tribological behaviour

Cell-type specific regulation of MARCH1 E3 ubiquitin ligase by the anti-inflammatory cytokine IL-10

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Open Journal of Immunology 2012年第4期2卷 161-167页

作者： Tristan Galbas Jacques thibodeau Department of Microbiology and Immunology University of Montreal Montreal Canada

Membrane-associated RING-CH-1 (MARCH1) is an E3 ubiquitin ligase which targets MHC-II, CD86 and various other molecules for degradation. It is one of the most efficient post-translational regulators of antigen presentation. MARCH1 is expressed in resting immature dendritic cells and B cells but can be induced in other cell types. While activation of most immune cells results in a reduction in MARCH1 gene expression, its anti-inflammatory properties are highlighted by its induction in response to IL-10. Here, we review what is known about the regulation of MARCH1 gene expression in response to IL-10 by various immune cells. We speculate on the role of MARCH1 ininfection, its differential expression pattern and the promise that this E3 ubiquitin ligase holds to influence immune responses and mitigate immune pathologies.

关键词： MARCH1 Interleukin-10 MHC-II Ubiquitin Antigen-Presenting Cells

Structure & function of the body

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The human body in health & disease 2nd ed.

1000年

作者： thibodeau Gary A.

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The human body in health & disease

Estimating Probability of Instability of Haulage Drift with Respect to Mining Sequences

1997年

作者： thibodeau Gary A.

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Journal of Civil Engineering and Architecture 2013年第7期7卷 887-896页

作者： Wael Abdellah Hani S. Mitri Denis thibodeau Lindsay Moreau-Verlaan Department of Mining and Materials Engineering Faculty of Engineering McGill University Quebec H3A OE8 Canada Vale Ltd. Ontario POM 1NO Canada

Haulage drifts play a vital role in providing personnel and equipment access to ore extraction areas for mine production. Thus, their stability is of crucial importance during the life of a mine plan. Many Canadian mines use longhole mining methods or one of its variants. These methods require access to the orebody through haulage drifts on multiple levels. This paper examines the stability of mine haulage drifts with respect to planned mining sequence. A case study of an underground mine is presented. The case study examines # l Shear East of the Garson Mine in Sudbury, Ontario. A two-dimensional, elastoplastic, finite difference model （FLAC 2D） is developed for a haulage drift situated 1.5 km below surface in the footwall of the orebody. The stability of the haulage drift is evaluated in terms of the spread of yield zones into the rockmass due to nearby mining activities. The performance of the drift stability is evaluated at various mining stages, employing the RMC （Random Monte-Carlo） technique in conjunction with finite difference modeling to study the probability of unsatisfactory performance of the drift. The results are presented and categorized with respect to probability, instability and mining stage.

关键词： Haulage drifts stability numerical modeling RMC yielding zone.

The human body in health & disease /

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Detection of Campylobacter sp. from Poultry Feces in Ouagadougou, Burkina Faso

2010年

作者： Gary A. thibodeau KevinT.Patton.

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Food and Nutrition Sciences 2021年第2期12卷 107-114页

作者： Assèta Kagambèga Alexandre thibodeau Daniel K. Soro Nicolas Barro Philippe Fravalo Laboratoire de Biologie Moléculaire d’épidémiologie et de surveillance des bactéries et virus transmissibles par les aliments (LaBESTA)/Ecole Doctorale Sciences et Technologies (EDST)/Université Joseph KI-ZERBOOuagadougou Burkina Faso Institut Des Sciences (IDS) Ouagadougou Burkina Faso Veterinary Medicine Faculty Department of Pathology and Microbiology NSERC Industrial Research Chair in Meat-Safety (CRSV) University of Montreal Saint-Hyacinthe QC Canada

Background: Campylobacter contamination in poultry and poultry product has been reported worldwide. The present study aims to determine the prevalence of Campylobacter in poultry feces using selective enrichment Bolton broth and multiplex PCR. Method: Two methods were used in this study: the first was direct plating of poultry feces into mCCDA agar plates. The second, three antibiotics were used at different concentrations to add in Bolton broth supplemented. These antibiotics were Rifampicin (Oxoid, Nepean, Ontario) with 10 mg/L, colistin (Oxoid, Nepean, Ontario) with 1 mg/mL and 2 mg/mL;trimethoprim (Oxoid, Nepean, Ontario) with 10 mg/L. The colonies with typical campylobacter morphology on blood agar (little, red and

金属蛋白酶在皮肤构造与老化中所扮的角色(英文)

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日用化学品科学 2000年第S2期23卷 160-162页

作者： Alain thibodeau 加拿大魁北克省艾俊生化技术公司

皮肤细胞间质体 (ECM)是由表皮与真皮产生的各种蛋白构成。破坏ECM的金属蛋白酶(MMP)是引起皮肤老化的重要原因。年龄的增长、环境的影响使皮肤逐渐老化。从分子与细胞层面的角度出发 ,着重分析了ECM与MMP对此所起的根本作用。年龄与紫... 详细信息

皮肤细胞间质体 (ECM)是由表皮与真皮产生的各种蛋白构成。破坏ECM的金属蛋白酶(MMP)是引起皮肤老化的重要原因。年龄的增长、环境的影响使皮肤逐渐老化。从分子与细胞层面的角度出发 ,着重分析了ECM与MMP对此所起的根本作用。年龄与紫外线影响会激增MMP2 (MMP的一种 )的活性 ,降低内在TIMP (抑制MMP2的酶 )的作用 ,使胶原蛋白纤维逐渐衰败 ,失去健康的平衡。MMP2激增的活性破坏在表皮与真皮间起支托作用的胶原蛋白 7型 ,可导致皱纹 ;MMP2还破坏胶原蛋白 1型 ,使ECM缺损、萎缩 ,导致微细血管扩张。

关键词：皮肤细胞间质体胶原蛋白金属蛋白酶皮肤老化皮肤构造

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水溶性橄榄叶提取物

中国化妆品 2010年第12期 97-100页

作者： Alain thibodeau 意大利B&T公司科学事务部

Eurol BT提取自Olea europaea（油橄榄）树叶，是100％纯天然的水溶性活性成分，用于化妆品和药用化妆品。Eurol BT的多种功效主要归功于其清除自由基的能力。橄榄树被认为是世界上最古老的植物之一；同时，它可以抵抗各种疾病，因此橄... 详细信息

Eurol BT提取自Olea europaea（油橄榄）树叶，是100％纯天然的水溶性活性成分，用于化妆品和药用化妆品。Eurol BT的多种功效主要归功于其清除自由基的能力。橄榄树被认为是世界上最古老的植物之一；同时，它可以抵抗各种疾病，因此橄榄树树叶的应用也一直受到人们的关注。值得一提的是，当橄榄叶从树上落下，其颜色可以在很长一段时间内仍然保持绿色，充分显示了它高效的抗氧化能力。

关键词：叶提取物水溶性油橄榄抗氧化能力清除自由基活性成分化妆品橄榄树