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Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system

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Neural Regeneration Research 2024年第7期19卷 1437-1445页

作者： Steinunn Sara Helgudóttir Anne Skøttrup Mørkholt jacek lichota Preben Bruun-Nyzell Mads Christian Andersen Nanna Marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John Dirk Vestergaard Nieland 2N Pharma ApS NOVI Science ParkAalborgDenmark Molecular Pharmacology Group Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s *** the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these *** considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological *** innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers *** this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative *** provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ***,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter ***,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关键词： brain disease carnitine palmitoyl transferase 1 epigenetics metabolism gut microbiome mitochondrial dysfunction neurodegeneration oxidative stress

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Condensing Heat Exchanger

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Journal of Energy and Power Engineering 2014年第9期8卷 1511-1542页

作者： Janusz lichota Krzysztof Polko Kazimierz Wojs Faculty of Mechanical and Power Engineering Wroclaw University of Technology Wroctaw 27 50-370 Poland

The paper shows a method of designing a heat exchanger recovering heat from the condensation of water vapour contained in flue gases. A heat exchanger condenses water vapour and SO2 （sulphur dioxide） in the presence of inert gases （CO2, CO, N2, O2） contained in flue gases. A mathematical model and a sample design of a heat exchanger were presented. The heat exchange is capable of recovering from a dozen or so to several dozen percent of heat from flue gases escaping into the atmosphere. A second advantage of the heat exchanger is the possibility to reduce the emissions of SO2 considerably. Depending on the parameters, it can be even a sevenfold reduction in the emissions. The main mathematical tool used for designing the condensing heat exchanger is the Colburn-Hougen method. The authors omitted that part of the method which requires iterative calculations. The Mollier diagram was used instead.

关键词： Heat exchanger condensation heat recovery flue gases.

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