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艾滋病患者在高活化抗逆转录病毒治疗期间死亡的危险因素

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 51-52页

作者： jabs D.A. Holbrook J.T. Van Natta m.L. 王大江 550 North Broadway Baltimore MD 21205 United States Dr.

Objective: To evaluate risk factors formortality among patients with AIDS in the era of highly active antiretroviral therapy (HAART), particularly the effect of cytomegalovi-rus (CmV). Design: Prospective cohort study of patients with AIDS, conducted from 1998 through 2003. Participants: One thousand five hundred eighty-three patients with AIDS, of whom 374 had CmV retinitis. methods: Patients were contacted every 3 months, with examinations at least every 6 months, in which standardized data were collected on AIDS history and treatment, eye examinations, and hematologic, virologic, and immunologic laboratory data. main Outcome measure: mortality. Results: The overall mortality rate was 0.07 deaths/ person-year. In a multivariate analysis, the following baseline risk factors were associated with an increased mortality: higher human immunodeficiency virus (HIV) viral load (relative risk [RR]= 4.6 for HIV viral load > 100 000 copies/ml vs. ml; P ment (RR=3.8 forCD4+T cell count 0-49 cells/μl vs. ≥200 cells/μl; P mV viral load ≥400 copies/ml (RR=1.9; P= 0.002), lower hemoglobin (RR=1.7 for hemoglobin meningitis (RR=1.7; P= 0.02), CmV retinitis (RR=1.6; P=0.0002), and Karnofsky score ≤80 (RR=1.4; P=0.008). Conclusions: In the era of HAART, CmV disease as manifested by CmV retinitis and a detectable CmV viral load were associated with an increased risk for mortality, even after adjusting for demographic, treatment, immunologic, and HIV virologic factors.

关键词：细胞计数人免疫缺陷病毒病毒载量视网膜炎隐球菌性脑膜炎巨细胞病毒总死亡率病毒负荷检查数据免疫学

ROR2 gene is associated with risk of non-syndromic cleft palate in an Asian population

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Chinese medical Journal 2012年第3期125卷 476-480页

作者： Wang Hong Hetmanski, Jacqueline B. Ruczinski, Ingo Liang, Kung Yee Fallin, m. Daniele Redett, Richard J. Raymond, Gerald V. Chou, Yah-Huei Wu Chen, Philip Kuo-Ting Yeow, Vincent Chong, Samuel S. Cheah, Felicia S. H. jabs, Ethylin Wang Scott, Alan F. Beaty, Terri H. Peking Univ Dept Epidemiol & Biostat Sch Publ Hlth Beijing 100191 Peoples R China Johns Hopkins Bloomberg Sch Publ Hlth Dept Epidemiol Baltimore MD USA Johns Hopkins Bloomberg Sch Publ Hlth Dept Biostat Baltimore MD USA Natl Yang ming Univ Dept Life Sci Taipei 112 Taiwan Natl Yang ming Univ Inst Genome Sci Taipei 112 Taiwan Johns Hopkins Univ Sch Med Dept Surg Baltimore MD 21205 USA Johns Hopkins Univ Sch Med Kennedy Krieger Inst Baltimore MD USA Johns Hopkins Univ Sch Med Dept Pediat Baltimore MD 21205 USA Johns Hopkins Univ Sch Med Dept Med Baltimore MD 21205 USA Chang Gung mem Hosp Dept Med Res Tao Yuan Taiwan Chang Gung mem Hosp Craniofacial Ctr Tao Yuan Taiwan KK Womens & Childrens Hosp Dept Plast Reconstruct & Aesthet Surg Singapore Singapore Natl Univ Singapore Dept Pediat Singapore 117548 Singapore mt Sinai Sch med New York NY USA

Background The receptor tyrosine kinase-like orphan receptor 2 （ROR2） gene has been recently shown to play important roles in palatal development in animal models and resides in the chromosomal region linked to non syndromic cleft lip with or without cleft palate in *** aim of this study was to investigate the possible association between ROR2 gene and non-syndromic oral *** Here we tested 38 eligible single-nucleotide polymorphisms （SNPs） in ROR2 gene in 297 non-syndromic cleft lip with or without cleft palate and in 82 non-syndromic cleft palate case parent trios recruited from Asia and *** Based Association Test was used to test for deviation from mendelian *** software was used to test potential parent of origin *** maternally mediated in utero effects were assessed using the TRlad multi-marker approach under an assumption of mating symmetry in the *** Significant evidence of linkage and association was shown for 3 SNPs （rs7858435,rs10820914 and rs3905385） among 57 Asian non-syndromic cleft palate trios in Family Based Association Tests.P values for these 3 SNPs equaled to 0.000068,0.000115 and 0.000464 respectively which were all less than the significance level （0.05/38=0.0013） adjusted by strict Bonferroni *** odds ratios for the risk allele were 3.42 （1.80-6.50）,3.45 （1.75-6.67） and 2.94 （1.56-5.56）,*** evidence of linkage and association was not shown for study groups other than non-syndromic cleft *** evidence for parent-of-origin nor maternal genotypic effect was shown for any of the ROR2 markers in our analysis for all study *** Our results provided evidence of linkage and association between the ROR2 gene and a gene controlling risk to non-syndromic cleft palate.

关键词： receptor tyrosine kinase-like orphan receptor 2 cleft lip cleft palate association transmission disequilibrium test

巨细胞病毒性视网膜炎经高度抗逆转录病毒治疗的发展过程:1.视网膜病变的进展

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 61-61页

作者： jabs D.A. Van Natta m.L. Thorne J.E. 张少娟

To describe the course of cytomegalovirus (CmV) retinitis in patients with AID S in the era of highly active antiretroviral therapy (HAART). multicenter, prosp ective, observational study. Two hundred seventy-one patients with AIDS and CmV retinitis. Follow-up every 3 months with medical history, ophthalmologic exami nation, laboratory testing, and fundus photographs. Photographs were evaluated f or relapse of the retinitis (progression) by graders at a centralized reading ce nter. Retinitis progression (movement of the border of a CmV lesionm ove r a m front or occurrence of a new lesion one-quarter disc area or mor e in size). The overall rate of retinitis progression was 0.10/person-year (PY) ; among those with CD4+T-cell counts ofmpared to 0 .02/PY among those with CD4+T-cell counts of mul tivariate analysis, significant risk factors for retinitis progression included a low CD4+T-cell count, positive CmV load, longer time from AIDS diagnosis, an d low Karnofsky score. Compared with the rate of retinitis progression (～3.0/PY ) reported in the pre-HAART era, the rate of retinitis progression was reduced among patients in the HAART era, even among those with low CD4+T-cell counts, who might be expected to behave most like patients from the pre-HAART era. Howe ver, these events also occurred among patients with high CD4+T-cell counts and presumed immune recovery. Continued ophthalmologic follow-up of patients with immune recovery is recommended to detect early retinitis progression.

关键词：视网膜病变视网膜炎眼底照相细胞计数眼科检查巨细胞病毒进展率免疫水平区域边界病例研究

巨细胞病毒性视网膜炎经高度抗逆转录病毒治疗的发展过程:2.健眼受累与视网膜脱离

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世界核心医学期刊文摘（眼科学分册） 2005年第4期1卷 58-58页

作者： jabs D.A. Van Natta m.L. Thorne J.E. 张少娟

To describe the course of cytomegalovirus (CmV) retinitis in patients with AIDS in the era of highly active antiretroviral therapy (HAART). multicenter, prospective, observational study. Two hundred seventy- one patients with AIDS and CmV retinitis. Follow- up every 3 months with medical history, ophthalmologic examination, laboratory testing, and fundus photographs. Second (contralateral) eye involvement among patients with unilateral disease and retinal detachment (RD). The overall rate of second eye involvement among patients with unilateral CmV retinitis was 0.07 per person- year (PY); among those with CD4+ T- cell counts of mpared with 0.02/PY among those with CD4+ T- cell counts of ment included low CD4+ T- cell count and detectable CmV load. The overall rate of RD was 0.06/PY; among those with CD4+ T- cell counts of mpared with 0.02/PY among those with CD4+ T- cell counts of mV retinitis. Compared with the rates reported in the pre- HAART era of second eye involvement (0.40/PY) and RD (0.50/PY), the rates of these events were reduced among patients in the HAART era. However, among patients with CD4+ T- cell counts of more similar to those from the pre- HAART era .

关键词：视网膜脱离对侧眼视网膜炎细胞计数眼底照相眼科检查巨细胞病毒病例研究观察性评价指标