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双氢青蒿素哌喹片治疗缅甸拉咱市恶性疟的疗效和安全性评价

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中国寄生虫学与寄生虫病杂志 2011年第5期29卷 372-375页

作者：孙晓东张再兴王剑邓艳杨沅川 Lasi ja-hkawn 孙晓英王恒中国医学科学院基础医学研究所北京协和医学院基础学院北京100005 云南省寄生虫病防治所普洱665000 英国无国界卫生组织德宏项目组潞西678400

目的评价双氢青蒿素哌喹片治疗中缅边境地区缅甸拉咱市恶性疟的疗效和安全性。方法 2008年9～12月,在缅甸拉咱市及隶属于该市的4个自然村开展临床试验,选择2～60岁、原虫密度≥250个/μl血、单纯恶性疟现症病例,用双氢青蒿素哌喹片(每... 详细信息

目的评价双氢青蒿素哌喹片治疗中缅边境地区缅甸拉咱市恶性疟的疗效和安全性。方法 2008年9～12月,在缅甸拉咱市及隶属于该市的4个自然村开展临床试验,选择2～60岁、原虫密度≥250个/μl血、单纯恶性疟现症病例,用双氢青蒿素哌喹片(每片含双氢青蒿素40 mg,磷酸哌喹320 mg)2天4次疗法治疗,总剂量因体重而异,如50 kg体重患者总剂量8片均分4次口服,每次2片,每次间隔8～10 h,按体重剂量表给药。于服药当天、服药后的第1、2、3、7、14、21和28天随访观察患者症状、原虫密度、体温和药物不良反应。用WHO抗疟药治疗效果分类、退热时间、无性体原虫转阴时间和配子体转阴率评价其疗效。结果共64例完成全程随访,100%完全临床原虫治疗成功,平均退热时间为(22.5±8.2)h,无性体原虫转阴时间中位数为30.0 h[(17.1～168.2)h];服药后第3天和第7天无性体原虫转阴率和退热率分别为(93.8%、100%)和(100%、100%),服药后第28天配子体转阴率为75.0%;仅7例出现轻度不良反应,不良反应率为9.9%(7/71)。结论双氢青蒿素哌喹片治疗缅甸拉咱市恶性疟安全有效。

关键词：双氢青蒿素哌喹片恶性疟疗效缅甸

Large-Scale Group Decision making:A Systematic Review and a Critical Analysis

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IEEE/CAA Journal of Automatica Sinica 2022年第6期9卷 949-966页

作者： Diego García-Zamora Alvaro Labella Weiping Ding Rosa.m.Rodríguez Luis martínez Department of Computer Science University of JaénJaén 23071Spain IEEE School of Information Science and Technology Nantong UniversityNantong 226019China

The society in the digital transformation era demands new decision schemes such as e-democracy or based on social *** novel decision schemes require the participation of many experts/decision makers/stakeholders in the decision *** a result,large-scale group decision making(LSGDm)has attracted the attention of many researchers in the last decade and many studies have been conducted in order to face the challenges associated with the ***,this paper a.ms at reviewing the most relevant studies about LSGDm,identifying the most profitable research trends and analyzing them from a critical point of *** do so,the Web of Science database has been consulted by using different *** these results a total of 241 contributions were found and a selection process regarding language,type of contribution and actual relation with the studied topic was then carried *** 87 contributions finally selected for this review have been analyzed from four points of view that have been highly remarked in the topic,such as the preference structure in which decision-makers’opinions are modeled,the group decision rules used to define the decision making process,the techniques applied to verify the quality of these models and their applications to real world problems ***,a critical analysis of the main limitations of the existing proposals is ***,taking into account these limitations,new research lines for LSGDm are proposed and the main challenges are stressed out.

关键词： Challenges large-scale consensus models large-scale group decision making(LSGDm) systematic review

Consensus Delphi study on guidelines for the assessment of anterior cruciate ligament injuries in children

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World Journal of Orthopedics 2022年第9期13卷 777-790页

作者： Angélica Campón Chekroun Jorge Velázquez-Saornil Isabel Guillén Vicente Zacarías Sánchez milá David Rodríguez-Sanz Carlos Romero-morales Tomas Fernandez-jaén JoséIgnacio Garrido González miguelÁngel Sánchez-Garrido Pedro Guillén García Campus San Jerónimo Guadalupe Universidad Católica de MurciaMurcia 30107MurciaSpain Department of Physiotherapy Universidad Católica deÁvilaÁvila 05005ÁvilaSpain Department of Orthopaedic and Tra.ma Surgery Clínica CemtroMadrid 28035MadridSpain Nursing Physiotherapy and PodiatryUniversidad Complutense de MadridMadrid 28040MadridSpain Department of Physical Therapy Universidad Europea de MadridMadrid 28023MadridSpain Department of Orthopaedic and Tra.ma Surgery Gabinete Médico GarridoSalamanca 37003SalamancaSpain

Background:Knee examination guidelines in minors are intended to aid decisionmaking in the management of knee *** question:A Delphi study was conducted with a formal consensus process using a validated methodology with sufficient scientific evidence.A group consensus meeting was held to develop recommendations and practical guidelines for use in the assessment of instability injuries in *** findings:there is a lack of evidence to analyse anterior cruciate ligament injuries in children and their subsequent surgical management if *** guidelines and clinical assessment of the patient based on a thorough examination of the knee are performed and a guide to anterior cruciate ligament exploration in children is *** application:In the absence of a strong evidence base,these established guidelines are intended to assist in that decision-making process to help the clinician decide on the most optimal trea.ment with the a.m of benefiting the patient as much as *** this expert consensus,surgical trea.ment is advised when the patient has a subjective sensation of instability accompanied by a pivot shift test++,and may include an anterior drawer test+and a Lachman test+.If these conditions are not present,the conservative approach should be chosen,as the anatomical and functional development of children,together with a physiotherapy progra.me,may improve the evolution of the injury.

关键词： Anterior cruciate ligament Diagnoses and examinations Sports injuries Knee Injury to minors

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超声背向散射显微镜对鼠黑色素瘤生长的分析

上海生物医学工程 1997年第3期18卷 60-63,59页

作者： Tumbull DH Ramsay ja Shivji GS 王志刚

皮肤黑色素瘤在全世界的发生率和死亡率不断增加。对黑色素瘤的生物学研究,是目前的一个重要研究领域。最近,转基因鼠的技术突破,导致了可以建立鼠皮肤黑色素瘤模型的可能。目前,还没有对皮下黑色素瘤的生长进行定量研究的报告。我们首... 详细信息

皮肤黑色素瘤在全世界的发生率和死亡率不断增加。对黑色素瘤的生物学研究,是目前的一个重要研究领域。最近,转基因鼠的技术突破,导致了可以建立鼠皮肤黑色素瘤模型的可能。目前,还没有对皮下黑色素瘤的生长进行定量研究的报告。我们首次应用一种被称为超声背向散射显微镜(UBm)的影像学方法,以轴向30μm和横向60μm的空间分辨率对鼠早期黑色素进行影像研究。从最早期的检测,鼠的B16F10黑色素瘤已经成像,直到几天后,它们的径长到2-5mm。用UBm测量黑色素瘤与肿瘤组织的病理检查有极好的吻合性。用UBm测量的黑色素瘤的高、宽相对的rms的误差分别是8.7％和4.2％,早期黑色素瘤的平均增加是0.37±0.06mm/天。影像图的三维显示获得黑色素瘤的体积,由计算机测得其大小,并与肿瘤进行比较。用假设的肿瘤的椭圆模型,用UBm测量的体积的相对误差小于17％。这些结果表明,用鼠的皮肤模型进行黑色素瘤的生物学研究是有益的,有助于用高频超声图像进行皮肤黑色素瘤的检测。

关键词：黑色素瘤 USB 超声诊断散射显微镜

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跨音速绕流时薄翼后方扰动速度场的计算

南京航空航天大学学报 1977年 1-9页

作者：杨岞生

本文从跨音速非线性小扰动位流方程出发,导得在m~<m_∞≤1跨音速绕流时机翼后方的扰动速度场(侧洗场,下洗场)的计算公式,并建立了它与满足线性小扰动位流方程的基元旋涡的涡系所诱导速度场之间的关系,从而统一了亚跨音速绕流时机翼后方... 详细信息

本文从跨音速非线性小扰动位流方程出发,导得在m~m_∞≤1跨音速绕流时机翼后方的扰动速度场(侧洗场,下洗场)的计算公式,并建立了它与满足线性小扰动位流方程的基元旋涡的涡系所诱导速度场之间的关系,从而统一了亚跨音速绕流时机翼后方扰动速度场的计算方法。

关键词：薄翼音速薄型机翼机翼跨音速流跨音速气流可压缩流马蹄涡系速度场绕流

Habitat, occurrence and conservation status of the Saharo-macaronesian and Southern-mediterranean element Fagonia cretica L. (Zygophyllaceae) in Italy

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Journal of Arid Land 2018年第1期10卷 140-151页

作者： giovanni spampinato ca.melo m musarella ana cano-ortiz giuseppe signorino department of agriculture mediterranea university of reggio calabriaFeo di Vito89124 Reggio CalabriaItaly department of animal and plant biology and ecology section of botanyuniversity of jaéncampus universitario las lagunillas s/n23071 jaénSpain

Fagonia cretica L. is an important component of mediterranean dry grasslands and a rare and isolated species of Italian flora. In this study, an assessment is presented on the distribution, habitat, and conservation status of F. cretica in Italy. The results of field investigation and herbarium analysis show that this species grows in a small area within the southern Calabria region characterized by a wa.mest and driest mediterranean climate on the Italian peninsula. F. cretica is a semi-desert plant species growing in Italy in only one peripheral and isolated population at the northern limit of its distribution. Plant community analysis, using the phytosociological method, shows that F. cretica grows in wintergreen perennial dry grasslands dominated by Lygeum {partum and Hyparrhenia hirta. F. crelica plant communities are located in thermo-xeric habits such as south-, southeast- and east-facing slopes on clays and sandy clays in southern Calabria. The population of F. cretica is fra.mented in six neighbouring localities, with two of which belonging to a Site of Community Importance （SC1）. The conservation status of F. cretica population is not very good, and is defined as ＂Critically Endangered＂ in accordance with IUCN criteria. There are many threats affecting the F. crelica population in ltaly, primarily the changes in land uses due to urban expansion and reforestation with exotic plants. The southern end of the Italian peninsula hosts other plants from thermo-xeric habits that do not adapt to the current local climate. This territory can be considered as a.microrefugia for plants currently distributed in the arid territory of the southern mediterranean. These results contribute to the discussion of some conservation measures, and the possibility of establishing a.micro-reserve. For all these reasons, we propose to include F. cretica in the lists of protected plant species at regional （Calabria） and country （Italy） scales in Italy.

关键词： biodiversity ecology peripheral isolated populations phytosociology microrefugia southern Italy

微量白蛋白尿在原发性高血压患者降压治疗中的预后价值

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中华高血压杂志 2014年第10期22卷 999-999页

作者： Pascual Jm Rodilla E Costa ja Garcia-Escrich m Gonzalez C Redon J 刘莉叶鹏

该研究旨在评估降压治疗过程中,尿微量白蛋白排泄随时间的变化对心血管风险是否有预测价值。方法：对平均年龄55岁、无心血管疾病的高血压患者2835例进行随访研究,其中47.0%为男性,血压138/80mm Hg（1mm Hg=0.133kPa）,19.

关键词：原发性高血压患者微量白蛋白尿降压治疗预后价值心血管风险白蛋白排泄心血管疾病预测价值

Severity Based Light-Weight Encryption model for Secure medical Information System

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Computers, materials & Continua 2023年第3期74卷 5691-5704页

作者： Firas Abedi Subhi R.m.Zeebaree Zainab Salih Ageed Hayder m.A.Ghanimi a.med Alkhayyat moha.med a.m.Sadeeq Sa.mad Nozad ma.mood Ali S.Abosinnee Zahraa H.Kareem Ali Hashim Abbas Waleed Khaild Al-Azzawi mustafa.musa jaber moha.med Dauwed Department of mathematics College of EducationAl-Zahraa University for WomenKarbalaIraq Energy Eng.Department Technical College of EngineeringDuhok Polytechnic UniversityDuhokIraq Computer Science Department College of ScienceNawroz UniversityDuhokIraq Biomedical Engineering Department College of EngineeringUniversity of Warith Al-AnbiyaaKarbalaIraq College of Technical Engineering The Islamic UniversityNajafIraq ITm Department Technical College of AdministrationDuhok Polytechnic UniversityDuhokIraq Computer Technology Engineering College of Engineering TechnologyAl-Kitab UniversityIraq Altoosi University College NajafIraq Department of medical Instrumentation Techniques Engineering Al-Mustaqbal University CollegeHillah51001Iraq College of Information Technology Imam Ja’afar Al-Sadiq UniversityAl-Muthanna66002Iraq Department of medical Instruments Engineering Techniques Al-Farahidi UniversityBagdadIraq Department of medical Instruments Engineering Techniques Al-Turath University CollegeBaghdad10021Iraq Department of medical Instruments Engineering Techniques Al-Farahidi UniversityBaghdad10021Iraq Department of medical Instrumentations Techniques Engineering Dijlah University CollegeBaghdadIraq

As the amount of medical images transmitted over networks and kept on online servers continues to rise,the need to protect those images digitally is becoming increasingly ***,due to the massive amounts of multimedia and medical pictures being exchanged,low computational complexity techniques have been *** commonly used algorithms offer very little security and require a great deal of communication,all of which add to the high processing costs associated with using ***,a deep learning classifier is used to classify records according to the degree of concea.ment they *** images that aren’t needed can be saved by using this method,which cuts down on security *** is one of the most effective methods for protecting medical images after this *** and dispersion are two fundamental encryption processes.A new encryption algorithm for very sensitive data is developed in this *** splitting with image blocks is nowdeveloped by using Zigzag patterns,rotation of the image blocks,and random permutation for scrambling the *** that,this research suggests a Region of Interest(ROI)technique based on selective picture *** the first step,we use an active contour picture segmentation to separate the ROI from the Region of Background(ROB).Permutation and diffusion are then carried out using a Hilbert curve and a Skew Tent *** all of the blocks have been encrypted,they are combined to create encrypted *** investigational analysis is carried out to test the competence of the projected ideal with existing techniques.

关键词： Deep learning encryption medical images scrambling security skew tent map rotation zigzag pattern

脉搏波反射幅度对死亡率的预测作用:动脉粥样硬化多种族研究

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中华高血压杂志 2014年第11期22卷 1042-1042页

作者：刘莉叶鹏 Zamani P jacobs DR Jr Segers P Duprez DA Brumback L Kronmal RA Lilly Sm Townsend RR Budoff m Lima ja Hannan P Chirinos ja

研究表明,纯亚裔人群中脉搏波反射与死亡率相关。但是,多种族人群中是否存在这样的关系,以及其是否独立于亚临床动脉粥样硬化,尚未确定。该研究人员假设,以社区为基础的多种族成人样本中,脉搏波反射幅度（定义为后向波振幅Pb与前向波振... 详细信息

研究表明,纯亚裔人群中脉搏波反射与死亡率相关。但是,多种族人群中是否存在这样的关系,以及其是否独立于亚临床动脉粥样硬化,尚未确定。该研究人员假设,以社区为基础的多种族成人样本中,脉搏波反射幅度（定义为后向波振幅Pb与前向波振幅Pf的比值）与全因死亡率相关。方法与结果：纳入多种族动脉粥样硬化研究中,行动脉张力波形分析的5984名受试者作为研究对象。

关键词：亚临床动脉粥样硬化全因死亡率种族人群波反射预测作用脉搏社区为基础研究人员