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Combination of Korean Red Ginseng Extract and Hydrogen-Rich Water Improves Spermatogenesis and Sperm Motility in Male Mice

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Chinese Journal of Integrative Medicine 2020年第5期26卷 361-369页

作者： ja Yoon Ku Min Jung Park Hyun Jun Park Nam Cheol Park Bo Sun Joo Department of Urology Pusan National University HospitalPusan National University School of MedicineBusan(49241)Republic of Korea Biomedical Research Institute Pusan National University HospitalBusan(49241)Republic of Korea The Korea Institute for Public Sperm Bank Busan(49241)Republic of Korea

Objective: To investigate the effect of hydrogen-rich Korean Red Ginseng(KRG) water(HRGW) mixture on the spermatogenesis and sperm motility of mice of different ages. Methods: Eighty young(3 month-old) and aged(12 month-old) male mice were randomly assigned to 4 groups(n=10 per group) including control group, hydrogen-rich water(HRW) group(10 m L/kg daily), KRG group(50 mg/kg daily) and HRGW group(10 m L/kg HRW and 50 mg/kg KRG daily) by an oral zoned needle for 4 weeks. Sperm count and motility were measured using sperm suspension released from cauda epididymis. Serum follicle stimulating hormone(FSH), luteinizing hormone(LH), testosterone, and reactive oxygen species(ROS) in serum have also been estimated. Tubular changes were examined through histological hematoxylin and eosin staining. Expression of antioxidation(PPx3, PPx4, GSTm5 and GPx4), spermatogenesis(inhibin-α, neptin-2 and CREM), antiaging(SIRT1 and SIRT2), and angiogenesis [visfatin and vascular endothelial growth factor(VEGF)] related genes were examined through realtime polymerase chain reaction. Results: HRW and KRG treatment stimulated spermatogenesis followed by increasing sperm production and sperm motility(Ppermatogenesis related genes and VEGF especially in aged mice(Pperm production and motility by enhancing antioxidation and stimulating spermatogenesis and sex hormone production, particularly in aged mice.

关键词： aging ginseng infertlit mineral waters sperm mtility

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Comparative growth, dry matter accumulation and photosynthetic rate of seven species of Eucalypt in response to phosphorus supply

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Journal of Forestry Research 2014年第2期25卷 377-383页

作者： Peng-fei Wu Xiang-qing Ma Mulualem Tigabu Yong Huang Li-li Zhou Liping Cai Xiao-long Hou per Christer Oden Forestry College Fujian Agriculture and Forestry University Swedish University of Agricultural Sciences Faculty of Forest ScienceSouthern Swedish forest Research Centre Ningde Forestry Bureau

Plantations of eucalypts as short-rotation tree crops are rapidly expanding in tropical and sub-tropical regions, including southern China, where the soils are acidic and available phosphorus （P） is limited. We investigated seedling growth, dry matter accumulation, and the dynamics of photosynthetic rate and chlorophyll content of seven Eucalyptus spe- cies/hybrids （E. dunnii, E. grandis, E. grandis x E. camaldulensis, E. urophylla x E. camaldulensis, E. urophylla x E. tereticornis, E. grandis x E. tereticornis, E. urophylla x E. grandis） in response to different levels of P supply （0, 6, 12 and 18 mg-kg-l KH2PO4）. The photosynthetic rate and the chlorophyll content significantly declined as the P supply declined in almost a linear fashion for all species as the P stress period extended. In the absence of P supply, height growth of seedlings of all species was significantly impaired, while root collar diameter growth and whole plant dry matter accumulation was not affected by the level of P supply in most of the species. Significant inter-species variations in growth, dry matter accumulation and photosynthetic rate in response to P supply were detected. Eucalyptus dunnii had the lowest growth perform- ance across all levels of P supply while E. urophylla x E. tereticornis showed superior growth performance. From a practical point of view, E. urophylla x E. tereticornis is suggested as a candidate hybrid for planting on slightly P-deficient sites in southern China while E. dunnii, being a slow-growing species, is not suitable for short-rotation plantation. On plantation sites where severe P deficiency exists, P fertilization needs to be considered to boost rapid growth of seedlings so as to meet the man- agement objectives of short-rotation plantation.

关键词： biomass Eucalyptus phosphorus stress pulp short-rotation forestry

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Hepatocellular carcinoma in patients with chronic kidney disease

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World Journal of Gastroenterology 2013年第16期19卷 2466-2472页

作者： Chern-Horng Lee Sen-Yung Hsieh ja-Liang Lin Maw-Sen Liu Tzung-Hai Yen College of Medicine Chang Gung University Department of General Internal Medicine and Geriatrics Chang Gung Memorial Hospital Liver Research Unit Chang Gung Memorial Hospital Department of Nephrology Chang Gung Memorial Hospital

AIM: To investigate outcomes of hepatocellular carcinomas (HCCs) in patients with chronic kidney disease (CKD). METHODS: Four hundred and forty patients referred between 2000 and 2002 for management of HCCs were categorized according to their CKD stage, i.e. , estimated glomerular filtration rate (eGFR) > 90 (stage 1), 60-90 (stage 2), 30-60 (stage 3), 15-30 (stage 4), and per 1.73 m 2 , respectively. Demographic, clinical and laboratory data were collected and mortality rates and cause of mortality were analyzed. The mortality data were examined with Kaplan-meier method and the significance was tested using a log-rank test. An initial univariate Cox regression analysis was performed to compare the frequency of possible risk factors associated with mortality. To control for possible confounding factors, a multivariate Cox regression analysis (stepwise backward approach) was performed to analyze those factors that were significant in univariate models (P < 0.05) and met the assumptions of a proportional hazard model. RESULTS: Most HCC patients with CKD were elderly, with mean age of diagnosis of 60.6 ± 11.9 years, and mostly male (74.8%). Hepatitis B, C and B and C coinfection virus were positive in 61.6%, 45.7% and 14.1% of the patients, respectively. It was found that patients with stages 4 and 5 CKD were not only older (P = 0.001), but also had higher hepatitis C virus carrier rate (P = 0.001), lower serum albumin level (P = 0.001), lower platelet count (P = 0.037), longer prothrombin time (P = 0.001) as well as higher proportions of advanced cirrhosis (P = 0.002) and HCCs (P = 0.001) than patients with stages 1 and 2 CKD. At the end of analysis, 162 (36.9%) patients had died. Kaplan-Meier analysis revealed that patients with stages 4 and 5 CKD suffered lower cumulative survival than stages 1 and 2 CKD (log-rank test, χ 2 = 11.764, P = 0.003). In a multivariate Cox-regression model, it was confirmed that CKD stage [odds ratio (OR) = 1.988, 95

关键词： Hepatocellular carcinoma Hepatitis B virus Hepatitis C virus Chronic kidney disease End-stage renal disease

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Modifications of L-Glutamine and L-Leucine Transport in Proliferating Lymphocytes

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Journal of Biosciences and Medicines 2015年第3期3卷 104-109页

作者： Francisco Sanchez Jose Luis Gil Macarena perán Department of Biochemistry Molecular Biology and Immunology University of Málaga Málaga Spain Department of Health Sciences University of Jaén Jaén Spain

Lymphocytes respond to mitogens that stimulate proliferation by increasing theirs metabolic activity. In this study we investigate L-Glutamine and L-Leucine uptake as markers of cell response to Concavalina A (ConcaA) stimulation, using a high-resolution flow technique. We found that lymphocytes induced to blast transformation enhanced rate and efficiency of amino acid uptake during cell proliferation. Considering that increases in transport is the first quantifiable response of cells during malignant transformation, amino acid uptake could also be useful as an early marker of malignancy.

关键词： Cell Membrane Transport Lymphocytes L-Glutamine L-Leucine Malignancy Biomarkers

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Kitesurf injury trauma evaluation study:A prospective cohort study evaluating kitesurf injuries

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World Journal of Orthopedics 2020年第4期11卷 243-251页

作者： Christiaan ja van Bergen Rik IK Weber Tim Kraal Gino MMJ Kerkhoffs Daniel Haverkamp Department of Orthopedic Surgery Amphia HospitalBreda 4818 CKthe Netherlands Academic Center for Evidence based Sports Medicine Amsterdam 1105 AZthe Netherlands Department of Sports Medicine University Medical CenterUtrecht 3584 CXthe Netherlands Department of Orthopedic Surgery Spaarne HospitalHoofddorp 2134 TMthe Netherlands Department of Orthopedic Surgery Amsterdam University Medical CenterAmsterdam 1105 AZthe Netherlands Department of Orthopedic Surgery Xpert ClinicAmsterdam 1103 TBthe Netherlands

BACKGROUND Kitesurfing is an increasingly popular and potentially dangerous extreme water *** hypothesized that kitesurfing has a higher injury rate than other(contact)sports and that the minority of injuries are *** To investigate the incidence and epidemiology of kitesurfing injuries in a Dutch cohort during a complete kitesurfing *** Injury data of 194 kitesurfers of various skill levels,riding styles and age were surveyed prospectively during a full kitesurf *** participants were recruited through the Dutch national kitesurf association,social media,local websites and kitesurf *** completed digital questionnaires *** amount of time kitesurfing was registered along with all sustained *** an injury was reported,an additional questionnaire explored the type of injury,injury location,severity and the circumstances under which the injury *** The mean age of participants was 31 years(range,13-59)and the majority of the study population was male(74.2%).A total of 177 injuries were sustained during 16816 kitesurf *** calculated injury rate was 10.5 injuries per 1000 h of *** most common injuries were cuts and abrasions(25.4%),followed by contusions(19.8%),joint sprains(17.5%)and muscle sprains(10.2%).The foot and ankle were the most common site of injury(31.8%),followed by the knee(14.1%)and hand and wrist(10.2%).Most injuries were reported to occur during a trick or *** the majority of injuries were mild,severe injuries like an anterior cruciate ligament tear,a lumbar spine fracture,a bimalleolar ankle fracture and an eardrum rupture were *** The injury rate of kitesurfing is in the range of other popular(contact)*** injuries are relatively mild,although kitesurfing has the potential to cause serious injuries.

关键词： Kite boarding Water sports Sports medicine Injuries Epidemiology Extreme sports

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Windsurfing vs kitesurfing:Injuries at the North Sea over a 2-year period

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World Journal of Orthopedics 2016年第12期7卷 814-820页

作者： Christiaan ja van Bergen Joris P Commandeur Rik IK Weber Daniel Haverkamp Roelf S Breederveld Department of Orthopaedic Surgery Spaarne Gasthuis Department of Surgery Luzerner Kantonsspital Department of Orthopaedic Surgery Slotervaartziekenhuis Department of Trauma Surgery Red Cross Hospital

AIM To analyze all windsurfing and kitesurfing(kiteboarding) injuries presented at our coastal hospital over a 2-year period. METHODS Twenty-five windsurfers(21 male; aged 31 ± 8 years) and 32 kitesurfers(23 male; aged 29 ± 11 years) presented at our hospital during the 2-year study period. Various injury data were recorded,including transport to hospital and treatment. After a median follow-up of 16 mo(range,7-33 mo),18 windsurfers(72%) and 26 kitesurfers(81%) completed questionnaires on the trauma mechanisms,the use of protective gear,time spent on windsurfing or kitesurfing,time to return to sports,additional injuries,and chronic disability. RESULTS Most patients sustained minor injuries but severe injuries also occurred,including vertebral and tibial plateau fractures. The lower extremities were affected the most,followed by the head and cervical spine,the upperextremities,and the trunk. The injury rates were 5.2 per 1000 h of windsurfing and 7.0 per 1000 h of kitesurfing(P = 0.005). The injury severity was the same between groups(P = 1.0). Less than 30% of the study population used protective gear. Kitesurfers had a higher number of injuries,and required transport by ambulance,inpatient hospital stay and operative treatment more often than windsurfers,but these differences were not statistically significant(P > 0.05). The median time to return to windsurfing and kitesurfing was 5 and 4 wk,respectively(P = 0.79). Approximately one-third of the patients in each group experienced chronic *** Kitesurfing results in a significantly higher injury rate than windsurfing in the same environmental conditions but the severity of the injuries does not differ.

关键词： General sports trauma Extreme sports Surfing Epidemiology Prevention

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Second-line bismuth-containing quadruple therapy for Helicobacter pylori eradication and impact of diabetes

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World Journal of Gastroenterology 2017年第6期23卷 1059-1066页

作者： Sung Eun Kim Moo In Park Seun ja Park Won Moon jae Hyun Kim Kyoungwon Jung Hae Koo Kim Young Dal Lee Department of Internal Medicine Kosin University College of MedicineBusan 49267South Korea

To investigate Helicobacter pylori (H. pylori) eradication rates using second-line bismuth-containing quadruple therapy and to identify predictors of eradication *** study included 636 patients who failed first-line triple therapy and received 7 d of bismuth-containing quadruple therapy between january 2005 and December 2015. We retrospectively demonstrated H. pylori eradication rates with respect to the year of therapy as well as demographic and clinical factors. H. pylori eradication was confirmed by a 13C-urea breath test or a rapid urease test at least 4 wk after the completion of bismuth-based quadruple therapy: proton pump inhibitor, metronidazole, bismuth, and *** overall eradication rates by intention-to-treat analysis and per-protocol analysis were 73.9% (95%CI: 70.1%-77.4%) and 94.5% (95%CI: 92.4%-96.5%), respectively. Annual eradication rates from 2005 to 2015 were 100.0%, 92.9%, 100.0%, 100.0%, 100.0%, 97.4%, 100.0%, 93.8%, 84.4%, 98.9%, and 92.5%, respectively, by per-protocol analysis. A multivariate analysis showed that diabetes mellitus (OR = 3.99, 95%CI: 1.56-10.20, P = 0.004) was associated with H. pylori eradication therapy *** second-line bismuth-containing quadruple therapy for H. pylori infection is still effective in Korea, and diabetes mellitus is suggested to be a risk factor for eradication failure.

关键词： Helicobacter pylori Disease eradication Treatment failure Bismuth Diabetes mellitus

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Optimal postoperative surveillance strategies for stage III colorectal cancer

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 1012-1024页

作者： Min Young Park In ja Park Hyo Seon Ryu jay Jung Minsung Kim Seok-Byung Lim Chang Sik Yu Jin Cheon Kim Colon and Rectal Surgery Asan Medical CenterSeoul 05505South Korea Colon and Rectal Surgery Asan Medical Center and University of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Optimal surveillance strategies for stage III colorectal cancer(CRC)are lacking,and intensive surveillance has not conferred a significant survival *** To examine the association between surveillance intensity and recurrence and survival rates in patients with stage III *** Data from patients with pathologic stage III CRC who underwent radical surgery between january 2005 and December 2012 at Asan Medical Center,Seoul,Korea were retrospectively *** consisted of abdominopelvic computed tomography(CT)every 6 mo and chest CT annually during the 5 year follow-up period,resulting in an average of three imaging studies per *** who underwent more than the average number of imaging studies annually were categorized as high intensity(HI),and those with less than the average were categorized as low intensity(LI).RESULTS Among 1888 patients,864(45.8%)were in HI ***,sex,and location were not different between *** group had more advanced T and N stage(P=0.002,0.010,each).perineural invasion(PNI)was more identified in the HI group(21.4%vs 30.3%,P<0.001).The mean overall survival(OS)and recurrence-free interval(RFI)was longer in the LI group(P<0.001,each).Multivariate analysis indicated that surveillance intensity[odds ratio(OR)=1.999;95%confidence interval(CI):1.680–2.377;P<0.001],pathologic T stage(OR=1.596;95%CI:1.197–2.127;P=0.001),PNI(OR=1.431;95%CI:1.192–1.719;P<0.001),and circumferential resection margin(OR=1.565;95%CI:1.083–2.262;P=0.017)in rectal cancer were significantly associated with *** mean post-recurrence survival(PRS)was longer in patients who received curative resection(P<0.001).Curative resection rate of recurrence was not different between HI(29.3%)and LI(23.8%)groups(P=0.160).PRS did not differ according to surveillance intensity(P=0.802).CONCLUSION Frequent surveillance with CT scan do not improve OS in stage III CRC *** need to evaluate role of other surveillance method rather tha

关键词： Colorectal cancer Surveillance intensity Survival Recurrence

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中国草鱼和泰国草鱼利用牧草作食饵的比较

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浙江农业大学学报 1995年第1期21卷 61-65页

作者：邵庆均 Gart.,ja 浙江农业大学动物科学学院

通过对中国草鱼（Ｃｔｅｎｏｐｈａｒｙｎｇｏｄｏｎｉｄｅｌｌａ）和泰国草鱼（Ｐｕｎｔｉｕｓｇｏｎｉｏｎｏｔｕｓ）分别在常规的尼罗罗非鱼（Ｏｒｅｃｈｒｏｍｉｓ，ｎｉｌｏｔｉｃｕｓ）、鲤鱼（Ｃｙｐｒｉｎｕｓｃａｒｐｉｏ）和... 详细信息

通过对中国草鱼（Ｃｔｅｎｏｐｈａｒｙｎｇｏｄｏｎｉｄｅｌｌａ）和泰国草鱼（Ｐｕｎｔｉｕｓｇｏｎｉｏｎｏｔｕｓ）分别在常规的尼罗罗非鱼（Ｏｒｅｃｈｒｏｍｉｓ，ｎｉｌｏｔｉｃｕｓ）、鲤鱼（Ｃｙｐｒｉｎｕｓｃａｒｐｉｏ）和黑鱼（Ｃｈａｎｎａｓｔｒｉａｔａ）混养体系中养殖７个月，比较两者对牧草（Ｂｒａｃｈｉａｒｉａｍｕｔｉｃａ）的利用效果。试验结果表明，中国草鱼与泰国草鱼相比，无论是每尾体重，还是每尾体长、平均每尾日增重都有明显优势（Ｐ＜０．０５）．而且，放养３个月后，中国草鱼每尾体重和每尾日增重均极显著地优于泰国草鱼（Ｐ＜０．０１）．中国草鱼和泰国草鱼的年产量分别为２１８６ｋｇ／ｈｍ￣２，１２３３ｋｇ／ｈｍ￣２．中国草鱼的成活率比泰国草鱼低，两者分别为３８％和８６％。

关键词：牧草中国草鱼泰国草鱼混养

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高性能同步相量测量装置守时钟研制

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电力系统自动化 2006年第1期30卷 68-72,97页

作者：钟山付家伟王晓茹西南交通大学电气工程学院四川省成都市610031 株洲时代电子技术有限公司湖南省株洲市412007

同步相量测量装置(PMU)可靠工作的关键是作为同步采样脉冲源的全球定位系统(GPS) 的秒脉冲的可靠性。针对由于气候、故障及其他因素可能造成秒脉冲失效的情况,采用数字锁相环技术,利用复杂可编程逻辑器件(CPLD)及高精度晶振,研制了一... 详细信息

同步相量测量装置(PMU)可靠工作的关键是作为同步采样脉冲源的全球定位系统(GPS) 的秒脉冲的可靠性。针对由于气候、故障及其他因素可能造成秒脉冲失效的情况,采用数字锁相环技术,利用复杂可编程逻辑器件(CPLD)及高精度晶振,研制了一种高性能的PMU守时钟。GPS 信号正常时,守时钟跟踪输入的秒脉冲;秒脉冲失效时,守时钟则提供一定误差范围内与秒脉冲同步的替代信号。文中分析了其性能,通过仿真和实验进行了验证。

关键词：同步相量测量装置全球定位系统秒脉冲复杂可编程逻辑器件数字锁相环守时钟

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