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Measurement　of　excursion　of　Finger　Flexor　Tendons　Produced　by　a　Continuous　Passive　Motion　Machine

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中华骨科杂志 1995年第2期15卷 76-83页

作者： Yoshida e Dent ja Rowley JI University of Dundee 苏格兰

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关键词：掌指关节指尖手指指间关节指关节 Continuous excursion Finger Flexor Machine Measurement Motion Passive Produced Tendons

Association between Tropical Convection and Boreal Wintertime extratropical Circulation in 1982/83 and 1988/89

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Advances in Atmospheric Sciences 2003年第4期20卷 593-603页

作者： ja-Yeon MOON Kyung-ja HA Climate Research Laboratory Meteorological Research InstituteSeoul156-720KoreaDepartment of Atmospheric SciencesPusan National UniversityPusan609-735Korea

Boreal wintertime extratropical circulation is studied in relation to the tropical convection during the 1982/83 el Niño and 1988/89 La Niña. The anomaly structure of 1982/83 and 1988/89 over the extratropics reveals remarkably different features as the longitudinal tropical forcing region changes. The Rossby wave source (Positive) shows the largest maximum over east Asia in both years due to the persistent heating from the western Pacific warm pool area. However, the sink term shows contrasting features over the subtropics and extratropics between the two years. In the el Niño year, enhanced tropical convection over the eastern Pacific produces the Rossby wave sink at 10°N and shifted eastward over the North Pacific, while in the La Niña year, the sink area is shifted westward over the North Pacific. The contrasting features between the two events in mean-eddy interaction appears especially over the downstream area of the east Asian Jet. The extension (retraction) of the meanflow eastward (westward) to the east (west) of the dateline is related with the effect of the westward (eastward) e-vector and the strengthening (weakening) of the negative anomalies of the barotropic growth of kinetic energy. Hence, almost opposite characteristics between the two events can explain the close relationship of tropical convection and the extratropical internal variability.

关键词： tropical convection extratropical circulation rossby wave source mean-eddy interaction

Genome-wide markers for seed yield and disease resistance in perennial ryegrass

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The Crop Journal 2022年第2期10卷 508-514页

作者： Kristina jaškune Vilma Kemešyte Andrius Aleliūnas Grazina Statkeviciute Institute of Agriculture Lithuanian Research Centre for Agriculture and Forestry(LAMMC)Instituto av.1Akademija LT-58344Lithuania

The market success of perennial ryegrass(Lolium perenne L.) cultivars depends on sufficient seed production, as they are propaga.ed by seed. However, breeding for high quality forage production reduces seed yield, and breaking the negative correlation would help to overcome the problem. The foliar disease crown rust is another factor affecting reproductive capacity and thereby seed yield. We evaluated seed yield-related traits and resistance to crown rust in a collection of commercial cultivars and ecotypes of perennial ryegrass and identified genome-wide markers associated with the traits. The study revealed high variation between the ecotype and cultivar groups as well as between years. A genome-wide association study identified 17 DNA single-nucleotide polymorphisms(SNPs) of which eight were associated with crown rust and nine with flag-leaf length. The SNP markers were located within or near predicted genes functioning in defense against pathogens. The identified genes are strong candidates for a further in-depth functional study to continue unravel determination of leaf architecture and crown rust resistance in perennial ryegrass.

关键词： Crown rust Puccinia coronata f.sp.lolli Flag-leaf length Genome-wide association study(GWAS) Seed yield Lolium perenne L.

Male masturbation device for the treatment of delayed ejaculation: A case report

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Asian pacific Journal of Reproduction 2017年第4期6卷 191-192页

作者： Rodríguez Je Picazo ja López e Research Department of Instituto Sexológico Murciano C/Periodista Encarna Sánchez22030007 MurciaSpain

Delayed ejaculation is a rare condition with different etiologies. Majority of cases of delayed ejaculation have a strong psychological/behavior component. A 48-year-old male with a diagnostic of delayed ejaculation acquired was encouraged to make an exercise protocol using a masturbation device for 8 wk, the percentage of intercourse successful a month after finish protocol exercise was 81%.

关键词： Delayed ejaculation Male Device Treatment ejaculation disorders

Trace elements and stable sulfur isotopes in plants of acid mine drainage area:Implications for revegetation of degraded land

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Journal of environmental Sciences 2020年第8期32卷 128-136页

作者： Agnieszka gałuszka Zdzisław MMigaszewski Andrzej Pelc Andrzej Trembaczowski Sabina Doł˛egowska Artur Michalik Geochemistry and the environment Division Institute of ChemistryJan Kochanowski University7 Uniwersytecka St.25-406 KielcePoland Mass Spectrometry Laboratory Institute of PhysicsMaria Curie-Skłodowska University1 Maria Curie-Skłodowska Sq.20-031 LublinPoland

The abundances of trace elements,a low pH of water and soil in areas impacted by the acid mine drainage(AMD)may cause an excessive uptake of potentially toxic elements and nutritional imbalances in ***-tolerant,native plants are used for revegetation of degraded mining *** established levels of selected trace elements and stable sulfur isotopes in the above-ground plant biomass collected in a mining area in south-central *** 2016,20 samples of the most common species were collected from sites with a different influence of acid mine drainage and analyzed for trace elements by the inductively coupled plasma mass spectrometry *** the basis of the results obtained in 2016,the most contaminated site was selected for a more detailed study,in which sulfur contents and stable sulfur isotope ratios were determined together with trace elements in 17 *** results confirmed that the plants native to the AMD area efficiently accumulated trace elements,especially As and rare earth *** showed the highest content of trace elements,but exhibited the lowest concentrations of sulfur accompanied by the highestδ34S *** has been shown for the first time that stable sulfur isotope composition of AMD plants in south-central Poland is significantly depleted in the 34S isotope showing an averageδ34 S value of–10.5‰in comparison with positiveδ34S values in local vegetation growing outside the AMD area and in local precipitation.

关键词： Trace elements Stable sulfur isotopes Pyrite oxidation Rare earth elements Plants

An accelerated K-means clustering algorithm using selection and erasure rules

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Journal of Zhejiang University-Science C(Computers and electronics) 2012年第10期13卷 761-768页

作者： Suiang-Shyan Lee ja-Chen LIN Department of Computer Science National Chiao Tung University

The K-means method is a well-known clustering algorithm with an extensive range of applications,such as biological classification,disease analysis,data mining,and image ***,the plain K-means method is not fast when the number of clusters or the number of data points becomes large.A modified K-means algorithm was presented by Fahim et al.(2006).The modified algorithm produced clusters whose mean square error was very similar to that of the plain K-means,but the execution time was *** this study,we try to further increase its *** are two rules in our method:a selection rule,used to acquire a good candidate as the initial center to be checked,and an erasure rule,used to delete one or many unqualified centers each time a specified condition is *** clustering results are identical to those of Fahim et al.(2006).However,our method further cuts computation time when the number of clusters *** mathematical reasoning used in our design is included.

关键词： K-means clustering Acceleration Vector quantization Selection erasure

Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione:Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions

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Journal of Pharmaceutical Analysis 2021年第6期11卷 791-798页

作者： Agnieszka Potega Michal Kosno Zofia Mazerska Department of Pharmaceutical Technology and Biochemistry Faculty of ChemistryGda nsk University of TechnologyGdansk80-233Poland

Unsymmetrical bisacridines(UAs) are a novel potent class of antitumor-active therapeutics.A significant route of phase II drug metabolism is conjugation with glutathione(GSH),which can be non-enzymatic and/or catalyzed by GSH-dependent *** aim of this work was to investiga.e the GSHmediated metabolic pathway of a representative UA,***-supplemented incubations of C-2028 with rat,but not with human,liver cytosol led to the formation of a single GSH-related ***,it was also revealed with rat liver *** formation was NADPH-independent and was not inhibited by co-incubation with the cytochrome P450(CYP450) inhibitor ***,the direct conjugation pathway occurred without the prior CYP450-catalyzed bioactivation of the *** turn,incubations of C-2028 and GSH with human recombinant glutathione S-transferase(GST) P1-1 or with heat-/ethacrynic acid-inactivated liver cytosolic enzymes resulted in the presence or lack of GSH conjuga.ed form,*** findings proved the necessary participation of GST in the initial activation of the GSH thiol group to enable a nucleophilic attack on the substrate *** C-2028-GSH S-conjuga.e was also formed during non-enzymatic *** GSH S-conjuga.es were characterized by combined liquid chromatography/tandem mass *** for their formation were *** ability of C-2028 to GST-mediated and/or direct GSH conjugation is suspected to be clinically *** may affect the patient’s drug clearance due to GST activity,loss of GSH,or the interactions with GSH-conjuga.ed ***,GST-mediated depletion of cellular GSH may increase tumor cell exposure to reactive products of UA metabolic transformations.

关键词： Antitumor agent Unsymmetrical bisacridine Metabolic detoxification Glutathione S-Conjuga.e Glutathione S-transferase Non-enzymatic conjugation

electrochemical and in silico approaches for liver metabolic oxidation of antitumor-active triazoloacridinone C-1305

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Journal of Pharmaceutical Analysis 2020年第4期10卷 376-384页

作者： Agnieszka Potega Dorota Zelaszczyk Zofia Mazerska Department of Pharmaceutical Technology and Biochemistry Faculty of ChemistryGdansk University of TechnologyGabriela Narutowicza St.11/12Gdansk80-233Poland Department of Organic Chemistry Faculty of PharmacyJagiellonian UniversityMedyczna St.9Krakow30-688Poland

5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone(C-1305)is a promising antitumor compound developed in our laboratory.A better understanding of its metabolic transformations is still needed to explain the multidirectional mechanism of pharmacological action of triazoloacridinone derivatives at ***,the aim of the current work was to predict oxidative pathways of C-1305 that would reflect its phase I *** multi-tool analysis of C-1305 metabolism included electrochemical conversion and in silico sites of metabolism predictions in relation to liver microsomal *** the framework of the first approach,an electrochemical cell was coupled on-line to an electrospray ionization mass *** effluent of the electrochemical cell was also injected onto a liquid chromatography column for the separation of different products formed prior to mass spectrometry *** silico studies were performed using MetaSite *** microsomal incubation was employed as a reference *** found that C-1305 underwent electrochemical oxidation primarily on the dialkylaminoalkylamino *** unknown N-dealkylated and hydroxylated C-1305 products have been *** electrochemical system was also able to simulate oxygenation *** pattern of C-1305 metabolism has been predicted using in silico *** proposed strategies showed high agreement in relation to the generated metabolic products of ***,we conclude that they can be considered as simple alternatives to enzymatic assays,affording time and cost efficiency.

关键词： Antitumor triazoloacridinone P450-catalyzed reactions electrochemistry/mass spectrometry In silico metabolism Prediction Liver microsomal assay

Nanomechanics of Fiber-like Nanomaterials

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Journal of Materials Science & Technology 2001年第3期17卷 303-305页

作者： Z.L. Wang School of Materials Science and engineering, Georgia Institute of Technology, Atlanta, ga 30332-0245, USA e-mail: zhong.wang@mse.ga.ech.edu Georgia Inst Technol Sch Mat Sci & Engn Atlanta GA 30332 USA

Property characterization of nanomaterials is challenged by the small size of the structure be-cause of the difficulties in manipulation Here we demonstrate a novel approach that allows a direct measurement of the mechanical properties of individual nanotube-like structures by in-situ transmission electron microscopy (TeM). The technique is powerful in a way that it can directly correlate the atomic-scale microstructure of the carbon nanotube with its physical properties, providing a one-to-one correspondence in structure-property characterization Applications of the technique will be demonstrated on mechanical properties, the electron field emission and the ballistic quantum conductance in individual nanotubes.

关键词： Nanomechanics of Fiber-like Nanomaterials