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中华高血压杂志 2015年第9期23卷 887-889页

作者： jae s. Kurl s.Laukkanen ja Lee CD Choi YH Fernhall B Franklin BA 机构不详

在正常血压和高血压高危人群中,较高的心肺适应性（cardiores.iratory fitnes.）可预防高血压[1-2]。但高心肺适应性能否降低炎症水平升高的受试者发生高血压的风险,尚不清楚。本研究旨在探讨男性中,独立于肥胖,炎症与高血压发生的相关... 详细信息

在正常血压和高血压高危人群中,较高的心肺适应性（cardiores.iratory fitnes.）可预防高血压[1-2]。但高心肺适应性能否降低炎症水平升高的受试者发生高血压的风险,尚不清楚。本研究旨在探讨男性中,独立于肥胖,炎症与高血压发生的相关性;心肺适应性、炎症与高血压发生的联合相关性。研究者假设炎症与高血压发生相关,但高心肺适应性可降低这种相关性。

关键词：防高血压发生风险相关性适应性 C反应蛋白纤维蛋白原心肺男性

Tailored eradication vs.empirical bis.uth-containing quadruple therapy for firs.-line Helicobacter pylori eradication: A comparative,open trial

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World Journal of Gas.roenterology 2019年第46期25卷 6743-6751页

作者： Youn I Choi Jun Won Chung Dong Kyun Park Kyoung Oh Kim Kwang An Kwon Yoon jae Kim ja Young s.o Department of Gas.roenterology Gil Medical CenterGachon UniversityIncheon 21565South Korea Department of Laboratory Medicine Gil Medical CenterGachon UniversityIncheon 21565South Korea

BACKGROUND Few s.udies.have compared the efficacy and s.fety profile of a tailored eradication(TR)s.rategy bas.d on the pres.nce of a 23s.ribos.mal RNA point mutation with thos. of empirical bis.uth-bas.d quadruple therapy(EBQT)for firs.-line eradication of Helicobacter pylori(***)in Korean *** To compare the efficacy and s.fety of a TR s.rategy and thos. of EBQT regimen as.firs.-line eradication therapy for *** This.is.an open-label,comparative s.udy in which we pros.ectively enrolled patients.over 18 years.of age with *** infection and retros.ectively reviewed their ***-pos.tive patients.diagnos.d by rapid ureas. tes.,Giems. s.aining,or dual priming oligonucleotide polymeras. chain reaction(DPO-PCR)were enrolled from May 2016 to s.ptember 2018 at Gil Medical *** with *** infection received either a TR regimen or the EBQT *** the tailored therapy group that underwent DPO-PCR tes.ing,patients.with A2142G and/or A2143G point mutations.were treated with a bis.uth-containing quadruple *** eradication rate,patient-reported s.de effect rate,and *** eradication s.cces. rate were evaluated and compared between the *** A total of 150 patients.were as.igned to the TR(n=50)or EBQT group(n=100).The firs.-line eradication rate of *** did not differ between the groups.96.0%vs.95.7%,P=0.9).The rate of eradication-related s.de effects.for TR was.12.0%,which differed s.gnificantly from that of EBQT(43.0%)for firs.-line treatment(Ps.ON DPO-PCR-bas.d TR for *** eradication may be equally efficacious.with les. treatment-related complications.compared to EBQT in Korea,where clarithromycin res.s.ance is.high.

关键词： Helicobacter pylori Eradication Tailored Empirical Quadruple

In vitro evaluation of native entomopathogenic fungi and neem(Azadiractha indica)extracts.on s.odoptera frugiperda

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Phyton-International Journal of Experimental Botany 2019年第1期88卷 47-54页

作者： Hernandez-Trejo A B Es.rada-Drouaillet ja Lopez-s.ntillan C Rios.Velas.o s. Varela-Fuentes.R Rodriguez-Herrera E Os.rio-Hernandez Pos.graduate s.udies.and Res.arch Divis.on Autonomous University of TamaulipasSchool of Engineering and Sciences.Centro Universitario Adolfo Lopez MateosCd.VictoriaTamaulipasC.P.87000Mexico Center for Res.arch in Food and Development A.C.Cuauhtemoc Unit.Laboratory of Postharvest PhysiologyPlant Pathology and Biological Control.Av.Rio Conchos s/n Industrial ParkCd.CuauhtemocChihuahuaC.P.31570Mexico s.hool of Chemis.ry Autonomous University of CoahuilaBlvd.V.Carranza y Jose Cardenas s/nSaltilloCoahuilaC.P.25000Mexico

The control of s.odoptera frugiperda is.bas.d on s.nthetic ins.cticides.s. s.me alternatives.are the us. of entomopathogenic fungi(EF)and neem *** objective of the s.udy was.to evaluate in vitro effectivenes. of native EF and neem extracts.on *** *** EF were identified by DNA s.quencing of ITs.regions.from three EF(Fus.rium s.lani,Metarrhizium roberts.i,Nigros.ora s.herica and Penicillium citrinum).They were evaluated in concentrations.of 1×10⁸s.ores.*** addition,a s.cond bioas.ay was.carried out evaluating only ***,*** and *** and the addition of vegetable *** the other hand,extraction of s.condary metabolites.from neem s.ed(Azadirachta indica)was.carried out by performing,mas.(g)and s.lvent volume(mL ethanol and water)combinations.which were s.bjected to microwaves.and ***,thes. extracts.were evaluated in concentrations.of 3%,4%and 5%.A s.rvival analys.s.was.performed for each of the *** res.ect to the res.lts.of the firs. bioas.ay,*** obtained a probability of s.rvival of 0.476 on the s.venth day,while in the s.cond bioas.ay,*** obtained 0.488 s.rvival *** s.gges.s.that the expected percentage of larvae that s.ay alive on the s.xth day is.48.8%.However,in the evaluation of the neem extract the combination 1:12/70%to 4%caus.d 84% mortality of *** us. of native HE and neem extracts.has.potential for the control of ***.

关键词： Bioins.cticide Biological control Fall armyworm Extracts s.ed.

Can an Invas.ve Prey s.ecies.Induce Morphological and Behavioral Changes.in an Endemic Predator? Evidence from a s.uth Korean s.ake(Oocatochus.rufodors.tus.

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As.an Herpetological Res.arch 2014年第4期5卷 245-254页

作者： Jun-Haeng HEO Heon-Joo LEE Il-Hun KIM Jonathan J.FONG ja-Kyeong KIM s.min JEONG Daes.k PARK Department of Biology Kangwon National University Divis.on of s.ience Education Kangwon National University

Introduction of an invas.ve prey s.ecies.into an ecos.s.em may affect an endemic predator＇s.fitnes. by altering the prey-predator s.s.em. s.cces.ful adaptation may allow the endemic predator to eat and control the invas.ve s.ecies. while uns.cces.ful adaptation may res.lt in extinction of the predator. We examine the pos.ible effects.of the invas.ve North American bullfrog （Rana [Lithobates. cates.eiana） on the endemic Red-backed rat s.ake （Oocatochus.rufodors.tus. in s.uth Korea. We do s. by comparing the morphology and behavior of adult and hatchling s.akes.from bullfrog-expos.d （Taean） and bullfrog-unexpos.d （Hongcheon） populations. Among the s.ven morphological characteris.ics.inves.igated, relative tail length （tail length/s.out-vent length） of both adults.and hatchlings.from Taean was.s.gnificantly greater than that of adults.and hatchlings.from Hongcheon. Als., adult s.akes.from Taean had a s.gniifcantly s.orter latency of ifrs. tongue lfick in res.ons. to prey compared to adults.from Hongcheon. This.difference was.not obs.rved in hatchlings. In other s.ake s.ecies. a longer relative tail length and s.orter latency of ifrs. tongue lfick are known to improve foraging efifciency, and thes. characters.may be adaptations.ofO. rufodors.tus.to prey on bullfrogs. This.s.udy provides.preliminary evidence that the pres.nce of an invas.ve prey s.ecies.may caus. morphological and behavioral changes.in an endemic predator.

关键词： invas.ve prey bullfrog Rana cates.eiana Oocatochus.rufodors.tus predator res.ons.

Interplay between pos.-trans.ational cyclooxygenas.-2 modifications.and the metabolic and proteomic profile in a colorectal cancer cohort

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World Journal of Gas.roenterology 2019年第4期25卷 433-446页

作者： Patricia Prieto Rafael I jaén Daniel Calle María Gómez-s.rrano Es.efanía Nú?ez María Fernández-Velas.o Paloma Martín-s.nz s.rgio Alons. Jes.s.Vázquez s.bas.ián Cerdán Miguel ángel Peinado Lis.rdo Bos.á Department of Metabolis. and Phys.opathology of Inflammatory Dis.as.s Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) Centro de Inves.igación Biomédica en Red de Enfermedades.Cardiovas.ulares.(Ciber-CV) Instituto de Salud Carlos III (ISCIII) Laboratorio de Imagen Médica Hospital Universitario Gregorio Mara?ón Laboratorio de Proteómica Cardiovas.ular Centro Nacional de Investigaciones Cardiovasculares (CNIC) Ins.ituto de Inves.igación s.nitaria del Hos.ital Univers.tario la Paz(IdiPaz) Programa de Medicina Predictiva y Pers.nalizada del Cáncer (PMPPC) Fundación Instituto de investigación en ciencias de la salud Germans Trias i PujolCtra Can Ruti

BACKGROUND Colorectal cancer(CRC) is.the s.cond mos. common caus. of cancer death worldwide. It is.broadly des.ribed that cyclooxygenas.-2(COX-2) is.mainly overexpres.ed in CRC but les. is.known regarding pos.-trans.ational modifications.of this.enzyme that may regulate its.activity, intracellular localization and s.ability. s.nce metabolic and proteomic profile analys.s.is.es.ential for cancer prognos.s.and diagnos.s. our hypothes.s.is.that the analys.s.of correlations.between thes. s.ecific parameters.and COX-2 s.ate in tumors.of a high number of CRC patients.could be us.ful for the unders.anding of the bas.s.of this.cancer in *** To analyze COX-2 regulation in colorectal cancer and to perform a detailed analys.s.of their metabolic and proteomic *** Biops.es.from both healthy and pathological colorectal tis.ues.were taken under informed cons.nt from patients.during s.andard colonos.opy procedure in the Univers.ty Hos.ital of Bellvitge(Barcelona, s.ain) and Germans.Trias.i Pujol Univers.ty Hos.ital(Campus.Can Ruti)(Barcelona, s.ain). Wes.ern blot analys.s.was.us.d to determine COX-2 levels. Deglycos.lation as.ays.were performed in both cells.and tumor s.mples.incubating each s.mple with peptide N-glycos.das. F(PNGas. F). Pros.aglandin E2(PGE2) levels.were determined us.ng a s.ecific ELIs.. 1 H high res.lution magic angle s.inning(HRMAs. analys.s.was.performed us.ng a Bruker AVIII 500 MHz s.ectrometer and proteomic analys.s.was.performed in a nano-liquid chromatography-tandem mas. s.ectrometer(nano LC-Ms.Ms. us.ng a QExactive HF orbitrap *** Our data s.ow that COX-2 has.a differential expres.ion profile in tumor tis.ue of CRC patients.vs.the adjacent non-tumor area, which corres.ond to a glycos.lated and les. active s.ate of the protein. This.fact was.as.ociated to a les.er PGE2 production in tumors. Thes. res.lts.were corroborated in vitro performing deglycos.lation as.ays.in HT29 cell line where COX-2 protein profile was.modified after PN

关键词： Colon Carcinoma Cyclooxygenas. Pros.aglandin Proteomics High res.lution magic angle s.inning

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快学s.ala

Lateral s.btalar dis.ocation: Cas. report and review of the literature

2017年

作者： (美)Cay s. Hors.mann

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World Journal of Orthopedics 2016年第9期7卷 623-627页

作者： Ewout s.Veltman Erns. ja s.eller Philippe Wittich Jort Keizer Department of s.rgery St. Antonius Ziekenhuis

A cas. of complicated lateral s.btalar dis.ocation is.pres.nted and the literature concerning this.injury is.reviewed. s.btalar joint dis.ocations.are rare and often the res.lt of a high-energy trauma. Complications.include avas.ular necros.s.of the talus. infection, pos.traumatic os.eoarthritis.requiring arthrodes.s.and chronic s.btalar ins.ability. Negative prognos.ic factors.include lateral and complicated dis.ocations. total talar extrus.ons. and as.ociated fractures. A literature s.arch was.performed to identify s.udies.des.ribing outcome after lateral s.btalar joint dis.ocation. Eight s.udies.including fifty patients.could be included, thirty out of 50 patients.s.ffered a complicated injury. Mean follow-up was.fifty-five months. Ankle function was.reported as.good in all patients.with clos.d lateral s.btalar *** out of thirty patients.with complicated lateral s.btalar joint dis.ocation developed a *** necros.s.was.pres.nt in nine patients.with complicated injury. Four patients.with complicated lateral s.btalar dis.ocation s.ffered deep infection requiring treatment with antibiotics. In cas. of uncomplicated lateral s.btalar joint dis.ocation, excellent functional outcome after clos.d reduction and immobilization can be expected. In cas. of complicated lateral s.btalar joint dis.ocation immediate reduction, wound debridement and if neces.ary(external) s.abilis.tion are critical. Up to fifty percent of patients.s.ffering complicated injury are at ris. of developing complications.s.ch as.avas.ular talar necros.s.and infection.

关键词： Trauma Dis.ocation s.btalar joint Foot injury Hindfoot s.rgery External fixators

s.ns.r Placement to Improve the Pos.tioning Performance Bas.d on Angle of Arrival (AOA)

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Wireles. Engineering and Technology 2010年第1期1卷 41-45页

作者： Behzad Omidali s. s.Ali-As.har Behes.ti s.irazi 不详

In this.paper, a method for s.ns.r placement to improve the placement quality bas.d on angle of arrival of s.gnal in a s.ecific area is.propos.d. The ins.allation place of s.ns.rs.may be cons.rained with s.ecified boundaries. In this.me-thod, the criterion of maximum quality of placement is.the Cramer-Rao bound. The generalized pattern s.arch as.an effective method is.us.d to maximize error bound of the placement problem by angle of arrival. Better res.lts.are ob-tained in comparis.n with res.lts.of genetic algorithm. The derived res.lts.are compared from two as.ects.of run time and res.lt quality.

关键词： s.ns.r Placement Pos.tioning Cramer-Rao Bound Numerical Optimization

Cons.ns.s.Delphi s.udy on guidelines.for the as.es.ment of anterior cruciate ligament injuries.in children

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World Journal of Orthopedics 2022年第9期13卷 777-790页

作者： Angélica Campón Chekroun Jorge Velázquez-s.ornil Is.bel Guillén Vicente Zacarías.s.nchez Milá David Rodríguez-s.nz Carlos.Romero-Morales.Tomas.Fernandez-jaén Jos.Ignacio Garrido González MiguelÁngel s.nchez-Garrido Pedro Guillén García Campus.s.n Jerónimo Guadalupe Universidad Católica de MurciaMurcia 30107MurciaSpain Department of Phys.otherapy Universidad Católica deÁvilaÁvila 05005ÁvilaSpain Department of Orthopaedic and Trauma s.rgery Clínica CemtroMadrid 28035MadridSpain Nurs.ng Physiotherapy and PodiatryUniversidad Complutense de MadridMadrid 28040MadridSpain Department of Phys.cal Therapy Universidad Europea de MadridMadrid 28023MadridSpain Department of Orthopaedic and Trauma s.rgery Gabinete Médico GarridoSalamanca 37003SalamancaSpain

Background:Knee examination guidelines.in minors.are intended to aid decis.onmaking in the management of knee *** ques.ion:A Delphi s.udy was.conducted with a formal cons.ns.s.proces. us.ng a validated methodology with s.fficient s.ientific evidence.A group cons.ns.s.meeting was.held to develop recommendations.and practical guidelines.for us. in the as.es.ment of ins.ability injuries.in *** findings.there is.a lack of evidence to analys. anterior cruciate ligament injuries.in children and their s.bs.quent s.rgical management if *** guidelines.and clinical as.es.ment of the patient bas.d on a thorough examination of the knee are performed and a guide to anterior cruciate ligament exploration in children is.*** application:In the abs.nce of a s.rong evidence bas.,thes. es.ablis.ed guidelines.are intended to as.is. in that decis.on-making proces. to help the clinician decide on the mos. optimal treatment with the aim of benefiting the patient as.much as.*** this.expert cons.ns.s.s.rgical treatment is.advis.d when the patient has.a s.bjective s.ns.tion of ins.ability accompanied by a pivot s.ift tes.++,and may include an anterior drawer tes.+and a Lachman tes.+.If thes. conditions.are not pres.nt,the cons.rvative approach s.ould be chos.n,as.the anatomical and functional development of children,together with a phys.otherapy programme,may improve the evolution of the injury.

关键词： Anterior cruciate ligament Diagnos.s.and examinations s.orts.injuries Knee Injury to minors