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Targeting calcium signaling in Alzheimer’s disease: challenges and promising therapeutic avenues

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Neural Regeneration Research 2024年第3期19卷 501-502页

作者： LinLin Song YongPei Tang Betty Yuen Kwan law Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao Special Administration RegionChina

The critical role of calcium dyshomeostasis in the pathogenesis of Alzheimer’s disease(AD):AD is a progressive neurodegenerative disease characterized by cognitive decline,memory impairment,and behavioral *** an estimated 50 million people being affected worldwide,the incidence of AD is constantly increasing *** hallmark of AD is the accumulation of amyloid-beta protein(Aβ)in the form of amyloid plaques and hyperphosphorylated tau protein in the form of neurofibrillary ***,increasing evidence suggests that calcium ion(Ca2+)dysregulation also plays a crucial role in the pathogenesis of AD(Calvo-Rodriguez and Bacskai,2021).As a key second messenger,Ca2+regulates a wide range of cellular processes,including the release of neurotransmitters,gene expression,and cell ***^(2+)also regulates the activity of Calcium/calmodulin-dependent protein kinase II,which is critical for synaptic plasticity,learning,and memory(Kaushik et al.,2022).Alternation in the Ca^(2+)signal is an early event in the pathogenesis of AD,which can lead to synaptic dysfunction,neuronal loss,and cognitive impairment.

关键词： Alzheimer homeostasis globally

Interactions between maternal parity and feed additives drive the composition of pig gut microbiomes in the post‑weaning period

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1241-1257页

作者： Kayla law Eduardo Rosa Medina Garcia Chad Hastad Deborah Murray Pedro E.Urriola Andres Gomez Department of Animal Science University of Minnesota1364 Eckles AvenueSaint PaulMN 55108USA New Fashion Pork 164 Industrial ParkwayJacksonMN 56143USA

Background Nursery pigs undergo stressors in the post-weaning period that result in production and welfare *** challenges disproportionately impact the offspring of primiparous sows compared to those of mul-tiparous *** is known regarding potential interactions between parity and feed additives in the post-weaning period and their effects on nursery pig ***,the objective of this study was to investigate the effects of maternal parity on sow and offspring microbiomes and the influence of sow parity on pig fecal microbi-ome and performance in response to a prebiotic *** weaning,piglets were allotted into three treat-ment groups:a standard nursery diet including pharmacological doses of Zn and Cu(Con),a group fed a commercial prebiotic only(Preb)based on an Aspergillus oryzae fermentation extract,and a group fed the same prebiotic plus Zn and Cu(Preb+ZnCu).Results Although there were no differences in vaginal microbiome composition between primiparous and mul-tiparous sows,fecal microbiome composition was different(R^(2)=0.02,P=0.03).The fecal microbiomes of primiparous offspring displayed significantly higher bacterial diversity compared to multiparous offspring at d 0 and d 21 post-weaning(Pommunity composition observed at d 21(R^(2)=0.03,P=0.04).When analyzing the effects of maternal parity within each treatment,only the Preb diet triggered significant microbiome distinc-tions between primiparous and multiparous offspring(d 21:R^(2)=0.13,P=0.01;d 42:R^(2)=0.19,P=0.001).Composi-tional differences in pig fecal microbiomes between treatments were observed only at d 21(R^(2)=0.12,P=0.001).Pigs in the Con group gained significantly more weight throughout the nursery period when compared to those in the Preb+ZnCu *** Nursery pig gut microbiome composition was influenced by supplementation with an Aspergillus oryzae fermentation extract,with varying effects on performance

关键词： Aspergillus prebiotic Copper Feed additives Maternal Nursery pig microbiome Parity Swine microbiome Trace minerals Zinc

A Multi-Channel CMoS Analog Front-End Interface IC with 157.8 d B Current Detection Dynamic Range

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Chinese Journal of Electronics 2024年第2期33卷 393-402页

作者： Kunyu WANG Wenjing XU Chengbin ZHANG Yanjun YANG Man-Kay law Li ZHoU Jie CHEN Ming CHEN Institute of Microelectronics of the Chinese Academy of Science University of Chinese Academy of Sciences Zunyi Normal University Institute of Microelectronics and Dept.of ECE FST University of Macau

A high dynamic range and low-noise CMoS(complementary metal-oxide-semiconductor transistor)front-end interface integrated circuit(IC) with multi-channel detection is presented in this paper. Two different current detection channels, composed of a trans-impedance amplifier(TIA) and an integrator-differentiator TIA, are used to boost the current detection range. A capacitance-coupled instrument amplifier(CCIA) is also included to realize high precision voltage detection. A fourth-order sigma-delta modulator using a second-order loop filter and a second-order noise shaping integral quantizer is adopted to realize effective number of bits above 16 bits. The presented interface IC is implemented in 0.18-μm CMoS process with supply voltage of 3.3 V, and a proto-type electrochemical sensor platform with miniaturized sensor array is developed to verify the functionality of the interface IC. Measurement results indicate that the designed interface IC achieves 157.8 d B current detection dynamic range, and the measured input-referred current noise and voltage noise floor are 1.04 p A and 58.4 n V within 10 k Hz integration bandwidths,respectively.

关键词： Integrated circuits Sigma-delta modulation Semiconductor device measurement Voltage measurement Current measurement Noise Bandwidth

Mass-Based Environmental Factor and Energy Assessment of Microwave-Assisted Synthesized Transition Metal Nanostructures

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American Journal of Analytical Chemistry 2024年第6期15卷 201-218页

作者： Victor J. law School of Mechanical and Materials Engineering University College Dublin Dublin Ireland

This paper describes mass-based energy phase-space projection of microwave-assisted synthesis of transition metals (zinc oxide, palladium, silver, platinum, and gold) nanostructures. The projection uses process energy budget (measured in kJ) on the horizontal axes and process density (measured in kJg−1) on the vertical axes. These two axes allow both mass usage efficiency (Environmental-Factor) and energy efficiency to be evaluated for a range of microwave applicator and metal synthesis. The metrics are allied to the: second, sixth and eleventh principle of the twelve principle of Green Chemistry. This analytical approach to microwave synthesis (widely considered as a useful Green Chemistry energy source) allows a quantified dynamic environmental quotient to be given to renewable plant-based biomass associated with the reduction of the metal precursors. Thus allowing a degree of quantification of claimed “eco-friendly” and “sustainable” synthesis with regard to waste production and energy usage.

关键词： Microwave-Assisted Synthesis Transition Metals Nanostructures Allometry Scaling Power-law Signature Green Chemistry

optimal control of differential quasivariational-hemivariational inequalities with applications

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Science China Mathematics 2024年

作者： Dong-ling Cai Stanis law Migórski Yi-bin Xiao School of Mathematical Sciences University of Electronic Science and Technology of China College of Applied Mathematics Chengdu University of Information Technology Chair of optimization and Control Jagiellonian University in Krakow

In this paper, we study a new class of differential quasivariational-hemivariational inequalities of the elliptic type. The problem consists of a system coupling the Cauchy problem for an ordinary differential equation with the variational-hemivariational inequalities, unilateral constraints, and history-dependent operators. First,based on the Minty formulation and the continuity of the solution map of a parametrized quasivariationalhemivariational inequality, and a fixed point theorem for a history-dependent operator, we prove a result on the well-posedness. Next, we examine optimal control problems for differential quasivariational-hemivariational inequalities, including a time-optimal control problem and a maximum stay control problem, for which we show the existence of solutions. In all the optimal control problems, the system is controlled through a distributed and boundary control, a control in initial conditions, and a control that appears in history-dependent ***, we illustrate the results by considering a nonlinear controlled system for a time-dependent elliptic equation with unilateral constraints.

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A Review on the Advancement of Renewable Natural Fiber Hybrid Composites: Prospects, Challenges, and Industrial Applications

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Journal of Renewable Materials 2024年第7期12卷 1237-1290页

作者： Mohammed Mohammed jawad K.oleiwi Aeshah M.Mohammed Anwar ja’afar Mohamad jawad Azlin F.osman Tijjani Adam Bashir o.Betar Subash C.B.Gopinath Center of Excellence Geopolymer&Green Technology(CEGeoGTech) Universiti Malaysia PerlisArau02600Malaysia Faculty of Chemical Engineering Technology Universiti Malaysia Perlis(UniMAP)Arau02600Malaysia Department of Materials Engineering University of TechnologyBaghdad10070Iraq Department of Chemical Materials University of Bagdad College of Education for Pure Science Ibn-AlhaithamBaghdad10001Iraq Department of Computer Techniques Engineering Al-Rafidain University CollegeBaghdad10001Iraq Faculty of Electronics Engineering Technology Universiti Malaysia PerlisKampus Uniciti Alam Sg.ChuchuhPerlis02100Malaysia Research Center(NANoCAT) University of MalayaKuala Lumpur50603Malaysia Institute of Nano Electronic Engineering Universiti Malaysia PerlisPerlis01000Malaysia Center for Global Health Research Saveetha Medical College&HospitalSaveetha Institute of Medical and Technical Sciences(SIMATS)Tamil Nadu602105India

Naturalﬁbre(NFR)reinforced functional polymer composites are quickly becoming an indispensable sustainable material in the transportation industry because of their lightweight,lower cost in manufacture,and adaptability to a wide variety of ***,the major difﬁculties of using theseﬁbres are their existing poor dimensional stability and the extreme *** assessing the mechanical properties(MP)of composites,the interfacial bonding(IB)happening between the NFR and the polymer matrix(PM)plays an incredibly signiﬁcant *** compared to NFR/syntheticﬁbre hybrid composites,hybrid composites(HC)made up of two separate NFR are less prevalent;yet,these hybrid composites also have the potential to be valuable materials in terms of environmental issues.A new dimension to theﬂexibility of composites reinforced with NFR is added by the cost-effective manufacture of hybrid composites utilising *** purpose of this study is to offer an over-view of the keyﬁndings that were presented on hybrid *** emphasis was focused on the factors that inﬂuence the performance of the naturalﬁber composites,diverse approaches to enhancing MP,physical,electri-cal,and thermal characteristics of the *** study in polymer science gains interest for applications in con-struction and automotive industries.

关键词： Renewable naturalﬁber hybrid composites sustainability nanomaterial greener material

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灵光独耀:沈宗灵与中国法理学

中国法律评论 2024年第4期 149-154页

作者： Peking University law School 北京大学法学院

在其诸多弟子的追忆中,沈宗灵先生一生专心治学、淡泊名利,由此常常对世事保持一种有意的疏离。“灵光独耀,迥脱根尘”,或许便是这位法理学大家的灵魂写照。壹“经国济民”:沈宗灵的早年岁月1923年2月24日,沈宗灵出生于浙江杭州的一个... 详细信息

在其诸多弟子的追忆中,沈宗灵先生一生专心治学、淡泊名利,由此常常对世事保持一种有意的疏离。“灵光独耀,迥脱根尘”,或许便是这位法理学大家的灵魂写照。壹“经国济民”:沈宗灵的早年岁月1923年2月24日,沈宗灵出生于浙江杭州的一个商人家庭,后随家人迁居上海。

关键词：沈宗灵淡泊名利法理学浙江杭州灵光

Stability analysis of a time-delayed Van der Pol–Helmholtz–Duffing oscillator in fractal space with a non-perturbative approach

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Communications in Theoretical Physics 2024年第4期76卷 22-31页

作者： Yusry o El-Dib Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt

The time-delayed fractal Van der Pol–Helmholtz–Duffing(VPHD)oscillator is the subject of this paper,which explores its mechanisms and highlights its stability *** time-delayed technologies are currently garnering significant attention,the focus of this research remains crucially relevant.A non-perturbative approach is employed to refine and set the stage for the system under *** innovative methodologies introduced yield an equivalent linear differential equation,mirroring the inherent nonlinearities of the ***,the incorporation of quadratic nonlinearity into the frequency formula represents a cutting-edge *** analytical solution's validity is corroborated using a numerical *** conditions are ascertained through the residual Galerkin ***,it is observed that the delay parameter,in the context of the fractal system,reverses its stabilizing influence,impacting both the amplitude of delayed velocity and the *** analytical solution's precision is underscored by its close alignment with numerical ***,the study reveals that fractal characteristics emulate damping *** its applicability across diverse nonlinear dynamical systems,this non-perturbative approach emerges as a promising avenue for future research.

关键词： Van der Pol-Helmholtz-Duffing oscillator fractal space time-delay non-perturbative approach stability analysis El-Dib's frequency formula

Valorization of Tree Bark-Derived Suberin in Applications for the Bio-Based Composites Industry–A Recent Review

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Journal of Renewable Materials 2024年第6期12卷 1029-1042页

作者： Aleksandra Jeżo Institute of Wood Sciences and Furniture SGGWNowoursynowska St.159Warsaw02-776Poland

Bark extracts are sustainable sources of biopolymers and hold great promise for replacing fossil fuel-based polymers,for example,in wood-based *** addition to primary and secondary metabolites,tree bark also contains suberin,which plays a major role in protecting the tree from environmental *** is a natural aliphatic-aromatic cross-linked polyester present in the cell walls of both normal and damaged external tissues,the main component of which are long-chain aliphatic *** main role as a plant ingredient is to protect against microbiological factors and water *** of the most important suberin monomers are suberin fatty acids,known for their hydrophobic and barrier ***,due to the diverse chemical composition of suberin,it is an attractive alternative to hydrocarbon-based *** its potential is recognized,it is not widely used in biocomposites technology,including wood-based composites and the polymer *** article will discuss the current knowledge about the potential of suberin and its components in biocomposites technology,which will include surface finishes,composite adhesives and polymer blends.

关键词： Suberin suberinic acids wood composites biocomposites biopolyester