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Establishing a child and adolescent mental health center in Herat,Afghanistan:a project description

Global Health Journal 2023年第4期7卷 194-199页

作者： Abdul Fattah Najm Aziz-ur-rahman Niazi mina Alekozay Emily B.Allan Kaaren Mathias Technical Director International Assistance MissionHerat 3001Afghanistan Department of Public Health and Infectious Diseases Faculty of MedicineHerat 3001Afghanistan Independent Consultant RedcarNorth YorkshireTS103JAUK Faculty of Health University of CanterburyChristchurch 8140New Zealand

Objective:Afghanistan has witnessed a long-lasting 4-decade armed conflict,which together with high levels of poverty and interpersonal violence,resulted in high incidence and prevalence of mental disorders in general population,including children and *** mid-2018,there was neither mental health care facility nor a child psychiatrist in ***,we report the establishment of the first children and adolescents'mental health center(CAMHC)in Herat province of ***:In July 2018,CAMHC was initiated at Mental Health Training *** was initially planned by the International Assistance Mission(IAM)and Herat Public Health Directorate;and financially supported by the Tearfund UK,the United Methodist Committee on Relief and Tearfund *** target population of CAMHC was children and adolescents in Herat and neighboring provinces,healthcare professionals,staff of government and non-governmental organizations,school teachers and community ***:A group of eight mental health professionals were trained and made the interdisciplinary board for diagnosis and management of mental disorders in children and *** the initial three-year period,2448 patients,including 1264(51.6%)boys and 1184(48.4%)girls,presented with mental disorders to *** and management of mental disorders were performed according to standard international *** awareness-raising seminars were held;2000 leaflets,10000 posters,and 30000 brochures were prepared and distributed;and two short video clips were produced and broadcast via IAM website,social media and local TV channels.A database was developed to house for project data,assessment of outcomes and reporting to ***:Establishment of CAMHC resulted in significant achievements in diagnosis and management of mental disorders among children and adolescents,healthcare staff capacity building,and awareness-raising about mental *** o

关键词： Child and adolescent Mental health Herat Afghanistan

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A Single jaZ Repressor Controls the jasmonate Pathway in Marchantia polymorpha

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Molecular Plant 2019年第2期12卷 185-198页

作者： Isabel Monte Jose M. Franco-Zorrilla Gloria Garcia-Casado Angel M. Zamarreno Jose M. Garcia-mina Ryuichi Nishihama Takayuki Kohchi Roberto Solano Department of Plant Molecular Genetics Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientificas (CNB-CSIC) 28049 Madrid Spain Genomics Unit Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientificas (CNB-CSIC) 28049 Madrid Spain Environmental Biology Department University of Navarra Navarre Spain Graduate School of Biostudies Kyoto University Kyoto 606-8502 Japan

jaZ proteins are negative regulators of jasm onate responses,acting both as repressors of transcription factors and as co-receptors of ja-lle. The high redundancy of jaZ genes in angiosperms has hindered the characterization of a complete depletion of jaZ function. Moreover, the recent discovery that dn- OPDA is the jasmonate ligand in Marchantia polymorpha demonstrates that ja-lle is not the sole COI1/ jaZ ligand in land plants and highlights the importance of studying jaZ co-receptors in bryophytes? Here, we have exploited the low gene redundancy of the liverwort M. polymorpha to characterize the single MpJ4Z in this early diverging plant lineage. We clarify the phylogenetic history of the TIFY family, demonstrate that MpjaZ is the ortholog of AtjaZ with a conserved function, and characterize its repressor activity of dn-OPDA resp on ses. Our results show that, con sistent with previous findings in Arabidopsis, MpjaZ represses jasmonates biosynthesis, senescence, and plant defenses, and promotes cell growth and reproductive fitness, highlighting the power of studies in Marchantia.

关键词： jasmonate repressors Marchantia Hormone signaling evolution gene redundancy

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