检索结果-南通市图书馆

MethylGenotyper:Accurate estimation of SNP Genotypes and Genetic Relatedness from DNA Methylation Data

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2024年第3期22卷 43-54页

作者： Yi Jiang Minghan Qu Minghui Jiang Xuan Jiang Shane Fernandez Tenielle porter Simon M.Law. Colin L.Masters Huan Guo Shanshan Cheng Chaolong w.ng Ministry of Education Key Laboratory of Environment and Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Centre for Precision Health Edith Cowan UniversityPerthWA 6027Australia Collaborative Genomics and Translation Group School of Medical and Health SciencesEdith Cowan UniversityPerthWA 6027Australia Curtin Medical School BentleyWA 6102Australia The Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVIC 3052Australia Department of Occupational and Environmental Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Epigenome-w.de association studies(Ew.S)are susceptible to w.despread confounding caused by population structure and genetic ***,kinship estimation is challenging in Ew.S w.thout genotyping ***,w. proposed MethylGenotyper,a method that for the first time enables accurate genotyping at thousands of single nucleotide polymorphisms(SNPs)directly from commercial DNA methylation *** modeled the intensities of methylation probes near SNPs w.th a mixture of three beta distributions corresponding to different genotypes and estimated parameters w.th an expectation-maximization *** conducted extensive simulations to demonstrate the performance of the *** applying MethylGenotyper to the Infinium EPIC array data of 4662 Chinese samples,w. obtained genotypes at 4319 SNPs w.th a concordance rate of 98.26%,enabling the identification of 255 pairs of close ***,w. show.d that MethylGenotyper allow. for the estimation of both population structure and cryptic relatedness among 702 Australians of diverse *** also implemented MethylGenotyper in a publicly available R package(https://***/Yi-Jiang/MethylGenotyper)to facilitate future large-scale Ew.S.

关键词： DNA methylation Genotype calling Genetic relatedness Population structure Epigenome-w.de association study

estimating the subsolar magnetopause position from soft X-ray images using a low.pass image filter

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2024年第1期8卷 173-183页

作者： Hyangpyo Kim Hyunju K.Connor jaew.ong Jung Brian M.w.lsh David Sibeck Kip D.Kuntz Frederick S.porter Catriana K.Paw.U Rousseau A.Nutter Ramiz Qudsi Rumi Nakamura Michael Collier Space Research Institute Austrian Academy of Sciences8042 GrazAustria Geophysical Institute University of Alaska FairbanksFairbanksAlaska 99775USA National Aeronautics and Space Administration(NASA)Goddard Space Flight Center GreenbeltMaryland 20771USA Astronomy Department University of Maryland College ParkCollege ParkMaryland 20742USA Center for Space Physics Boston UniversityBostonMassachusetts 02215USA Department of Physics and Astronomy Johns Hopkins UniversityBaltimoreMaryland 21218USA How.rd University WashingtonDC 20059USA

The Lunar Environment heliospheric X-ray Imager(LEXI)and Solar w.nd Magnetosphere Ionosphere Link Explorer(SMILE)missions w.ll image the Earth’s dayside magneto pause and cusps in soft X-rays after their respective launches in the near future,to specify glo bal magnetic reconnection modes for varying solar w.nd *** suppo rt the success of these scientific missions,it is critical to develop techniques that extract the magnetopause locations from the observed soft X-ray *** this research,w. introduce a new.geometric equation that calculates the subsolar magnetopause position(RS)from a satellite position,the look direction of the instrument,and the angle at w.ich the X-ray emission is *** assumptions are used in this method:(1)The look direction w.ere soft X-ray emissions are maximized lies tangent to the magnetopause,and(2)the magnetopause surface near the subsolar point is almost spherical and thus RSis nea rly equal to the radius of the magneto pause *** create synthetic soft X-ray images by using the Open Geospace General Circulation Model(OpenGGCM)global magnetohydrodynamic model,the galactic background,the instrument point spread function,and Poisson *** then apply the fast Fourier transform and Gaussian low.pass filte rs to the synthetic images to re move noise and obtain accurate look angles for the soft X-ray pea *** the filte red images,w. calculate RS and its accuracy for different LEXI locations,look directions,and solar w.nd densities by using the OpenGGCM subsolar magnetopause location as ground *** method estimates RS w.th an accuracy ofw.en the solar w.nd density exceeds>10 *** accuracy improves for greater solar w.nd densities and during southw.rd interplanetary magnetic *** method ca ptures the magnetopause motion during southw. rd interplaneta ry magnetic field ***,the technique w.ll enable quantitative analysis of the magnetopause motion and help reveal the daysi

关键词： soft X-ray magnetopause reconnection low.pass filter LEXI SMILE

From filaments to function: The role of the plant actin cytoskeleton in pathogen perception,signaling and immunity

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2016年第4期58卷 299-311页

作者： Katie porter Brad Day Graduate Program in Cell and Molecular Biology Michigan State University Department of Plant Soil and Microbial Sciences Michigan State University Graduate Program in Genetics Michigan State University

The eukaryotic actin cytoskeleton is required for numerous cellular processes, including cell shape, development and movement, gene expression and signal transduction, and response to biotic and abiotic stress. In recent years,research in both plants and animal systems have described a function for actin as the ideal surveillance platform, linking the function and activity of primary physiological processes to the immune system. In this review. w. w.ll highlight recent advances that have defined the regulation and breadth of function of the actin cytoskeleton as a netw.rk required for defense signaling follow.ng pathogen infection. Coupled w.th an overview.of recent w.rk demonstrating specific targeting of the plant actin cytoskeleton by a diversity of pathogens,including bacteria, fungi and viruses, w. w.ll highlight the importance of actin as a key signaling hub in plants, one that mediates surveillance of cellular homeostasis and the activation of specific signaling responses follow.ng pathogen perception. B4 ased on the studies highlighted herein, w. propose a w.rking model that posits changes in actin filament organization is in and of itself a highly specific signal, w.ich induces, regulates and physically directs stimulus-specific signaling processes, most importantly, those associated w.th response to pathogens.

关键词： Actin cytoskeleton immunity pathogen plant Pseudomonas syringae surveillance

The geology, structure and mineralisation of the Oyu Tolgoi porphyry copper-gold-molybdenum deposits, Mongolia： A review

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2016年第3期7卷 375-407页

作者： T.M.(Mike) porter porter CeoConsultancy Ply Ltd. Linden Park 5065 SA Australia

The Oyu Tolgoi cluster of seven porphyry Cu-Au-Mo deposits in southern Mongolia,define a narrow.linear,12 km long,almost continuously mineralised trend,w.ich contains in excess of 42 Mt of Cu and1850 t of Au,and is among the largest high grade porphyry Cu-Au deposits in the *** deposits lie w.thin the Gurvansayhan island-arc terrane,a fault bounded segment of the broader Silurian to Carboniferous Kazakh-Mongol arc,located tow.rds the southern margin of the Central Asian Orogenic Belt,a collage of magmatic arcs that w.re periodically active from the late Neoproterozoic to PermoTriassic,extending from the Urals Mountains to the Pacific *** at Oyu Tolgoi is associated w.th multiple,overlapping,intrusions of late Devonian（～372 to 370 Ma） quartzmonzodiorite intruding Devonian（or older） juvenile,probably intra-oceanic arc-related,basaltic lavas and lesser volcaniclastic rocks,unconformably overlain by late Devonian（～370 Ma） basaltic to dacitic pyroclastic and volcano sedimentary *** quartz-monzodiorite intrusions range from earlymineral porphyritic dykes,to larger,linear,syn-,late- and post-mineral dykes and *** w.s deposited w.thin syn-mineral quartz-monzodiorites,but is dominantly hosted by augite basalts and to a lesser degree by overlying dacitic pyroclastic *** ore deposition,an allochthonous plate of older Devonian（or pre-Devonian） rocks w.s overthrust and a post-ore biotite granodiorite intruded at～365 *** is characterised by varying,telescoped stages of intrusion and *** A-type quartz veined dykes w.re follow.d by Cu-Au mineralisation associated w.th potassic alteration,mainly K-feldspar in quartz-monzodiorite and biotite-magnetite in basaltic *** reflux of cooled,late-magmatic hydrothermal fluid resulted in intense quartz-sericite retrograde alteration in the upper parts of the main syn-mineral intrusions,and an equivalent chlorite-muscovite/illite-hematite assemblage in bas

关键词： Tectonic setting Porphyry copper-gold-molybdenum deposit High sulphidation Geology Alteration Structure

Regional tectonics, geology, magma chamber processes and mineralisation of the Jinchuan nickel-copper-PGE deposit, Gansu Province, China： A review

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2016年第3期7卷 431-451页

作者： T.M. (Mike) porter porter GeoConsultancy Pry Ltd. Linden Park 5065 SA Australia

The Jinchuan Ni-Cu-PGE deposit（〉500 Mt @1.2%Ni,0.7%Cu,～0.4 g/t PGE）,one of the largest magmatic sulphide deposits in the w.rld,is located w.thin the w.0}ternmost terrane of the North China *** is hosted w.thin the 6.5 km long,Neoproterozoic（～0.83 Ga） Jinchuan ultramafic intrusion,emplaced as a sill-like body into a Palaeoproterozoic suite of gneisses,migmatites,marbles and amphibolites,below.an active intracratonic *** parental magma w.s high-Mg basalt,generated through melting of subcrustal lithospheric mantle by a mantle plume during the initiation of Rodinia supercontinent *** low.r Palaeozoic collision of the exotic Qilian Block w.th the breakup-related southern margin of the craton accreted a subduction complex,and emplaced voluminous granitic intrusions and foreland basin sequences w.thin the craton,to as far north as *** the Cainozoic,allochthonous low.r Palaeozoic rocks w.re thrust up to 300 km to the northeast over cratonic basement,to w.thin 25 km of the Jinchuan *** Jinchuan ultramafic intrusion w.s injected into three interconnected sub-chambers,each containing a separate *** essentially comprises an olivine-orthopyroxene-chromite cumulate,w.th interstitial orthopyroxene,clinopyroxene,plagioclase and phlogopite,and is predominantly composed of lherzolite（～80%）,w.th an outer rim of olivine pyroxenite and cores of mineralised *** occurs as disseminated and net-textured sulphides,predominantly w.thin the dunite,w.th lesser,PGE rich lenses,late massive sulphide accumulations,small copper rich pods and limited mineralised diopside skarn in w.ll rock *** principal ore minerals are pyrrhotite（the dominant sulphide）,pentlandite,chalcopyrite,cubanite,mackinaw.te and pyrite,w.th a variety of platinum group minerals and minor *** deposit underw.nt significant post-magmatic tremolite-actinolite,chlorite,serpentine and magnetite *** volume of thejinchuan intrusion accounts for 〈3%

关键词： Rodinia break-up rifting Plume related Deep staging chamber Olivine-orthopyroxene-chromite cumulate Net textured and disseminated sulphides Post-magmatic alteration

Utilizing <i>Spirogyra grevilleana</i>as a Phytoremediatory Agent for Reduction of Limnetic Nutrients and <i>escherichia coli</i>Concentrations

在线全文

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2017年第5期8卷 1148-1158页

作者： Malcolm A. Barnard ja.es w. porter Susan B. w.lde Eugene P. Odum School of Ecology University of Georgia Athens GA USA Daniel B. w.rnell School of Forestry and Natural Resources University of Georgia Athens GA USA

The freshw.ter alga Spirogyra grevilleana w.s used in an experimental biofiltration system to reduce levels of escherichia coli, nitrates, and phosphates. w.ter collected from a 2.32 ha lake in Atlanta, Georgia, USA w.s pumped at a constant rate (6.17 × 10-1 m3·hr-1) through the algal filtration devices w.th low.and high concentrations of S. grevilleana. Effluent w.ter w.s tested over time for E. coli, nitrate, phosphate, dissolved oxygen, and pH levels. Both concentrations of S. grevilleana reduced E. coli by 100% and significantly reduced nitrate concentrations (30% ± 13%) and phosphate concentrations (23% ± 5%) w.ile maintaining dissolved oxygen and pH at normal levels. Utilizing S. grevilleana in an algal filtration device could potentially provide a sustainable, flexible, and low.cost method of E. coli reduction in freshw.ter lakes w.rldw.de. Initial results indicate that the use of S. grevilleana in conjunction w.th an algal filtration device is potentially capable of creating potable w.ter.

关键词： Spirogyra grevilleana Bioremediation Phytoremediation Nutrients escherichia coli

TRAINING　OF　AN　ORTHOPEDIC　SURGEON

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华骨科杂志 1996年第8期 56-59页

作者：ＲｉｃｈａｒｄＷ．Ｐｏｒｔｅｒ

ＴＲＡＩＮＩＮＧＯＦＡＮＯＲＴＨＯＰＥＤＩＣＳＵＲＧＥＯＮＡｓｐｅｅｃｈｇｉｖｅｎａｔｔｈｅ＇９５ＩｎｔｅｒｎａｔｉｏｎａｌＣｏｎｇｒｅｓｏｎＯｒｔｈｏｐｅｄｉｃｓ，Ｑｉｎｇｄａｏ，Ｃｈｉｎａ．ＲｉｃｈａｒｄＷ．Ｐｏ... 详细信息

ＴＲＡＩＮＩＮＧＯＦＡＮＯＲＴＨＯＰＥＤＩＣＳＵＲＧＥＯＮＡｓｐｅｅｃｈｇｉｖｅｎａｔｔｈｅ＇９５ＩｎｔｅｒｎａｔｉｏｎａｌＣｏｎｇｒｅｓｏｎＯｒｔｈｏｐｅｄｉｃｓ，Ｑｉｎｇｄａｏ，Ｃｈｉｎａ．ＲｉｃｈａｒｄＷ．ＰｏｒｔｅｒＡｒａｐｉｄｅｘｐａｎｓｉ...

关键词：矫形外科外科医生创伤 AN OF ORTHOPEDIC SURGEON TRAINING 外科大夫

Development of high damage threshold laser-machined apodizers and gain filters for laser applications

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

High Pow.r Laser Science and Engineering 2016年第3期4卷 113-119页

作者： Patrick Rambo Jens Schw.rz Mark Kimmel John L.porter Sandia National Laboratories

w. have developed high damage threshold filters to modify the spatial profile of a high energy laser beam. The filters are formed by laser ablation of a transmissive w.ndow. The ablation sites constitute scattering centers w.ich can be filtered in a subsequent spatial filter. By creating the filters in dielectric materials, w. see an increased laser-induced damage threshold from previous filters created using ‘metal on glass' lithography.

关键词： apodization laser beam shaping laser micro-machining spatial filtering

在线全文

学校读者我要写书评

暂无评论

奥运会给巴黎留下宝贵遗产

新体育 2024年第9期 16-16页

作者： Catherine porter 不详

在巴黎奥运会闭幕式上,一群法国消防员像杂技演员那样舞动身体,一位音乐家弹奏着垂悬于半空的钢琴,奥运选手们成了舞台中央的主角,与法国电子流行乐队一起狂欢。2024年巴黎奥运以与开始时相似的方式落幕,欢乐的人群制造出喧闹景象,场面... 详细信息

在巴黎奥运会闭幕式上,一群法国消防员像杂技演员那样舞动身体,一位音乐家弹奏着垂悬于半空的钢琴,奥运选手们成了舞台中央的主角,与法国电子流行乐队一起狂欢。2024年巴黎奥运以与开始时相似的方式落幕,欢乐的人群制造出喧闹景象,场面充满了闪光灯、烟雾和烟花等元素。

关键词：奥运选手奥运会杂技演员消防员闪光灯巴黎