检索结果-南通市图书馆

厄瓜多尔和马提尼克岛火山灰土侵蚀与管理研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国水土保持 2002年第7期 22-22页

作者： Bounmanh Khamsouk,Georges De noni,Eric Roose CIRAD-FLHOR BP53 97200 Fort de France Martinique IRD(Institut de recherche pourledéveloppement) BP 5045 34032 Montpellier-France IRD(Institut de recherche pourledéveloppement) BP 5045 34032 Montpellier-France

noni juice is not hepatotoxic

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2006年第22期12卷 3616-3619页

作者： Brett j West C jarakae jensen johannes Westendorf Research and Development Department Tahitian noni International American ForkUtahUnited States University Medical School of Hamburg Department of Toxicology HamburgGennany

noni juice （Morinda citrifolia） has been approved for use as a safe food within the European Union, following a review of safety. Since approval, three cases of acute hepatitis in Austrian noni juice consumers have been published, where a causal link is suggested between the liver dysfunction and ingestion of anthraquinones from the plant. Measurements of liver function in a human clinical safety study of TAHITIAN noni juice, as well as subacute and subchronic animal toxicity tests revealed no evidence of adverse liver effects at doses many times higher than those reported in the case studies. Additionally, M. citrifolia anthraquinones occur in the fruit in quantities too small to be of any toxicological significance. Further, these do not have chemical structures capable of being reduced to reactive anthrone radicals, which were implicated in previous cases of herbal hepototoxicity. The available data reveals no evidence of liver toxicity.

关键词： noni juice Morinda citrifolia Novel food Human clinical safety study

Morinda citrifolia （noni）: A literature review and recent advances in noni research1

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2002年第12期23卷 74-88页

作者： Brett j WesT,Cjarakae jENSEN,Diane NOWICKI,SU Chen,Afa K PALU,Gary ANDERSON Department of R＆D Morinda Inc Provo Utah 84606 USA Department of R＆D Morinda Inc Provo Utah 84606 USA Department of R＆D Morinda Inc Provo Utah 84606 USA Department of R＆D Morinda Inc Provo Utah 84606 USA Department of R＆D Morinda Inc Provo Utah 84606 USA University of Illinois College of Medicine Department of Pathology 1601 Parkview Avenue Rockford IL 61107 USA

Morinda citrifolia L (noni) has been used in folk remedies by Polynesians for over 2000 years, and is reported to have a broad range of therapeutic effects, including antibacterial, antiviral, antifungal, antitumor, antihelmin, analgesic, hypotensive, anti-inflammatory, and immune enhancing effects. In order to reveal the nutritional and medicinal value of the noni plant, and to summarize scientific evidence that supports the Polynesians' claim, a literature review and recent advances in noni research is given below.

关键词： Morinda citrifolia L noni proxeronine xeronine cancer prevention antioxidants selective COX-2 inhibitor Yin & Yang

Consumer Perceptions of noni juice Health Benefits during a 90-Day In-Home Use Test

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Health 2023年第3期15卷 266-279页

作者： Brett j. West Research and Development Department Partner.co American Fork Utah USA

noni juice, made from the fruit of Morinda citrifolia, is a health-promoting food from the Pacific Islands with an extensive history of traditional use. Human clinical trials have revealed that noni juice has antioxidant, immunomodulatory and anti-inflammatory properties. Previously, regular noni juice consumers in Europe and traditional healers in Fiji were surveyed to identify potential noni juice health benefits. But to better understand the perception of its health benefits among those with no previous experience with noni juice, an in-home study was conducted in the United States. Three hundred and nineteen adults with untreated chronic health conditions were provided with a 90-day supply of a blinded (unlabeled) commercial noni juice product (Tahitian noni® juice), instructed to consume 4 fluid ounces (1/2 cup) each day, and responded to a questionnaire given on days 30, 60 and 90 to evaluate product appeal and perceived effectiveness. A total of 299 people (94%) felt that their health improved in some way after drinking TNj for 90 days. More than 80% of the subjects reported feeling better or healthier in general. Most participants also concurred with more than two dozen additional positive health perception statements, especially on days 60 and 90. More than 70% of consumers also indicated that noni juice helped them feel better than other wellness supplements they had tried in the past, including other so-called “super fruit” products. These findings seem to corroborate the results of clinical trials and previous consumer surveys regarding the potential for noni juice to provide discernable health benefits when used consistently over time. Such findings may help guide additional placebo-controlled clinical trials in which specific effects may be evaluated more rigorously.

关键词： Morinda citrifolia noni juice In-Home Use Test Consumer Perception Perceived Health Benefits

The Influence of Morinda citrifolia(noni) Fruit juice on Collagen Deposition in the Skin: A Minireview

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Biosciences and Medicines 2018年第9期6卷 1-10页

作者： Brett j. West Research and Development Morinda Inc. American Fork UT USA

The fruit of Morinda citrifolia, commonly known as noni, has an extensive history of use as a food and medicine throughout the tropics. Among its many uses, noni was believed to promote skin health. In vivo wound healing studies reveal that noni fruit juice ingestion increases collagen production and deposition via increased expression of extracellular matrix protein genes. noni juice also appears to promote fibroblast proliferation. In vitro studies indicate that noni juice also protects fibroblasts via activation of the transcription factor Nrf2 and protects extracellular matrix collagen by inhibiting matrix metalloproteinases. In vitro and in vivo study findings are corroborated by a clinical trial where hospitalization times were reduced, and wound granulation quality was improved in pediatric burn patients. The findings of other human studies also indicate that noni juice has the potential to protect skin collagen. These include reduced plasma reactive oxygen species in cigarette smokers, lowered skin glycation levels in overweight and obese adults, as well as reduced skin glycation levels among noni juice consumers within the general population. These in vitro, in vivo and human studies reveal that there are multiple mechanisms of action through which noni juice promotes collagen synthesis and inhibits collagen degradation. The procollagen properties of noni juice aid wound healing, increase skin elasticity, and improve the overall appearance of the skin.

关键词： Morinda citrifolia noni Collagen Fibroblast Matrix Metalloproteinases

Morinda citrifolia(noni) Fruit juice Inhibits SARS-CoV-2 Spike Protein Binding of Angiotensin-Converting Enzyme 2 (ACE2)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Biosciences and Medicines 2021年第11期9卷 42-51页

作者： Brett j. West Shixin Deng Research and Development NewAge Inc. American Fork Utah USA

COVID-19 is a global pandemic that has claimed millions of lives. This disease is caused by a coronavirus, SARS-CoV-2, which requires the binding of its spike protein to angiotensin-converting enzyme 2 (ACE2) for infection of the host cell. Morinda citrifolia (noni) fruit juice has antiviral activity that involves enhancement of immune system function. SARS-CoV-2 spike-ACE2 interaction experiments were carried out to further investigate the antiviral properties of noni juice and its major iridoids. noni juice inhibited binding by approximately 69%. Scandoside was the most active of the three iridoids evaluated, reducing average spike protein-ACE2 interaction by 79.25%. The iridoids worked synergistically towards inhibiting spike protein binding when assayed together, improving activity by more than 22% above the expected level. But the modest activity of the most abundant iridoid, deacetylasperulosidic acid, indicates that other phytochemicals (i.e. scopoletin, quercetin, rutin and kaempferol) are also involved. Our results suggest that the presence of several biological active phytochemicals in noni juice enhances resistance to SARS-CoV-2 by interfering with its ability to bind ACE2. This is a new and significant anti-viral mechanism of noni juice that does not directly involve its immunomodulatory properties.

关键词： Coronavirus COVID-19 SARS-CoV-2 Spike Protein Morinda citrifolia noni Iridoid

Lignans from Morinda citrifolia(noni) Fruit Inhibit Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase in Vitro

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Biosciences and Medicines 2020年第3期8卷 143-152页

作者： Brett j. West Shixin Deng Claude jarakae jensen Research and Development New Age Beverages. American Fork Utah USA

Morinda citrifolia (noni) fruit juice has exhibited a variety of biological activities in human clinical trials, indicating that it influences multiple systems of the body. Since the 1990s, the endocannabinoid system (ECS) has been found to modulate the activity of other organ systems. To investigate noni’s potential impact on the ECS, extracts from freeze-dried noni fruit were evaluated in fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibition assays. The ethyl acetate extract demonstrated the greatest activity against both enzymes. Lignans in this extract also inhibited enzyme activities, with americanin A being the most active in both assays. Americanoic acid and 3,3’-bisdemethylpinoresinol were the next most active compounds. These results suggest that lignans in noni fruit may influence endocannabinoid levels within the body via FAAH and MAGL inhibition. This reveals another set of probable mechanisms of action by which noni juice affects human health.

关键词： Morinda citrifolia noni Endocannabinoid System Fatty Acid Amide Hydrolase Monoacylglycerol Lipase

Morinda citrifolia(noni) Fruit juice Inhibits Endocannabinoid Degradation Enzymes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Biosciences and Medicines 2019年第7期7卷 22-34页

作者： Brett j. West Shixin Deng C. jarakae jensen Research and Development Morinda Inc. American Fork Utah USA

Morinda citrifolia (noni) fruit juice has been shown to have a wide variety of potential health benefits in human clinical trials. It may also influence the endocannabinoid system of the body. Since the main ingredient of the product studied in these clinical trials was juice made from noni fruit puree from French Polynesia, it was evaluated for its ability to inhibit the two major endocannabinoid degradation enzymes in vitro. noni fruit juice inhibited both fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) in a concentration-dependent manner, suggesting that it may help maintain anandamide and 2-arachidonoylglycerol levels. Samples of the puree were also analyzed for the presence of characteristic phytochemical markers of authentic noni fruit such as scopoletin, rutin, quercetin, deacetylasperulosidic acid and asperulosidic acid, all of which were present. Also present was scandoside, which is reported for the first time as being identified in noni fruit or its juice. Some of these compounds may contribute to the FAAH and MAGL inhibiting activity of noni juice. These results reveal another set of mechanisms by which noni juice possibly supports mental health, maintains joint health, relieves discomfort and modulates the immune system.

关键词： Morinda citrifolia Endocannabinoid System Fatty Acid Amide Hydrolase Monoacylglycerol Lipase

noni Seed Oil Topical Safety, Efficacy, and Potential Mechanisms of Action

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Cosmetics, Dermatological Sciences and Applications 2012年第2期2卷 74-78页

作者： Afa K. Palu Brett j. West C. jarakae jensen Research and Development Department Morinda Inc. American Fork USA

Background: noni fruit and leaf juices were used to treat acne in Polynesian folk medicine. However, the potential benefit of noni seed oil (NSO) for human skin health is not as well known. Objective: The topical safety of NSO was evaluated in a repeat insult patch test with 49 adult volunteers. Comedogenicity was evaluated in 23 adolescent volunteers for four weeks. Anti-inflammatory activity was determined in-vitro with COX-2 and 5-LOX enzyme inhibition assays. Results: No reactions to NSO were observed in any of the volunteers. NSO also reduced the number of open and closed comedones in the comedogenicity test. NSO inhibited COX-2 and 5-LOX enzymes in a concentration dependent manner, but with COX-2 inhibition being more pronounced than 5-LOX. Conclusion: noni seed oil is safe for topical use and is non-comedogenic. It also has potential anti-inflammatory activity, being a dual inhibitor of COX-2 and 5-LOX enzymes. These results indicate the potential utility of NSO for skin care applications, as well as warrant further investigation of efficacy in 5-LOX and COX-2 related pathophysiological conditions.

关键词： Morinda citrifolia noni Seed Oil COX-2 5-LOX Comedones Safety