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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 59-59页

作者： Bhudia S. K Cosgrove D. m. /Naugle R. I. E.H. Blackstone 刘宇(译) 刘少伟(校) Naugle R. I. 不详 Section of Clinical Research Department of Thoracic and Cardiovascular Surgery ClevelandClinic 9500EuclidAve/JJ40 Cleveland OH44195 United States

Objective: We sought to evaluate magnesium as a neuroprotectant in patients un dergoing cardiac surgery with cardiopulmonary bypass. methods: From February 200 2 to September 2003, 350 patients undergoing elective coronary artery bypass gra fting, valve surgery, or both were enrolled in a randomized, blinded, placebo-c ontrolled trial to receive either magnesium sulfate to increase plasma levels 1( 1/2) to 2 times normal during cardiopulmonary bypass(n=174) or no intervention(n =176). Neurologic function, neuropsychologic function, and depression were asses sed preoperatively,at 24 and 96 hours after extubation(neurologic) and at 3 mont hs(neuropsychologic, depression). Neurologic scores were analyzed using ordinal longitudinal methods, and neuropsychologic and depression inventory data were su mmarized by principal component analysis, followed by linear regression analysis using component scores as response variables. Results: Seven(2%) patients had a postoperative stroke, 2(1%) in the magnesium and 5(3%) in the placebo group( P=.4). Neurologic score was worse postoperatively in both groups(Pmagnesium group patients performed better than placebo group patients(P=.00 01), who had prolonged declines in short-term memory and reemergence of primiti ve reflexes. Three-month neuropsychologic performance and depression inventory score were generally better than preoperatively, with few differences between gr oups(P > .6); however, older age(P=.0006), previous stroke(P=.003), and lower ed ucation level(P=.0007) were associated with worse performance. Conclusions: magn esium administration is safe and improves short-term postoperative neurologic f unction after cardiac surgery, particularly in preserving short-term memory and cortical control over brainstem functions. However, by 3 months, other factors and not administration of magnesium influence neuropsychologic and depression in ventory performance.

关键词：随机临床试验镁离子浓度心脏外科神经保护因子手术中神经心理学功能神经功能评分冠状动脉搭桥术

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CEPC Technical Design Report

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Radiation Detection Technology and methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti Vincent Boudry mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De maria Nicola De Filippis Christophe De La Taille Francesca De mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPm(AmU/IPhU&CNRS/INP) Marseille Dalian minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 mW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 mW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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发育中的小鼠海马星形胶质细胞功能性合胞体的产生

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神经损伤与功能重建 2023年第3期18卷 F0003-F0003页

作者：杜一星(编译) Department of Neuroscience Ohio State University Wexner Medical Center Department of Neurology Shanghai 10th Hospital of Tongji University School of Medicine Department of Physiology Tongji Medical College Department of Neurology Wuhan First Hospital

越来越多的证据表明星形胶质细胞在脑功能中起着等电位合胞体的作用。原生质星形胶质细胞通过以下方面获得了这种在功能上超越单细胞水平的能力:进化为海绵状形态、细胞质连接成合胞体,以及表达高密度的K+电导。然而,围生期新生星形胶... 详细信息

越来越多的证据表明星形胶质细胞在脑功能中起着等电位合胞体的作用。原生质星形胶质细胞通过以下方面获得了这种在功能上超越单细胞水平的能力:进化为海绵状形态、细胞质连接成合胞体,以及表达高密度的K+电导。然而,围生期新生星形胶质细胞中并不存在这些细胞/功能特征。由此我们提出了一个基本问题,即在发育中的大脑中功能性合胞体是何时形成的。我们的结果表明,海马CA1区的星形胶质细胞的海绵状形态及其空间组织均在出生后第15天达到稳定水平。在功能上,星形胶质细胞在出生11 d即开始统一表达成熟水平的被动K+电导。我们使用合胞体等电位来监测星形胶质细胞合胞体的成熟。在出生1 d小鼠的非偶联星形胶质细胞中,用Na+电极溶液([Na+]p)替代内源性K+导致了生理膜电位(Vm)以及Goldman-Hodgkin-Katz(GHK)方程预测的外向K+电导的完全消除。随着发育过程中更多的星形胶质细胞通过缝隙连接相互耦合,[Na+]p诱导的生理Vm和向外的K+电导的损失逐渐由邻近的星形胶质细胞所补偿。到出生后15 d,在所有[Na+]p记录的星形胶质细胞中均出现稳定建立的合胞体等电位(-73 mV)和完全补偿的外向K+电导。因此,鉴于单个合胞体在解剖和功能上用于合胞体内K+平衡功能建立的发育时间框架,星形胶质细胞合胞体在出生15 d的小鼠海马体中可全面行使其功能。

关键词： K+电导星形胶质细胞电耦合缝隙连接合胞体等电位

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