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Precise sensitivity recognizing,privacy preserving,knowledge graph-based method for trajectory data publication

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Frontiers of Computer Science 2022年第4期16卷 219-221页

作者： Xianxian Li Bing Cai Li-e Wang Lei Lei Guangxi Key Lab of Multi-source Information Mining and Security Guangxi Normal UniversityGuilin541004China College of Computer Science and Information engineering Guangxi Normal UniversityGuilin541004China Nanning Tiancheng Zhiyuan Intellectual Property Service Co.Ltd. Nanning530000China

1Introduction The existing privacy protection methods of trajectory data publication have two ***,existing methods[1-3]cannot resist attribute link attacks *** practical scenarios,it is necessary to integrate data from a variety of fields for data analysis,such as cross-domain *** usually need to obtain the user attributes outside of the trajectory data as background knowledge.

关键词： knowledge outside preserving

epidermal growth factor upregulates Skp2/Cks1 and p27^(kip1) in human extrahepatic cholangiocarcinoma cells

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World Journal of Gastroenterology 2014年第3期20卷 755-773页

作者： ja-yeon Kim Hong Joo Kim Jung Ho Park Dong Il Park Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Dong Hoon Kim Seoung Wan Chae Jin Hee Sohn Kangbuk Samsung Medical Research Institute Sungkyunkwan University Kangbuk Samsung Hospital Department of Internal Medicine Sungkyunkwan University Kangbuk Samsung Hospital Department of Pathology Sungkyunkwan University Kangbuk Samsung Hospital

AIM:To evaluate the expression status of S-phase kinase-associated protein 2(Skp2)/cyclin-dependent kinases regulatory subunit 1(Cks1)and p27kip1,and assess the prognostic significance of Skp2/Cks1 expression with p27kip1in patients with extrahepatic ***:Seventy-six patients who underwent curative resection for histologically confirmed extrahepatic cholangiocarcinoma at our institution from December1994 to March 2008 were *** staining for Skp2,Cks1,p27kip1,and Ki67,along with other relevant molecular biologic experiments,were ***:By Cox regression analyses,advanced age(>65 years),advanced AJCC tumor stage,poorly differentiated histology,and higher immunostaining intensity of Skp2 were identified as independent prognostic factors in patients with extrahepatic *** epidermal growth factor(eGF,especially 0.1-10 ng/mL)significantly increased the proliferation indices by MTT assay and the mRNA levels of Skp2/Cks1 and p27kip1in SNU-1196,SNU-1079,and SNU-245 *** protein levels of Skp2/Cks1(from nuclear lysates)and p27kip1(from cytosolic lysate)were also significantly increased in these *** were significant reductions in the protein levels of Skp2/Cks1and p27kip1(from nuclear lysate)after the treatment of *** chromatin immunoprecipitation assay,we found that e2F1 transcription factor directly binds to the promoter site of ***:Higher immunostaining intensity of Skp2/Cks1 was an independent prognostic factor for patients with extrahepatic *** upregulates the mRNA and protein levels of Skp2/Cks1and p27kip1via the PI3K/Akt pathway and direct binding of e2F1 transcription factor with the Skp2 promoter.

关键词： S-phase kinase-associated protein 2 Cyclindependent kinases regulatory subunit 1 P27kip1 Cholangiocarcinoma e2F1 PI3K/Akt

e1 Paso天然气公司数字微波通信系统改造方案论证

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国外油气储运 1992年第4期10卷 42-45页

作者： R.,ja

emerging jasmonate Transporters

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Molecular Plant 2017年第5期10卷 659-661页

作者： Chi Tam Nguyen enrico Martinoia edward e. Farmer Department of Plant Molecular Biology Biophore University of Lausanne 1015 Lausanne Switzerland Department of Plant and Microbial Biology University of Zurich Zollikerstrasse 107 8008 Zurich Switzerland

jasmonic acid （ja） and methyl jasmonate （Meja） are highly mobile and, when applied to intact plants,, these compounds powerfully modulate gene expression. Moreover, activation of jasmonate-responsive genes usually occurs in tissues distal to the treatments. It therefore comes as no surprise that there are jasmonate transporters; these proteins are only now emerging and their discovery is important for a number of reasons. Firstlv.

关键词： emerging jasmonate Transporters

Modeling and Simulation Study of Space Data Link Protocol

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International Journal of Communications, Network and System Sciences 2014年第10期7卷 440-452页

作者： Ismail Hababeh Rizik M. H. Al-Sayyed ja’far Alqatawna Yousef Majdalawi Marwan Nabelsi Faculty of Computer engineering and Information Technology German Jordanian University Amman Jordan King Abdullah II School for Information Technology The University of Jordan Amman Jordan Digital Signal Processing & Information Technology Bremen Germany

This research paper describes the design and implementation of the Consultative Committee for Space Data Systems (CCSDS) standards ReF _Ref401069962 \r \h \* MeRGeFORMAT [1] for Space Data Link Layer Protocol (SDLP). The primer focus is the telecommand (TC) part of the standard. The implementation of the standard was in the form of DLL functions using C++ programming language. The second objective of this paper was to use the DLL functions with OMNeT++ simulating environment to create a simulator in order to analyze the mean end-to-end Packet Delay, maximum achievable application layer throughput for a given fixed link capacity and normalized protocol overhead, defined as the total number of bytes transmitted on the link in a given period of time (e.g. per second) divided by the number of bytes of application data received at the application layer model data sink. In addition, the DLL was also integrated with Ground Support equipment Operating System (GSeOS), a software system for space instruments and small spacecrafts especially suited for low budget missions. The SDLP is designed for rapid test system design and high flexibility for changing telemetry and command requirements. GSeOS can be seamlessly moved from eM/FM development (bench testing) to flight operations. It features the Python programming language as a configuration/scripting tool and can easily be extended to accommodate custom hardware interfaces. This paper also shows the results of the simulations and its analysis.

关键词： Consultative Committee for Space Data Systems Standards Space Data Link Protocol Mean end-to-end Packet Delay Maximum Achievable Application Layer Throughput Normalized Protocol Overhead Telecommand Spacecrafts Space Instruments

Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort

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World Journal of Gastroenterology 2019年第4期25卷 433-446页

作者： Patricia Prieto Rafael I jaén Daniel Calle María Gómez-Serrano estefanía Nú?ez María Fernández-Velasco Paloma Martín-Sanz Sergio Alonso Jesús Vázquez Sebastián Cerdán Miguel ángel Peinado Lisardo Boscá Department of Metabolism and Physiopathology of Inflammatory Diseases Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) Centro de Investigación Biomédica en Red de enfermedades Cardiovasculares (Ciber-CV) Instituto de Salud Carlos III (ISCIII) Laboratorio de Imagen Médica Hospital Universitario Gregorio Mara?ón Laboratorio de Proteómica Cardiovascular Centro Nacional de Investigaciones Cardiovasculares (CNIC) Instituto de Investigación Sanitaria del Hospital Universitario la Paz(IdiPaz) Programa de Medicina Predictiva y Personalizada del Cáncer (PMPPC) Fundación Instituto de investigación en ciencias de la salud Germans Trias i PujolCtra Can Ruti

BACKGROUND Colorectal cancer(CRC) is the second most common cause of cancer death worldwide. It is broadly described that cyclooxygenase-2(COX-2) is mainly overexpressed in CRC but less is known regarding post-translational modifications of this enzyme that may regulate its activity, intracellular localization and stability. Since metabolic and proteomic profile analysis is essential for cancer prognosis and diagnosis, our hypothesis is that the analysis of correlations between these specific parameters and COX-2 state in tumors of a high number of CRC patients could be useful for the understanding of the basis of this cancer in *** To analyze COX-2 regulation in colorectal cancer and to perform a detailed analysis of their metabolic and proteomic *** Biopsies from both healthy and pathological colorectal tissues were taken under informed consent from patients during standard colonoscopy procedure in the University Hospital of Bellvitge(Barcelona, Spain) and Germans Trias i Pujol University Hospital(Campus Can Ruti)(Barcelona, Spain). Western blot analysis was used to determine COX-2 levels. Deglycosylation assays were performed in both cells and tumor samples incubating each sample with peptide N-glycosidase F(PNGase F). Prostaglandin e2(PGe2) levels were determined using a specific eLISA. 1 H high resolution magic angle spinning(HRMAS) analysis was performed using a Bruker AVIII 500 MHz spectrometer and proteomic analysis was performed in a nano-liquid chromatography-tandem mass spectrometer(nano LC-MS/MS) using a Qexactive HF orbitrap *** Our data show that COX-2 has a differential expression profile in tumor tissue of CRC patients vs the adja.ent non-tumor area, which correspond to a glycosylated and less active state of the protein. This fact was associated to a lesser PGe2 production in tumors. These results were corroborated in vitro performing deglycosylation assays in HT29 cell line where COX-2 protein profile was modified after PN

关键词： Colon Carcinoma Cyclooxygenase Prostaglandin Proteomics High resolution magic angle spinning

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香港陆架第四纪海平面变化

广东地质 1998年第1期13卷 51-60页

作者： Fyfe,ja 面贤彪香港地质调查组

用高分辨率地震剖面和钻了连续取样方法研究香港地区覆盖于风化在岩之上的近滨第四纪沉积，可将其分为４个组。位于最底部的为赤Ｌｉｅ角组，岩性主要为河相的砂和泥，沉积年龄大多数早于距今１３０００ａ，即处于中更新世（氧同位素第... 详细信息

用高分辨率地震剖面和钻了连续取样方法研究香港地区覆盖于风化在岩之上的近滨第四纪沉积，可将其分为４个组。位于最底部的为赤Ｌｉｅ角组，岩性主要为河相的砂和泥，沉积年龄大多数早于距今１３０００ａ，即处于中更新世（氧同位素第６期）海平面低水位期；地层顶面具有特征的河或潮间侵蚀面。赤Ｌｉｅ角组之上覆地层为代表海侵环境的细粒相沉积物（深屈组），形成于海平面标高与现有相当的Ｅｅｍ间冰期（５期ｅ阶段）。

关键词：地震剖面地层层序海平面变化香港陆架

Hepatocellular carcinoma in patients with chronic kidney disease

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World Journal of Gastroenterology 2013年第16期19卷 2466-2472页

作者： Chern-Horng Lee Sen-Yung Hsieh ja-Liang Lin Maw-Sen Liu Tzung-Hai Yen College of Medicine Chang Gung University Department of General Internal Medicine and Geriatrics Chang Gung Memorial Hospital Liver Research Unit Chang Gung Memorial Hospital Department of Nephrology Chang Gung Memorial Hospital

AIM: To investigate outcomes of hepatocellular carcinomas (HCCs) in patients with chronic kidney disease (CKD). MeTHODS: Four hundred and forty patients referred between 2000 and 2002 for management of HCCs were categorized according to their CKD stage, i.e. , estimated glomerular filtration rate (eGFR) > 90 (stage 1), 60-90 (stage 2), 30-60 (stage 3), 15-30 (stage 4), and e 5) mL/min per 1.73 m 2 , respectively. Demographic, clinical and laboratory data were collected and mortality rates and cause of mortality were analyzed. The mortality data were examined with Kaplan-meier method and the significance was tested using a log-rank test. An initial univariate Cox regression analysis was performed to compare the frequency of possible risk factors associated with mortality. To control for possible confounding factors, a multivariate Cox regression analysis (stepwise backward approach) was performed to analyze those factors that were significant in univariate models (P et the assumptions of a proportional hazard model. ReSULTS: Most HCC patients with CKD were elderly, with mean age of diagnosis of 60.6 ± 11.9 years, and mostly male (74.8%). Hepatitis B, C and B and C coinfection virus were positive in 61.6%, 45.7% and 14.1% of the patients, respectively. It was found that patients with stages 4 and 5 CKD were not only older (P = 0.001), but also had higher hepatitis C virus carrier rate (P = 0.001), lower serum albumin level (P = 0.001), lower platelet count (P = 0.037), longer prothrombin time (P = 0.001) as well as higher proportions of advanced cirrhosis (P = 0.002) and HCCs (P = 0.001) than patients with stages 1 and 2 CKD. At the end of analysis, 162 (36.9%) patients had died. Kaplan-Meier analysis revealed that patients with stages 4 and 5 CKD suffered lower cumulative survival than stages 1 and 2 CKD (log-rank test, χ 2 = 11.764, P = 0.003). In a multivariate Cox-regression model, it was confirmed that CKD stage [odds ratio (OR) = 1.988, 95

关键词： Hepatocellular carcinoma Hepatitis B virus Hepatitis C virus Chronic kidney disease end-stage renal disease

Reply to comment by Durkin et *** “Using a modern analogue to interpret depositional position in ancient fluvial-tidal channels:example from the McMurray Formation,Canada” by *** Croix,***,and ***

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Geoscience Frontiers 2020年第3期11卷 1087-1092页

作者： Andrew D.La Croix Shahin e.Dashtgard ja.es A.Maceachern School of Science University of WaikatoHamilton3240New Zealand Applied Research in Ichnology and Sedimentology(ARISe)Group Department of Earth SciencesSimon Fraser UniversityBurnabyBCV5A 1S6Canada

*** We are pleased to have the opportunity to discuss our paper (La Croix et al.,2019) with Durkin et al.(2020).Their critique demonstrates the wide interest in the McMurray Formation held by both academic and industry geoscientists,especially given the economic importance of the stratigraphic ***,it highlights the various working interpretations for the unit’s paleoenvironmental setting and stratigraphic architecture;two highly contested scientific *** et al.

关键词： al. Canada fluvial