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Diagnosis,treatment and complications of radial head and neck fractures in the pediatric patient

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World Journal of Orthopedics 2022年第3期13卷 238-249页

作者： Arno A Macken Denise Eygendaal Christiaan ja van Bergen Department of Orthopedic Surgery Amphia HospitalBreda 4818 CKNoord-BrabantNetherlands Department of Orthopedic Surgery and Sports medicine Erasmus Medical CentreRotterdam 3015 GDSouth-HollandNetherlands

Radial head and neck fractures represent up to 14%of all pediatric elbow fractures and can be a difficult challenge in the pediatric *** up to 39%of proximal radius fractures,there is a concomitant fracture,which can easily be overlooked on the initial standard *** treatment options for proximal radius fractures in children range from non-surgical treatment,such as immobilization alone and closed reduction followed by immobilization,to more invasive options,including closed reduction with percutaneous pinning and open reduction with internal *** choice of treatment depends on the degree of angulation and displacement of the fracture and the age of the patient;an angulation of less than 30 degrees and translation of less than 50%is generally accepted,whereas a higher degree of displacement is considered an indication for surgical *** with limited displacement and non-surgical treatment generally result in superior outcomes in terms of patient-reported outcome measures,range of motion and complications compared to severely displaced fractures requiring surgical *** proper management,good to excellent results are achieved in most cases,and long-term sequelae are ***,severe complications do occur,including radio-ulnar synostosis,osteonecrosis,rotational impairment,and premature physeal closure with a malformation of the radial head as a result,especially after more invasive *** follow-up is therefore warranted.

关键词： Radial head Proximal radius Fracture Pediatrics Closed fracture reduction Open reduction fracture Fracture fixation Synostosis Osteonecrosis

Treatment satisfaction after I year high-power potassiumtitanyl-phosphate photoselective vaporization of the prostate

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Asian Journal of Andrology 2010年第5期12卷 728-734页

作者： ja Hyeon Ku Min Chul Cho Hyeong Seok Kim jae-Seung Paick Soo Woong Kim Department of Urology Seoul National University Hospital Seoul 100-744 Korea

To investigate the factors that influence treatment satisfaction after high-power potassium-titanyl-phosphate （KTP） laser vaporization of the prostate, we compared the characteristics between patients who were satisfied and those who were not satisfied. In all, 97 patients aged between 53-82 years （median age 67 years） underwent high-power KTP laser vaporization of the prostate for lower urinary tract symptoms due to benign prostatic hyperplasia. At 12 months postoperatively, 60 patients were satisfied with the treatment, whereas 37 were dissatisfied. Although there were no differences in International Prostate Symptom Score （IPSS） values at baseline, the satisfied group scored better in total IPSS at 1, 3, 6, and 12 months postoperatively （P 〈 0.05）. At baseline, the maximum flow rate （Qmax） was lower in the dissatisfied group and remained low throughout the follow-up period, with the exception of 1 month postoperatively （P 〈 0.05）, compared with the satisfied group. There were no differences in other objective data between the two groups, including post-void residual and the number of voids based on the frequency-volume charts. In a multivariate model, a higher bladder contractility index was associated with a greater likelihood of treatment satisfaction 12 months after high-power KTP laser vaporization （odds ratio 1.024, 95% confidence interval 1.001-1.048, P 〈 0.05）. Patients who were not satisfied following the surgery had a smaller improvement in subjective symptoms and Qmax. In addition, our findings suggest that the relative risk of treatment dissatisfaction following high-power KTP laser vaporization was increased in patients with weak detrusor contractility.

关键词： benign prostatic hyperplasia potassium-titanyl-phosphate prostate satisfaction vaporization

Bamboo salt suppresses skin inflammation in mice with 2, 4-dinitrofluorobenzene-induced atopic dermatitis

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Chinese Journal of Natural Medicines 2018年第2期16卷 97-104页

作者： Myoung-schook Yoou Sun-Young Nam Kyoung Wan Yoon Hyun-ja Jeong Hyung-Min Kim Department of Pharmacology College of Korean Medicine Kyung Hee University Department of Biotechnology Hoseo University Department of Food Science & Technology and Research Institute for Basic Science Hoseo University

Bamboo salt(BS) is a traditional Korean food, and has been reported to have anti-cancer, anti-inflammatory, and anti-metastatic effects. However, the anti-atopic dermatitis(AD) activity of BS has not been described yet. In the present study, we examined the preventive effect of BS on AD. The effect of oral administration of BS was tested in a 2, 4-dinitrofluorobenzene(DNFB)-induced AD animal model, by histological analysis, enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, caspase-1 assay, and Western blotting analysis. BS administration reduced the total clinical severity and scratching frequencies, compared with the AD group. In the serum of DNFB-induced AD mice, the levels of IgE, histamine, thymic stromal lymphopoietin(TSLP), interleukin(IL)-5, and IL-13 were significantly reduced by BS treatment. BS significantly reduced the protein and mRNA expression of TSLP, IL-6, and tumor necrosis factor-α in the AD skin lesions. BS markedly reduced the infiltration of inflammatory cells. Furthermore, the activation of caspase-1 was reduced by BS in the AD skin lesions. Our results suggested that BS should be considered as a candidate treatment for allergic inflammatory diseases including AD.

关键词： Bamboo salt Atopic dermatitis Thymic stromal lymphopoietin Caspase-1

Report of a Dicephalic Steppes Ratsnake (Elaphe dione) Collected in South Korea

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Asian Herpetological Research 2013年第3期4卷 182-186页

作者： Il-Hun KIM ja-Kyeong KIM Jonathan J.FONG daesik PARK Department of Biology Kangwon National University School of Biological Sciences Seoul National University Division of Science Education Kangwon National University

In this report, we describe morphological characteristics of a dicephalic Steppes Ratsnake （Elaphe dione） collected from the wild in 2011 in South Korea. The specimen has two heads and two long necks. Unlike normal individuals, the dicephalic snake has divided ventral scales under the necks of the bifurcated columns. The snout- vent length （SVL） and overall total length of the individual are shorter than those of normal snakes of the same age. Nevertheless, the counts of nine different scale types that are often used for classification are all within the ranges of normal individuals. As far as we know, this is the first detailed morphological description of a dicephalic E. dione in the scientific literature.

关键词： dicephalism morphology Steppes Ratsnake Elaphe dione

Effect of pineapple peel extract on total phospholipids and lipid peroxidation in brain tissues of rats

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Asian Pacific Journal of Tropical Medicine 2011年第3期4卷 182-184页

作者： Erukainure OL Ajiboye ja Adejobi RO Okafor OY Kosoko SB Owolabi FO Food Technology Division Federal Institute of Industrial ResearchOshodiNigeria College of Natural and Applied Sciences Bells University of TechnologyOtaNigeria

Objective:To investigate the ability of the methanolic extract of pineapple peel to attenuate alcohol-induced changes in total phospholipids and lipid peroxidation in brain tissues. Methods:Oxidative stress was induced by oral administration of ethanol(20%w/v) at a dosage of 5 mL/kg bw in *** 28 days of treatment,the rats were fasted overnight and sacrificed by cervical *** tissues were assayed for total phospholipid(TP) content and malondialdehyde(Mda).Results:Administration of alcohol significantly caused a reduction in TP *** with pineapple peel extract significantly increased the TP content. Significant high levels of Mda was observed in alcohol-fed rats,treatment with pineapple peel extract significantly reduced the Mda ***:Results obtained from this study indicates that pineapple peel extract protects against alcohol-induced changes in total phospholipids and lipid peroxidation in brain tissues.

关键词： Brain Malondialdehyde Total phospholipids Alcohol

Male masturbation device for the treatment of delayed ejaculation: A case report

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Asian pacific Journal of Reproduction 2017年第4期6卷 191-192页

作者： Rodríguez JE Picazo ja López E Research Department of Instituto Sexológico Murciano C/Periodista Encarna Sánchez22030007 MurciaSpain

Delayed ejaculation is a rare condition with different etiologies. Majority of cases of delayed ejaculation have a strong psychological/behavior component. A 48-year-old male with a diagnostic of delayed ejaculation acquired was encouraged to make an exercise protocol using a masturbation device for 8 wk, the percentage of intercourse successful a month after finish protocol exercise was 81%.

关键词： Delayed Ejaculation Male Device Treatment Ejaculation disorders

High-performance and current crowding-free InGaN-GaN- based LEDs integrated by an electrically-reverse-connected Schottky diode and a Mg-delta doped p-GaN

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Frontiers of Optoelectronics 2012年第2期5卷 127-132页

作者： Sei-Min KIM Seon-Ho jaNG ja-Soon jaNG Department of Electronic Engineering LED-IT Fusion Technology Research Center (LIFTRC) Yeungnam University Gyeongbuk 712 749 Korea

This work demonstrates high-performance and current crowding-free InGaN/GaN light-emitting diodes （LEDs） using an electrically-reverse-connected Schottky diode （SD） and an Mg-delta （δ） doped layer. Possible mechanism of carrier transport at the interface between transparent conducting electrode （TCE） and p-GaN with the δ-doped layer is also investigated. Results show that the LED with the SD and Mg delta （δ）-doping layer yields lower series resistance, higher output power, and lower reverse leakage current compared to normal LEDs. In addition, unlike the normal LED, there is no occurrence for the current crowding effect in the proposed LED even at high current density of 380mA/cm2. These remarkable behaviours clearly indicate that the use of the SD and δ- doping in the p-GaN region is very promising to achieve high-brightness and excellent-reliability GaN-based LEDs.

关键词： GaN light-emitting diode (LED) Schottkydiode (SD) integration current crowding

Gastrointestinal side effects in children with Wilson's disease treated with zinc sulphate

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World Journal of Gastroenterology 2013年第27期19卷 4356-4362页

作者： Anna Wiernicka Wojciech jańczyk Maciej Dαdalski Yesim Avsar Hartmut Schmidt Piotr Socha Department of Gastroenterology Hepatology and Malnutritionthe Children's Memorial Health Institute Klinik und Poliklinik für Transplantationsmedizin University Hospital of Muenster

AIM:To investigate the side effects of a zinc sulphate therapy in a cohort of Polish pediatric patients with Wilson's disease. METHODS:We retrospectively analyzed a cohort of 53 pediatric patients with Wilson's disease treated at the Children's Memorial Health Institute in Warsaw, Poland between the years 1996 and 2011 with zinc sulphate. Patients were diagnosed with Wilson's disease according to the scoring system of Ferenci, with 49 cases confirmed by mutation analysis. data about the dosage scheme of zinc sulphate, side effects and efficacy and toxicity of the treatment were collected and recorded in the patient's medical chart at each visit to the hospital. RESULTS:Mean age of diagnosis for the entire cohort was 10 years (range, 2.5-17 years). Duration of treatment with zinc sulfate was 83.3 wk (range, 8-344 wk). Side effects, all of gastrointestinal origin, were observed in 21 patients (40% 9 males and 12 females), irrespective of the duration of therapy. Thirteen out of 21 patients were over the age of 10 years. The most common ATP7B mutation was p.H1069Q. Esophagogastroduodenoscopy, performed in 7 patients (33.3%) suffering from persistent and severe abdominal pain, revealed gastrointestinal ulcerations or erosions with negative Helicobacter pylori tests in all subjects investigated. The above mentioned 7 patients were treated with proton pump inhibitors. Three of those experienced resolution of symptoms, whereas proton-pump inhibitors failed to alleviate symptoms of the remaining four children and conversion of therapy to D-penicillamine was needed. CONCLUSION:Zinc sulphate appears to cause significant gastrointestinal side effects, which children on therapy for Wilson's disease should be closely monitored for.

关键词： Wilson’s disease Zinc Abdominal pain Gastrointestinal ulcer Therapy

Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer:An update

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World Journal of Gastroenterology 2018年第48期24卷 5454-5461页

作者： Rafael I jaén Patricia Prieto Marta Casado Paloma Martín-sanz Lisardo Boscá Department of Metabolism and Physiopathology of Inflammatory Diseases Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) Department of Biomedicine Instituto de Biomedicina de Valencia (CSIC) Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares y Hepáticas y DigestivasISCⅢ Unidad Asociada IIBMULPGC Universidad de las Palmas de Gran Canaria (ULPGC)

The biosynthesis of prostanoids is involved in both physiological and pathological processes. The expression of prostaglandin-endoperoxide synthase 2(PTGS2; also known as COX-2) has been traditionally associated to the onset of several pathologies, from inflammation to cardiovascular, gastrointestinal and oncologic events. For this reason, the search of selective PTGS2 inhibitors has been a focus for therapeutic interventions. In addition to the classic non-steroidal anti-inflammatory drugs, selective and specific PTGS2 inhibitors, termed coxibs, have been generated and widely used. PTGS2 activity is less restrictive in terms of substrate specificity than the homeostatic counterpart PTGS1, and it accounts for the elevated prostanoid synthesis that accompanies several pathologies. The main regulation of PTGS2 occurs at the transcription level. In addition to this, the stability of the mRNA is finely regulated through the interaction with several cytoplasmic elements, ranging from specificmicroR NAs to proteins that control mR NA degradation. Moreover, the protein has been recognized to be the substrate for several post-translational modifications that affect both the enzyme activity and the targeting for degradation via proteasomal and non-proteasomal mechanisms. Among these modifications, phosphorylation, glycosylation and covalent modifications by reactive lipidic intermediates and by free radicals associated to the proinflammatory condition appear to be the main changes. Identification of these post-translational modifications is relevant to better understand the role of PTGS2 in several pathologies and to establish a correct analysis of the potential function of this protein in diseases progress. Finally, these modifications can be used as biomarkers to establish correlations with other parameters, including the immunomodulation dependent on molecular pathological epidemiology determinants, which may provide a better frame for potential therapeutic interventions.

关键词： Prostaglandins Prostaglandin-endoperoxide synthase 2 Post-translational modifications Glycosylation Colorectal cancer Inflammation