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Kitesurf injury trauma evaluation study:A prospective cohort study evaluating kitesurf injuries

World Journal of Orthopedics 2020年第4期11卷 243-251页

作者： Christiaan ja van Bergen Rik IK Weber Tim Kraal gino MMJ Kerkhoffs Daniel haverkamp Department of Orthopedic Surgery Amphia HospitalBreda 4818 CKthe Netherlands Academic Center for Evidence based Sports Medicine Amsterdam 1105 AZthe Netherlands Department of Sports Medicine University Medical CenterUtrecht 3584 CXthe Netherlands Department of Orthopedic Surgery Spaarne HospitalHoofddorp 2134 TMthe Netherlands Department of Orthopedic Surgery Amsterdam University Medical CenterAmsterdam 1105 AZthe Netherlands Department of Orthopedic Surgery Xpert ClinicAmsterdam 1103 TBthe Netherlands

BACKgROUND Kitesurfing is an increasingly popular and potentially dangerous extreme water *** hypothesized that kitesurfing has a higher injury rate than other(contact)sports and that the minority of injuries are *** To investigate the incidence and epidemiology of kitesurfing injuries in a Dutch cohort during a complete kitesurfing *** Injury data of 194 kitesurfers of various skill levels,riding styles and age were surveyed prospectively during a full kitesurf *** participants were recruited through the Dutch national kitesurf association,social media,local websites and kitesurf *** completed digital questionnaires *** amount of time kitesurfing was registered along with all sustained *** an injury was reported,an additional questionnaire explored the type of injury,injury location,severity and the circumstances under which the injury *** The mean age of participants was 31 years(range,13-59)and the majority of the study population was male(74.2%).A total of 177 injuries were sustained during 16816 kitesurf *** calculated injury rate was 10.5 injuries per 1000 h of *** most common injuries were cuts and abrasions(25.4%),followed by contusions(19.8%),joint sprains(17.5%)and muscle sprains(10.2%).The foot and ankle were the most common site of injury(31.8%),followed by the knee(14.1%)and hand and wrist(10.2%).Most injuries were reported to occur during a trick or *** the majority of injuries were mild,severe injuries like an anterior cruciate ligament tear,a lumbar spine fracture,a bimalleolar ankle fracture and an eardrum rupture were *** The injury rate of kitesurfing is in the range of other popular(contact)*** injuries are relatively mild,although kitesurfing has the potential to cause serious injuries.

关键词： Kite boarding Water sports Sports medicine Injuries Epidemiology Extreme sports

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Tailored eradication vs empirical bismuth-containing quadruple therapy for first-line helicobacter pylori eradication: A comparative,open trial

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World Journal of gastroenterology 2019年第46期25卷 6743-6751页

作者： Youn I Choi Jun Won Chung Dong Kyun Park Kyoung Oh Kim Kwang An Kwon Yoon jae Kim ja Young Seo Department of gastroenterology Gil Medical CenterGachon UniversityIncheon 21565South Korea Department of Laboratory Medicine Gil Medical CenterGachon UniversityIncheon 21565South Korea

BACKgROUND Few studies have compared the efficacy and safety profile of a tailored eradication(TR)strategy based on the presence of a 23S ribosomal RNA point mutation with those of empirical bismuth-based quadruple therapy(EBQT)for first-line eradication of helicobacter pylori(***)in Korean *** To compare the efficacy and safety of a TR strategy and those of EBQT regimen as first-line eradication therapy for *** This is an open-label,comparative study in which we prospectively enrolled patients over 18 years of age with *** infection and retrospectively reviewed their ***-positive patients diagnosed by rapid urease test,giemsa staining,or dual priming oligonucleotide polymerase chain reaction(DPO-PCR)were enrolled from May 2016 to September 2018 at gil Medical *** with *** infection received either a TR regimen or the EBQT *** the tailored therapy group that underwent DPO-PCR testing,patients with A2142g and/or A2143g point mutations were treated with a bismuth-containing quadruple *** eradication rate,patient-reported side effect rate,and *** eradication success rate were evaluated and compared between the *** A total of 150 patients were assigned to the TR(n=50)or EBQT group(n=100).The first-line eradication rate of *** did not differ between the groups(96.0%vs 95.7%,P=0.9).The rate of eradication-related side effects for TR was 12.0%,which differed significantly from that of EBQT(43.0%)for first-line treatment(Ph less treatment-related complications,compared to EBQT in Korea,where clarithromycin resistance is high.

关键词： helicobacter pylori Eradication Tailored Empirical Quadruple

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Windsurfing vs kitesurfing:Injuries at the North Sea over a 2-year period

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World Journal of Orthopedics 2016年第12期7卷 814-820页

作者： Christiaan ja van Bergen Joris P Commandeur Rik IK Weber Daniel haverkamp Roelf S Breederveld Department of Orthopaedic Surgery Spaarne Gasthuis Department of Surgery Luzerner Kantonsspital Department of Orthopaedic Surgery Slotervaartziekenhuis Department of Trauma Surgery Red Cross Hospital

AIM To analyze all windsurfing and kitesurfing(kiteboarding) injuries presented at our coastal hospital over a 2-year period. METhODS Twenty-five windsurfers(21 male; aged 31 ± 8 years) and 32 kitesurfers(23 male; aged 29 ± 11 years) presented at our hospital during the 2-year study period. Various injury data were recorded,including transport to hospital and treatment. After a median follow-up of 16 mo(range,7-33 mo),18 windsurfers(72%) and 26 kitesurfers(81%) completed questionnaires on the trauma mechanisms,the use of protective gear,time spent on windsurfing or kitesurfing,time to return to sports,additional injuries,and chronic disability. RESULTS Most patients sustained minor injuries but severe injuries also occurred,including vertebral and tibial plateau fractures. The lower extremities were affected the most,followed by the head and cervical spine,the upperextremities,and the trunk. The injury rates were 5.2 per 1000 h of windsurfing and 7.0 per 1000 h of kitesurfing(P = 0.005). The injury severity was the same between groups(P = 1.0). Less than 30% of the study population used protective gear. Kitesurfers had a higher number of injuries,and required transport by ambulance,inpatient hospital stay and operative treatment more often than windsurfers,but these differences were not statistically significant(P > 0.05). The median time to return to windsurfing and kitesurfing was 5 and 4 wk,respectively(P = 0.79). Approximately one-third of the patients in each group experienced chronic *** Kitesurfing results in a significantly higher injury rate than windsurfing in the same environmental conditions but the severity of the injuries does not differ.

关键词： general sports trauma Extreme sports Surfing Epidemiology Prevention

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hIgh STRAIN RATE SUPERPLASTICITY OF A AIN PARTICULATE REINFORCED 6061Al COMPOSITE

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Acta Metallurgica Sinica(English Letters) 2001年第2期14卷 127-131页

作者： L.h. han, J.T. Niu and D.M. Jiang (The National Key Laboratory of Advanced Welding Production Technology, harbin Institute of Technology,harbin 150001, China) T. Imai (National Industrial Research Institute of Nagoya, 1 hirate-cho, Kita-ku, Nagoya 462, ja harbin Inst. of Technol. Harbin 150001 China

The superplasticity of AINp/6061Al composite, fabricated by powder metallurgy method and hot-rolled after extrusion, was investigated. The AINp/6061Al composite exhibits an m-value of 0.49 and a maximum elongation of 438% in the strain rates ranging hem 10-2-100s-1 and at temperatures from 823K to 893K. Diffirential scanning calorimeter was used to ascertain the possibility of any partial melting in the vicinity of optimum superplastic temperature. These results suggested that liquid phase existed where maximum elongation was obtained.

关键词： superplasticity aluminum matrix composite AIN particulate

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A Short Amino-Terminal Part of Arabidopsis Phytochrome A Induces Constitutive Photomorphogenic Response

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Molecular Plant 2012年第3期5卷 629-641页

作者： Andra＇s Viczia＇n E＇va Ada＇m Iris Wolf ja＇nos Bindics Stefan Kircher Marc heijde Roman Ulm Eberhard Scha＇fer Ferenc Nagy Institute of Plant Biology Biological Research Centre of the Hungarian Academy of Sciences Temesva＇ri krt. 62. H-6726 Szeged Hungary Biologie II/Institut for Botanik University of Freiburg Freiburg Dermany Department of Botany and Plant Biology University of Geneva Geneva Switzerland Centre for Biological Signalling Studies （BIOSS） University of Freiburg Freiburg Germany School of Biological Sciences University of Edinburgh Edinburgh UK

Phytochrome A （phyA） is the dominant photoreceptor of far-red light sensing in Arabidopsis thaliana, phyA accumulates at high levels in the cytoplasm of etiolated seedlings, and light-induced phyA signaling is mediated by a com- plex regulatory network. This includes light- and FhY1/FhL protein-dependent translocation of native phyA into the nucleus in vivo. It has also been shown that a short N-terminal fragment of phyA （PhYA406） is sufficient to phenocopy this highly regulated cellular process in vitro. To test the biological activity of this N-terminal fragment of phyA in planta, we produced transgenic phyA-201 plants expressing the PhYA406-YFP （YELLOW FLUORESCENT PROTEIN）-DD, PhYA406- YFP-DD-NLS （nuclear localization signal）, and PhYA406-YFP-DD-NES （nuclear export signal） fusion proteins. here, we report that PhYA406-YFP-DD is imported into the nucleus and this process is partially light-dependent whereas PhYA406-YFP-DD-NLS and PhYA406-YFP-DD-NES display the expected constitutive localization patterns. Our results show that these truncated phyA proteins are light-stable, they trigger a constitutive photomorphogenic-like response when localized in the nuclei, and neither of them induces proper phyA signaling. We demonstrate that in vitro and in vivo PhYA406 Pfr and Pr bind COP1, a general repressor of photomorphogenesis, and co-localize with it in nuclear bodies. Thus, we conclude that, in planta, the truncated PhYA406 proteins inactivate COP1 in the nuclei in a light-independent fashion.

关键词： Arabidopsis cop phenotype phytochrome A COP1

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Second-line bismuth-containing quadruple therapy for helicobacter pylori eradication and impact of diabetes

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World Journal of gastroenterology 2017年第6期23卷 1059-1066页

作者： Sung Eun Kim Moo In Park Seun ja Park Won Moon jae hyun Kim Kyoungwon Jung hae Koo Kim Young Dal Lee Department of Internal Medicine Kosin University College of MedicineBusan 49267South Korea

To investigate helicobacter pylori (h. pylori) eradication rates using second-line bismuth-containing quadruple therapy and to identify predictors of eradication *** study included 636 patients who failed first-line triple therapy and received 7 d of bismuth-containing quadruple therapy between january 2005 and December 2015. We retrospectively demonstrated h. pylori eradication rates with respect to the year of therapy as well as demographic and clinical factors. h. pylori eradication was confirmed by a 13C-urea breath test or a rapid urease test at least 4 wk after the completion of bismuth-based quadruple therapy: proton pump inhibitor, metronidazole, bismuth, and *** overall eradication rates by intention-to-treat analysis and per-protocol analysis were 73.9% (95%CI: 70.1%-77.4%) and 94.5% (95%CI: 92.4%-96.5%), respectively. Annual eradication rates from 2005 to 2015 were 100.0%, 92.9%, 100.0%, 100.0%, 100.0%, 97.4%, 100.0%, 93.8%, 84.4%, 98.9%, and 92.5%, respectively, by per-protocol analysis. A multivariate analysis showed that diabetes mellitus (OR = 3.99, 95%CI: 1.56-10.20, P = 0.004) was associated with h. pylori eradication therapy *** second-line bismuth-containing quadruple therapy for h. pylori infection is still effective in Korea, and diabetes mellitus is suggested to be a risk factor for eradication failure.

关键词： helicobacter pylori Disease eradication Treatment failure Bismuth Diabetes mellitus

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Distinct patterns of mucosal apoptosis in h pylori-associated gastric ulcer are associated with altered FasL and perforin cytotoxic pathways

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World Journal of gastroenterology 2006年第38期12卷 6133-6141页

作者： heitor SP Souza Marcelo S Neves Celeste CS Elia Claudio ja Tortori Ilana Dines Cesonia A Martinusso Kalil Madi Leonardo Andrade Morgana TL Castelo-Branco Departamento de Clínica Médica Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro 21941-590 Brazil Laboratório Multidisciplinar de Pesquisa e Departamento de Anatomia Patologica Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro 21941-590 Brazil hospital Universitário Clementino Fraga Filho Departamento de histologia e Embriologia Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro 21941-590 Brazil Laboratório de Imunologia Celular Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro 21941-590 Brazil

AIM: To analyze the level of apoptosis in different mucosal compartments and the differential expression of Fas/Fas-ligand and perforin in h pylori-associated gastric ulcer. METhODS: Antral specimens from patients with h pylori-related active gastric ulcer (gU), h pylori-related gastritis, and non-infected controls were analysed for densities and distribution of apoptotic cells determined by the TdT-mediated dUDP-biotin nick-end-labelling method. gU patients were submitted to eradication therapy with follow-up biopsy after 60 d. Fas, FasL, and perforin-expressing cells were assessed by immunoper- oxidase, and with anti-CD3, anti-CD20 and anti-CD68 by double immunofluorescence and confocal microscopy. Quantitative analysis was performed using a computer- assisted image analyser. RESULTS: h pylori-infected antrum showed greater surface epithelial apoptosis which decreased after eradi- cation therapy. In the lamina propria, higher rates of mononuclear cell apoptosis were observed in h pylori- gastritis. Co-expression of Fas with T-cell and macro- phage markers was reduced in gU. FasL- and perforin-expressing cells were increased in h pylori-infection and correlated with epithelial apoptosis. Perforin-expressing cells were also increased in gU compared with h pylori- gastritis. CONCLUSION: Epithelial apoptosis is increased in h pylori-infection and correlates to FasL- and perforin- expression by T cells. Expression of perforin is correlated with the tissue damage, and may represent the enhance- ment of a distinct cytotoxic pathway in gU. Increased expression of FasL not paralleled by Fas on T-cells and macrophages may indicate a reduced susceptibility to the Fas/FasL-mediated apoptosis of lymphoid cells in h pylori-infection.

关键词： gastric ulcer h pylori Apoptosis Fas receptor Fas ligand Perforin

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尼卡地平静脉给药治疗手术后高血压

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国外医学（心血管疾病分册） 1990年第6期17卷 349-350页

作者： Kaplan ja 蔡鑫

新型短效钙拮抗剂尼卡地平是强力的血管扩张剂,选择性地扩张冠状循环,增加脑血管血流量。尼卡地平适宜静脉给药,开始给予10～15mg/h,持续25分钟,继以3～5mg/h维持,这是尼卡地平优于现有二氢吡啶类蓟物处。其作用时间短暂,易于调整剂量,... 详细信息

新型短效钙拮抗剂尼卡地平是强力的血管扩张剂,选择性地扩张冠状循环,增加脑血管血流量。尼卡地平适宜静脉给药,开始给予10～15mg/h,持续25分钟,继以3～5mg/h维持,这是尼卡地平优于现有二氢吡啶类蓟物处。其作用时间短暂,易于调整剂量,象硝酸甘油和硝普钠一样可有效地控制术后高血压。

关键词：尼卡地平静脉给药术后高血压

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hgP's Success Applauded in China

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Bulletin of the Chinese Academy of Sciences 2000年第2期14卷 69-70页

作者： Z.B. g.h.

The Chinese goverment andthe scientific community applaudthe rough sequencing of the humangenetic code, the result of inspiredefforts by scientists from five coun-tries: the U.S. Britain, China, ja-pan, and Prance. Th... 详细信息

关键词： code hgP’s Success Applauded in China

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甲烷部分氧化制合成气　Ⅰ．甲烷在过渡金属上的活化

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分子催化 1994年第4期8卷 271-277页

作者：姜玄珍 Laps.,ja 浙江大学化学系

文中用同位素交换（Ｄ_２─ＣＨ_４）反应来测量四种过渡金属负载型催化剂对甲烷的活化能力，并与Ｓｖｅｎｓｓｏｎ等从头算的计算结果作了比较，表明最有效活化甲烷分子的Ｃ─Ｈ键的金属是铑（Ｒｈ）．文中还测定了在甲烷部分氧化制合... 详细信息

文中用同位素交换（Ｄ_２─ＣＨ_４）反应来测量四种过渡金属负载型催化剂对甲烷的活化能力，并与Ｓｖｅｎｓｓｏｎ等从头算的计算结果作了比较，表明最有效活化甲烷分子的Ｃ─Ｈ键的金属是铑（Ｒｈ）．文中还测定了在甲烷部分氧化制合成气反应中，四个不同催化剂的催化活性与选择性，并与它们对甲烷的活化能力进行对比，可以看出甲烷部分氧化反应中，反应活性高的催化剂有效地活化甲烷，断裂Ｃ─Ｈ键，而且氘代甲烷产物分布以形成ＣＤ_４产物为主要成份．

关键词：甲烷负载型催化剂过渡元素氧化合成气

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