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modulational Instability of Optical Vortices in Engineered Saturable media

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Engineering 2022年第10期17卷 31-43页

作者： D.G.Pires N.m.Litchinitser Department of Electrical and Computer Engineering Duke UniversityDurhamNC 27708USA

Propagation of light beams in turbid media such as underwater environments,fog,clouds,or biological tissues finds increasingly important applications in science and technology,including bio-imaging,underwater communication,and free-space communication *** many of these applications traditionally relied on conventional,linearly polarized Gaussian beams,light possesses many degrees of freedom that are still largely unexplored,such as spin angular momentum(SAm)and orbital angular momentum(OAm).Here,we present nonlinear light-matter interactions of such complex light beams with"rotational"degrees of freedom in engineered nonlinear colloidal *** making use of both variational and perturbative approach,we consider non-cylindrical optical vortices,elliptical optical vortices,and higher-order Bessel beams integrated in time(HOBBIT)to predict the dynamics and stability of the evolution of these *** results may find applications in many scenarios involving light transmission in strongly scattering environments.

关键词： Optical vortex Orbital angular momentum modulation instability Turbid media

Biophysical interactions between silver nanoparticle-albumin interface and curcumin

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Journal of Pharmaceutical Analysis 2020年第2期10卷 164-177页

作者： Vinod D.jaiswal P.m.Dongre Department of Biophysics University of MumbaiVidyanagariSantacruzMumbai400098India

Active targeted drug delivery methods facilitate effective uptake of functionalized nanoparticles through receptor-mediated *** recent years,albumin-nanoparticle interaction has been critically examined so that this functionalized nanoparticle can be efficiently loaded with *** present investigation aims at understanding the adsorption of Bovine Serum Albumin(BSA)on Silver Nano-particle(SNP)surface,preparation of soft conjugates(SC)and hard conjugates(HC)of BSA-functionalized SNP(SNP-BSA),and their interaction with curcumin(CUR).HC contains tightly bound BSA whereas SC involves tightly and loosely bound *** in the hydrodynamic radii of conjugates was observed upon SNP incubation with increased concentration of *** different SNP-BSA conjugate ratios were selected to study their interaction with *** spectroscopy showed a strong association between CUR and SNP:BSA ***,binding varied with a change in the conjugate *** Dichroism(CD)/Fourier Transform Infrared(FTIR)spectroscopy revealed the alterations in the secondary structure of BSA upon CUR binding to the *** potential data indicated stable conjugate *** in SNP:BSA conjugate was found to have a higher half-life as compared to the *** believe that this is the first biophysical characterization report of conjugates that can be effectively extrapolated for targeted drug delivery.

关键词： CUR Bovine serum albumin Silver nanoparticles Soft conjugates Hard conjugates Spectroscopy

Is there a potential of circulating miRNAs as biomarkers in rheumatic diseases?

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Genes & Diseases 2023年第4期10卷 1263-1278页

作者： Klára Prajzlerová Ladislav Senolt mária Filková Institute of Rheumatology Prague 12800Czech Republic Department of Rheumatology First Faculty of MedicineCharles UniversityPrague 12800Czech Republic

t microRNAs(miRNAs)are small non-coding single-stranded RNAs of about 22 nucle-otides in length that act as post-transcriptional regulators of gene *** on the complementarity between miRNA and target mRNA,cleavage,destabilization,or transla-tional suppression of mRNA occurs within the RISC(RNA-induced silencing complex).As gene expression regulators,miRNAs are involved in a variety of biological *** of miRNAs and their target genes contribute to the pathophysiology of many diseases,including autoimmune and inflammatory *** are also present extracellularly in their sta-ble form in body *** incorporation into membrane vesicles or protein complexes with Ago2,HDL,or nucleophosmin 1 protects them against ***-free miRNAs can be deliv-ered to another cell in vitro and maintain their functional ***,miRNAs can be considered mediators of intercellular *** remarkable stability of cell-free miRNAs and their accessibility in body fluid makes them potential diagnostic or prognostic bio-markers and potential therapeutic *** we provide an overview of the potential role of circulating miRNAs as biomarkers of disease activity,therapeutic response,or diagnosis in rheumatic *** circulating miRNAs reflect their involvement in the pathogenesis,while for plenty,their pathogenetic mechanisms remain to be *** miRNAs described as biomarkers were also shown to be of therapeutic potential,and some miRNAs arealready tested in clinical trials.

关键词： Biomarker Diagnosis miRNA Rheumatic diseases Therapy

Energy transfer in solid-state dye lasers based on methyl methacrylate co-doped with sulforhodamine B and crystal violet

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Chinese Physics B 2013年第11期22卷 319-324页

作者： R.G.Geethu mani m.Basheer Ahamed Department of Physics KCG College of Technology Research Centre Bharathiar University Department of Physics B.S. Abdur Rahman University

Laser action in methyl methacrylate （mmA） co-doped with sulforhodamine B and crystal violet dyes was investi- gated. The dye mixture was incorporated into a solid polymeric matrix and was pumped by a 532-nm Nd：YAG laser. Distributed feedback dye laser （DFDL） action was induced in the dye mixture using a prism arrangement both in the donor and acceptor regions by an energy transfer mechanism. Theoretically, the characteristics of acceptor and donor DFDLs, and the dependence of their pulse widths and output powers on acceptor-donor concentrations and pump power, were studied. Experimentally, the output energy of DFDL was measured at the emission peaks of donor and acceptor dyes for different pump powers and different acceptor-donor concentrations. Tuning of the output wavelength was achieved by varying the period of the gain modulation of the laser medium. The laser wavelength showed continuous tunability from 563 nm to 648 nm.

关键词： sulforhodamine B crystal violet distributed feedback dye laser solid state distributed feedbackdye laser

Preliminary evaluation of the radiotherapeutic efficacy of 131I-atorvastatin in rats with hepatocellular carcinoma

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Nuclear Science and Techniques 2020年第11期31卷 1-11页

作者： Nourihan S.Farrag Abeer m.Amin Labeled Compounds Department Hot Laboratories CentreEgyptian Atomic Energy Authority(EAEA)P.O.Box 13759CairoEgypt

As one of the most critical types of cancer,hepatocellular carcinoma(HCC)affects many people *** study demonstrated the prospective use of atorvastatin,a drug that inhibits the mevalonate pathway,causing hypolipidemia,as a carrier to deliver the iodine-131(131I)isotope to liver tissues for HCC *** atorvastatin radioiodination method was optimized for utilizing the131I *** radiochemical quality and the in vitro stability of the generated[131I]atorvastatin were *** addition,the biodistribution experiments of[131I]atorvastatin were evaluated in both normal and HCC-induced rat models.[131I]atorvastatin was produced at a maximum radiochemical yield of 86.7±0.49%.The[131I]atorvastatin solution purified via high-performance liquid chromatography showed good in vitro stability for 12 h after *** analyses revealed remarkable liver targeting capacity of[131I]atorvastatin and good localization of131I in liver ***,the encouraging biochemical profile and histopathologicalfindings have been reported,and preliminary investigations on the possible use of[131I]atorvastatin as a radiotracer and its impact on HCC radiotherapy in rats show promise.

关键词： Hepatocellular carcinoma [131I]Atorvastatin Biodistribution Radiotherapy

Physical-Chemical Characterization of Nanodispersed Powders Produced by a Plasma-Chemical Technique

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Plasma Science and Technology 2007年第3期9卷 273-279页

作者： m.GEORGIEVA G.VISSOKOV Iv.GRANCHAROV Department of Technology of Inorganic Substances University of Chemical Technology and Metallurgy8St.Kliment Ohridski Blvd.1756 SofiaBulgaria

This article presents a review on the physical-chemical properties and characteristics of plasma-chemically produced nanodispersed powders （NDP）, such as metals, oxides, nitrides, carbides, and catalysts. The plasma-chemical preparatior~ of the powders was carried out in thermal plasma （TP） created by means of high-current electric arcs, plasma jets, high-frequency （HF） discharges, etc. We also discuss certain properties and characteristics of the NDPs, which are determined largely by the conditions of preparation.

关键词： plasma-chemical treatment nitrides thermodynamic analysis

Nonlinear beam formulation incorporating surface energy and size effect:application in nano-bridges

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Applied mathematics and mechanics(English Edition) 2016年第5期37卷 583-600页

作者： A.KOOCHI H.HOSSEINI-TOUDESHKY m.ABADYAN Department of Aerospace Engineering Amirkabir University of TechnologyTehran 15875-4413Iran mechanical Engineering Group Shahrekord BranchIslamic Azad UniversityShahrekord ***Iran

A nonlinear beam formulation is presented based on the Gurtin-murdoch surface elasticity and the modified couple stress theory. The developed model theoretically takes into account coupled effects of the energy of surface layer and microstructures size- dependency. The mid-plane stretching of a beam is incorporated using von-Karman nonlinear strains. Hamilton＇s principle is used to determine the nonlinear governing equation of motion and the corresponding boundary conditions. As a case study, pull-in instability of an electromechanical nano-bridge structure is studied using the proposed formulation. The nonlinear governing equation is solved by the analytical reduced order method （ROm） as well as the numerical solution. Effects of various parameters including surface layer, size dependency, dispersion forces, and structural damping on the pull- in parameters of the nano-bridges are discussed. Comparison of the results with the literature reveals capability of the present model in demonstrating the impact of nano- scale phenomena on the pull-in threshold of the nano-bridges.

关键词： surface energy size effect nonlinear beam formulation electromechanicalnano-bridge pull-in instability

A Seismic Hazard map Based on Geology and Shear-wave Velocity in Rawalpindi–Islamabad,Pakistan

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Acta Geologica Sinica(English Edition) 2021年第2期95卷 659-673页

作者： Sarfraz KHAN muhammad WASEEm m.Asif KHAN National Centre of Excellence in Geology University of Peshawar 25130KPPakistan University of Peshawar 25120 KPPakistan

The‘twin cities’district of Rawalpindi–Islamabad is among the most endangered seismic regions in Pakistan,with the seismic hazard assessed(0.32 g)to intensity IX mmI for a 475-year return period.A seismic hazard map for Rawalpindi–Islamabad is presented herein,based on 85 shear-wave velocity(VS)profiles obtained through geophysical H/V measurements and from the geological map of the *** between the average top thirty-meter shear-wave velocities(VS30)and surficial geological units have been *** peak ground acceleration(PGA)maps for 150,475 and 2475-year return periods were converted into a seismic intensity *** increments for different soils were used to compute PGA values for 150,475 and 2475-year return *** located on softer ground experienced a higher degree of damage from moderate *** to the presence of soft clay or liquefiable soil and lateral spreading,a few locations may be classified as hybrid sites class C and *** map is a critical step in facilitating code-based site classification and seismic design throughout Rawalpindi–*** the seismic hazard map based on seismic intensities is no longer used in engineering geology,it is still important in seismological analysis and for civil protection purposes.

关键词： seismic hazard site classification intensity increment engineering geology Rawalpindi-Islamabad

Dendritic cells in cancer immunology

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Cellular & molecular Immunology 2022年第1期19卷 3-13页

作者： Theresa L.murphy Kenneth m.murphy Department of Pathology and Immunology Washington University in St.LouisSchool of MedicineSt.LouisMO 63110USA

The clinical success of immune checkpoint therapy(ICT)has produced explosive growth in tumor immunology research because ICT was discovered through basic studies of immune *** of the current translational efforts are aimed at enhancing ICT by identifying therapeutic targets that synergize with CTLA4 or PD1/PD-L1 blockade and are solidly developed on the basis of currently accepted *** these principles through continuous basic research may help broaden translational *** this mindset,we focused this review on three threads of basic research directly relating to mechanisms underlying ***,this review covers three aspects of dendritic cell(DC)biology connected with antitumor immune responses but are not specifically oriented toward therapeutic ***,we review recent advances in the development of the cDC1 subset of DCs,identifying important features distinguishing these cells from other types of ***,we review the antigen-processing pathway called cross-presentation,which was discovered in the mid-1970s and remains an *** pathway serves an essential in vivo function unique to cDC1s and may be both a physiologic bottleneck and therapeutic ***,we review the longstanding field of helper cells and the related area of DC licensing,in which CD4 T cells influence the strength or quality of CD8 T cell *** topic is connected with ICT in some manner but is also a fundamental aspect of cell-mediated immunity directed toward intracellular pathogens.

关键词： Dendritic cells transcription factors cross-presentation tumor rejection CD4 help