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Male masturbation device for the treatment of delayed eja.ulation: A case report

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Asian pacific Journal of Reproduction 2017年第4期6卷 191-192页

作者： Rodríguez JE Picazo ja.lópez E Research Department of Instituto Sexológico Murciano C/Periodista Encarna Sánchez22030007 MurciaSpain

Delayed eja.ulation is a rare condition with different etiologies. Majority of cases of delayed eja.ulation have a strong psychological/behavior component. A 48-year-old male with a diagnostic of delayed eja.ulation acquired was encouraged to make an exercise protocol using a masturbation device for 8 wk, the percentage of intercourse successful a month after finish protocol exercise was 81%.

关键词： Delayed Eja.ulation Male Device Treatment Eja.ulation disorders

Mitochondrial alterations in MS lesions

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Mitochondrial alterations in MS lesions

Spectrum and Singular Integrals on a New Weighted Function Space

第14届国际自由基学术大会

作者： ME. Witte l. Bφ RJ. Rodenburg ja. Belien R. Musters T. Hazes lT. Wintjes ja. Smeitink JJG. Geurts HE. De Vries P. van der Valk J. van Horssen Departments of Pathology VU University Medical Center Amsterdam De Boelelaan 1117 1081 HVThe Netherlands Department of Neurology Haukeland University Hospital University of Bergen N- 5021 Bergen Norway Departments of Physiology VU University Medical Center Amsterdam De Boelelaan 1117 1081 HVThe Netherlands Departments of Radiology VU University Medical Center Amsterdam De Boelelaan 1117 1081 HVThe Netherlands Departments of Molecular Cell Biology and Immunology VU University Medical Center Amsterdam De Boelelaan 1117 1081 HVThe Netherlands Departments of Molecular Cell Biology and Immunology VU University Medical Center Amsterdam De Boelelaan 1117 1081 HVThe Netherlands.

＜正＞Multiple sclerosis （MS） is a chronic inflammatory disease of the central nervous system, characterized by demyelination and neurodegeneration. Although MS pathogenesis is not completely understood, several studies suggest that mitochondrial dysfunction and subsequent free radical production play important roles in MS lesion development and progression

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Acta Mathematica Sinica,English Series 2018年第11期34卷 1692-1702页

作者： Hee Chul PAK Young ja.PARK Department of Mathematics Dankook University Dandae-ro 119 Dongnam-gu Cheonan-si Chungnam 31116 Republic of Korea Department of Mathematics Hoseo University Hoeo-ro 79 Asan-si Chungnam 31499 Republic of Korea

We introduce a new function space that is much finer than the classical lebesgue spaces, and investigate the continuity and the discontinuity of the Calderon-Zygmund operators on the new weighted spaces. In order to identify the continuity of singular integrals, we prove an interpolation theorem on the new spaces and propose a concept of the spectrum of base functions.

关键词： Function spaces singular integrals interpolation Calderdn Zygmund operators Holder's inequality l log l

表面活性剂对CaO_(2)修复石油烃污染土壤的影响研究

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环境科技 2024年第2期37卷 1-6,12页

作者：张祥孙勇向甲甲上海市政工程设计研究总院(集团)有限公司上海200092 上海申环环境工程有限公司上海200092

将合成的纳米级过氧化钙(nCaO_(2))用于石油烃污染土壤修复,研究过氧化钙(CaO_(2))、柠檬酸(CA)螯合二价铁(Fe(Ⅱ))投加量对石油烃去除效果的影响,并将不同表面活性剂对石油烃氧化的影响进行比较。结果表明,随着CaO_(2)或CA螯合Fe(Ⅱ)... 详细信息

将合成的纳米级过氧化钙(nCaO_(2))用于石油烃污染土壤修复,研究过氧化钙(CaO_(2))、柠檬酸(CA)螯合二价铁(Fe(Ⅱ))投加量对石油烃去除效果的影响,并将不同表面活性剂对石油烃氧化的影响进行比较。结果表明,随着CaO_(2)或CA螯合Fe(Ⅱ)的投加量增大,石油烃去除率均呈先增后降趋势。当n(CaO_(2)):n(Fe(Ⅱ)):n(CA)为4:1:1时,石油烃去除效果最佳,达到70.98%。十二烷基硫酸钠和曲拉通X-100对土壤中石油烃均有较好的增溶效果。质量浓度为3g/l的十二烷基硫酸钠对石油烃的降解可起促进作用,而曲拉通X-100则不利于石油烃的降解。

关键词：过氧化钙石油烃表面活性剂化学氧化纳米材料

山楂叶总黄酮通过miR-21a-5p对血管紧张素Ⅱ诱导的心肌细胞肥大的影响

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中国临床药理学杂志 2024年第15期40卷 2182-2186页

作者：田林燕朱冉代聚平王佳佳张斌南阳医学高等专科学校内科教研室河南南阳473000 南阳医学高等专科学校临床实训室河南南阳473000 南阳医学高等专科学校第一附属医院心血管内科河南南阳473000 南阳医学高等专科学校第一附属医院病理科河南南阳473000

目的探讨山楂叶总黄酮对血管紧张素Ⅱ(AngⅡ)诱导的心肌肥大的影响,及其可能作用机制。方法将H9c2细胞分为对照组(正常培养),模型组(100 nmol·l^(-1)AngⅡ处理24 h),低、中、高剂量实验组(先给予100 nmol·l^(-1)AngⅡ处理24 h后,再分... 详细信息

目的探讨山楂叶总黄酮对血管紧张素Ⅱ(AngⅡ)诱导的心肌肥大的影响,及其可能作用机制。方法将H9c2细胞分为对照组(正常培养),模型组(100 nmol·l^(-1)AngⅡ处理24 h),低、中、高剂量实验组(先给予100 nmol·l^(-1)AngⅡ处理24 h后,再分别给予25、50、100 mg·l^(-1)的山楂叶总黄酮处理24 h),anti-miR-NC、anti-miR-21a-5p组(分别转染anti-miR-NC、anti-miR-21a-5p后,给予100 nmol·l^(-1)AngⅡ处理24 h),miR-NC+高剂量组和miR-21a-5p+高剂量组(分别转染miR-NC、miR-21a-5p mimics,再给予100 nmol·l^(-1)AngⅡ+100 mg·l^(-1)山楂叶总黄酮各处理24 h)。用CCK-8法和流式细胞术检测细胞活力和凋亡情况,用实时荧光定量聚合酶链反应法检测miR-21a-5p的表达水平,用蛋白质印迹法检测环氧化酶-2(COX2)/前列腺素E2(PGE2)的表达水平。结果对照组、模型组和高剂量实验组的细胞活力分别为1.03±0.09、0.51±0.05和0.93±0.08,凋亡率分别为(7.69±0.61)%、(23.04±1.82)%和(9.43±0.71)%,miR-21a-5p表达水平分别为1.00±0.09、2.43±0.18和1.09±0.08,COX2蛋白相对表达水平分别为0.42±0.03、0.85±0.08和0.40±0.04,PGE2蛋白相对表达水平分别为0.34±0.03、0.75±0.07和0.35±0.03,模型组的上述指标与高剂量实验组和对照组相比,在统计学上差异均有统计学意义(均P<0.05)。anti-miR-NC组、anti-miR-21a-5p组、miR-NC+高剂量组和miR-21a-5p+高剂量组的细胞活力分别为0.52±0.04、1.12±0.08、0.94±0.09和0.57±0.04,凋亡率分别为(23.04±1.82)%、(9.86±0.73)%、(9.47±0.64)%和(24.96±1.94)%,miR-21a-5p表达水平分别为1.00±0.10、0.43±0.04、1.00±0.09和2.12±0.18,COX2蛋白相对表达水平分别为0.86±0.05、0.39±0.04、0.41±0.03、0.78±0.07,PGE2蛋白相对表达水平分别为0.74±0.06、0.38±0.07、0.36±0.02、0.71±0.05,anti-miR-21a-5p组的上述指标与anti-miR-NC组比较,miR-21a-5p+高剂量组的上述指标与miR-NC+高剂量组比较,在统计学上差异均有统计学意义(均P<0.05)。结论山楂叶总黄酮通过调控miR-21a-5p和COX2/PGE2通路的表达,从而抑制AngⅡ诱导的心肌肥大。

关键词：山楂叶总黄酮心肌肥大血管紧张素Ⅱ 细胞增殖凋亡

CONJUGATE FlOWS OVER A STEP IN A THREE-lAYER FlUID

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Journal of Hydrodynamics 2002年第4期14卷 15-23页

作者： Wei, Gang le, ja.Chun Dai, Shi-Qiang Inst. of Appl. Math. and Mech. Shanghai Univ. Shanghai 200072 China Sch. of Sci. P.L.A Univ. of Sci. and Eng. Nanjing 211101 China

The conjugate flows over a step with the height h_0, which might be positive or negative, was studied in a three-layer fluid and the coupled nonlinear equations were derived, with which the effects of varying height h_0 on the existence and evolution of conjugate flows were examined. It is concluded that the conjugate flow is sharply sensitive to the thickness of fluid layers and its characteristics alters remarkably due to the existence of the step. As the flow climbs up a step (h_0>0), the conjugate flow with a convex lower interface and a concave upper interface is allowed to appear, while the flow with the concave lower interface or the simultaneous concave interfaces will be depressed. As the flow goes down a step (i.e., h_0ly one kind of conjugate flow could exist, which prossesses the form with the simultaneous convex interfaces and will disappear rapidly with the increase of the step depth.

关键词： conjugate flow flat solitary wave stratified flow step topography three-layer fluid

Trichoderma *** Bacillus *** growth promoters in maize(Zea mays l.)

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Phyton-International Journal of Experimental Botany 2019年第1期88卷 37-46页

作者： lópez-Valenzuela BE Armenta-Bojórquez AD Hernández-Verdugo S Apodaca-Sánchez MA Samaniego-Gaxiola ja.Valdez-Ortiz A Universidad Autónoma de Sinaloa.Facultad de Agricultura del Valle del Fuerte.Avenida ja.araqui y Calle 16 s/n Juan JoséRíosSinaloaC.P 81110México Universidad Autónoma de Baja.California.Instituto de Ciencias Agrícolas.Carretera a Delta s/n Ejido Nuevo leónBaja CaliforniaC.P.21705México Instituto Politécnico Nacional.Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Sinaloa.Blvd.Juan de Dios Bátiz Paredes#250 Colonia San JoachinGuasaveSinaloaC.P.81101México Universidad Autónoma de Sinaloa Facultad de Agronomía.Km.17.5Carretera Culiacán-El DoradoCuliacán RosalesSinaloaC.P.80000México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Campo Experimental La LagunaBlvd.JoséSantos Valdez 1200 Pte.MatamorosCoahuilaC.P.27440México Universidad Autónoma de Sinaloa Facultad de Ciencias Químico Biológicas.Calzada de las Américas y Calle Universitarioss/n.Ciudad UniversitariaCuliacánSinaloaC.P.80013México

Microbes that are beneficial to plants are used to enhance the crop growth,yield and are alternatives to chemical *** and Bacillus are the predominant plant growth-promoting fungi and *** objective of this study was select,characterize,and evaluate isolates of Trichoderma *** Bacillus *** from the northern region of Sinaloa,Mexico,and assess their effect on growth promotion in maize(Zea mays l.).In greenhouse conditions,four Trichoderma isolates and twenty Bacillus isolates,as well as two controls,were tested in a completely randomized design with three *** selected the two best strains of Trichoderma and Bacillus:TB=Trichoderma asperellum,TF=Trichoderma virens,B14=Bacillus cereus sensu lato and B17=Bacillus cereus,which were evaluated in the field in a completely randomized blocks in factorial arrangement design with three replicates applying different rates of nitrogen fertilizer(0,150 kg N/ha,and 300 kg N/ha).Treatments 5(B17=***)and 11(TF=***)both fertilized with 150 kg N/ha showed similar yields and they did not reveal significant differences from the treatments fertilized with 300 kg N/*** indicated that treatment 5(B17=*** with 150 kg N/ha)and treatment 11(TF=*** with 150 kg N/ha)were efficient as growth promoters,by not showing significant differences in root volume and dry weight of *** results indicated a reduction of 50% in the rate of nitrogen to fertilizer required for maize(Zea mays l.)*** microorganisms Trichoderma and Bacillus could be an alternative to reduce the use of chemical fertilizers in maize.

关键词： Trichoderma Bacillus Native strains Biofertilizers

lactic Acid Fermentation from Coffee Ground Waste Hydrolysate by lactobacillus rhamnosus

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Journal of Renewable Materials 2019年第4期7卷 365-372页

作者： ja.Ryong Koo Hye Min Park Se Kyung Kim Hyun Shik Yun Department of Biological Engineering Inha UniversityIncheon 22212Korea Institute of Industrial Biotechnology Inha University Research and Business FoundationIncheon 22212Korea

lactic acid is an important organic acid that is widely used in the food,pharmaceutical,and cosmetic *** acid was produced from coffee ground waste which contains fermentable sugars and is increasingly generated from our daily dietary *** 114 strains of lactobacillus species,lactobacillus rhamnosus ATCC 10863 was selected for the production of lactic acid from coffee ground *** alkali pretreatment and saccharification,cellulose and hemicellulose in coffee ground waste were converted into fermentable *** experiments were conducted at various alkali solution,concentrations,and *** pretreatment with 35 g/l of KOH at 121oC for 60 min,the highest concentration of fermentable sugars was *** optimum concentration of Viscozyme l was 2%when saccharification was proceeded at 55oC for 7 *** productivity of lactic acid fermentation was the highest(0.59 g/l/h)at 100 g of coffee ground waste(1x concentration),whereas the lactic acid concentration was the highest at 600 g of coffee ground waste(6x concentration).As the concentration of coffee ground increased,the lactic acid concentration was also increased,however,the amount was not proportional to the coffee ground waste *** this study,it was found that coffee ground waste could be used as a culture medium for lactobacillus rhamnosus ATCC 10863 through pretreatment and saccharification for the production of lactic acid.

关键词： Coffee ground waste lactobacillus rhamnosus lactic acid fermentable sugars saccharification alkali pretreatment

Genome-wide markers for seed yield and disease resistance in perennial ryegrass

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The Crop Journal 2022年第2期10卷 508-514页

作者： Kristina ja.kune Vilma Kemešyte Andrius Aleliūnas Grazina Statkeviciute Institute of Agriculture Lithuanian Research Centre for Agriculture and Forestry(LAMMC)Instituto av.1Akademija LT-58344Lithuania

The market success of perennial ryegrass(lolium perenne l.) cultivars depends on sufficient seed production, as they are propagated by seed. However, breeding for high quality forage production reduces seed yield, and breaking the negative correlation would help to overcome the problem. The foliar disease crown rust is another factor affecting reproductive capacity and thereby seed yield. We evaluated seed yield-related traits and resistance to crown rust in a collection of commercial cultivars and ecotypes of perennial ryegrass and identified genome-wide markers associated with the traits. The study revealed high variation between the ecotype and cultivar groups as well as between years. A genome-wide association study identified 17 DNA single-nucleotide polymorphisms(SNPs) of which eight were associated with crown rust and nine with flag-leaf length. The SNP markers were located within or near predicted genes functioning in defense against pathogens. The identified genes are strong candidates for a further in-depth functional study to continue unravel determination of leaf architecture and crown rust resistance in perennial ryegrass.

关键词： Crown rust Puccinia coronata f.sp.lolli Flag-leaf length Genome-wide association study(GWAS) Seed yield lolium perenne l.