检索结果-南通市图书馆

CD24 expression predicts distant metastasis in extrahepatic bile duct cancer

World Journal of Gastroenterology 2013年第9期19卷 1438-1443页

作者： Kyubo Kim Hye Sook Min Eui Kyu Chie Jin-Young jang Sun Whe Kim Sae-Won Han Do-Youn Oh Seock-Ah Im Tae-You Kim Yung-Jue Bang ja-june jang Sung W Ha Department of Radiation Oncology Seoul National University College of Medicine Seoul 110-744 South Korea Department of Pathology Seoul National University College of Medicine Seoul 110-744 South Korea Institute of Radiation Medicine Medical Research Center Seoul National University Seoul 151-742 South Korea Department of Surgery Seoul National University College of Medicine Seoul 110-744 South Korea Department of Internal Medicine Seoul National University College of Medicine Seoul 110-744 South Korea

AIM: To evaluate the prognostic significance of CD24 expression in patients undergoing adjuvant chemoradiotherapy for extrahepatic bile duct (EHBD) cancer. METHODS: Eighty-four patients with EHBD cancer who underwent curative resection followed by adjuvant chemoradiotherapy were enrolled in this study. Postoperative radiotherapy was delivered to the tumor bed and regional lymph nodes up to a median of 40 Gy (range: 40-56 Gy). All patients also received fluoropyrimidine chemotherapy for radiosensitization during radiotherapy. CD24 expression was assessed with immunohistochemical staining on tissue microarray. Clinicopathologic factors as well as CD24 expression were evaluated in multivariate analysis for clinical outcomes including loco-regional recurrence, distant metastasisfree and overall survival. RESULTS: CD24 was expressed in 36 patients (42.9%). CD24 expression was associated with distant metastasis, but not with loco-regional recurrence nor with overall survival. The 5-year distant metastasis-free survival rates were 55.1% and 29.0% in patients with negative and positive expression, respectively (P=0.0100). On multivariate analysis incorporating N stage, histologic differentiation and CD24 expression, N stage was the only significant factor predicting distant metastasis-free survival (P=0.0089), while CD24 expression had borderline significance (P=0.0733). In subgroup analysis, CD24 expression was significantly associated with 5-year distant metastasis-free survival in node-positive patients (38.4% with negative expression vs 0% with positive expression, P=0.0110), but not in nodenegative patients (62.0% with negative expression vs 64.0% with positive expression,P=0.8599). CONCLUSION: CD24 expression was a significant predictor of distant metastasis for patients undergoing curative resection followed by adjuvant chemoradiotherapy especially for node-positive EHBD cancer.

关键词： CD24 Tissue microarray Extrahepatic bile duct cancer Adjuvant chemoradiotherapy Distant metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simple colonoscopy reporting system checking the detection rate of colon polyps

引用

World Journal of Gastroenterology 2015年第31期21卷 9380-9386页

作者： jae Hyun Kim Youn Jung Choi Hye Jung Kwon Seun ja Park Moo In Park Won Moon Sung Eun Kim Department of Internal Medicine Kosin University College of Medicine

AIM: To present a simple colonoscopy reporting system that can be checked easily the detection rate of colon ***: A simple colonoscopy reporting system Kosin Gastroenterology(KG quality reporting system) was developed. The polyp detection rate(PDR),adenoma detection rate(ADR),serrated polyp detection rate(SDR),and advanced adenoma detection rate(AADR) are easily calculated to use this ***: In our gastroenterology center,the PDR,ADR,SDR,and AADR test results from each gastroenterologist were updated,every month. Between june 2014,when the program was started,and December 2014,the overall PDR and ADR in our center were 62.5% and 41.4%,respectively. And the overall SDR and AADR were 7.5% and 12.1%,***: We envision that KG quality reporting system can be applied to develop a comprehensive system to check colon polyp detection rates in other gastroenterology centers.

关键词： Colon polyp Detection rate Reporting system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship between petroleum hydrocarbon and plankton in a mesocosm experiment

引用

Acta Oceanologica Sinica 2001年第2期20卷 231-240页

作者： Shi Xiaoyong, Wang Xiulin, Han Xiurong, Jiang Yu Zhu Mingyuan, Chen Shang, Koshikawa Hiroshi (1. Ocean University of Qingdao, Qingdao 266003, China 2. First Institute of Oceanology, Qingdao 266061, China 3. National Institute for Environmental Studies, ja Ocean University of Qingdao Qingdao 266003 China

A mesocosm experiment was carried out from May 26 to june 1, 1998 at the location of 30'52'N, 122'36'E, the Changjiang Estuary, in order to measure the influence of petroleum hydrocar- bon to the ecosystem, furthermore, to estimate the environmental capacity. In the experiment, it is found that the petroleum hydrocarbon can, in some degree, enhance the growth of diatom, but inhibit the growth of dinoflagellate. In general, the petroleum hydrocarbon can inhibit the growth of both Phytoplankton and zooplankton, and can the inhibit the growth of total plankton (including phytoplankton and zooplankton) as well. A kinetic model was presented to estimate the uptake/release rate constants of petroleum hydrocarbon by plankton, and thereafter, the uptake and release rate constants (k1, k2), bioconcentration factor (BCF) as well as the petroleum bydrocarbon influenced influenced uptake and release rate constants of nutrients by phytoplankton (kup, krel) were obtained. The results imply that the bioconcentration of petroleum hydrocarbon by plankton is fairly large and petroleum hydrocarbon caused no significant influence on the uptake of N- NO3, but significant influence on that of P -PO4. In addition, the application of kinetic model for the bioconcentration of volatile organic toxic compound by organism suggests that the uptake of petroleum hydrocarbon by plankton was an important process for the environmental capacity of petroleum hydrocarbon.

关键词： Masochism petroleum hydrocarbon plankton nutrients kinetic model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bevacizumab as a second- or later-line of treatment for metastatic colorectal cancer

引用

World Journal of Gastroenterology 2012年第10期18卷 1104-1109页

作者： Lee Chun Park Ho Sup Lee Seong Hoon Shin Seun ja Park Moo In Park Sung Yong Oh Hyuk Chan Kwon Jin ho Baek Young Jin Choi Myoung Joo Kang Yang Soo Kim Department of Internal Medicine Kosin University College of Medicine Busan 602-703 South Korea Department of Internal Medicine Dong-A University Hospital Busan 602-715 South Korea Jin ho Baek Department of Internal Medicine Ulsan University Hospital Ulsan 682-714 South Korea Department of Internal Medicine Busan National University Hospital Busan 626-770 South Korea Department of Internal Medicine Busan Paik Hospital Busan 614-735 South Korea

AIM: To determine the efficacy of bevacizumab in patients with metastatic colorectal cancer (MCRC) who have failed prior chemotherapy without bevacizumab. METHODS: Between March 2002 and june 2010, 40 patients in South Korea with MCRC who were treated with bevacizumab plus chemotherapy as a second or later-line treatment were analyzed retrospectively for their overall response rate (ORR), overall survival (OS), and progression-free survival (PFS). The tumor responses were assessed using the RECIST (Response Evaluation Criteria in Solid Tumors) guidelines. RESULTS: All of the patients had progressed under prior chemotherapy without bevacizumab. Three patients (7.5%) exhibited an ORR, twenty one patients (52.5%) exhibited stable disease (SD), and fifteen patients (37.5%) exhibited disease progression. The median duration of the OS and PFS were 14.0 and 6.13 mo respectively. The median OSs were 16.60, 14.07 and 13.00 mo for second-line, third-line and fourth- or later-line treatments, respectively. The median PFSs were 7.23, 7.30 and 3.87 mo for the second-line, third-line and fourth- or later-line treatments, respectively. CONCLUSION: In patients with MCRC, bevacizumab combined chemotherapy may be beneficial during second- or later-line treatment.

关键词： Colorectal cancer Metastasis Bevacizumab Efficacy Second- or later-line

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

养殖鲥鱼性腺发育的年周期变化

引用

水产学报 1999年第S1期 15-21页

作者：王汉平魏开金姚红麦家柏林加敬熊邦喜中国水产科学研究院长江水产研究所!荆州434000 东莞市水产养殖良种试验场!511768 华中农业大学水产学院!武汉430070

养殖鲥鱼经生态和激素调控，大多数在４、５龄性腺发育成熟，雌鱼最小成熟为４龄，雄鱼为３龄。秋季，完成第一次性成熟并产卵的鲥鱼，卵巢逐步由第Ⅵ期退化至第Ⅱ期。冬季卵巢中老一代卵母细胞基本退化吸收完毕，新生的卵母细胞均处于... 详细信息

养殖鲥鱼经生态和激素调控，大多数在４、５龄性腺发育成熟，雌鱼最小成熟为４龄，雄鱼为３龄。秋季，完成第一次性成熟并产卵的鲥鱼，卵巢逐步由第Ⅵ期退化至第Ⅱ期。冬季卵巢中老一代卵母细胞基本退化吸收完毕，新生的卵母细胞均处于原生质生长期，卵巢处于第Ⅱ期。春季的２－３月，体内开始积累脂肪。后期，新生的卵母细胞开始积累卵黄，４月卵巢处于 Ⅱ－Ⅲ期。夏季卵巢发育迅速，５月份进入第Ⅳ期初，７月中旬大部分卵巢发育至Ⅳ期末甚至Ⅴ期，６月全部达到第Ⅴ期。而精巢６－７月初已全部为第Ⅴ期。因此，精卵巢的发育在繁殖前存在不同步现象。

关键词：鲥鱼性腺发育周期变化

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

伴铅中毒注意缺陷多动障碍患儿神经心理及行为特征

引用

中国组织工程研究与临床康复 2007年第17期11卷 3313-3315页

作者：刘建安静进俞红梁小红刘勇陈学彬中山大学公共卫生学院妇幼卫生系广东省广州市510089 佛山市妇幼保健院儿保科广东省佛山市528000 珠海市妇幼保健院儿保科广东省珠海市519000 中山市博爱医院儿科广东省中山市528403

目的:了解伴铅中毒注意缺陷多动障碍患儿的认知和行为特点。方法:研究对象为2002-09/2005-06在佛山、珠海市妇幼保健院和中山市博爱医院儿童心理科确诊的注意缺陷多动障碍儿童102例。根据患儿血铅水平及儿童铅中毒的诊断标准,分为非铅... 详细信息

目的:了解伴铅中毒注意缺陷多动障碍患儿的认知和行为特点。方法:研究对象为2002-09/2005-06在佛山、珠海市妇幼保健院和中山市博爱医院儿童心理科确诊的注意缺陷多动障碍儿童102例。根据患儿血铅水平及儿童铅中毒的诊断标准,分为非铅中毒注意缺陷多动障碍组(简称单纯组)52例和铅中毒注意缺陷多动障碍组(简称合并组)50例。采用韦氏儿童智力量表、韦氏记忆量表、数字划销测验、节律测验、连线测验(甲式)、威斯康星卡片分类测验及Achenbach教师报告量表,对两组患儿的智力、记忆力、注意力、计划功能和学业行为情况进行测评。结果:102例患儿均进入结果分析。①在韦氏儿童智力量表和韦氏记忆量表测试中,合并组患儿全量表智商、注意/不分心及长时记忆分显著低于单纯组(97±10,101±9;96±10,101±10;38±9,42±7,P<0.05)。②在数字划销、节律、连线测试中,合并组患儿数字划消净分显著低于单纯组(158.21±32.92,182.12±45.09);而连线测试得分合并组显著高于单纯组(33.08±15.02,27.19±11.02,P<0.05),而在威斯康星卡片分类测验分类测试中,合并组患儿持续性错误数则显著高于单纯组(21.82±11.18,14.85±8.06,P<0.05)。③在Achenbach教师报告量表评定中,合并组患儿学业情况显著差于单纯组(2.11±1.01,2.52±0.92,P<0.05),同时,注意问题、违纪问题、攻击性行为及外化性行为、行为问题总分则显著高于单纯组(10.02±3.01,8.29±2.91;7.21±3.11,6.01±2.59;13.82±5.88,10.62±6.11;19.69±8.84,16.08±8.14;55.14±20.98,46.09±21.29,P<0.05)。④相关分析表明:血铅水平与注意问题和攻击性行为得分显著正相关(r=0.201,0.181,P<0.05)。结论:伴铅中毒注意缺陷多动障碍患儿的认知和行为受损更广泛和严重。

关键词：注意力缺陷障碍伴多动铅中毒认知行为

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

转录因子T-bet与哮喘大鼠气道炎症及川芎嗪的干预效应

引用

中国组织工程研究与临床康复 2007年第49期11卷 9868-9872页

作者：吉宁飞卞涛王建安潘晓东周辰殷凯生江苏省老年医院干部保健科江苏省南京市210024 南京医科大学第一附属医院呼吸科江苏省南京市210029

目的:转录因子T-bet在支气管哮喘的发病中起重要作用,川芎嗪治疗哮喘有效。实验拟观察川芎嗪对哮喘大鼠气道炎症的影响和转录因子T-bet的调控作用。方法:实验于2005-11/2006-06在南京医科大学完成。①实验材料及分组:72只SPF级SD大鼠随... 详细信息

目的:转录因子T-bet在支气管哮喘的发病中起重要作用,川芎嗪治疗哮喘有效。实验拟观察川芎嗪对哮喘大鼠气道炎症的影响和转录因子T-bet的调控作用。方法:实验于2005-11/2006-06在南京医科大学完成。①实验材料及分组:72只SPF级SD大鼠随机分为正常对照组、哮喘模型组、川芎嗪小剂量组(20mg/kg)、川芎嗪中剂量组(40mg/kg)、川芎嗪大剂量组(80mg/kg)和地塞米松组,每组12只。实验用磷酸川芎嗪注射液为丽珠集团利民制药厂生产)。②实验过程及评估:以卵蛋白腹腔注射并雾化吸入制备大鼠哮喘模型,末次雾化后24h内麻醉后处死大鼠。观察6组大鼠肺组织形态学变化;测定支气管壁厚度、支气管平滑肌厚度、嗜酸粒细胞和淋巴细胞数。采用免疫组织化学半定量法测定肺组织T-bet蛋白的表达;进行转录因子T-bet蛋白表达量与气道炎症的相关性分析。实验过程中对动物处置符合动物伦理学标准。结果:①哮喘模型组嗜酸粒细胞、淋巴细胞、支气管壁厚度和支气管平滑肌厚度,明显高于正常对照组相应指标(P均<0.01);与哮喘模型组比较,川芎嗪小、中、大剂量组和地塞米松组上述4项指标均减少(P均<0.01)。②哮喘模型组、川芎嗪小、中、大剂量组和地塞米松组的T-bet表达量低于正常对照组(P均<0.01);与哮喘模型组比较,川芎嗪小、中、大剂量组T-bet表达量增加(P均<0.01);随着川芎嗪剂量增加,T-bet表达量亦相应增加,川芎嗪小、中、大剂量组之间两两比较,差异均有统计学意义(P均<0.01)。③相关分析显示哮喘模型组T-bet蛋白表达量与嗜酸性粒细胞和淋巴细胞浸润数呈负相关(r=-0.81,-0.85,P<0.01),与支气管管壁厚度和支气管平滑肌厚度呈负相关(r=-0.77,-0.79,P<0.01)。结论:支气管哮喘大鼠存在T-bet低表达;川芎嗪可抑制气道炎症,增加转录因子T-bet蛋白的表达,纠正Th1/Th2失衡,从而治疗支气管哮喘。

关键词：川芎嗪哮喘炎症转录因子组织构建

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy of Pegylated Interferon Monotherapy versus Sequential Therapy of Entecavir and Pegylated Interferon in Hepatitis B e Antigen-Positive Hepatitis B Patients： A Randomized, Multicenter, Phase IIIb Open-Label Study （POTENT Study）

引用

Chinese Medical Journal 2018年第14期131卷 1645-1651页

作者： Dae Won Jun Sang Bong Ahn Tae Yeob Kim Joo Hyun Sohn Sang Gyune Kim Se Whan Lee Byung Ho Kim Dong Joon Kim ja Kyung Kim Hyoung Su Kim Seong Gyu Hwang Won Choong Choi Won Young Tak Heon Ju Lee Ki Tae Yoon Byung Cheol Yun Sung Wook Lee Soon Koo Baik Seung Ha Park Ji Won Park Sol Ji Park Ji Sung Lee Department of Internal Medicine Hanyang University Seoul Hospital Hanyang University Seou104763 Korea Department of Internal Medicine Nowon Eulji Hospital Eulji University Seou101830 Korea Department of Internal Medicine Hanyang University Guri Hospital Hanyang University Guri 11923 Korea Department of Internal Medicine SoonChunHyang University Bucheon Hospital SoonChunHyang University Bucheon 14584 Korea Department of Internal Medicine SoonChunHyang University Cheonan Hospital SoonChunHyang University Cheonan 31151 Korea Department of Internal Medicine Kyung Hee University Hospital Kyung Hee University Seoul 02453 Korea Department of Internal Medicine Chuncheon Sacred Heart Hospital Hallym University Chuncheon 24252 Korea Department of Internal Medicine Kangdong Sacred Heart Hospital Hallym University Seou105355 Korea Department of Internal Medicine Gangnam Severance Hospital Yonsei University Seou106273 Korea Department of Internal Medicine CHA Bundang Medical Center CHA University Seongnam 13496 Korea Department of Internal Medicine Sanggye Paik Hospital Inje University Seoul 01757 Korea Department of Internal Medicine Kyungpook National University Hospital Kyungpook National University Daegu 41944 Korea Department of Internal Medicine Yeungnam University Medical Center Yeungnam University Daegu 42415 Korea Department of Internal Medicine Pusan National University Yangsan Hospital Pusan National University Yangsan 50612 Korea Department of Internal Medicine Kosin University Gospel Hospital Kosin University Pusan 49267 Korea Department of Internal Medicine Dong A University Medical Center Dong A University Pusan 49201 Korea Department of Internal Medicine Wonju Severance Christian Hospital Yonsei University Wonju 26426 Korea Department of Internal Medicine Haeundae Paik Hospital Inje University Pusan 48108 Korea Department of Internal Medicine Hallym University Sacred Heart Hospital Hallym University Anyang 14068 Korea Department of Cli

Background： Until now, various types of combined therapy with nucleotide analogs and pegylated interferon （Peg-INF） in patients with hepatitis B patients have been tried. Howe6ver, studies regarding the benefits of de novo combination, late-add on, and sequential treatmentare very limited. The objective of the current study was to identify the efficacy of sequential treatment of Peg-INF after short-term antiviral treatment. Methods： Between june 2010 and june 2015, hepatitis 13 e antigen （HBeAg）-positive patients （n = 162） received Peg-IFN for 48 weeks （mono-treatment group, n = 81） and entecavir （ETV） for 12 weeks with a 48-week course of Peg-IFN starting at week 5 of ETV therapy （sequential treatment group, n = 81）. The primary endpoint was HBeAg seroconversion at the end of follow-up period after the 24-week treatment. The primary endpoint was analyzed using Chi-square test, Fisher＇s exact test, and regression ***： HBeAg seroconversion rate （18.2% vs. 18.2%, t = 0.03, P = 1.000） and seroclearance rate （19.7% vs. 19.7%, t = 0.03, P = 1.000） were same in both mono-treatment and sequential treatment groups. The rate of alanine aminotransferase （ALT） normalization （45.5% vs. 54.5%, t = 1.12, P = 0.296） and serum hepatitis B virus （HBV）-DNA 〈2000 U/L （28.8% vs. 28.8%, t = 0.10, P = 1.000） was not different in sequential and mono-treatment groups at 24 weeks of Peg-INF. Viral response rate （HBeAg seroconversion and serum HBV-DNA 〈2000 U/L） was not different in the two groups （12.1% vs. 16.7%, t = 1.83, P = 0.457）. Baseline HBV-DNA level （7 log10 U/ml vs. 7.5 log10 U/ml, t = 1.70, P = 0.019） and hepatitis B surface antigen titer （3.6 log10 U/ml vs. 4.0 log10 U/ml, t = 2.19, P = 0.020） were lower and predictors of responder in mono-treatment and sequential treatment groups, respectively. Conclusions： The current study shows no differences in HBeAg seroconversion rate, ALT normalization, and HBV-DNA levels between mono-therapy and sequential therapy regimens.

关键词： Entecavir Hepatitis B Peginterferon Alfa-2a

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

体素内不相干运动扩散加权成像参数对肝脏肿瘤性质的鉴别诊断效果

引用

中国肿瘤临床与康复 2017年第5期24卷 549-552页

作者：韩秉艳邓佳敏贾文宵王皓谢超王云玲新疆医科大学第二附属医院影像科乌鲁木齐830028

目的分析体素内不相干运动扩散加权成像(IVIM-DWI)参数对肝脏肿瘤性质的鉴别诊断效果。方法选取2014年6月至2016年11月间新疆医科大学第二附属医院收治的68例肝脏肿瘤患者,均行常规磁共振成像平扫,磁共振THRIVE动态增强扫描及多b值(b=0... 详细信息

目的分析体素内不相干运动扩散加权成像(IVIM-DWI)参数对肝脏肿瘤性质的鉴别诊断效果。方法选取2014年6月至2016年11月间新疆医科大学第二附属医院收治的68例肝脏肿瘤患者,均行常规磁共振成像平扫,磁共振THRIVE动态增强扫描及多b值(b=0、50、100、200、400、600、800、1000和1200s/mm2)扫描,DWI采用双指数模型获得慢速扩散系数(D)、快速扩散系数(D*)和快速扩散成分的百分比(f)。对不同肿瘤性质病人的D和D*值进行分析比较。结果良性肝脏肿瘤患者D值为(1.71±0.61)×10^(-3)mm^2/s,D*值为(22.1±18.6)×10^(-3)mm^2/s,f值为(34.1±23.8)×10^(-3)mm^2/s;恶性肿瘤患者D值为(1.05±0.41)×10^(-3)mm^2/s,D*值为(16.7±15.1)×10^(-3)mm^2/s,f值为(24.1±15.4)×10^(-3)mm^2/s。两组f值无明显差异,D值和D*值比较,差异均有统计学意义(均P<0.05)。参数D的曲线下面积、特异性、敏感性以及准确性均高于D*,差异均有统计学意义(均P<0.05)。结论 IVIM-DWI参数D和D*值能够有效提高肝脏肿瘤性质的鉴别诊断效果,为定性诊断提供可靠依据,其中,D值有助于更好的区分肿瘤性质。

关键词：体素内不相干运动扩散加权成像肝脏肿瘤诊断效果

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

骨髓红系比例≥50%的骨髓增生异常综合征患者临床特征及预后分析

引用

中华血液学杂志 2024年第7期45卷 651-659页

作者：曾燕平李冰秦铁军徐泽锋曲士强潘丽娟高清妍焦蒙吴君颖王慧君李承文贾玉娇孙琦肖志坚中国医学科学院血液病医院(中国医学科学院血液学研究所) 实验血液学国家重点实验室国家血液系统疾病临床医学研究中心细胞生态海河实验室天津300020 天津医学健康研究院天津301600

目的分析骨髓红系比例≥50%的骨髓增生异常综合征(MDS-E)患者临床和实验室特征及预后。方法收集2014年5月至2023年6月于中国医学科学院血液病医院确诊的1 436例MDS初治患者病例资料, 回顾性分析MDS-E患者临床特征、分子学等实验室特征... 详细信息

目的分析骨髓红系比例≥50%的骨髓增生异常综合征(MDS-E)患者临床和实验室特征及预后。方法收集2014年5月至2023年6月于中国医学科学院血液病医院确诊的1 436例MDS初治患者病例资料, 回顾性分析MDS-E患者临床特征、分子学等实验室特征以及总生存(OS)情况。结果①MDS-E患者共337例(23.5%), 与骨髓红系比例<50%的MDS(MDS-NE)患者相比, 发病年龄、ANC、PLT更低(P值均<0.05)。MDS-E中诊断伴环状铁粒幼红细胞增多的MDS(MDS-RS)患者比例更高, 多打击TP53基因突变检出率更高(P值均<0.05)。②在MDS-RS患者中, 与MDS-NE相比, MDS-E组复杂染色体核型比例显著减低(0对11.9%, P=0.048), TP53基因突变检出率更低(2.4%对15.1%, P=0.053)。③在TP53突变的MDS患者中, MDS-E患者复杂染色体核型比例(87.5%对63.3%, P=0.002)及多打击TP53突变检出率(84.0%对53.4%, P<0.001)均显著高于MDS-NE患者。④在MDS-RS患者中, MDS-E组的中位OS时间较MDS-NE组更长[未达到对63(95%CI 53~73)个月, P=0.029]。在TP53突变且原始细胞增多的MDS患者中, MDS-E组中位OS时间较MDS-NE组更短[6(95%CI 2~10)个月对12(95%CI 9~15)个月, P=0.022]。⑤多因素分析示, 年龄≥65岁(HR=2.47, 95%CI 1.43~4.26, P=0.001)、MCV≤100 fl(HR=2.62, 95%CI 1.54~4.47, P<0.001)、TP53突变(HR=2.31, 95%CI 1.29~4.12, P=0.005)是MDS-E患者独立于修订的国际预后积分系统(IPSS-R)预后分层的不良预后因素。结论 MDS-RS患者中, MDS-E与更低的复杂染色体核型占比及TP53突变检出率相关, MDS-E组OS时间显著延长。TP53突变的MDS患者中, MDS-E与更高的复杂染色体核型占比和多打击TP53突变检出率相关, 原始细胞增多伴TP53突变的患者中, MDS-E组OS时间显著缩短。年龄≥65岁、MCV≤100 fl及TP53突变是影响MDS-E患者生存的独立不良预后因素。

关键词：骨髓增生异常综合征红系细胞环状铁粒幼红细胞 TP53基因预后

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：