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Early prediction of myocardial viability after acute myocardial infarction by two-dimensional speckle tracking imaging

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Journal of Geriatric Cardiology 2015年第5期12卷 474-481页

作者： Jong Shin Woo Tae-kyung Yu Woo-Shik kim Kwon Sam kim Weon kim Division of Cardiology Department of lnternal Medicine Kyung Hee University Hospital Kyung Hee University Seoul South Korea

Background Identifying the transmural extent of myocardial necrosis and the degree of myocardial viability in acute myocardial infarction （AMI） is important clinically. The aim of this study was to assess myocardial viability using two-dimensional speckle tracking imaging （2D-STI） in patients with AMI. Methods 2D-STI was performed at initial presentation, three days, and six months after primary percutaneous coronary intervention （PCI） in 30 patients with AMI, who had a left anterior descending coronary artery （LAD） culprit lesion. In addition, 20 patients who had minimal stenotic lesions （〈 30% stenosis） on coronary angiography were also included in the control group. At six months dobutamine echocardiography was performed for viability assessment in seven segments of the LAD territory. According to the recovery of wall motion abnormality, segments were classified as viable or non-viable. Results A total of 131 segments were viable, and 44 were nonviable. Multivariate analysis revealed significant differences between the viable and nonviable segments in the peak systolic strain, the peak systolic strain rate at initial presentation, and peak systolic strain rate three days after primary PCI. Among these, the initial peak systolic strain rate had the highest predictive value for myocardial viability （hazard ratio： 31.22, P 〈 0.01）. Conclusions 2D-STI is feasible for assessing myocardial viability, and the peak systolic strain rate might be the most reliable predictor of myocardial viability in patients with AMI.

关键词： Acute myocardial infarction Two-dimensional speckle tracking imaging Viable myocardium

Characteristics of pupillo-accommodative functions according to time of onset,gender and age in tonic pupil

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 659-661页

作者： kyung-Min Koh Ungsoo Samuel kim Department of Ophthalmology Kim's Eye Hospital Department of Ophthalmology Konyang University College of Medicine

AIMTo evaluate the characteristics of pupillo-accommodative functions in patients with idiopathic tonic pupil according to the time of onset, gender, and age.

关键词： tonic pupil accommodation cholinergic supersensitivity

Treatment of intractable orbital implant exposure with a large conjunctival defect by secondary insertion of the implant after preceding dermis fat graft

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International Journal of Ophthalmology(English edition) 2013年第2期6卷 193-197页

作者： Hyun kyung kim Tae Yoon La Department of Ophthalmology St. Vincent's Hospital College of Medicine The Catholic University of Korea

AIM: To report a procedure and results of a two-stage operation to manage intractable extensive orbital implant exposure with a large conjunctival defect which was difficult to treat with dermis fat grafts due to repeated graft necrosis. METHODS: A retrospective chart review of four patients who had extensive orbital implant exposures with large conjunctival defects and had past histories of repeated autologous or preserved dermis graft failures was done. As a first-stage operation, the problematic pre-existing orbital implants were removed and autologous dermis fat grafts alone were performed on the defect area. Four months later, new orbital implants were secondarily inserted after confirmation of graft survival. The size of the conjunctival defects and state of the extraocular muscles were checked preoperatively. Success of the operations and complications were ***: The mean size of the conjuctival defects was 17.3mm×16.0mm, and the mean time from the initial diagnosis of orbital implant exposure to implant removal and autologous dermis fat graft was 20.8 months. After implant removal and autologous dermis fat graft, no graft necrosis was observed in any patients. Also, implant exposure or fornix shortening was not observed in any patients after new orbital implant insertion. CONCLUSION: The secondary insertion of a new orbital implant after pre-existing implant removal and preceding dermis fat graft is thought to be an another selective management of intractable orbital implant exposure in which dermis fat grafts persistently fail.

关键词： conjunctival defect dermis fat graft orbital implant exposure

Rational strategy for power doubling of monolithic multijunction III-V photovoltaics by accommodating attachable scattering waveguides

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Light(Science & Applications) 2024年第11期13卷 2734-2744页

作者： Shin Hyung Lee Hyo Jin kim jae-Hyun kim Gwang Yeol Park Sun-kyung kim Sung-Min Lee School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Optoelectronic Convergence Research Center Korea Photonics Technology InstituteGwangju 61007Republic of Korea Department of Applied Physics Kyung Hee UniversityYongin 17104Republic of Korea Department of Electrical Engineering Hanyang UniversitySeoul 04763Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea

While waveguide-based light concentrators offer significant advantages,their application has not been considered an interesting option for assisting multijunction or other two-terminal tandem solar *** this study,we present a simple yet effective approach to enhancing the output power of transfer-printed multijunction InGaP/GaAs solar *** utilizing a simply combinable waveguide concentrator featuring a coplanar waveguide with BaSO4 Mie scattering elements,we enable the simultaneous absorption of directly illuminated solar flux and indirectly waveguided *** deployment of cells is optimized for front-surface photon collection in monofacial *** systematic comparisons across various waveguide parameters,supported by both experimental and theoretical quantifications,we demonstrate a remarkable improvement in the maximum output power of a 26%-efficient cell,achieving an enhancement of~93%with the integration of the optimal scattering ***,a series of supplementary tests are conducted to explore the effective waveguide size,validate enhancements in arrayed cell module performance,and assess the drawbacks associated with rear *** findings provide a comprehensive understanding of our proposed approach towards advancing multi-junction photovoltaics.

关键词： waveguide scattering power

Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma

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World Journal of Gastroenterology 2012年第6期18卷 557-562页

作者： Hyung Hun kim You Sun kim Yun kyung Kang Jeong Seop Moon Department of Internal Medicine Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea Department of Pathology Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea Hyung Hun Kim Department of Internal Medicine Kosin University College of MedicineBusan 602-702South Korea

AIM： To investigate the expressions of leptin and per- oxisome proliferator-activated receptor y （PPARG） in relation to body mass index （BMI）. METHODS： We evaluated leptin and PPARG expres- sion in 30 adenomas over 1 cm in size by immunohisto- chemical staining. In addition, clinicopathologic features including BMI were assessed. RESULTS： PPARG and leptin expression showed a strong positive correlation （P = 0.035）. The average BMI of the leptin-positive group was higher than that of the leptin-negative group （25.4 ＋ 3.4 kg/m2 vs 22.6 ＋ 2.4 kg/m2, P = 0.018）, and leptin expression was sig- nificantly correlated with high BMI （P = 0.024）. Leptinexpression was more frequently observed in intermedi- ate/high grade dysplasia than in low grade dysplasia （P = 0.030）. However, PPARG expression was not cor- related with BMI and grade of dysplasia. CONCLUSION： BMI has influenced on the leptin ex- pression of colorectal adenoma. The exact mechanism underlies the strong correlation between leptin and PPARG expression needs further study.

关键词： Leptin Peroxisome proliferator-activated re-ceptor y Obesity Body mass index Colorectal adenoma

Identification of phytohormone changes and its related genes under abiotic stresses in transgenic rice

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BIOCELL 2019年第3期43卷 215-224页

作者： MOHAMMAD UBAIDILLAH MISWAR FAPERTA kyung-MIN kim School of Applied Biosciences College of Agriculture&Life ScienceKyungpook National UniversityDaegu41566Korea Department of Agronomy Faculty of AgricultureJember UniversityJl.Kalimantan 37Jember68121Indonesia

Abiotic stresses,such as drought and salinity,adversely affect plant growth and *** between non transgenic and transgenic rice harboring CaMsrB2 gene,which induces tolerance to abiotic stress,is important to observe response of gene under abiotic *** showed a tendency to increase under the drought stress or salinity stress in the transgenic ***-PCR analysis showed that gene expression and phytohormone levels under abiotic stress,to be closely *** CaMsrB2 gene is related to the expression of ja and ABA ***,the level of expression of these genes and hormones was *** transcription levels of LOX2 and OsWRKY45 were substantially higher in the wild type rice in comparison to the transformants,which suggested that phytohormone are also required for the regulation of leaf and *** between control and transgenic rice overexpressing a CaMsrB2 gene,resulted in different pattern of ABA,ja levels under different stress *** both drought and salinity stresses,the expression of OsWRKY45 gene was similar in both treatments with *** results suggest that gene involved in the plant physiology response in mechanism to abiotic stress.

关键词： Abiotic stress CaMsrB2 Drought Rice Salinity

Analysis of opto-thermal interaction of porcine stomach tissue with 808-nm laser for endoscopic submucosal dissection

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Journal of Innovative Optical Health Sciences 2015年第6期8卷 81-91页

作者： Seongjun kim M.Tamim Hossain Don Haeng Lee Jung kyung kim Department of Mechanical Engineering Graduate School Kookmin University Seoul 136-702Republic of Korea Department of Integrative Biomedical Science and Engineering Graduate SchoolKookmin University Seoul 136-702Republic of Korea Division of Gastroenterology Department of Internal Medicine Inha University School of Medicine National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorders Utah-Inha DDS&Advanced Therapeutics Research Center 27 Inhang-ro Jung-guIncheon 400-711Republic of Korea Department of Mechanical Engineering Kookmin University Seoul 136-702 Republic of Korea

In endoscopic submucosal dissection(ESD),the narrow gastrointestinal space can cause difficulty in surgical *** ablation apparatuses with high-power CO_(2) lasers or Nd:YAG lasers have been developed to facilitate endoscopic surgical *** studied the interaction of 808-nm laser light with a porcine stomach tissue,with the aim of developing a therapeutic medical device that can remove lesions at the gastrointestinal wall by irradiating a near-infrared laser light incorporated in an endoscopic *** perforation depths at the porcine fillet and the stomach tissues linearly increased in the range of 2–8mm in proportion to the laser energy density of 63.7–382 kJ/cm^(2).Despite the distinct structural and compositional di®erence,the variation of the perforation depth between the stomach and the fillet was not found at 808-nm wavelength in our *** further studied the laser–tissue interaction by changing the concentration of the methyl blue solution used conventionally as a submucosal fluidic cushion(SFC)in ESD *** temperature of the mucosal layer increased more rapidly at higher concentration of the methyl blue solution,because of enhanced light absorption at the SFC *** insertion of the SFC would protect the muscle layer from thermal *** confirmed that more effective laser treatment should be enabled by tuning the opto-thermal properties of the *** study can contribute to the optimization of the driving parameters for laser incision techniques as an alternative to conventional surgical interventions.

关键词： Near-infrared laser surgical intervention laser-tissue interaction submucosal fluid cushion temperature distribution

Numerical modeling of sedimentation control scenarios in the approach channel of the Nakdong River Estuary Barrage,South Korea

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International Journal of Sediment Research 2016年第3期31卷 257-263页

作者： Un Ji Eun-kyung jang Gwonhan kim Hydro Science and Engineering Research Institute Korea Institute of Civil Engineering and Building Technology

The effects of sedimentation reduction at the Nakdong River Estuary Barrage(NREB) in Korea were quantitatively analyzed with respect to different sediment control methods using the calibrated and validated two-dimensional *** countermeasures of sediment dredging,sediment flushing,channel geometry change,and a combination of flushing and channel geometry change were examined for the approach channel of the *** flood event and channel geometries of the 3.8 km section upstream of the NREB surveyed before and after dredging in 2007 were used for modeling *** a result,the half of sediments dredged in 2007 could be eliminated naturally by floods without *** numerical simulation of sediment flushing indicated that the deposition height decreased in the entire simulation section with the minimum and maximum reductions from 0.3 in to1.3 m in deposition *** channel contraction method produced quantitatively the largest amount of sedimentation reduction and sediment flushing and dredging *** reduction by a combination of flushing and channel contraction was up 10%compared to the individual method of channel contraction.

关键词： Channel contraction Nakdong River Estuary Barrage Sediment dredging Sediment flushing Sedimentation reduction

Efficacy and safety of newly developed preservative-free latanoprost 0.005% eye drops versus preserved latanoprost 0.005% in open angle glaucoma and ocular hypertension: 12-week results of a randomized,multicenter, controlled phase Ⅲ trial

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1539-1547页

作者： Joon Mo kim kyung Rim Sung Ji Woong Lee Haksu kyung Seungsoo Rho Chan Yun kim Department of Ophthalmology Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 03181Republic of Korea Department of Ophthalmology Seoul Asan Medical CenterUlsan University College of MedicineSeoul 05505Republic of Korea Department of Ophthalmology Pusan National University HospitalPusan National University Medical SchoolBusan 49241Republic of Korea Department of Ophthalmology National Medical CenterSeoul 04564Republic of Korea Department of Ophthalmology CHA Bundang Medical CenterCHA UniversitySeongnam 13496Republic of Korea Department of Ophthalmology Severance HospitalYonsei University College of MedicineSeoul 03722Republic of Korea

AIM: To evaluate the therapeutic efficacy, safety and tolerability of newly developed preservative-free(PF) latanoprost generic [TJO-002] and compare it with benzalkonium chloride(BAK)-preserved latanoprost [Xalatan?] in patients with primary open angle glaucoma(POAG) and ocular hypertension(OHT).METHODS: Included patients were aged ≥19 y with POAG/OHT. After a washout period, patients with IOP 21-35 mm Hg at 9 a.m. were enrolled. After a full ophthalmic and glaucoma examination, 144 patients with POAG and OHT participated in this study. Subjects were randomly assigned either PF latanoprost(74 eyes) or BAK-preserved latanoprost(70 eyes). All subjects were examined at 4, 8, and 12 wk after first administration. At each follow-up visit,IOP was measured at 9 a.m. and 5 p.m. and compliance was assessed. Throughout the study, all adverse events were recorded and monitored by the masked investigators who measured ***: Both groups showed a statistically significant decrease of average diurnal IOP at 12 wk compared to baseline(-7.21±3.10 mm Hg in the PF latanoprost group and-7.02±3.17 mm Hg in the BAK latanoprost group, both P<0.0001). There was no statistically significant diurnal IOP variation between the groups. In terms of tolerability, pruritus, burning/stinging, and sticky eye sensation, severity was significantly lower in the PF latanoprost group than in the BAK latanoprost group(P<0.05). CONCLUSION: PF latanoprost has at least similar efficacy in terms of IOP reduction and better tolerability compared with BAK latanoprost.

关键词： latanoprost benzalkonium chloride intraocular pressure preservative-free