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Food intake regulation by leptin:Mechanisms mediating gluconeogenesis and energy expenditure

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Asian Pacific Journal of Tropical Medicine 2017年第10期10卷 940-944页

作者： Zulfia Hussain junaid ali Khan Institute of Pharmacy Physiology and PharmacologyUniversity of AgricultureFaisalabad38040Pakistan

Regulation of blood glucose levels and body fat is critical for *** circulates freely in blood and controls body weight and food intake mainly through hypothalamic receptors and regulates glucose metabolism in the liver both directly through leptin receptors and indirectly via the hypothalamic receptors of central nervous *** affects food intake regulation and eventually glucose metabolism, lipometabolism,endocrine and immune functions, reproductive function, adipose tissue metabolism and energy *** also exerts peripheral effects directly on glucose metabolism and *** of obese human subjects have elevated plasma levels of leptin associated to the size of their total adipose tissue *** gluconeogenic function may be an essential factor in the regulation of nutritional intake and weight *** aim of this review is therefore to identify and module the possible effects of leptin with special application in *** addition, this review includes the study of fat consumption and energy expenditure in the *** modulation of leptin receptors and adipose tissues functioning could have important inference on therapeutic strategies.

关键词： Leptin Adipocyte Glycogen breakdown Gluconeogenesis Homeostasis Energy expenditure

High-performance asymmetric supercapacitors based on reduced graphene oxide/polyaniline composite electrodes with sandwich-like structure

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Journal of Materials Science & Technology 2018年第7期34卷 1103-1109页

作者： Jun Ma Shaochun Tang junaid ali Syed Dongyun Su Xiangkang Meng Institute of Materials Engineering National Laboratory of Solid State Microstructures and College of Engineering and Applied Sciences Nanjing University School of Mechatronics & Traffic Engineering Nantong College of Science and Technology College of Mechanical Engineering Nantong Vocational University

The sandwich-like structure of reduced graphene oxide/polyaniline （RGO/PANI） hybrid electrode was prepared by electrochemical deposition. Both the voltage windows and electrolytes for electrochemical deposition of PANI and RGO were optimized. In the composites, PANI nanofibers were anchored on the surface of the RGO sheets, which avoids the re-stacking of neighboring sheets. The R（;O/PANI composite electrode shows a high specific capacitance of 466 F/g at 2 mA/cm2 than that of previously reported RGO/PANI composites. Asymmetric flexible supercapacitors applying RGO/PANI as positive electrode and carbon fiber cloth as negative electrode can be cycled reversibly in the high-voltage region of 0-1.6 V and displays intriguing performance with a maximum specific capacitance of 35.5 mF cm^-2. Also, it delivers a high energy density of 45.5 mW h cm^-2 at power density of 1250 mW cm^-2. Furthermore, the asymmetric device exhibits an excellent long cycle life with 97.6Z initial capacitance retention after 5000 cycles. Such composite electrode has a great potential for applications in flexible electronics, roll-up display, and wearable devices.2017 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science ＆ Technology.

关键词： Hybrid electrode Asymmetric supercapacitor Sandwich-like Electrochemical reduced graphene oxide

Stochastic Computational Approach for Complex Nonlinear Ordinary Differential Equations

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Chinese Physics Letters 2011年第2期28卷 20-23页

作者： junaid ali Khan Muhammad Asif Zahoor Raja Ijaz Mansoor Qureshi Department of Electronic Engineering International Islamic UniversityIslamabadPakistan Department of Electrical Engineering Air UniversityIslamabadPakistan

We present an evolutionary computational approach for the solution of nonlinear ordinary differential equations(NLODEs).The mathematical modeling is performed by a feed-forward artificial neural network that defines an unsupervised *** training of these networks is achieved by a hybrid intelligent algorithm,a combination of global search with genetic algorithm and local search by pattern search *** applicability of this approach ranges from single order NLODEs,to systems of coupled differential *** illustrate the method by solving a variety of model problems and present comparisons with solutions obtained by exact methods and classical numerical *** solution is provided on a continuous finite time interval unlike the other numerical techniques with comparable *** the advent of neuroprocessors and digital signal processors the method becomes particularly interesting due to the expected essential gains in the execution speed.

关键词： technique methods ordinary

Novel Approach for a van der Pol Oscillator in the Continuous Time Domain

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Chinese Physics Letters 2011年第11期28卷 16-19页

作者： junaid ali Khan Muhammad Asif Zahoor Raja Ijaz Mansoor Qureshi Department of Electronic Engineering International Islamic UniversityIslamabadPakistan

We investigate the continuous time domain numerical treatment of a van der Pol oscillator,applying the trial solution as an artificial feed-forward neural network model containing unknown adjustable *** optimization of the network is performed by simulated annealing in an unsupervised *** proposed scheme is tested successfully by its application in both non-stiff and stiff *** reliability and effectiveness is validated through comprehensive statistical *** obtained results are in good agreement with the classical RK45 method.

关键词： artificial neural stiff

Graphene Nanosheets Decorated with Copper Oxide Nanoparticles for the Photodegradation of Methylene Blue

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Chemical Research in Chinese Universities 2022年第6期38卷 1518-1525页

作者： Samavia RAFIQ Zulfiqar ali RAZA Muhammad ASLAM Muhammad junaid BAKHTIYAR Department of Applied Sciences National Textile UniversityFaisalabad37610Pakistan

Textile industries extensively use colorants,such as methylene blue,and if disposed off untreated,they contaminate the effluent streams,causing a severe impact on the environment and aquatic *** degradation has been found as an inevitable approach to treat ***,we decorated the copper oxide nanoparticles on graphene nanosheets during the reflux *** resultant copper oxide/graphene nanocomposites were analyzed for structural and functional *** was observed that on increasing the copper oxide contents,the z-average size of the resultant nanocomposites *** X-ray diffraction analysis demonstrated the crystalline nature of the *** surface morphology of the copper oxide nanoparticles appeared to be spherical and that of the copper oxide/graphene composite somehow *** infrared analysis indicated successful intercalation of precursors in the *** bandgap of copper oxide/graphene nanocomposites varied in the range of 1.03—1.30 eV,which indicated their effective photocatalytic *** results demonstrated that after 120 min of exposure,the methylene blue removal efficiency reached 94.0%,92.2%,and 89.4%(mass fraction)on the copper oxide/graphene nanocomposite at copper oxide nanoparticles to graphene nanosheets ratios of 1:1,1.5:1,and 2:1(mass ratio),*** photodegradation performance of the prepared nano-catalyst was found satisfactory even after five cycles.

关键词： Copper oxide Graphene nanosheet Methylene blue Photocatalysis

Modeling and Classification of Photovoltaic Hotspot Fault with Shaded and Un-Shaded Conditions Using Mamdani-type Fuzzy Inference

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Modeling and Classification of Photovoltaic Hotspot Fault wi...

作者： junaid ali KHAN 河北工业大学

学位级别：硕士

Photovoltaic power generation as the main content of the energy revolution has attracted more and more attention and research all over the *** detection techniques play a decisive role in reliability as well as boost the output power and overall performance of a photovoltaic system(PVS).Faults that are shading and hotspots can be found in the PV module(PVM).Shading faults can occur due to continuous changes in the irradiance level of a module,soiling,dust or other shadows can cause such ***(HS)occurs when a cell in a module considerably heats up instead of generating power,and starts consuming power from adjacent cells or dissipates power which further results in reducing optimum power and leading to cell cracking and other degradation *** fault can be further categorized as shaded and unshaded *** HS is an HS fault with shading PV cells while unshaded HS is due to the cell's internal defects such as low *** this work,the photovoltaic system explores techniques to enhance the overall performance of the PVS by detection and classification of *** faults can occur in a module of a PVS which can degrade the system's reliability as well as reduce the optimal *** mitigate these PV faults,investigation of detection and classification techniques is of significance.A hotspot and shading faults are sometimes confusing and are of significance in identifying these *** this thesis,an algorithm has been proposed to identify these *** confusion causes such as environments,shading,and HS are *** the main objection is to classify the HS faults under shaded and un-shaded *** Impacts of HS on the overall performance of a PV system are also *** this thesis,HS fault is categorized as shaded and un-shaded HS,and hotspot in both shaded and un-shaded conditions has been analyzed,and then a technique called Mamdani-type Fuzzy logic system for detection and classification of Shading and HS bot

关键词： Photovoltaic System Hot spot faults Shading faults Faults Detection and Classification Fuzzy logic system

Energy and Life Cycle Assessment of Zinc/Water Nanofluid Based Photovoltaic Thermal System

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Energy Engineering 2022年第2期119卷 827-846页

作者： junaid Khan Rashid ali Muzammil Zubair Syed Mohd Yahya SEARL Laboratory Department of Mechancial EngineeringAligarh Muslim UniversityAligarh202002India

Cooling the PV surface in a Photovoltaic Thermal system is a pivotal operational aspect to be taken into account to achieve optimized values of performance parameters in a Photovoltaic Thermal *** experimental design used in this study facilitates the flow of varying concentrations of Zn-water nanofluid in serpentine copper tubing installed at the rear of the PV panel thereby preventing the PV surface temperature from increasing beyond the threshold value at which a decrease in electrical efficiency starts to *** fusion of solar thermal with PV devices leads to better electrical and thermal efficiency values resulting in decreased cell degradation over time and maximization of the lifespan of the PV module and the energy output from the PV *** to the superior thermal heat properties of nanofluids,their usage in such systems has become increasingly *** cycle metrics which include Energy Payback period,Energy Production Factor and life cycle conversion efficiency were evaluated for the PVT system by exhaustively chalking fundamental parameters such as embodied energy of the PVT setup and the total energy output from the PVT *** research aims to be a major milestone in the evolutionary journey of Photovoltaic Thermal modules by guiding the engineers working on the theory,design and implementation of PVT systems towards its economic feasibility,environmental impact and energy sustainability.

关键词： Photovoltaic thermal system nanofluids performance parameters life cycle assessment

Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance

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Hepatobiliary & Pancreatic Diseases International 2017年第3期16卷 245-256页

作者： Hilal Ahmad Khan Muhammad Zishan Ahmad junaid ali Khan Muhammad Imran Arshad Institute of Microbiology University of Agriculture Faisalabad Pakistan Institute of Pharmacy Physiology and Pharmacology University of Agriculture Faisalabad Pakistan Department of Pathology The University of Faisalabad (TUF) Faisalabad Pakistan

BACKGROUND： Liver inflammation or hepatitis is a result of pluripotent interactions of cell death molecules, cytokines, chemokines and the resident immune cells collectively called as microenvironment. The interplay of these inflammatory mediators and switching of immune responses during hepatotoxic, viral, drug-induced and immune cell-mediated hepatitis decide the fate of liver pathology. The present review aimed to describe the mechanisms of liver injury, its relevance to human liver pathology and insights for the future therapeutic *** SOURCES： The data of mouse hepatic models and rele- vant human liver diseases presented in this review are system- atically collected from PubMed, ScienceDirect and the Web of Science databases published in English. RESULTS： The hepatotoxic liver injury in mice induced by the metabolites of CC14, acetaminophen or alcohol represent ne- crotic cell death with activation of cytochrome pathway, for- mation of reactive oxygen species （ROS） and mitochondrial damage. The Fas or TNF-a induced apoptotic liver injury was dependent on activation of caspases, release of cytochrome c and apoptosome formation. The ConA-hepatitis demonstrat- ed the involvement of TRAIL-dependent necrotic/necroptotic cell death with activation of RIPK1/3. The a-GalCer-induced liver injury was mediated by TNF-a. The LPS-induced hepatitis involved TNF-a, Fas/FasL, and perforin/granzyme cell death pathways. The MHV3 or Poly（I：C） induced liver injury was mediated by natural killer cells and TNF-a signaling. The necrotic ischemia-reperfusion liver injury was mediated by hypoxia, ROS, and pro-inflammatory cytokines; however, necroptotic cell death was found in partial hepatectomy. The crucial role of immune ceils and cell death mediators in viral hepatitis （HBV, HCV）, drug-induced liver injury, non-alcohol- ic fatty liver disease and alcoholic liver disease in human were discussed. CONCLUSIONS： The mouse animal models of hepatitis provide a parallel appro

关键词： liver immunobiology hepatitis therapy mode of cell death

Numerical evaluation of new Austrian tunneling method excavation sequences: A case study

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International Journal of Mining Science and Technology 2020年第3期30卷 381-386页

作者： Hafeezur Rehman Abdul Muntaqim Naji Wahid ali Muhammad junaid Rini Asnida Abdullah Han-kyu Yoo Department of Civil and Environmental Engineering Hanyang UniversityAnsan 15588South Korea Department of Mining Engineering Faculty of EngineeringBUITEMSQuetta 87300Pakistan Department of Geological Engineering Faculty of EngineeringBUITEMSQuetta 87300Pakistan Department of Geotechnics and Transportation Faculty of Civil EngineeringUniversiti Teknologi Malaysia81310 Johor BahruJohorMalaysia

The main aspects that require attention in tunnel design in terms of safety and economy are the precise estimation of probable ground conditions and ground behavior during construction. The variation in rock mass behavior due to tunnel excavation sequence plays an important role during the construction *** purpose of this research is to numerically evaluate the effect of excavation sequence on the ground behavior for the Lowari tunnel project, Pakistan. For the tunnel stability, the ground behavior observed during the actual partial face excavation sequence is compared with the top heading and bench excavation sequence. For this purpose, the intact rock parameters are used along with the characterization of rock mass joints related parameters to provide input for numerical modelling via FLAC 2D. The in-situ stresses for the numerical modelling are obtained using empirical equations. From the comparison of the two excavation sequences, it was observed that the actual excavation sequence used for Lowari tunnel construction utilized more support than the top heading and bench method. However, the actual excavation sequence provided good results in terms of stability.

关键词： Conventional excavation Excavation sequence Numerical modelling High in-situ stresses Jointed rock mass