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Exploring the vital role of microglial membrane receptors in Alzheimer’s disease pathogenesis: a comprehensive review

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BIOCELL 2024年第7期48卷 1011-1022页

作者： jun-feng zhao YI-RAN JIANG TIAN-LIN GUO YONG-QING JIAO XUN WANG Department of Neurointervention Center Dalian No.3 People’s HospitalDalian Medical UniversityDalianChina Department of Clinical Medicine China Medical UniversityShenyangChina

Neurodegenerative diseases constitute a broad category of diseases caused by the degeneration of the *** are mainly manifested by the gradual loss of neuron structure and function and eventually can cause death or loss of *** the global population ages rapidly,increased people are being diagnosed with neurodegenerative *** has been established that the onset of Alzheimer’s disease(AD)is closely linked with increasing age and its major pathological features include amyloid-beta plaques(Aβ),Tau hyperphosphorylation,Neuroﬁbrillary tangles(NFTs),neuronal death as well as synaptic *** involvement of microglia is crucial in the pathogenesis and progression of AD and exhibits a dual *** instance,in the early stage of AD,microglia surface membrane proteins or receptors can participate in immunophagocytosis,and anti-inﬂammatory functions and act as a physical barrier after recognizing various ligands such as Aβand ***,in the later stage of the disease,membrane receptors on the surface of microglia can cause its activation to release a substantial quantity of pro-inﬂammatory *** can amplify the neuroinﬂammatory *** rapid decline of normal immune phagocytosis can result in the continuous accumulation of abnormal proteins,leading to neuronal dysfunction and destruction of the formed physical barrier as well as the neurovascular *** can also increase the transformation of microglia from anti-inﬂammatory phenotype M2 to pro-inﬂammatory phenotype M1,induce severe neuronal injury or apoptosis,and aggravate the progression of *** to few articles have focused on the AD-related membrane protein receptors on microglia,thus in this paper,we have reviewed several representative microglial membrane proteins or receptors about their speciﬁc roles and functions implicated in AD,and expect that there will be more in-depth research and scientiﬁc research results in the treatment of AD by targeted regulation of mi

关键词： Neurodegeneration Glial cell Receptor Alzheimer’s disease

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Strategies and Methods for Cloud Migration

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International Journal of Automation and computing 2014年第2期11卷 143-152页

作者： jun-feng zhao Jian-Tao Zhou College of Computer Science Inner Mongolia University

Legacy system migration to the cloud brings both great challenges and benefits, so there exist various academic research and industrial applications on legacy system migration to the cloud. By analyzing the research achievements and application status,we divide the existing migration methods into three strategies according to the cloud service models integrally. Different processes need to be considered for different migration strategies, and different tasks will be involved accordingly. The similarities and differences between the migration strategies are discussed, and the challenges and future work about legacy system migration to the cloud are proposed. The aim of this paper is to provide an overall presentation for legacy system migration to the cloud and identify important challenges and future research directions.

关键词： Migration legacy system cloud infrastructure as a service(IaaS) platform as a service(PaaS) software as a service(SaaS).

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Analysis of wave propagation in micro/nanobeam-like structures: A size-dependent model

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Acta Mechanica Sinica 2012年第6期28卷 1659-1667页

作者： Bing-Lei Wang jun-feng zhao Shen-Jie Zhou Xi Chen Department of Engineering Mechanics Shandong University School of Mechanical Engineering Shandong University Department of Earth and Environmental Engineering Columbia University International Center for Applied Mechanics SV Lab School of Aerospace Xi'an Jiaotong University

By incorporating the strain gradient elasticity into the classical Bernoulli-Euler beam and Timoshenko beam models, the size-dependent characteristics of wave propaga- tion in micro/nanobeams is studied. The formulations of dis- persion relation are explicitly derived for both strain gradi- ent beam models, and presented for different material length scale parameters （MLSPs）. For both phenomenological size- dependent beam models, the angular frequency, phase veloc- ity and group velocity increase with increasing wave num- ber. However, the velocity ratios approach different values for different beam models, indicating an interesting behavior of the asymptotic velocity ratio. The present theory is also compared with the nonlocal continuum beam models.

关键词： Strain gradient elasticity theory ~ Bernoulli-Euler beam theory. Timoshenko beam theory Wave propa-gation

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Influence of shrinkage porosity on fatigue performance of iron castings and life estimation method

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China Foundry 2016年第1期13卷 47-53页

作者： Wei Liu Wei-hao Zhai jun-feng zhao School of Mechanics Civil Eng.&ArchitectureNorthwestern Polytechnical UniversityXi'an 710129China China Helicopter Research and Development Institute Jingdezhen 333000China

Shrinkage porosity exists more or less in heavy castings, and it plays an important role in the fatigue behavior of cast materials. In this study, fatigue tests were carried out on the QT400-18 cast iron specimens containing random degrees of shrinkage porosity defect. Experimental results showed that the order of magnitude of life scattered from 103 to 106 cycles when the shrinkage percentage ranged from 0.67% to 5.91%. SEM analyses were carried out on the shrinkage porosity region. The inter-granular discontinuous, micro cracks and inclusions interfered with the fatigue sliding or hindering process. The slip in shrinkage porosity region was not as orderly as the ordinary continuous medium. The shrinkage porosity area on fracture surface(SPAFS) and alternating stress intensity factor(ASIF) were applied to evaluate the tendency of residual life distribution; their relationship was fitted by negative exponent functions. Based on the intermediate variable of ASIF, a fatigue life prediction model of nodular cast iron containing shrinkage porosity defects was established. The modeling prediction was in agreement with the experimental results.

关键词： shrinkage porosity iron castings fatigue life alternating stress intensity factor equivalent initial crack

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Self-Triggered Set Stabilization of Boolean Control Networks and Its Applications

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1631-1642页

作者： Rong zhao jun-e feng Dawei Zhang the School of Mathematics Shandong UniversityShandong UniversityJinan 250100China

Set stabilization is one of the essential problems in engineering systems, and self-triggered control(STC) can save the storage space for interactive information, and can be successfully applied in networked control systems with limited communication resources. In this study, the set stabilization problem and STC design of Boolean control networks are investigated via the semi-tensor product technique. On the one hand, the largest control invariant subset is calculated in terms of the strongly connected components of the state transition graph, by which a graph-theoretical condition for set stabilization is derived. On the other hand, a characteristic function is exploited to determine the triggering mechanism and feasible controls. Based on this, the minimum-time and minimum-triggering open-loop, state-feedback and output-feedback STCs for set stabilization are designed,respectively. As classic applications of self-triggered set stabilization, self-triggered synchronization, self-triggered output tracking and self-triggered output regulation are discussed as well. Additionally, several practical examples are given to illustrate the effectiveness of theoretical results.

关键词： Boolean control networks(BCNs) output regulation self-triggered control semi-tensor product of matrices set stabilization synchronization

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Solidification behavior and elimination of undissolved Al_(2)CuMg phase during homogenization in Ce-modified Al–Zn–Mg–Cu alloy

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Rare Metals 2020年第11期39卷 1279-1287页

作者： Xin-Xiang Yu Jie Sun Zhu-Tie Li Han Dai Hong-Jie Fang jun-feng zhao Deng-feng Yin School of Engineering Yantai Nanshan UniversityYantai 265713China Testing and Analysis Center Shandong Nanshan Aluminum Co.Ltd.Yantai 264006China

The solidification behavior and intermetallic phase evolution during homogenization annealing of an Al-Zn-Mg-Cu alloy with 0.12 wt%Ce addition were *** residual Al_(2)CuMg phase is completely dissolved after homogenization and is replaced by a large number of dispersed micro/nanoscaled AlCuCe enrichment phases within Al *** change occurs because of the formation of a large number of finer lamellar eutectic network structures which are more easily dissolved into Al matrix during the homogenization *** addition,the trapping of Cu atoms in the stable AlCuCe phase also prevents the formation of Al_(2)CuMg phase,leading to the complete dissolution of Al_(2)CuMg phase in the Al-Zn-MgCu *** grain refinement behavior in Al alloy with Ce addition is similar to that in alloys with the addition of Sc,because of the formation of primary Ce-enriched Al_(11)Ce_(3)phase as the nucleation agent ofα(Al)during solidification.

关键词： Al–Zn–Mg–Cu alloy Al_(2)CuMg phase Homogenization Grain refinement

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Intelligent Development Environment and Software Knowledge Graph

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Journal of Computer Science & Technology 2017年第2期32卷 242-249页

作者： Ze-Qi Lin Bing Xie Yan-Zhen Zou jun-feng zhao Xuan-Dong Li jun Wei Hai-Long Sun Gang Yin Key Laboratory of High Confidence Software Technologies (Peking University) Ministry of Education Beijing 100871 China Beida ( Binhai) Information Research Tianjin 300450 China National Key Laboratory for Novel Software Technology Nanjing University Nanjing 210023 China Technology Center of Software Engineering Institute of Software Chinese Academy of Sciences Beijing 100190 China School of Computer Science and Engineering Beihang University Beijing 100191 China College of Computer National University of Defense Technology Changsha 410073 China

Software intelligent development has become one of the most important research trends in software engineering. In this paper, we put forward two key concepts -- intelligent development environment （IntelliDE） and software knowledge graph -- for the first time. IntelliDE is an ecosystem in which software big data are aggregated, mined and analyzed to provide intelligent assistance in the life cycle of software development. We present its architecture and discuss its key research issues and challenges. Software knowledge graph is a software knowledge representation and management framework, which plays an important role in IntelliDE. We study its concept and introduce some concrete details and examples to show how it could be constructed and leveraged.

关键词： intelligent development environment software big data software knowledge graph semantic search

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Evaporation of a nanodroplet on a rough substrate

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Frontiers of physics 2017年第5期12卷 191-197页

作者： Yong-Juan Sun Tao Huang jun-feng zhao Yong Chen Center of Soft Matter Physics and its Applications Beihang University Beijing 100191 China Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China

The wettability and roughness of a substrate are crucial to the evolution of the contact angle and three-phase contact line in the evaporation of sessile droplets. In this paper, by performing moleoilar dynamics simulations for droplet evaporation at the nanoscale, we show that the wettability is more important than the roughness. For a smooth substrate, the evaporation behavior of a nanodroplet is similar to that at the macroscopic scale. This similarity is also observed in the case of a rough hydrophilic substrate. However, for a rough hydrophobic substrate, both the constant contact angle and contact line pinning appear in turn during evaporation. This suggests that the roughness of the hydrophobic substrate is useful for the evaporation technique in self-assembly at the nanoscale.

关键词： evaporation nanodroplet roughness wettability

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Correlation between serum free fatty acids levels and Gensini score in elderly patients with coronary heart disease

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Journal of Geriatric Cardiology 2014年第1期11卷 57-62页

作者： Li-Yun HE jun-feng zhao Jiang-Li HAN Shan-Shan SHEN Xu-Jiao CHEN Department of Cardiology Peking University Third Hospital and Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry ofHealth Beijing 100191 China Department of Emergency the Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310005 Zhejiang Province China Department of Geriatrics Zhejiang Hospital Hangzhou 310013 Zhejiang Province China

Objectives To investigate the relationship between serum fxee fatty acids （FFAs） levels and the severity of coronary artery lesions in elderly patients with coronary heart disease （CAD）. Methods A total of 172 elderly patients who underwent coronary angiography were divided into CAD group （n = 128） and non-CAD group （n = 44） according to the results of coronary angiography. Serum FFAs and lipid levels were measured and the Gensini score were calculated. Results No matter the differences between age, gender and the usage of stat- ins or not, there was no statistical significance in FFAs levels （P 〉 0.05）. In terms of the Gensini score, it was higher in patients aged 70-79 years than in patients 60-69 years old [15.00 （5.00, 34.00） vs. 10.00 （2.00, 24.00）, P 〈 0.05], higher in men than women [14.00 （4.00, 34.00） vs. 7.00 （2.50, 19.75）, P 〈 0.05], and higher in patients on statins [13.50 （4.25, 33.50）vs. 6.50 （2.00, 18.00）, P 〈 0.05]. The serum FFAs lev- els [449.50 （299.00, 624.75） mEq/L vs. 388.00 （258.50, 495.25） mEq/L, P 〈 0.05J and Gensini score [17.50 （8.00, 41.75） vs. 1.00 （0, 5.00）, P 〈 0.05] were higher in the CAD group than in the non-CAD group. In the CAD group, there was no statistical significance in FFAs levels among patients with different numbers of diseased coronary vessels （P 〉 0.05）. Furthermore, the FFAs levels were positively correlated with the Gensini score （r = 0.394, P = 0.005）. Regression analysis showed that the FFAs levels were related to the Gensini score independently after adjusting for the other risk factors. Conclusions The serum FFAs levels were associated with the Gensini score in elderly patients with CAD. It might indicate FFAs as a biomarker predicting the severity of coronary artery lesions.

关键词： Coronary heart disease Free fatty acids Gensini score The elderly

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High-performance martensitic stainless steel nanocomposite powder for direct energy deposition prepared by ball milling

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Rare Metals 2023年第7期42卷 2419-2432页

作者： Zhen Wang Shu-Rong Xu Qing-Xuan Sui Jiang Wang Bo Liu Hao Wen Tian-Yi Xiao Quan Yuan feng-jun zhao jun Liu School of Materials Science and Engineering Central South UniversityChangsha410083China Jinchuan Nickel Cobalt Research and Design Institute Jinchuan Group Co.LtdJinchang737100China

Direct energy deposition(DED)has great potential for the production of stainless steel matrix nanocomposite ***,the propensity of nanoparticle agglomeration leads to the difficulty in realizing homogenous dispersion of nanoparticles in the *** this study,a series of agglomeration-free nanoWC-Co-reinforced 420 stainless steel matrix nanocomposite powders with high flowability were prepared by ball milling under the optimal *** effect of ball milling time on the properties of the composite powders was *** powder properties ensure the DED processing ***,the corresponding composites were fabricated by DED,and the effects of nano-WC-Co content on the properties of the composites were comprehensively *** contact angles between the single pass cladding layer and the substrate change with increasing nano-WC-Co content(decrease from 127.38°to 113.07°).The different contact angles will significantly influence the quality of the multipass cladding ***,the addition of nanoWC-Co leads not only to further grain refinement but also to more pronounced isotropy of the micros *** the increase in nano-WC-Co content,the corrosion resistance is significantly improved(62.28%lower corrosion current for 420-15 wt%nano-WC-Co than for 420).

关键词： Steel matrix composites Direct energy deposition(DED) Ball milling time Contact angle Microstructure Mechanical property

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