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Protective Mechanism of Electroacupuncture on Peripheral Neurotoxicity Induced by Oxaliplatin in Rats

Chinese Journal of Integrative Medicine 2022年第9期28卷 833-839页

作者： WANG Feng-jiao SHI She WANG yong-qiang WANG Ke FAN Shen-dong ZHANG Ya-nan FENG Chen-chen JU Zi-yong College of Acumox and Tuina Shanghai University of Traditional Chinese MedicineShanghai201203China Department of Anesthesiology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200120China Acupuncture Anesthesia Clinical Research Institute Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China

Objective:To study the effect of electroacupuncture(EA)on oxaliplatin-induced peripheral neuropathy(OIPN)in rats.Methods:Male Sprague-Dawley rats were equally divided into 3 groups using a random number table:the control group,the OIRN group,and the EA(OIPN+EA)group,with 10 rats in each.The time courses of mechanical,cold sensitivity,and microcirculation blood flow intensity were determined.The morphology of the dorsal root ganglion(DRG)was observed by electron microscopic examination.The protein levels of nuclear factor E2-related factor 2(Nrf2),heme oxygenase-1(HO-1),and the transient receptor potential(TRP)protein family in DRGs were assayed by Western blot.Results:EA treatment significantly reduced mechanical allodynia and cold allodynia in OIPN rats(P<0.01).Notably,oxaliplatin treatment resulted in impaired microcirculatory blood flow and pathomorphological defects in DRGs(P<0.01).EA treatment increased the microcirculation blood flow and attenuated the pathological changes induced by oxaliplatin(P<0.01).In addition,the expression levels of Nrf2 and HO-1 were down-regulated,and the TRP protein family was over-expressed in the DRGs of OIPN rats(P<0.01).EA increased the expression levels of Nrf2 and HO-1 and decreased the level of TRP protein family in DRG(P<0.05 or P<0.01).Conclusion:EA may be a potential alternative therapy for OIPN,and its mechanism may be mainly mediated by restoring the Nrf2/HO-1 signaling pathway.

关键词： electroacupuncture oxaliplatin peripheral neuropathy dorsal root ganglion nuclear factor-erythroid-2-related factor 2

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Dermoscopic and reflectance confocal microscopic findings of cutaneous Rosai-Dorfman disease

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Chinese Medical Journal 2021年第1期134卷 112-114页

作者： Xue Shen Wen-ju Wang zi-Yi Wang yong Cui Department of Dermatology Chengdu Second People's HospitalChengduSichuan 610017China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China Graduate School Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China.

To the Editor:Rosai-Dorfman disease(RDD),also known as sinus histiocytosis with massive lymphadenopathy,is a rare non-Langerhans cell histiocytic proliferative disorder.RDD is characterized by bilateral cervical lymphadenopathy accompanied by extranodal involvement,with the skin being the most commonly affected organ.[1]Cutaneous RDD(CRDD),affecting only the skin without systemic symptoms,is even rarer.[2]Herein,we report the dermoscopic and reflectance confocal miscroscopy(RCM)findings in a patient with CRDD.

关键词： involvement finding reflectance

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A conceptual analysis of the meaning of comfort at the end-of-life using the Walker and Avant(2014)Framework

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Frontiers of Nursing 2021年第2期8卷 91-97页

作者： yong-Chao Hou Fiona Timmins Qian Zhou ju-zi Wang Emergency Department Shanxi Provincial People’s HospitalTaiyuanShanxi 030012China School of Nursing and Midwifery Trinity College DublinDublin 2Ireland

Objective:The aim of the authors is to clarify the concept of comfort at the end-of-life in order to support understandings of fundamental nursing care needed at this stage of healthcare.Methods:The Walker and Avant framework was applied to develop a deeper understanding of the concept of comfort at the end of life.Results:Five defining attributes of comfort in the end-of-life were identified and they are having a peaceful home-life environment,trust and consolation,proximity and social-cultural support,alleviation of suffering,and a process of integrated intervention by nurses.Conclusions:At the end-of-life patients commonly experience physical,psychological,social-cultural,and environmental discomfort.Patients’families also encounter significant challenges.However,their comfort needs are often secondary to that of the patient.Additionally,a lack of clarity exists regarding the holistic meaning of comfort at the end-of-life,which can largely be confined to understandings of physical comfort for the patient,with a limited understanding of addressing family/caregivers’needs.Therefore,this concept analysis may provide some guidance in this regard and also provides support toward a more integrated understanding of the concept.

关键词： comfort end-of-life care concept analysis death dying

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A novel spiking neural network of receptive field encoding with groups of neurons decision

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Frontiers of Information Technology & Electronic Engineering 2018年第1期19卷 139-150页

作者： yong-qiang MA zi-ru WANG Si-yu YU Ba-dong CHEN Nan-ning ZHENG Peng-ju REN Institute of Artificial Intelligence and Robotics Xi'an Jiaotong University

Human information processing depends mainly on billions of neurons which constitute a complex neural network,and the information is transmitted in the form of neural spikes.In this paper,we propose a spiking neural network(SNN),named MD-SNN,with three key features:(1) using receptive field to encode spike trains from images;(2) randomly selecting partial spikes as inputs for each neuron to approach the absolute refractory period of the neuron;(3) using groups of neurons to make decisions.We test MD-SNN on the MNIST data set of handwritten digits,and results demonstrate that:(1) Different sizes of receptive fields influence classification results significantly.(2) Considering the neuronal refractory period in the SNN model,increasing the number of neurons in the learning layer could greatly reduce the training time,effectively reduce the probability of over-fitting,and improve the accuracy by 8.77%.(3) Compared with other SNN methods,MD-SNN achieves a better classification;compared with the convolution neural network,MD-SNN maintains flip and rotation invariance(the accuracy can remain at 90.44% on the test set),and it is more suitable for small sample learning(the accuracy can reach 80.15%for 1000 training samples,which is 7.8 times that of CNN).

关键词：神经网络神经原编码小说信息处理随机选择图象输入

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Risk assessment of malignancy in solitary pulmonary nodules in lung computed tomography:a multivariable predictive model study

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Chinese Medical Journal 2021年第14期134卷 1687-1694页

作者： Hai-Yang Liu Xing-Ru Zhao Meng Chi Xiang-Song Cheng zi-Qi Wang Zhi-Wei Xu yong-Li Li Rui Yang yong-jun Wu Xiao-ju Zhang Department of Respiratory and Critical Care Medicine Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhouHenan 450000China Henan Joint International Research Laboratory of Diagnosis and Treatment of Pulmonary Nodules Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhouHenan 450000China Department of Medical Imaging Henan Provincial Chest HospitalZhengzhouHenan 450000China Department of Respiratory and Critical Care Medicine Fuwai Central China Cardiovascular HospitalZhengzhouHenan 450000China Department of Radiology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhouHenan 450000China College of Public Health Zhengzhou UniversityZhengzhouHenan 450000China.

Background:Computed tomography images are easy to misjudge because of their complexity,especially images of solitary pulmonary nodules,of which diagnosis as benign or malignant is extremely important in lung cancer treatment.Therefore,there is an urgent need for a more effective strategy in lung cancer diagnosis.In our study,we aimed to externally validate and revise the Mayo model,and a new model was established.Methods:A total of 1450 patients from three centers with solitary pulmonary nodules who underwent surgery were included in the study and were divided into training,internal validation,and external validation sets(n=849,365,and 236,respectively).External verification and recalibration of the Mayo model and establishment of new logistic regression model were performed on the training set.Overall performance of each model was evaluated using area under receiver operating characteristic curve(AUC).Finally,the model validation was completed on the validation data set.Results:The AUC of the Mayo model on the training set was 0.653(95%confidence interval[CI]:0.613–0.694).After re-estimation of the coefficients of all covariates included in the original Mayo model,the revised Mayo model achieved an AUC of 0.671(95%CI:0.635–0.706).We then developed a new model that achieved a higher AUC of 0.891(95%CI:0.865–0.917).It had an AUC of 0.888(95%CI:0.842–0.934)on the internal validation set,which was significantly higher than that of the revised Mayo model(AUC:0.577,95%CI:0.509–0.646)and the Mayo model(AUC:0.609,95%CI,0.544–0.675)(P<0.001).The AUC of the new model was 0.876(95%CI:0.831–0.920)on the external verification set,which was higher than the corresponding value of the Mayo model(AUC:0.705,95%CI:0.639–0.772)and revised Mayo model(AUC:0.706,95%CI:0.640–0.772)(P<0.001).Then the prediction model was presented as a nomogram,which is easier to generalize.Conclusions:After external verification and recalibration of the Mayo model,the results show that they are not suitable for the prediction of malignant pulmonary nod

关键词： CT image Lung cancer Prediction model Pulmonary nodules Regression algorithm

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Viral and Bacterial Etiology of Acute Diarrhea among Children under 5 Years of Age in Wuhan, China

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Chinese Medical Journal 2016年第16期129卷 1939-1944页

作者： Xu-Hui Zhu Lei Tian Zhong-ju Cheng Wei-yong Liu Song Li Wei-Ting Yu Wen-Qian Zhang Xu Xiang zi-yong Sun Department of Clinical Laboratory Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China

Background： Acute diarrhea remains the serious problem in developing countries, especially among children under 5 years of age. Currently, only two or three common diarrhea pathogens were screened at most hospitals in China. The aim of this study was to provide a wide variety of diarrhea pathogens and their antimicrobial resistance patterns in children under 5 years of age. Methods： Totally 381 stool samples collected from Tongji Hospital between july 1, 2014 and june 30, 2015 were tested by culture and/or polymerase chain reaction for eight kinds of bacteria and five kinds of viruses. An antimicrobial sensitivity test was performed using dilution method recommended by the Clinical and Laboratory Standards Institute. Results： Viral infections were mainly identified in infants （0-11 months）, whereas bacterial infections were more prevalent in the age of 24-59 months. About 69.8% of samples were positive for at least one pathogen, 51.7% of samples were virus positive, followed by bacteria positive cases （19.4%）, and 12.6% of cases displayed co-infections with two viruses or a virus and a bacterium. Rotavirus was the most prevalent pathogen, followed closely by norovirus, while Salmonella was the most commonly isolated bacteria, followed by diarrheagenic Escherichia coli （DEC） and Campylobacter. More than 40% of Salmonella spp. and DEC isolates were resistant to first-line antibiotics （ampicillin, trimethoprim-sulfamethoxazole, and tetracycline）. Around 10% of Salmonella spp. isolates were resistant to ceftriaxone and ciprofloxacin simultaneously. Campylobacter spp. displayed high resistance to ciprofloxacin but kept low resistance to azithromycin and doxycycline. Conclusions： The etiology of acute diarrhea varies in children of different age groups. The high frequency of infection with viruses suggests the urgent demand for new viral vaccine development. Proper use of antibiotics in the treatment of acute diarrhea is crucial due to the high level of antibiotic resistance.

关键词： Acute Diarrhea Bacteria Children Etiology Virus

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Comparison between Bilateral and Unilateral Sudden Sensorineural Hearing Loss

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Chinese Medical Journal 2018年第3期131卷 307-315页

作者： Dan Bing Da-yong Wang Lan Lan Li-Dong Zhao zi-Fang Yin Lan Yu Guo-Hui Chen Jing Guan Qiu-ju Wang Department of Otolaryngology-Head and Neck Surgery Institute of Otolaryngology Chinese People's Liberation Army General Hospital Beijing t00853 China

Background：Bilateral sudden sensorineural hearing loss （BSSHL） is rare and assumed to be a different clinical entity compared to unilateral SSHL （USSHL）.This study examined the differences between the idiopathic BSSHL and USSHL.Methods：Forty-six sequential BSSHL patients （Se-BSSHL） and 68 simultaneous BSSHL （Si-BSSHL） were consecutively admitted between june 2008 and December 2015.Two sets of patients served as control groups：（1） USSHL patients with healthy contralateral ear and （2） USSHL patients with contralateral preexisting hearing loss （USSHLwCHL）.We retrospectively analyzed differences among four cohorts using analysis of variance,Kruskal-Wallis test,Welch＇s t-test,and Chi-square test as appropriate before and after propensity score matching （PSM） based on age,gender,and body mass index （BMI）.Results：The prevalence of idiopathic BSSHL was 8.6% （114/1329） among the total SSHL patients.In the total cohort,USSHL patients tended to be younger,female,and tended to have lower BMI,renal parameters,and total cholesterol in addition to higher high-density lipoprotein compared to the other three groups.Most routine blood indicators,some coagulation markers,and immunoglobulin M （H =13.4,P =0.004） were significantly different among the study groups.After PSM,the major significant differences were found in audiometric characteristics.Si-BSSHL and Se-BSSHL patients demonstrated similar hearing thresholds as USSHL but were significantly better than the USSHLwCHL patients across most frequencies before and after treatment （H =30.0,P 〈 0.001 for initial hearing and H =12.0,P =0.007 for final hearing）.Moreover,the BSSHL patients showed different hearing loss distribution patterns （more descending type,x2 =33.8,P =0.001） with less hearing gain （H =17.5,P 〈 0.001） compared to the USSHL patients.Conclusions：Idiopathic BSSHL is a relatively rare subtype of SSHL with a higher rate of descending audiogram type and inferior hearing outcome rather than being classified as a completely different disease entity compared to USSHL.

关键词： Bilateral Hearing Loss Propensity Score Sudden Hearing Loss Unilateral Hearing Loss

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Relation Between the Eventual Continuity and the E-property for Markov-Feller Semigroups

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 1-16页

作者： yong Liu zi-yu Liu LMAM School of Mathematical SciencePeking UniversityBeijing100871China

We investigate some relations between two kinds of semigroup regularities, namely the e-property and the eventual continuity, both of which contribute to the ergodicity for Markov processes on Polish spaces.More precisely, we prove that for Markov-Feller semigroup in discrete time and stochastically continuous MarkovFeller semigroup in continuous time, if there exists an ergodic measure whose support has a nonempty interior,then the e-property is satisfied on the interior of the support. In particular, it implies that, restricted on the support of each ergodic measure, the e-property and the eventual continuity are equivalent for the discrete-time and the stochastically continuous continuous-time Markov-Feller semigroups.

关键词： Markov-Feller semigroup ergodicity e-property eventual continuity

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基于仿真的城市轨道交通客流分配

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计算机仿真 2022年第2期39卷 73-77,202页

作者：陈锦渠殷勇鞠子奇西南交通大学交通运输与物流学院四川成都611756 综合交通运输智能化国家地方联合工程实验室四川成都611756 综合交通大数据应用技术国家工程实验室四川成都611756

建立仿真客流分配模型可实现城市轨道交通(URT)客流的分配。首先,定义URT网络并确定了乘客生成方法;其次,结合改进Logit模型及有界理性模型建立乘客出行路径选择模型;接着,基于列车运行图实现列车运行控制及乘客上、下车决策;然后,建立... 详细信息

建立仿真客流分配模型可实现城市轨道交通(URT)客流的分配。首先,定义URT网络并确定了乘客生成方法;其次,结合改进Logit模型及有界理性模型建立乘客出行路径选择模型;接着,基于列车运行图实现列车运行控制及乘客上、下车决策;然后,建立了自反馈机制实现乘客出行路径计算结果的校正;最后,以成都地铁为例,验证了所建立模型的有效性。结果表明:所建立的仿真客流分配模型能够有效实现URT客流的分配,客流分配结果能够为运营部门制定调度指挥策略、乘客制定出行策略提供依据。

关键词：城市轨道交通仿真客流分配出行路径选择模型列车运行图

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Hybrid-augmented intelligence： collaboration and cognition

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Frontiers of Information Technology & Electronic Engineering 2017年第2期18卷 153-179页

作者： Nan-ning ZHENG zi-yi LIU Peng-ju REN yong-qiang MA Shi-tao CHEN Si-yu YU Jian-ru XUE Ba-dong CHEN Fei-yue WANG Institute of Artificial Intelligence and Robotics Xi ' an Jiaotong University Xi ' an 710049 China National Engineering Laboratory of Visual Information Processing Applications Xi 'an Jiaotong University Xi'an 710049 China State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing 100190 China

人工智能追求的长期目标是使机器能像人一样学习和思考。由于人类面临的许多问题具有不确定性、脆弱性和开放性,任何智能程度的机器都无法完全取代人类,这就需要将人的作用或人的认知模型引入到人工智能系统中,形成混合-增强智能的形态... 详细信息

人工智能追求的长期目标是使机器能像人一样学习和思考。由于人类面临的许多问题具有不确定性、脆弱性和开放性,任何智能程度的机器都无法完全取代人类,这就需要将人的作用或人的认知模型引入到人工智能系统中,形成混合-增强智能的形态,这种形态是人工智能或机器智能的可行的、重要的成长模式。混合-增强智能可以分为两类基本形式:一类是人在回路的人机协同混合增强智能,另一类是将认知模型嵌入机器学习系统中,形成基于认知计算的混合智能。本文讨论人机协同的混合-增强智能的基本框架,以及基于认知计算的混合-增强智能的基本要素:直觉推理与因果模型、记忆和知识演化;特别论述了直觉推理在复杂问题求解中的作用和基本原理,以及基于记忆与推理的视觉场景理解的认知学习网络;阐述了竞争-对抗式认知学习方法,并讨论了其在自动驾驶方面的应用;最后给出混合-增强智能在相关领域的典型应用。

关键词：人-机协同混合增强智能认知计算直觉推理因果模型认知映射视觉场景理解自主驾驶汽车

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