检索结果-南通市图书馆

诱导肝星状细胞铁死亡在肝纤维化防治中的研究进展

在线全文

学校读者我要写书评

暂无评论

中国中药杂志 2024年第9期49卷 2281-2289页

作者：牛媛媛樊泽坤汪龙德李正菊杜晓娟胥文娟郭林静甘肃中医药大学甘肃兰州730000 甘肃中医药大学附属医院甘肃兰州730020 甘肃省中医院甘肃兰州730050

肝纤维化是慢性肝病进展的关键病理阶段,若本病失治误治,则可进一步恶化为肝衰竭事件,严重影响患者生活质量,并伴随沉重医疗成本消耗。肝星状细胞(hepatic stellate cell,HSC)活化引发细胞外基质(extracellular matrix,ECM)沉积是肝纤... 详细信息

肝纤维化是慢性肝病进展的关键病理阶段,若本病失治误治,则可进一步恶化为肝衰竭事件,严重影响患者生活质量,并伴随沉重医疗成本消耗。肝星状细胞(hepatic stellate cell,HSC)活化引发细胞外基质(extracellular matrix,ECM)沉积是肝纤维化的重要驱动因素,而铁死亡是活化HSC清除或逆转为失活表型的有效策略,因此通过调节铁死亡来抑制HSC的激活与增殖是治疗本病的关键,进一步衍生出诱导HSC铁死亡(包括RNA结合蛋白、非编码RNA、化学制品、中药活性组分)以干预肝纤维化的前景方向。基于此,该文以活化HSC引发ECM沉积为切入点,重点梳理总结诱导HSC铁死亡在延缓肝纤维化进程中的作用机制,以期能不断丰富肝纤维化的临床实践,并为下一步的基础研究提供参考依据。

关键词：肝纤维化 HSC活化 ECM沉积铁死亡中药活性组分非编码RNA

“中医内科学”科研思维能力培养的实践与思考

在线全文

学校读者我要写书评

暂无评论

教育教学论坛 2024年第27期 45-48页

作者：胥文娟汪龙德李正菊甘肃省中医院针灸三科甘肃兰州730050 甘肃中医药大学中医临床学院甘肃兰州730000

“中医内科学”作为中医学的一门主干课程,在其发展中占有重要地位,是中医基础学科与临床学科的桥梁,亦是培养中医临床思维与中医科研思维的重要基础学科。然而传统的“中医内科学”教学方式单一,主要以教师“教”为中心,存在学生学习... 详细信息

“中医内科学”作为中医学的一门主干课程,在其发展中占有重要地位,是中医基础学科与临床学科的桥梁,亦是培养中医临床思维与中医科研思维的重要基础学科。然而传统的“中医内科学”教学方式单一,主要以教师“教”为中心,存在学生学习被动、学习兴趣较低、学习成果产出较少等不足。如何形成以学生“学”为中心的“中医内科学”教学模式,发挥学生的主动性和积极性,深入临床学习,培养科研思维,是当前“中医内科学”教学改革亟须解决的问题。以肝胆脾胃疾病为例,阐述如何改革“中医内科学”教学方式以提高学生中医临床思维能力,并不断培养中医科研思维能力。

关键词：中医内科学临床思维科研思维培养创新

Partition-based Network Equivalent Method for Power System Subsynchronous Oscillation Analysis

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 313-320页

作者： Chenxuan Wang Weimin zheng Zhen Wang Yangqing Dan Ping ju the Department of Electrical Engineering Zhejiang UniversityHangzhou 310027China the Economic Research Institute of State Grid Zhejiang Electric Power Co. Ltd.Hangzhou 310016China the College of Energy and Electrical Engineering Hohai UniverstiyNanjing 211100China

Given large-scale modern power systems with pow er electronic converters,the numerical simulation with subsyn chronous oscillation(SSO)faces great challenges in engineering practice due to sharply enlarged modeling scale and high com putational *** reduce the modeling scale,network parti tion and equivalent becomes a vital technique in numerical sim *** several methods have been developed for net work equivalent,a generally accepted rule for network parti tion is still *** paper proposes that the system can be partitioned into three parts,i.e.,the internal,the middle,and the external subsystems,in which the internal subsystem consists of all power electronic components,the middle subsys tem includes those selected AC dynamic components with de tailed models,and the remaining components and buses consti tute the external *** external subsystem is further represented by an equivalent RLC network determined by the frequency dependent network equivalent(FDNE)*** the proposed method,the observability index and the electrical distance index are used to identify the interface between the middle and the external *** studies based on a modified Hydro-Quebec system are used to verify the effective ness of the proposed method.

关键词： Electrical distance network equivalent subsyn chronous oscillation observability index

Dynamic evolution characteristics of the “source-reservoir” integration of gray marl and its geological significance to unconventional gas: Insights from pyrolysis experiments

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2023年第2期20卷 705-720页

作者： Zhang-Hu Wang Zhong-Liang Ma Lun-ju zheng jun-Yu Wang Zhi-Gang Wen Chen-Yang Si Cooperative Innovation Center of Unconventional Oil and Gas Yangtze UniversityWuhanHubei430100China Key Laboratory of Oil and Gas Resources and Exploration Technology Ministry of EducationCollege of Resources and EnvironmentYangtze UniversityWuhanHubei430100China Wuxi Research Institute of Petroleum Geology Sinopec Exploration and Production Research InstituteWuxiJiangsu214126China State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development WuxiJiangsu214126China School of Metallurgy and Environment Central South UniversityChangshaHunan410083China

The marl–limestone rhythmic strata of the Permian Maokou Formation have been identified as hosts of unconventional gas reservoirs with “source–reservoir” integration. The lack of research on the pore structure evolution of organic-rich carbonate rock restricts gas exploration of these strata. Here, pyrolysis experiments were performed on the Mao-1 carbonate to simulate hydrocarbon generation, expulsion and diagenesis in gray marl from low maturity to overmaturity. The pore structure of this marl is dominated by mesopores and macropores, and the proportion of macropores increases gradually with temperature. The macropores are mainly pores in the organic matter and shrinkage microcracks. Additionally, micropores and mesopores, dominated by clay mineral interlayer pores and pyrite intergranular pores, are developed in the high mature stage and subsequently compressed in the overmature stage. The main contributors to the specific surface area are micropores and mesopores, which are conducive to natural gas adsorption. After the same pyrolysis treatment, the available porosity of grey marl is higher than that of marine/lacustrine shales, and exhibits an obvious decrease in the low mature–mature stage. These suggest that the abundant residual oil generated blocked the organic and inorganic pores in the gray marl, providing a pivotal material foundation for the gas generation. Micropores and mesopores developed during the high mature stage ensure the gas accumulation and preservation. The above indicate the organic-rich carbonate at the high mature–overmature stage (Ro = 1.7%–2.5%) in the Sichuan Basin may be a favorable exploration horizon for unconventional oil and gas.

关键词： Residual oil Organic pores Porosity Sepiolite Hydrocarbon generation

Synthesis, Crystal Structure and Reactivity of (2,4-C_7H_(11) )_2Yb·DME

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2001年第1期17卷 14-19页

作者： ZHANG Suo-bo LIU ju-zheng ZHUANG Xiu-li HUANG Jing-qin HU Ning-hai CHEN Wen-qi Department of Chemistry Jilin UniversityChangchun 130023P.R.China Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022P.R.China

(2,4 C 7H 11 ) 2Yb·DME was synthesized by the reaction of YbCl 3 with K(2,4 C 7H 11 )(2,4 dimethylpentadienyl potassium), and the single crystal X ray diffraction showed that the complex exists in a cis staggered conformation. The crystal of the compound belongs to the monoclinic space group P2 1/n with a =0.875 2 (1) nm, b =1.490 6(1) nm, c =1.529 3(2) nm, β =97 55(2)° , V =1.977 79(4) nm 3, Z =4, F (000)=735.8 e, μ =49.49 cm -1 , R =0.033 and R w=0.032 . The title complex can be used as a catalyst for the polymerization of methyl methacrylate(MMA).

关键词： Dimethylpentadienyl Synthesis Crystal structure Catalyst Polymerization

Towards the universal defense for query-based audio adversarial attacks on speech recognition system

在线全文

学校读者我要写书评

暂无评论

Cybersecurity 2024年第1期7卷 53-70页

作者： Feng Guo zheng Sun Yuxuan Chen Lei ju School of Cyber Science and Technology Shandong UniversityQingdaoChina Quancheng Laboratory QCLJinanChina

Recently,studies show that deep learning-based automatic speech recognition(ASR)systems are vulnerable to adversarial examples(AEs),which add a small amount of noise to the original audio *** AE attacks pose new challenges to deep learning security and have raised significant concerns about deploying ASR systems and *** existing defense methods are either limited in application or only defend on results,but not on *** this work,we propose a novel method to infer the adversary intent and discover audio adversarial examples based on the AEs generation *** insight of this method is based on the observation:many existing audio AE attacks utilize query-based methods,which means the adversary must send continuous and similar queries to target ASR models during the audio AE generation *** by this observation,We propose a memory mechanism by adopting audio fingerprint technology to analyze the similarity of the current query with a certain length of memory ***,we can identify when a sequence of queries appears to be suspectable to generate audio *** extensive evaluation on four state-of-the-art audio AE attacks,we demonstrate that on average our defense identify the adversary’s intent with over 90%*** careful regard for robustness evaluations,we also analyze our proposed defense and its strength to withstand two adaptive ***,our scheme is available out-of-the-box and directly compatible with any ensemble of ASR defense models to uncover audio AE attacks effectively without model retraining.

关键词： Adversarial attacks Defense Memory mechanism Query-based

Sythesis, Characterization and Catalysis of [ η~5,η~1-C_5H_4-CHPh-PhO]TiCl_2

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2001年第1期17卷 115-116页

作者： WANG Jian hui MU Ying PU Wei ming ZHANG Yue tao YANG Guang di LIU ju zheng Department of Chemistry Jilin UniversityChangchun 130023P.R.China

The synthesis and structure of phenol groups containing ligand 2-[(cyclopentadienyl-phenyl)-methyl]phenol(CpH-PhCH-PhOH) were described. H Nuclear magnetic resonance (NMR) was used to show existence of ligand precursor in isomers of the group. Me3SiCp-PhCH-PhOSiMe3 was formed via treatment of 2 mol Me3SiCl with the dilithium salt of the ligand. New Ti compound [η+5, η1-C5H4-PhCH-PhO]TiCl2 was formed by reacting with titanium chloride.

关键词： Metallocene Catalyst Cyclopentadienyl group

Deciphering Ascorbic Acid Regulatory Pathways in Ripening Tomato Fruit Using a Weighted Gene Correlation Network Analysis Approach

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2013年第11期55卷 1080-1091页

作者： Chao Gao zheng ju Shan Li Jinhua Zuo Daqi Fu Huiqin Tian Yunbo Luo Benzhong Zhu Laboratory of Fruit Biology College of Food Science and Nutritional Engineering China Agricultural University Laboratory of Postharvest Storage and Processing of Vegetables National Engineering Research Center for Vegetables

Genotype is generally determined by the co-expression of diverse genes and multiple regulatory pathways in plants. Gene co-expression analysis combining with physiological trait data provides very important information about the gene function and regulatory mechanism. L-Ascorbic acid （AsA）, which is an essential nutrient component for human health and plant metabolism, plays key roles in diverse biological processes such as cell cycle, cell expansion, stress resistance, hormone synthesis, and signaling. Here, we applied a weighted gene correlation network analysis approach based on gene expression values and AsA content data in ripening tomato （Solanum lycopersicum L.） fruit with different AsA content levels, which leads to identification of AsA relevant modules and vital genes in AsA regulatory pathways. Twenty- four modules were compartmentalized according to gene expression profiling. Among these modules, one negatively related module containing genes involved in redox processes and one positively related module enriched with genes involved in AsA biosynthetic and recycling pathways were further analyzed. The present work herein indicates that redox pathways as well as hormone-signal pathways are closely correlated with AsA accumulation in ripening tomato fruit, and allowed us to prioritize candidate genes for follow-up studies to dissect this interplay at the biochemical and molecular level.

关键词： Gene co-expression L-ascorbic acid network system biology weighted gene correlation network analysis approach.

Is There any Hexazirconium Cluster in the Compounds [HP(t-Bu)_2Ph_3]_3[Zr_6Cl_(18)H_5] and Zr_6Cl_(14)(PPr_3)_4H_4?

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1997年第9期8卷 829-830页

作者： Wen LI ChunHua HU Pei ju zheng(Research Center of Analysis and Measurement, Fudan University, Shanghai 200433) FUDAN UNIV RES CTR ANAL & MEASUREMENTSHANGHAI 200433PEOPLES R CHINA

The [Zr6(μ2-Cl)12Cl6H4]3- ion with C4v Symmetry in the title compounds has been calculated by DV-Xα program. The calculated results show that ther is almost no available covalence bonding between zirconium atoms and significant Zr 4d AO compositions in the MOs. but there are much stronger Zr-Cl(bridging) bonding. All analysis results suggest that these compounds would be the cluster with Zr6Cl12 cage linked by Zr-Cl bridging bonding plus six Cl teminal ligands rather than the hexazirconium cluster in view of the chemical bonding.

关键词： and Zr6Cl PPr3 Is There any Hexazirconium Cluster in the Compounds t-Bu H5 Zr6Cl HP