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Croundwater Evolution and its Influence on the Fragile Ecology …

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中国沙漠 2000年第2期20卷 145-149页

作者：马金珠 ju,q

塔里木盆地南缘第四系松散沉积物以第三系弱透水层为隔水底板构成良好的储水场所含水层厚２００～９００ｍ，主要由冲洪积卵砾石、砂砾石和细砂组成。地下水位埋深由山前倾斜平原的５０～１００ｍ逐渐过渡为细土平原的１～３ｍ，矿化度... 详细信息

塔里木盆地南缘第四系松散沉积物以第三系弱透水层为隔水底板构成良好的储水场所含水层厚２００～９００ｍ，主要由冲洪积卵砾石、砂砾石和细砂组成。地下水位埋深由山前倾斜平原的５０～１００ｍ逐渐过渡为细土平原的１～３ｍ，矿化度相应地由１～３ｇ．Ｌ＾－１变化到３～５ｇ．Ｌ＾－１。大部分地下水由地表径流和渠系、田间灌溉水入渗转化而成，约占地下水补给总量的９４％以上。人类历史时期。

关键词：地下水脆弱生态水资源开发塔里木盆地

Evaluation of the intracellular lipid-lowering effect of polyphenols extract from highland barley in HepG2 cells

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Food Science and Human Wellness 2024年第1期13卷 454-461页

作者： Yijun Yao Zhifang Li Bowen qin Xingrong ju Lifeng Wang College of Food Science and Engineering/Collaborative Innovation Centre for Modern Grain Circulation and Safety Nanjing University of Finance and EconomicsNanjing 210023China

Active ingredients from highland barley have received considerable attention as natural products for developing treatments and dietary supplements against *** practical application,the research of food combinations is more significant than a specific food *** study investigated the lipid-lowering effect of highland barley polyphenols via lipase assay in vitro and HepG2 cells induced by oleic acid(OA).Five indexes,triglyceride(TG),total cholesterol(T-CHO),low density lipoprotein-cholesterol(LDL-C),aspartate aminotransferase(AST),and alanine aminotransferase(ALT),were used to evaluate the lipidlowering effect of highland barley *** also preliminary studied the lipid-lowering mechanism by Realtime fluorescent quantitative polymerase chain reaction(q PCR).The results indicated that highland barley extract contains many components with lipid-lowering effects,such as hyperoside and *** vitro,the lipase assay showed an 18.4%lipase inhibition rate when the additive contents of highland barley extract were 100μg/m *** intracellular lipid-lowering effect of highland barley extract was examined using 0.25 mmol/L OA-induced HepG2 *** results showed that intracellular TG,LDL-C,and T-CHO content decreased by 34.4%,51.2%,and 18.4%,*** and AST decreased by 51.6%and 20.7%compared with the untreated hyperlipidemic HepG2 cells.q PCR results showed that highland barley polyphenols could up-regulation the expression of lipid metabolism-related genes such as PPARγand Fabp4.

关键词： Highland barley Polyphenols extract Lipid-lowering effect HepG2 cells

Constraining the Earth-mass Primordial Black Hole Mergers Model of the Non-repeating FRBs Using the First CHIME/FRB Catalog

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Research in Astronomy and Astrophysics 2024年第9期24卷 76-82页

作者： Min Meng qiu-ju Huang Can-Min Deng Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

In this paper,we upgrade the constraints for the Earth-mass primordial black hole mergers model based on the first Canadian Hydrogen Intensity Mapping Experiment(CHIME)/fast radio burst(FRB)*** the null hypothesis that the observed non-repeating FRBs originate from Earth-mass primordial black hole mergers,we find that how the charges were distributed in the primordial black hole population is well described by a double powerlaw function with typical charge value of law function with typical charge value of q_(c)/10^(-5)=1.60_(-0.28)^(+0.28),where the power-law index α_(1)=2.33_(-0.18)^(+0.15) for qq_(c) and α_(2)=4.56_(-0.26)^(+0.30)for q≥q_(c).Here,q represents the charge of the black hole in units of√GM,where M is the mass of the black ***,we infer the local event rate of the bursts is 8.8_(-2.1)^(+5.7)×10^(4)Gpc^(-3) yr^(-1),which indicates that an abundance of the primordial black hole population f■10^(-4) is needed to account for the observed FRBs by *** results of this paper lay the basis for further research on the electromagnetic radiation background generated by the merger of primordial black hole mergers.

关键词： black hole physics (stars:)gamma ray burst:general (cosmology:)dark matter

Transfer RNA-derived fragment tRF-23-q99P9P9NDD promotes progression of gastric cancer by targeting ACADSB

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期25卷 438-450页

作者： Yu ZHANG Xinliang GU Yang LI Xun LI Yuejiao HUANG Shaoqing ju Medical School of Nantong University Nantong UniversityNantong 226001China Department of Laboratory Medicine Affiliated Hospital of Nantong UniversityNantong 226001China Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantong 226001China Department of Medical Oncology Affiliated Hospital of Nantong UniversityNantong 226001China

Gastric cancer(GC)is one of the most common gastrointestinal *** a newly discovered type of non-coding RNAs,transfer RNA(tRNA)-derived small RNAs(tsRNAs)play a dual biological role in *** previous studies have demonstrated the potential of tRF-23-q99P9P9NDD as a diagnostic and prognostic biomarker for *** this work,we confirmed for the first time that tRF-23-q99P9P9NDD can promote the proliferation,migration,and invasion of GC cells in *** dual luciferase reporter gene assay confirmed that tRF-23-q99P9P9NDD could bind to the 3'untranslated region(UTR)site of acyl-coenzyme A dehydrogenase short/branched chain(ACADSB).In addition,ACADSB could rescue the effect of tRF-23-q99P9P9NDD on GC ***,we used Gene Ontology(GO),the Kyoto Encyclopedia of Genes and Genomes(KEGG),and Gene Set Enrichment Analysis(GSEA)to find that downregulated ACADSB in GC may promote lipid accumulation by inhibiting fatty acid catabolism and ***,we verified the correlation between ACADSB and 12 ferroptosis genes at the transcriptional level,as well as the changes in reactive oxygen species(ROS)levels by flow *** summary,this study proposes that tRF-23-q99P9P9NDD may affect GC lipid metabolism and ferroptosis by targeting ACADSB,thereby promoting GC *** provides a theoretical basis for the diagnostic and prognostic monitoring value of GC and opens upnew possibilities for treatment.

关键词： Transfer RNA(tRNA)-derived small RNA(tsRNA) Gastric cancer(GC) Acyl-coenzyme A dehydrogenase short/branched chain(ACADSB) Molecular mechanism Treatment Ferroptosis

Privacy Preserving Distributed Bandit Residual Feedback Online Optimization Over Time-Varying Unbalanced Graphs

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IEEE/CAA Journal of Automatica Sinica 2024年第11期11卷 2284-2297页

作者： Zhongyuan Zhao Zhiqiang Yang Luyao Jiang ju Yang quanbo Ge the School of Automation Nanjing University of Information Science and Technology and also with Jiangsu Key Laboratory of Big Data Analysis Technology the School of Mechanical Engineering Shanghai Jiao Tong University IEEE

This paper considers the distributed online optimization(DOO) problem over time-varying unbalanced networks, where gradient information is explicitly unknown. To address this issue, a privacy-preserving distributed online one-point residual feedback(OPRF) optimization algorithm is proposed. This algorithm updates decision variables by leveraging one-point residual feedback to estimate the true gradient information. It can achieve the same performance as the two-point feedback scheme while only requiring a single function value query per iteration. Additionally, it effectively eliminates the effect of time-varying unbalanced graphs by dynamically constructing row stochastic matrices. Furthermore, compared to other distributed optimization algorithms that only consider explicitly unknown cost functions, this paper also addresses the issue of privacy information leakage of nodes. Theoretical analysis demonstrate that the method attains sublinear regret while protecting the privacy information of agents. Finally, numerical experiments on distributed collaborative localization problem and federated learning confirm the effectiveness of the algorithm.

关键词： Differential privacy distributed online optimization (DOO) federated learning one-point residual feedback (OPRF) time-varying unbalanced graphs

Interlaboratory validation for the in vivo flow cytometric micronucleus analysis method(MicroFlow)in China

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Interlaboratory validation for the in vivo flow cytometric m...

中国毒理学会第六届全国毒理学大会

作者： CHANG Y ZHOU C HUANG F DK TOROUS LUAN Y SHI C WANG H WANG X WEI N XIA Z ZHONG Z ZHANG M AN F CAO Y GENG X JIAMG Y ju q YU Y ZHU J SD DERTINGER LI B LIAO M YUAN B ZHANG T YU J ZHANG Z WANG q Ma J National Shanghai Center for New Drug Safety Evaluation & Research Center for Drug Evaluation China Food and Drug Administration

Although inter-laboratory validation efforts of the flow cytometry(FCM) based in vivo micronucleus (MN) assay have taken place in the EU and US,none have been organized in China. Therefore a high profile,inter-laboratory study was coordinated to validate the in vivo flow cytometric MicroFlow method for enumerating micronucleated reticulocytes(MN-RETs) in rat *** ultimate goal is to offer data to support revision of the China FDA guideline to approve the use of FCM in GLP *** degree of correspondence between MN-RET measurements in blood generated by FCM and micronucleated polychromatic erythrocytes(MN-PCEs) in bone marrow using microscopy was evaluated. Assay reliability and reproducibility were confirmed among eight laboratories using four known *** cytometric MN-RET measurements for each blood sample were performed at three separate sites(2 in China and 1 in the US).Exposure occurred on 3 consecutive days,and blood and bone marrow were obtained approximately 24 h after the final ***-RET frequencies were determined based on analyzing approximately 2000 PCEs(microscopy) and20000 RETs(FCM).Each genotoxic agent caused statistically significant dose-dependent MN ***’s correlation coefficient (rs) for MN-RET versus MN-PCE measurements was 0.723,indicating high correspondence between methods and *** rs value for all FCM MN-RET measurements performed at collaborative laboratories was 0.940,and between Chinese laboratories with reference laboratory was 0.933, suggesting the automated method is highly transferable between *** FCM MN analysis meth- od would therefore be recommended for evaluating the in vivo genotoxic potential of test chemicals.

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CGR-ZN型岩心伽马连续测量仪

石油仪器 1996年第6期 29-32页

作者：赵焕卿鞠晓东石油大学!华东

文章介绍一种用于连续测量岩心的自然伽马放射性强度的专用仪器．用彩色绘图仪绘出与测井曲线完全兼容的测量曲线。仪器以微处理机为核心．具有测量精度高．操作方便，可靠性高等优点。仪器的硬件采用模块化结构设计，因此硬件互换性强... 详细信息

文章介绍一种用于连续测量岩心的自然伽马放射性强度的专用仪器．用彩色绘图仪绘出与测井曲线完全兼容的测量曲线。仪器以微处理机为核心．具有测量精度高．操作方便，可靠性高等优点。仪器的硬件采用模块化结构设计，因此硬件互换性强，检修方便，软件便于维护并可根据需要升级。

关键词：测量仪器岩心放射性强度

Association of Human Whole-blood NAD+Levels with Nabothian Cyst

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Biomedical and Environmental Sciences 2024年第5期37卷 471-478页

作者： XU Ling WANG Yue Xuan WANG Wei FAN Xue CHEN Xue Yu ZHOU Tian Yun LIU Yu He YU Ye YANG Fan ju Zhen Yu ZHOU Yong WANG Deng Liang Clinical Research Institute Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China NHC Key Lab of Reproduction Regulation Shanghai Engineering Research Center of Reproductive Health Drugs and DevicesShanghai Institute for Biomedical and Pharmaceutical TechnologiesShanghai 200237China Department of Applied Statistics Johannes Kepler University LinzLinz 4040Austria Hematology Center Beijing Key Laboratory of Pediatric Hematology OncologyNational Key Discipline of Pediatrics(Capital Medical University)Key Laboratory of Major Diseases in ChildrenMinistry of EducationBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Biostatistics School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Clinical Medicine School of Basic MedicineShanghai Medical College Fudan UniversityShanghai 200032China Department of Biochemistry and Molecular Biology Hengyang Medical SchoolUniversity of South ChinaHengyang 421001HunanChina Administrative Office Total Quality Management OfficeTotal Quality Management InstituteShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China The First Affiliated Hospital of Jinan University Institute of Aging and Regenerative MedicineJinan UniversityJinan 510632GuangzhouChina Department of Scientific Research The First Affiliated Hospital of Huzhou UniversityHuzhou 313000ZhejiangChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005FujianChina Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou 350209FujianChina Fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated HospitalFujian Medical UniversityFuzhou 350005FujianChina Fujian Provincial Clinical Research Center for Neurological

Objective Little is known about the association between whole-blood nicotinamide adenine dinucleotide(NAD^(+))levels and nabothian *** study aimed to assess the association between NAD^(+)levels and nabothian cysts in healthy Chinese *** Multivariate logistic regression analysis was performed to analyze the association between NAD^(+)levels and nabothian *** The mean age was 43.0±11.5 years,and the mean level of NAD^(+)was 31.3±5.3μmol/*** cysts occurred in 184(27.7%)participants,with single and multiple cysts in 100(15.0%)and84(12.6%)participants,*** total nabothian cyst prevalence gradually decreased from37.4%to 21.6%from q1 to q4 of NAD^(+)and the prevalence of single and multiple nabothian cysts also decreased across the NAD^(+)*** compared with the highest NAD^(+)quartile(≥34.4μmol/L),the adjusted odds ratios with 95%confidence interval of the NAD^(+)q1 was 1.89(1.14–3.14)for total nabothian *** risk of total and single nabothian cysts linearly decreased with increasing NAD^(+)levels,while the risk of multiple nabothian cysts decreased more rapidly at NAD^(+)levels of 28.0 to35.0μmol/***:Low NAD^(+)levels were associated with an increased risk of total and multiple nabothian cysts.

关键词： Nicotinamide adenine dinucleotide Nabothian cyst Female Risk factor

D3DqN-CAA:一种基于DRL的自适应边缘计算任务调度方法

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湖南大学学报（自然科学版） 2024年第6期51卷 73-85页

作者：巨涛王志强刘帅火久元李启南兰州交通大学电子与信息工程学院甘肃兰州730070

为解决已有基于深度强化学习的边缘计算任务调度面临的动作空间探索度固定不变、样本效率低、内存需求量大、稳定性差等问题,更好地在计算资源相对有限的边缘计算系统中进行有效的任务调度,在改进深度强化学习模型D3DqN(Dueling Double ... 详细信息

为解决已有基于深度强化学习的边缘计算任务调度面临的动作空间探索度固定不变、样本效率低、内存需求量大、稳定性差等问题,更好地在计算资源相对有限的边缘计算系统中进行有效的任务调度,在改进深度强化学习模型D3DqN(Dueling Double DqN)的基础上,提出了自适应边缘计算任务调度方法 D3DqN-CAA.在任务卸载决策时,将任务与处理器的对应关系看作一个多维背包问题,根据当前调度任务与计算节点的状态信息,为任务选择与其匹配度最高的计算节点进行任务处理;为提高评估网络的参数更新效率,降低过估计的影响,提出一种综合性q值计算方法;为进一步加快神经网络的收敛速度,提出了一种自适应动作空间动态探索度调整策略;为减少系统所需的存储资源,提高样本效率,提出一种自适应轻量优先级回放机制.实验结果表明,和多种基准算法相比,D3DqN-CAA方法能够有效地降低深度强化学习网络的训练步数,能充分利用边缘计算资源提升任务处理的实时性,降低系统能耗.

关键词：边缘计算任务调度深度q学习深度强化学习