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On attitudes about colorectal cancer screening among gastrointestinal specialists and general practitioners in the Netherlands

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World Journal of Gastroenterology 2006年第32期12卷 5201-5204页

作者： js terhaar sive droste GDN Heine ME Craanen H Boot CJJ Mulder Department of Gastroenterology and Hepatology VU University Medical Centre AmsterdamThe Netherlands Department of Gastroenterology and Hepatology Antoni van Leeuwenhoek Hospital AmsterdamThe Netherlands

AIM： To find out whether there are differences in attitudes about colorectal cancer （CRC） screening among gastrointestinal （GI） specialists and general practitioners （GPs） and which method is preferred in a national screening program METHODS： Four hundred and twenty Dutch GI specialists in the Netherlands and 400 GPs in Amsterdam were questioned in 2004. Questions included demographics, affiliation, attitude towards screening both for the general population and themselves, methods of screening, family history and individual risk. RESULTS： Eighty-four percent of the GI specialists returned the questionnaire in comparison to 32% of the GPs （P〈0.001）. Among the GI specialists, 92% favoured population screening whereas 51% of GPs supported population screening （P〈0.001）. Of the GI specialists 95% planned to be screened themselves, while 30% of GPs intended to do so （P〈0.001）. Regarding the general population, 72% of the GI specialists preferred colonoscopy as the screening method compared to 27% of the GPs （P〈0.001）. The method preferred for personal screening was colonoscopy in 97% of the GI specialists, while 29% of the GPs favoured colonoscopy （P〈0.001）. CONCLUSION： Screening for CRC is strongly supported by Dutch GI specialists and less by GPs. The major health issue is possibly misjudged by GPs. Since GPs play a crucial role in a successful national screening program, CRC awareness should be realized by increasing knowledge about the incidence and mortality, thus increasing awareness of the need for screening among GPs.

关键词： Colorectal cancer General practitioner Screening Colonoscopy Awareness

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Digestive oncologist in the gastroenterology training curriculum

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World Journal of Gastroenterology 2011年第9期17卷 1109-1115页

作者： Chris Jacob Johan Mulder Marc Peeters Annemieke Cats Anna Dahele Jochim terhaar sive droste Department of Gastroenterology and Hepatology VU University Medical Center Department of Oncology Antwerp University Hospital Antwerp Department of Gastroenterology and Hepatology Netherlands Cancer Institute

Until the late 1980s, gastroenterology (GE) was considered a subspecialty of Internal Medicine. Today, GE also incorporates Hepatology. However, Digestive Oncology training is poorly defined in the Hepatogastroenterology (HGE)-curriculum. Therefore, a Digestive Oncology curriculum should be developed and this document might be a starting point for such a curriculum. HGE-specialists are increasingly resisting the paradigm in which they play only a diagnostic and technical role in the management of digestive tumors. We suggest minimum endpoints in the standard HGE-curriculum for oncology, and recommend a focus year in the Netherlands for Digestive Oncology in the HGE-curriculum. To produce welltrained digestive oncologists, an advanced Digestive Oncology training program with specific qualifications in Digestive Oncology (2 years) has been developed. The schedule in Belgium includes a period of at least 6 mo to be spent in a medical oncology department. The goal ofthese programs remains the production of well-trained digestive oncologists. HGE specialists are part of the multidisciplinary oncological teams, and some have been administering chemotherapy in their countries for years. In this article, we provide a road map for the organization of a proper training in Digestive Oncology. We hope that the World Gastroenterology Organisation and other (inter)national societies will support the necessary certifications for this specific training in the HGE-curriculum.

关键词： Gastroenterology Training Digestive oncologist Curriculum Chemotherapy Immunotherapy Oncology Targeted therapy

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World Journal of Gastroenterology 2012年第38期18卷 5397-5403页

作者： Sietze T van Turenhout Leo GM van Rossum Frank A Oort Robert JF Laheij Anne F van Rijn Jochim S terhaar sive droste Paul Fockens René WM van der Hulst Anneke A Bouman Jan BMJ Jansen Gerrit A Meijer Evelien Dekker Chris JJ Mulder Department of Gastroenterology and Hepatology VU University Medical Center1081 HV Amsterdam The Netherlands Department of Epidemiology Biostatistics and HTA Radboud University Nijmegen Medical Center6500 HB Nijmegen The Netherlands Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Center6500 HB Nijmegen The Netherlands Department of Gastroenterology and Hepatology Academic Medical Center1105 AZ Amsterdam The Netherlands Department of Gastroenterology and Hepatology Kennemer Gasthuis 2035 RC Haarlem The Netherlands Clinical Chemistry VU University Medical Center 1081 HV Amsterdam The Netherlands Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Center 6500 HB Nijmegen The Netherlands Department of Pathology VU University Medical Center 1081 HV Amsterdam The Netherlands Department of Gastroenterology and Hepatology Academic Medical Center 1105 AZ Amsterdam The Netherlands Department of Gastroenterology and Hepatology VU University Medical Center 1081 HV Amsterdam The Netherlands

AIM: To improve the interpretation of fecal immunochemical test (FIT) results in colorectal cancer (CRC) cases from screening and referral cohorts. METHODS: In this comparative observational study, two prospective cohorts of CRC cases were compared. The first cohort was obtained from 10 322 average risk subjects invited for CRC screening with FIT, of which, only subjects with a positive FIT were referred for colonoscopy. The second cohort was obtained from 3637 subjects scheduled for elective colonoscopy with a positive FIT result. The same FIT and positivity threshold (OC sensor; ≥ 50 ng/mL) was used in both cohorts. Colonoscopy was performed in all referral subjects and in FIT positive screening subjects. All CRC cases were selected from both cohorts. Outcome measurements were mean FIT results and FIT scores per tissue tumor stage (T stage). RESULTS: One hundred and eighteen patients with CRC were included in the present study: 28 cases obtained from the screening cohort (64% male; mean age 65 years, SD 6.5) and 90 cases obtained from the referral cohort (58% male; mean age 69 years, SD 9.8). The mean FIT results found were higher in the referral cohort (829 ± 302 ng/mLvs 613 ± 368 ng/mL,P = 0.02). Tissue tumor stage (T stage) distribution was dif-ferent between both populations [screening population: 13 (46%) T1, eight (29%) T2, six (21%) T3, one (4%) T4 carcinoma; referral population: 12 (13%) T1, 22 (24%) T2, 52 (58%) T3, four (4%) T4 carcinoma], and higher T stage was significantly associated with higher FIT results (P < 0.001). Per tumor stage, no significant difference in mean FIT results was observed (screening vs referral: T1 498 ± 382 ng/mL vs 725 ± 374 ng/mL, P = 0.22; T2 787 ± 303 ng/mL vs 794 ± 341 ng/mL, P = 0.79; T3 563 ± 368 ng/mLvs 870 ± 258 ng/mL,P = 0.13; T4 not available). After correction for T stage in logistic regression analysis, no significant differences in mean FIT results were observed between both types of cohorts (P = 0.10). CONCLUSION

关键词： Screening population Referral cohort Fecal immunochemical test Tumor stage distribution Colorectal cancer

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Colonoscopic yield of colorectal neoplasia in daily clinical practice

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World Journal of Gastroenterology 2009年第9期15卷 1085-1092页

作者： Jochim S terhaar sive droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder Department of Gastroenterology and Hepatology VU University Medical CentrePO Box 70571007 MBAmsterdamThe Netherlands Gastroenterology and Hepatology Kennemer Gasthuis2000 AKHaarlemThe Netherlands Gastroenterology and Hepatology Academic Medical Centre1100 DDAmsterdamThe Netherlands Epidemiology and Biostatistics VU University Medical Centre1007 MBAmsterdamThe Netherlands Pathology VU University Medical Centre1007 MBAmsterdamThe Netherlands Gastroenterology and Hepatology Slotervaart Hospital1006 BKAmsterdamThe Netherlands Gastroenterology and Hepatology Medical Centre Alkmaar1800 AMAlkmaarThe Netherlands Gastroenterology and Hepatology Sint Lucas Andreas Hospital1061 AEAmsterdamThe Netherlands

AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per ***:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or ***:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients.

关键词： Colorectal cancer Screening Advanced neoplasia Colonoscopy Adenoma

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Influence of Tree Density on Vegetation Composition and Soil Chemical Properties in Savanna Rangeland of Eastern Cape, South Africa

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Agricultural Sciences 2021年第10期12卷 991-1002页

作者： sive Tokozwayo Keletso Mopipi Eric Cofie Timpong-Jones Department of Rural Development & Agrarian Reform D&#246 hne Agricultural Development Institute Stutterheim Eastern Cape South Africa Department of Livestock & Pasture University of Fort Hare Alice Eastern Cape South Africa Livestock and Poultry Research Center School of Agriculture College of Basic and Applied Sciences University of Ghana Legon Ghana

The proliferation of woody species alters the vegetation structure, leading to loss of rangeland productivity. It aimed to assess the influence of tree density on vegetation and soil chemical properties at three levels of encroachment;open, moderate and dense. Each level of encroachment was replicated 3 times, a 5000 m2 plot was marked per replicate. Four belt transects 200 m2 were placed per plot. Woody species within each belt transect per replicate were identified and recorded to evaluate woody species composition. Grass species composition was assessed using a step point method. Soil was sampled per replicate and analysed for chemical properties. Results showed that 71% of grasses were increasers and 29% decreasers. Digitaria eriantha and Eragrostis obtusa were the most dominant species. Vachellia karoo and Aloe ferox were the most dominant woody species. The dense had high nitrogen (1.48%) compared to the moderate (0.23%) and the open (0.17%). Increaser species, soil carbon, soil pH increased with the increase of tree density. It was concluded that the replacement of highly palatable grasses with inferior ones was due to improper rangeland management practices. It was recommended that land users form rangeland management associations and set up conservation agreements for proper management of resources.

关键词： Encroachment Composition Density Rangeland

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Ethnopharmacological Assessment of Medicinal Plants Used in the Management of Livestock Ailments by Resource-Limited Farmers in the Eastern Cape Province

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Open Journal of Veterinary Medicine 2023年第6期13卷 96-109页

作者： Siza Mthi Jean Rust sive Tokozwayo Zimasa Busisiwe Dubeni Dö hne Agricultural Development Institute Stutterheim South Africa Department of Rural Development and Agrarian Reform Queenstown South Africa Department of Botany and Zoology Faculty of Science University of Fort Hare Alice South Africa

Medicinal plants play a major role in meeting people’s medical and health needs, especially in developing countries. However, due to a lack of access to modern veterinary facilities, poor visibility of animal health personnel, and high prices of orthodox medicines, most farmers rely on traditional healers and the administration of medicinal plants to treat livestock ailments. The present study was conducted to document Ethnopharmacological knowledge of medicinal plants used to manage livestock ailments in three rural communities of the Eastern Cape. This study was carried out in three rural communities between July 2009 and February 2010. Data were collected by administering pre-tested semi-structured questionnaires and participative field observations. For the interviews, a sample of 48 knowledgeable respondents was purposively selected. Data were analyzed using descriptive and inferential statistics, determination of information consensus factor, and fidelity level. A total of 12 medicinal plants belonging to 9 families were used by local people to cure different ailments. A high number of medicinal plants were claimed by males compared to females. Roots and barks were the major plant parts used, and the least were leaves (27.3%). Six plants were used to treat diarrhea and fertility, five plants to treat wounds, and two plants to treat scabs. This study has shown that Eastern Cape flora is rich with various plants which could be used to replace orthodox drugs. Further studies are needed to determine the minimum inhibitory concentrations, biological activities, and toxicities and characterize the plant’s chemical compounds.

关键词： Ethnopharmacology Medicinal Plants Livestock Ailments Farmers Eastern Cape

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Evaluation of a New Design to Improve the Flexibility of the Nucleus Standard Straight Array Cochlear Implant

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Chinese Journal of Biomedical Engineering(English Edition) 2018年第4期27卷 178-184页

作者： Benjamin Kuan Chen sive Naidoo Lingamanaik Roger La Brooy Romesh Nagarajah Department of Mechanical and Aerospace Engineering Monash University Melbourne Australia School of Aerospace Mechanical and Manufacturing Engineering RMIT University Melbourne Australia Faculty of Engineering and Industrial Sciences Swinburne University Melbourne Australia

Cochlear implants can successfully provide auditory information for bilaterally profoundly deaf patients by electrically stimulating auditory nerve fibres via an electrode array, which is surgically implanted into the scala tympani of the cochlea. It is therefore important that the electrode array does not cause damage to the fine intracochlear structures during the process of insertion, as this can result in the loss of spiral ganglion cells, which are necessary for the implant to evoke auditory percepts. There is strong evidence that trauma and damage during insertion of electrode arrays into the human cochlea are related to the stiffness of the electrode array. Previous studies were conducted to experimentally determine the stiffness properties of electrode arrays using three-point flexural bending and buckling *** this paper, the design of nucleus straight electrode array is modified to give a greater flexibility to further reduce the risk of trauma to delicate structures of the cochlea during surgical insertion of the electrode array. This is achieved by reducing the cross-sectional area of the electrode array at selected positions over its length. Improvements in the flexibility of the new straight electrode array and the bending behavior at its tip have been demonstrated using finite element analysis. Loads applied to the tip of the electrode array at different angles with respect to the longitudinal axis of the electrode array showed that the modified design caused the tip to be more flexible and therefore better able to curl around the inner spiral of the scala tympani and thus less likely to penetrate the basilar membrane during insertion. Loads applied at other positions along the electrode array showed that bending occurred more readily using the modified design thereby reducing the friction and shear stresses at the contact interface between the electrode array and the delicate cochlea structures.

关键词： stiffness properties cochlear implant electrode array nucleus straight tapered array finite element analysis

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Nutritive Value of Four Lucerne Cultivars Planted in Two Soil Types at Bathurst Research Station, Eastern Cape Province, South Africa

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Agricultural Sciences 2022年第10期13卷 1048-1056页

作者： Mhlangabezi Solontsi Mfundo Phakama Maqubela Johan Adam van Niekerk Jan Willem Swanepoel Gideon Jordaan Unathi Gulwa sive Tokozwayo Department of Rural Development and Agrarian Reform Dohne ADI Stutterheim South Africa Centre for Sustainable Agriculture University of Free State Bloemfontein South Africa Department of Rural Development and Agrarian Reform Cradock Experimental Farm Cradock South Africa

Medicago sativa (lucerne) is a widely used perennial fodder crop and ranked amongst the highly nutritive fodders globally. This study assessed the nutritive value (i.e. CP % and TDN %) of four lucerne cultivars under two soil types at Bathurst Research Station. A random grid (quadrant) sampling method was used for sampling and samples were submitted to the laboratory for analysis to determine forage quality. Data collection was carried out by separating harvested biomass for each cultivar using clean packs, weighed and dried at 70˚C for 48 hours then crude protein (CP %) and Total Digestible Nutrients (TDN %) were determined. The results of the study showed that soil type (site) had a significant (P < 0.05) effect on the overall quality of dry matter produced. In soil 1 (S1) the overall CP % content was 11.48% while it was 19.03% in soil 2 (S2). Cultivar 3 (KKS 9911) was the least nutritive cultivar in site 1, while the same cultivar was the most nutritive cultivar in site 2 pertaining CP content. Soil type also significantly affected (P < 0.05) the overall total digestible nutrient (TDN %) content of different lucerne cultivars. In S1, C4 (WL 525) had the highest (P < 0.05) TDN content in comparison to the rest of the cultivars while in the same soil type C1 (SA Std.) had the least TDN content. The four tested lucerne cultivars generally produced highly nutritive lucerne in S2 while they produced less nutritive lucerne in relation to both CP and TDN content in S1.

关键词： Forage Quality Nutritive Value Fodder

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Short-Term Effect of Grazing Exclusion and Uncontrolled Grazing on Species Abundance, Dry Matter Yield and Nutritive Value in an Invaded Area by Euryops floribundus in the Eastern Cape, South Africa

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Open Journal of Ecology 2023年第6期13卷 321-333页

作者： sive Tokozwayo Eric Cofie Timpong-Jones Keletso Mopipi Masibonge Gxasheka Unathi Gulwa Siza Mthi Mthunzi Mndela Mzwethu Dastile Azile Dumani Department of Rural Development & Agrarian Reform D&#246hne Agricultural Development Institute Stutterheim South Africa Livestock and Poultry Research Center School of Agriculture College of Basic and Applied Sciences University of Ghana Legon Ghana Department of Range and Forage Resources Botswana University of Agriculture & Natural Resources Gaborone Botswana Department of Plant Production Soil Science & Agricultural Engineering University of Limpopo Polokwane South Africa Department of Rural Development and Agrarian Reform Queenstown South Africa Department of Livestock & Pasture University of Fort Hare Alice South Africa Department of Rural Development and Agrarian Reform Cradock South Africa

Grazing exclusion (GE) is the most effective rangeland restoration technique which facilitates species diversity and forage quality. This study aimed at assessing short-term impact of GE and continuously grazed rangeland on relative frequency, dry matter yield and nutritive value of dominant grasses in an area invaded by Euryops floribundus. A plot of 2.5 ha was measured and the boundaries demarcated using tape measure and steal pins, the plot was further divided into two subplots of 1ha each which were 5 m apart. One subplot was fenced and protected from grazing livestock, while one subplot was grazed continuously and not fenced. Three parallel belt transects of 100 m × 2 m with 3 m apart were laid out in both subplots. Woody plants occurring within the transects were identified and recorded to determine density. In each subplot, a 0.25 m2 quadrant measuring was thrown randomly to take detailed records on plant species, relative frequency of species and herbage biomass. Four dominant species at the two sites were harvested to determine the nutritive value. Results indicate that grazing exclusion (GE) facilitates grass species diversity, subsequently sixteen and thirteen grasses species were recorded in the GE and uncontrolled grazed (UG) sites, respectively. Eragrostis chloromelas (21.7%), and Themeda triandra (13.2%) had high relative frequencies in the GE site. Highest biomass production was recorded in the GE site (1400 kg·ha-1) compared to UG site (1102 kg·ha-1). Crude protein content was relatively lower at UG site (5.4% - 5.8%) as compared to GE site (7.2% - 7.8%). It was concluded that, GE showed a positive impact on a relative frequency (%), dry matter yield and crude protein content. UG creates a conducive environment for Euryops recruitment. Further studies are required to examine the impact of GE in long-term trial setup.

关键词： Dry Matter Yield Crude Protein Nutritive Value Relative Frequency

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Productivity Evaluation of Four Medicago sativa Cultivars under Two Water Regimes (Irrigated and Non-Irrigated) and Two Soil Types at Bathurst Research Station in the Eastern Cape Province, South Africa

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Agricultural Sciences 2022年第3期13卷 438-447页

作者： Mhlangabezi Solontsi Mfundo Phakama Maqubela Johan Adam van Niekerk Jan Willem Swanepoel Gideon Jordaan Unathi Gulwa sive Tokozwayo Nkululeko Nyangiwe Department of Rural Development and Agrarian Reform D&#246 hne ADI Stutterheim South Africa Centre for Sustainable Agriculture University of Free State Bloemfontein South Africa Department of Rural Development and Agrarian Reform Cradock Experimental Farm Cradock South Africa Department of Agriculture and Animal Health University of South Africa Pretoria South Africa

Medicago sativa (lucerne) is a perennial and drought tolerant fodder crop which is widely used as feed for livestock in South Africa. This study evaluated four lucerne cultivars under two water regimes and also determined the effect of soil type on lucerne biomass production. To determine dry matter production per cultivar per treatment, a random grid (quadrant) sampling method was used and all biomass within that radius was cut to 5 cm above the ground level in each plot. All biomass sampling was done just before regrowth commences. Biomass data collection on four lucerne cultivars belonging to different dormancy groupings (WL 711, WL 525 HQ, KKS 9911 and SA Standard) were collected seasonally under different soil types on both irrigated and non-irrigated plots and analysed. Soil type (site) had a significant (P < 0.05) effect on the overall quantity of dry matter produced as more dry matter was produced in site 2 (S2) in comparison to site 1 (S2). Different levels of water application (moisture supplementation) also affected the quantity of dry matter produced in each soil type. The once-a-month irrigation treatment (Ir1) led to the production of superior dry matter yield on SI even though the effect was not significant. In S2 twice a month irrigation treatment (Ir2) produced the highest dry matter, however, this effect was significant (P < 0.05) only in comparison with zero irrigation (Ir0) treatment. Cultivar 3 (KKS 9911) was the least productive cultivar in S1, while the same cultivar was the least productive cultivar in S2. These findings show that both soil type and irrigation levels had a significant (P < 0.05) effect on the total dry matter production of the tested Lucerne cultivars belonging to different dormancy groupings.

关键词： Biomass Cultivar Dry Matter Dormancy Groupings

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