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Artemisia vulgaris Induces Tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) Signaling

Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： Lucas dos Santos Zamarioli Michele Rosana Maia Santos Adolfo Garcia Erustes Vanessa Marques Meccatti Thais Cristine Pereira Soraya S Smaili Maria Cristina Marcucci Carlos Rocha Oliveira Gustavo js Pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and SKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,SKBR-3 and K562 cells(P<0.05).The viability of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(P<0.05).Treatment of K562 cells with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(P<0.05).The use of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(P<0.01).HEAV-induced Ca^(2+)release mainly from lysosomes in K562 cells(P<0.01).Furthermore,BAPTA-AM,an intracellular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(P<0.05).Conclusions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

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SOME ESTIMATES WITH NONCONFORMING ELEMENTS IN DOMAIN DECOMPOSITION ANALYSIS

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Journal of Computational Mathematics 1998年第1期16卷 63-80页

作者： Gu, js Hu, XC Capital Normal Univ Dept Math Beijing Peoples R China Tsing Hua Univ Dept Appl Math Beijing 100084 Peoples R China

Some essential estimates, especially the so-called extension theorems, are established in this paper, for the nonconforming finite elements with their continuity at the vertices or the edge midpoints of the elements of the quasi-uniform mesh. As in the conforming discrete cases, these estimates play key roles in the theoretical analysis of the nonoverlap domain decomposition methods for the solving of second order self-adjoint elliptic problems discretized by the nonconforming finite element methods.

关键词： nonconforming finite element extension theorem domain decomposition elliptic problem

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Numerical Simulation of Wave Field at the Kemena River Mouth in Kalimantan Island

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China Ocean Engineering 1999年第2期14卷 217-224页

作者： Chen, Y Sun, js Tianjin Res Inst Water Transport Engn Tianjin 300456 Peoples R China

By use of the parabolic equation of numerical simulation of wave which is suitable for large-angle propagation anti Crank-Nicolson differential method, the wave field at the Kemema River mouth has been studied for analysis of sediment movement in the area. In order to reflect wave energy loss accurately, the Bretchneider-Reid formula is quoted and the friction coefficient in the formula is discussed in this paper. The calculation results indicate that the wave becomes a little damped at the mouth of Kemena River influenced by the topography and bottom friction, and the wave at the east beach is higher than that at the west beach, because the east beach extends out.

关键词： parabolic equation wave field numerical simulation river mouth sediment movement

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DUCHESIDE A,A NEW ELLAGIC GLYCOSIDE FROM DUCHESNEA INDICA FOCKE

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Chinese Chemical Letters 1996年第4期7卷 335-336页

作者： Ye, L Yang, js CHINESE ACAD MED SCI PEKING UNION MED COLLINST MED PLANT DEVBEIJING 100094PEOPLES R CHINA

A new ellagic acid glycoside named ducheside A has been isolated from Duchesnea indica Focke, and its structure was elucidated as 3'-0-methyl-ellagic acid-4-0-beta-D-xylopyranoside on the basis of spectral analysis an...

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A NEW ELECTROMAGNETIC IMAGING SCHEME

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中国有色金属学会会刊：英文版 1997年第2期7卷 2-4页

作者： Zhang, RF He, js CENT S UNIV TECHNOL COLL RESOURCE ENVIRONM & CIVIL ENGNCHANGSHA 410083PEOPLES R CHINA

ＡＮＥＷＥＬＥＣＴＲＯＭＡＧＮＥＴＩＣＩＭＡＧＩＮＧＳＣＨＥＭＥ①ＺｈａｎｇＲｏｎｇｆｅｎｇ，ＨｅＪｉｓｈａｎＣｏｌｅｇｅｏｆＲｅｓｏｕｒｃｅ，ＥｎｖｉｒｏｎｍｅｎｔａｎｄＣｉｖｉｌＥｎｇｉｎｅｒｉｎｇ，Ｃｅｎｔｒａ... 详细信息

ＡＮＥＷＥＬＥＣＴＲＯＭＡＧＮＥＴＩＣＩＭＡＧＩＮＧＳＣＨＥＭＥ①ＺｈａｎｇＲｏｎｇｆｅｎｇ，ＨｅＪｉｓｈａｎＣｏｌｅｇｅｏｆＲｅｓｏｕｒｃｅ，ＥｎｖｉｒｏｎｍｅｎｔａｎｄＣｉｖｉｌＥｎｇｉｎｅｒｉｎｇ，ＣｅｎｔｒａｌＳｏｕｔｈＵｎｉｖｅｒｓｉｔｙｏ...

关键词： electromagnetic imaging born approximation inversion

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ER Smart Fluids: Properties and Applications

引用

Journal of Materials Science & Technology 1997年第5期13卷 440-442页

作者： Liu, YJ Leng, js Wang, DF HARBIN INST TECHNOL COMPOSITE MAT RES LABHARBIN 150006PEOPLES R CHINA

ER fluid is one of the popular materials used in smart materials and structures (SMS). In this paper, several ER fluids were synthesized. The static and dynamic mechanic characteristics were measured and discussed. Th... 详细信息

关键词： Intelligent materials

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Sealing Interfaces of Pin in Colour Picture Tube

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Journal of Materials Science & Technology 1996年第1期12卷 78-80页

作者： Wang, GQ Tang, XY Ma, js Dept. of Materials Science and Engineering Tsinghua University Beijing 100084 China

interfacial geometric morphology, chemistry and microstructure have been studied by SEM, EDAX, HREM, and XPS. It is found that the oxide scale/metal interface consists of two layers. The first one is amorphous SiO2 growing inward metal matrix, and the second one under the first layer is TiO2 distributing in metal matrix. There is microstructural transition zone at Cr2O3/SiO2 interface, and an atomic mixed zone with 8 nm width at SiO2/metal interface. The transition zone which is saturated with Cr diffusing from oxide scale exists at the oxide scale/glass interface. The reasons why sand-blasting process can improve bonding strength of the oxide scale and the metal are also discussed. The ideal interfaces are proposed finally.

关键词： Television picture tubes

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ON AN ESSENTIAL ESTIMATE IN THE ANALYSIS OF DOMAIN DECOMPOSITION METHODS

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Journal of Computational Mathematics 1994年第2期12卷 132-137页

作者： GU, js HU, XC TSING HUA UNIV BEIJINGPEOPLES R CHINA

A class of nonconforming finite elements is considered in this paper, which is continuous only at the nodes of the quasi-uniform mesh. We show that there exists an essential estimate which indicates the equivalence relation, independent of the mesh parameter, between the energies of the nonconforming discrete harmonic extensions in different subdomains. The essential estimate is of great importance in the analysis of the nonoverlapping domain decomposition methods applied to second order partial differential equations discretized by nonconforming finite elements.

关键词： equivalence harmonic extensions elliptic priori quasi proof discretization approximate conform

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Numerical Modeling on Suspended Sediment Transportation in the Hangzhou Bay

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China Ocean Engineering 1998年第1期13卷 87-98页

作者： Zhang, js Lu, PD Xu, M Nanjing Hydraul Res Inst Dept River & Harbor Nanjing 210024 Peoples R China Nanjing Normal Univ Dept Geog Nanjing 210024 Peoples R China

In this paper the characteristics of tidal flow and seasonal variation of seidment content in the Hangzhou Bay and their affecting factors are studied. Field investigations and data analysis indicate that the sediment movement is mainly influenced by the Yangtze estuary and the sediment of the Yangtze estuary is induced by wind wave and tidal flow. Owing to the variation of dynamic conditions, the instantaneous sediment content is controlled by tidal flow, wind wave, depth of water and tidal range synthetically. A sediment content relationship formula is established with related factors. A non-equilibrium 2-dimensional numerical model of suspended sediment transportation is set up, and the finite element method is applied. The computation results of the model is in accordance with field data.

关键词： sediment sediment content sediment-carrying capacity finite element numerical model

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Endoscopic treatment of non-variceal gastrointestinal bleeding:hemoclips and other hemostatic techniques

引用

World Journal of Gastroenterology 2000年第1期6卷 42-44页

作者： Moura RM Barkin js University of Miami School of Medicine & Mount Sinai Medical Center Division of GastroenterologyMiamiFloridaUSA

Although the number of hospitalizations for non-variceal gastrointestinal bleeding has decreased inrecent years,acute upper gastrointestinalhemorrhage continues to be a common reason forhospital admission,and peptic ulcers account for atleast fifty percent of all *** the fact thatbleeding from ulcers ceases spontaneously inapproximately 80% of patients,it is still a

关键词： Subject headings gastrointestinal bleeding/therapy endoscopic/therapy hemoclip/therapy hemostatic technique

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