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Infectious Diseases of Poverty 2022年第5期11卷 87-89页

作者： Akinola Stephen Oluwole Uwem Friday Ekpo Obiageli Josephine Nebe Nse Michael Akpan Solomon Monday Jacob Uche Veronica Amazigo John Russell stothard Department of Pure and Applied Zoology Federal University of AgricultureAbeokutaOgun StateNigeria Neglected Tropical Disease Control Division Department of Public HealthFederal Ministry of HealthAbujaNigeria Pan-African Community Initiative on Education and Health(PACIEH) EnuguNigeria Department of Tropical Disease Biology Liverpool School of Tropical MedicineLiverpool L35QAUK.

Background With some 134,073,166 people living in endemic communities at risk of infection[1],Nigeria is the most endemic country in Africa and requires preventive chemotherapy(PC)for a total of 26.3 million persons[2].The National Schistosomiasis Elimination Programme(NSCHEP),with the support of international partners,has been implementing PC in Nigeria since 2009 and most recently will need to revise its current strategy(Additional file 1).For example,the new World Health Organization(WHO)guideline has six key recommendations that will dramatically change the implementation of schistosomiasis elimination in endemic countries[3].However,its impact and programmatic implications will vary from country to country,hence the need for a country-specific analysis.

关键词： schistosomiasis Schistosomiasis Nigeria

Towards interruption of schistosomiasis transmission in sub-Saharan Africa:developing an appropriate environmental surveillance framework to guide and to support‘end game’interventions

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Infectious Diseases of Poverty 2017年第1期6卷 78-88页

作者： J.Russell stothard Suzy J.Campbell Mike Y.Osei-Atweneboana Timothy Durant Michelle C.Stanton Nana-Kwadwo Biritwum David Rollinson Dieudonne R.Eloundou Ombede Louis-Albert Tchuem-Tchuente Department of Parasitology Liverpool School of Tropical MedicinePembroke PlaceLiverpool L35QAUK Department of Environmental Biology and Health Council for Scientific and Industrial Research-Water Research InsituteP.O.Box M 32AccraGhana Neglected Tropical Diseases Programme Ghana Health ServicesAccraGhana Department of Life Sciences Natural History MuseumCromwell RoadLondon SW75BDUK Centre for Schistosomiasis and Parasitology YaoundeCameroon Laboratory of Parasitology and Ecology Faculty of SciencesUniversity of YaoundeIYaoundeCameroon National Programme for the Control of Schistosomiasis and Intestinal Helminthiasis Ministry of Public HealthYaoundeCameroon

Schistosomiasis is a waterborne parasitic disease in sub-Saharan Africa,particularly common in rural populations living in impoverished *** the scale-up of preventive chemotherapy,national campaigns will transition from morbidity-to transmission-focused interventions thus formal investigation of actual or expected declines in environmental transmission is needed as‘end game’scenarios ***,there are no international or national guidelines to do so in sub-Saharan *** article therefore provides an introduction to key practicalities and pitfalls in the development of an appropriate environmental surveillance *** this context,we discuss how strategies need to be adapted and tailored to the local level to better guide and support future interventions through this *** detection of egg-patent infection in people becomes rare,careful sampling of schistosome larvae in freshwater and in aquatic snails with robust species-specific DNA assays will be *** metrics,derived from observed prevalence(s)as compared with predetermined thresholds,could each provide a clearer insight into contamination-and exposure-related *** could be twofold,first to certify areas currently free from schistosomiasis transmission or second to red-flag recalcitrant locations where extra effort or alternative interventions are needed.

关键词： Environmental monitoring Freshwater snails eDNA WASH Zoonosis

Building a global schistosomiasis alliance:an opportunity to join forces to fight inequality and rural poverty

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Infectious Diseases of Poverty 2017年第1期6卷 558-563页

作者： Lorenzo Savioli Marco Albonico Daniel G.Colley Rodrigo Correa-Oliveira Alan Fenwick Will Green Narcis Kabatereine Achille Kabore Naftale Katz Katharina Klohe Philip TLoVerde David Rollinson jru.sell stothard Louis-Albert Tchuem Tchuente Johannes Waltz Xiao-Nong Zhou Global Schistosomiasis Alliance GenevaSwitzerland Center for Tropical Diseases Sacro Cuore Hospital-WHO Collaborating Centre on strongyloidiasis and other intestinal parasitic infectionsNegrarVeronaItaly Schistosomiasis Consortium for Operational Research and Evaluation The University of GeorgiaAthensGeorgiaUSA Centro de Pesquisas ReneRachou-Fiocruz Belo HorizonteBrazil and Universidade Federal de Ouro PretoOuro PretoBrazil Department of Infectious Disease Epidemiology SCIImperial CollegeLondonUK Trinity College Cambridge CambridgeUK Imperial College London LondonUK RTI International WashingtonDCUSA Research Center Rene Rachou-Oswaldo Cruz Foundation Belo HorizonteBrazil Global Schistosomiasis Alliance MunichGermany University of Texas Health Science Center San AntonioTXUSA Life Sciences Department The Natural History MuseumLondonUK Department of Parasitology Liverpool School of Tropical MedicineLiverpool L35QAUK Centre for Schistosomiasis&Parasitology YaoundeCameroon Global Schistosomiasis Alliance LondonUK National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention ShanghaiChina

Schistosomiasis,one of the 17 neglected tropical diseases listed by the World Health Organization,presents a substantial public health and economic *** the 261 million people requiring preventive chemotherapy for schistosomiasis in 2013,92%of them lived in sub-Saharan Africa and only 12.7%received preventive ***,in 2010,the WHO reported that schistosomiasis mortality could be as high as 280000 per year in Africa *** May 2012 delegates to the sixty-fifth World Health Assembly adopted resolution WHA65.21 that called for the elimination of schistosomiasis,and foresees the regular treatment of at least 75%of school age children in at-risk *** resolution urged member states to intensify schistosomiasis control programmes and to initiate elimination campaigns where *** this,in June 2015,schistosomiasis was indicated to have the lowest level of preventive chemotherapy implementation in the spectrum of neglected tropical *** was also highlighted as the disease most lacking in *** is perhaps unsurprising,given that it was also the only NTD with access to drug donations but without a coalition of stakeholders that collaborates to boost commitment and *** a consequence,and to ensure that the WHO NTDs Roadmap Targets of 2012 and World Health Assembly Resolution WHA65.21 are met,the Global Schistosomiasis Alliance(GSA)has been set *** and representative,the GSA aims to be a partnership of endemic countries,academic and research institutions,international development agencies and foundations,international organizations,non-governmental development organizations,private sector companies and advocacy and resource mobilisation ***,the GSA calls for a partnership to work for the benefit of endemic countries by addressing health inequity and rural poverty.

关键词： Neglected tropical diseases Schistosomiasis Global Schistosomiasis Alliance Elimination

他达拉非对勃起焦虑的瑞典男性心理状态的影响：一项多中心、非随机、开放性临床研究

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中华男科学杂志 2010年第4期16卷 382-382页

作者： Fugl-Meyer KS stothard D Belger M 赵高高不详浙江省新华医院泌尿外科 310005

一项多中心、非随机、开放性研究评价了由勃起功能障碍（ED）引起的焦虑是否会影响他达拉非的治疗ED的心理疗效。本研究入选了18岁以上、至少有3个月ED病史的瑞典男性患者，并在人选时通过焦虑调查问卷分为明显焦虑和轻／无焦虑两组。... 详细信息

一项多中心、非随机、开放性研究评价了由勃起功能障碍（ED）引起的焦虑是否会影响他达拉非的治疗ED的心理疗效。本研究入选了18岁以上、至少有3个月ED病史的瑞典男性患者，并在人选时通过焦虑调查问卷分为明显焦虑和轻／无焦虑两组。所有患者均接受为期8周的他达拉非20mg按需服用的治疗方案。研究的主要终点为两组患者治疗后的心理和人际关系量表（PAIRS）的性自发性域评分与基线时的变化差异；次要终点是PAIRS性自信和时间顾虑评分、生活满意度（LiSat-11）目录以及治疗反应整体评价。

关键词：性心理状态他达拉非开放性临床研究多中心焦虑瑞典随机勃起功能障碍

Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar

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Infectious Diseases of Poverty 2021年第3期10卷 124-124页

作者： Caitlin Sheehy Heather Lawson Emmanuel H.Andriamasy Hannah J.Russell Alice Reid Gina U.Raderalazasoa Graham Dodge Robbie Kornitschky James M.StJPenney Tahiry N.Ranaivoson Antsa Andria niaina Jenny S.Emmanoela Amaya L.Bustinduy jru.sell stothard Louis Andrianjaka Stephen A.Spencer The University of Man Chester Medical School University of Man ChesterManchester M139NTUK 不详

School-aged children(SAC)have a considerable burden of intestinal schistosomiasis in Madagascar yet its burden in pre-school aged children(PSAC)is currently *** assess the at-risk status of PSAC,we undertook a pilot epidemiological survey in June 2019 examining children(n=89),aged 2-4-years of balanced gender,in six remote villages in Marolambo District,*** included use of urine-circulating cathodic antigen(CCA)dipsticks and coproscopy of stool with duplicate Kato-Katz(K-K)thick smears.

关键词： Schistosoma mansoni Soil-transmitted helminthiasis Paediatric Praziquantel Mass drug administration

细胞内氯化物通道4异常表达可导致肺动脉高压患者内皮功能紊乱

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中华高血压杂志 2014年第5期22卷 424-424页

作者：刘莉叶鹏 Wojciak-stothard B AbdulSalam VB Lao KH Tsang H Irwin DC Lisk C Loomis Z Stenmark KR Edwards JC Yuspa SH Howard LS Edwards RJ Rhodes CJ Gibbs JS Wharton J Zhao L Wilkins MR

细胞内氯化物通道4（chloride intracellular chan-nel4，CLIC4）在肺动脉高压（pulmonaryarterialhy-pertension，PAH）患者重塑的肺血管内皮和丛状病灶中高度表达。CLIC4通过形成内皮管腔调节血管生成，其异常表达可导致PAH患者肺血... 详细信息

细胞内氯化物通道4（chloride intracellular chan-nel4，CLIC4）在肺动脉高压（pulmonaryarterialhy-pertension，PAH）患者重塑的肺血管内皮和丛状病灶中高度表达。CLIC4通过形成内皮管腔调节血管生成，其异常表达可导致PAH患者肺血管病理性改变。方法和结果：CLIC4蛋白在特发性PAH（idiopathicPAH，IPAH）患者血浆和从血液中分离的内皮细胞，

关键词：内皮功能紊乱肺动脉高压氯化物通道异常表达细胞内患者肺血管内皮病理性改变