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中华医学会第七次全国消化病学术会议

作者：郭长存 jr fraser cummings Alessandra Geremia John Beckly Rachel Cooney Laura Hancock Saad Patham Derek P Jewell 第四军医大学西京医院消化内科 Wellcome Trust Centre for Human Genetics University of OxfordOxford OX3 7BN UK

背景以往的 Cho 等人的两项连锁研究显示染色体 lp36与 IBD 密切连锁,该基因作为命名为 IBD7, 目前为止 IBD7 位点的 IBD 相关基因尚未见报道。RUNX3和 CASP9基因座位均位于 IBD7位点。RUNX3 基因敲除小鼠模型具有溃疡性结肠炎表型,而 C...

背景以往的 Cho 等人的两项连锁研究显示染色体 lp36与 IBD 密切连锁,该基因作为命名为 IBD7, 目前为止 IBD7 位点的 IBD 相关基因尚未见报道。RUNX3和 CASP9基因座位均位于 IBD7位点。RUNX3 基因敲除小鼠模型具有溃疡性结肠炎表型,而 CASP9在 IBD 患者肠黏膜中表达显著下调。目的研究 CASP9和 RUNX3基因多态性是否与 IBD 相关,是否是 IBD7位点的易感基因。方法研究对象为高加索人群,包括555例克隆恩患者、651例溃疡性结肠炎患者和964例健康对照。采用 MALDI-TOF MS 分析

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Inflammatory bowel disease registries for collection of patient iron parameters in Europe

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World Journal of Gastroenterology 2018年第10期24卷 1063-1071页

作者： Jonas Halfvarson fraser cummings Olof Grip Guillaume Savoye Department of Gastroenterology Faculty of Medicine and HealthOebro UniversityObro SE 70182Sweden Department of Gastroenterology Southampton University Hospital NHS Foundation TrustSouthamptonHampshire SO16 6YDUnited Kingdom Department of Gastroenterology Skae University HospitalMalmo-20502Sweden Service d'heato-gastroenteologie CHU de Rouen-Hoital Charles NicolleRouen 76031France

Iron deficiency without anemia and iron deficiency anemia are common and frequently overlooked complications of inflammatory bowel disease. Despite the frequency and impact of iron deficiency in inflammatory bowel disease, there are gaps in our understanding about its incidence, prevalence and natural history and, consequently, patients may be undertreated. Medical registries have a key role in collecting data on the disease's natural history, the safety and effectiveness of drugs in routine clinical practice, and the quality of care delivered by healthcare services. Even though iron deficiency impacts inflammatory bowel disease patients and healthcare systems substantially, none of the established European inflammatory bowel disease registries systematically collects information on iron parameters and related outcomes. Collection of robust iron parameter data from patient registries is one way to heighten awareness about the importance of iron deficiency in this disease and to generate data to improve the quality of patient care, patient outcomes, and thus quality of life. This objective could be achieved through collection of specific laboratory, clinical, and patientreported measurements that could be incorporated into existing registries. This review describes the status of current European inflammatory bowel disease registries and the data they generate, in order to highlight their potential role in collecting iron data, to discuss how such information gathering could contribute to our understanding of iron deficiency anemia, and to provide practical information in regard to the incorporation of accumulated iron parameter data into registries.

关键词： Anemia Iron deficiency Registries Inflammatory bowel disease Patient care

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Low-dose morphine elicits ventilatory excitant and depressant responses in conscious rats: Role of peripheral <i>µ</i>-opioid receptors

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Open Journal of Molecular and Integrative Physiology 2013年第3期3卷 111-124页

作者： fraser Henderson jr. Walter J. May Ryan B. Gruber Alex P. Young Lisa A. Palmer Benjamin Gaston Stephen J. Lewis Pediatric Respiratory Medicine University of Virginia School of Medicine Charlottesville USA Division of Biology Galleon Pharmaceuticals Horsham USA Department of Pediatrics Case Western Reserve University Cleveland USA

The systemic administration of morphine affects ventilation via a mixture of central and peripheral actions. The aims of this study were to characterize the ventilatory responses elicited by a low dose of morphine in conscious rats;to determine whether tolerance develops to these responses;and to determine the potential roles of peripheral μ-opioid receptors (μ-ORs) in these responses. Ventilatory parameters were monitored via unrestrained whole-body plethysmography. Conscious male Sprague-Dawley rats received an intravenous injection of vehicle or the peripherally-restricted μ-OR antagonist, naloxone methiodide (NLXmi), and then three successive injections of morphine (1 mg/kg) given 30 min apart. The first injection of morphine in vehicle-treated rats elicited an array of ventilatory excitant (i.e., increases in frequency of breathing, minute volume, respiratory drive, peak inspiratory and expiratory flows, accompanied by decreases in inspiratory time and end inspiratory pause) and inhibitory (i.e., a decrease in tidal volume and an increase in expiratory time) responses. Subsequent injections of morphine elicited progressively and substantially smaller responses. The pattern of ventilatory responses elicited by the first injection of morphine was substantially affected by pretreatment with NLXmi whereas NLXmi minimally affected the development of tolerance to these responses. Low-dose morphine elicits an array of ventilatory excitant and depressant effects in conscious rats that are subject to the development of tolerance. Many of these initial actions of morphine appear to involve activation of peripheral μ-ORs whereas the development of tolerance to these responses does not.

关键词： Morphine Minute Ventilation Tolerance Peripheral and Central Opioid Receptors Conscious Rats

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Morphine has latent deleterious effects on the ventilatory responses to a hypoxic challenge

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Open Journal of Molecular and Integrative Physiology 2013年第3期3卷 166-180页

作者： Walter J. May Ryan B. Gruber Joseph F. Discala Veljko Puskovic fraser Henderson jr. Lisa A. Palmer Stephen J. Lewis Pediatric Respiratory Medicine University of Virginia School of Medicine Charlottesville USA Division of Biology Galleon Pharmaceuticals Horsham USA

The aim of this study was to determine whether morphine depresses the ventilatory responses elicited by a hypoxic challenge (10% O2, 90% N2) in conscious rats at a time when the effects of morphine on arterial blood gas (ABG) chemistry, Alveolar-arterial (A-a) gradient and minute ventilation (Vm) had completely subsided. In vehicle-treated rats, each episode of hypoxia stimulated ventilatory function and the responses generally subsided during each normoxic period. Morphine (5 mg/kg, i.v.) induced an array of depressant effects on ABG chemistry, A-a gradient and Vm (via decreases in tidal volume). Despite resolution of these morphine-induced effects, the first episode of hypoxia elicited substantially smaller increases in Vm than in vehicle-treated rats, due mainly to smaller increases in frequency of breathing. The pattern of ventilatory responses during subsequent episodes of hypoxia and normoxia changed substantially in morphine-treated rats. It is evident that morphine haslatent deleterious effects on ventilatory responses elicited by hypoxic challenge.

关键词： Morphine Hypoxia Minute Ventilation Arterial Blood Gas Chemistry Conscious Rats

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