检索结果-南通市图书馆

REVISITING THE SIMIlAR PROCESS TO ENGINEER THE CONTEMPORARY SYSTEMS

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science and Systems Engineering 2010年第3期19卷 321-350页

作者： Ana luísa RAMOS José Vasconcelos FERREIRA Jaume BARCEló GOVCOPP-Department of Economics Management and Industrial EngineeringUniversity of Aveiro Department of Statistics and Operations Research Technical University of Catalonia

This paper addresses the present-day context of Systems Engineering, revisiting and setting up an updated framework for the SIMIlAR process in order to use it to engineer the contemporary systems. The contemporary world is crowded of large interdisciplinary complex systems made of other systems, personnel, hardware, software, information, processes, and facilities. An integrated holistic approach is crucial to develop these systems and take proper account of their multifaceted nature and numerous interrelationships. As the system＇s complexity and extent grow, the number of parties involved （stakeholders and shareholders） usually also raises, bringing to the interaction a considerable amount of points of view, skills, responsibilities, and interests. The Systems Engineering approach aims to tackle the complex and interdisciplinary whole of those socio-technical systems, providing the means to enable their successful realization. Its exploitation in our modern world is assuming an increasing relevance noticeable by emergent standards, academic papers, international conferences, and post-graduate programmes in the field. This work aims to provide ＂the picture＂ of modern Systems Engineering, and to update the context of the SIMIlAR process model in order to use this renewed framework to engineer the challenging contemporary systems. The emerging trends in the field are also pointed-out with particular reference to the Model-Based Systems Engineering approach.

关键词： SIMIlAR process systems engineering standards MBSE

Transverse momentum balance of dijets in Xe+Xe collisions at the lHC

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第7期35卷 137-146页

作者： Yao li Shu-Wan Shen sa Wang Ben-Wei Zhang Key laboratory of Quark&lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan430079China College of Science China Three Gorges UniversityYichang443002China Center for Astronomy and Space Sciences and Institute of Modern Physics China Three Gorges UniversityYichang443002China Guangdong-Hong Kong Joint laboratory of Quantum Matter Guangdong Provincial Key Laboratory of Nuclear ScienceSouthern Nuclear Science Computing CenterSouth China Normal UniversityGuangzhou510006China

We present a theoretical study of the medium modifications of the p_(T)balance (x_(J)) of dijets in Xe+Xe collisions at■.The initial production of dijets was carried out using the POWHEG+PYTHIA8 prescription,which matches the next-toleading-order (NlO) QCD matrix elements with the parton shower (PS) *** SHEll model described the in-medium evolution of nucleus–nucleus collisions using a transport *** theoretical results of the dijet xJin the Xe+Xe collisions exhibit more imbalanced distributions than those in the p+p collisions,consistent with recently reported ATlAS *** utilizing the Interleaved Flavor Neutralisation,an infrared-and-collinear-safe jet flavor algorithm,to identify the flavor of the reconstructed jets,we classify dijets processes into three categories:gluon–gluon (gg),quark–gluon (qg),and quark–quark (qq),and investigated the respective medium modification patterns and fraction changes of the gg,qg,and qq components of the dijet sample in Xe+Xe *** is shown that the increased fraction of qg component at a small x_(J)contributes to the imbalance of the dijet;in particular,the q_(1)g_(2)(quark-jet-leading) dijets experience more significant asymmetric energy loss than the g_(1)q_(2)(gluon-jet-leading) dijets traversing the *** comparing the■of inclusive,■ dijets in Xe+Xe collisions,we observe■.Moreover,ρ_(Xe),P_(b),the ratios of the nuclear modification factors of dijets in Xe+Xe to those in Pb+Pb,were calculated,which indicates that the yield suppression of dijets in Pb+Pb is more pronounced than that in Xe+Xe owing to the larger radius of the lead nucleus.

关键词： Heavy-ion collisions Quark-gluon plasma Jet quenching Transverse momentum balance

From Self-assembled Monolayers to Chemically Patterned Brushes:Controlling the Orientation of Block Copolymer Domains in Films by Substrate Modification

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2016年第6期34卷 659-659,660-678页

作者： Xiao-sa Jin Yuan-yuan Pang 季生象 Key laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences

Block copolymer lithography is emerging as one of the leading technologies for patteming nanoscale dense features. In almost all potential applications of this technology, control over the orientation of cylindrical and lamellar domains is required for pattern transfer from the block copolymer film. This review highlights the state-of-art development of brushes to modify the substrates to control the assembly behaviors of block copolymers in films. Selected important contributions to the development of self-assembled monolayers, polymer brushes and mats, and chemically patterned brushes are discussed.

关键词： Self-assembly Block copolymer Neutral brush Chemical pattern Wetting behavior.

Kinetic modeling of high-temperature oxidation of pure Mg

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2020年第3期8卷 819-831页

作者： sa Ma Fangzhou Xing Na Ta lijun Zhang State Key laboratory of Powder Metallurgy Central South UniversityChangshaHunan 410083P.R.China Max-Planck-Institut fiir Eisenforschung GmbH Max-Planck-Straβe 140237DusseldorfGermany

A variety of experimental tracer diffusivities of Mg and O in magnesium oxide available in the literature were first *** mobilities including bulk and short-circuit diffusion of Mg and O were then obtained by means of the CAlPHAD(Calculation of Phase Diagram)***,the diffusion-controlled kinetic model of oxidation in a gas-MgO-Mg environment was developed based on the moving boundary model and Fick's law,coupling with the modified thermodynamic description of MgO.A mathematical expression for parabolic rate constant kp of the oxide scale was derived for magnesia and correlated with the thermodynamic and diffusion kinetic *** evaluated kp results were in line with the experimental ***,the oxidation process of pure magnesium at 673 K was model-predicted,and the predicted evolution of the oxide thicknesses agreed very well with the experimental *** was indicated that the grain boundaries diffusion of magnesium cations predominated the high temperature oxidation process.

关键词： MgO Diffusion Oxidation Atomic mobility CAlPHAD Wagner's model

Compatibility and stability studies involving polymers used in fused deposition modeling 3D printing of medicines

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2022年第3期12卷 424-435页

作者： Ihatanderson A.Silva Ana luiza lima Tais Gratieri Guilherme M.Gelfuso livia l.sa-Barreto Marcilio Cunha-Filho laboratory of Food Drugand Cosmetics(LTMAC)School of Health SciencesUniversity of Brasilia70910-900BrasíliaDFBrazil Faculty of Ceilandia University of Brasilia(UnB)72220-900BrasíliaDFBrazil

One of the challenges in developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high *** work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines,tested regarding their morphology and thermal,crystallographic,and spectroscopic ***,despite the strong drug-polymer interactions observed,the chemical stability of the model drugs was preserved under such *** fact,in the metoprolol and Soluplus®composition,the drug's solubilization in the polymer produced a delay in the drug decomposition,suggesting a protective effect of the *** and polyvinyl alcohol mixture,in turn,showed unmistakable signs of thermal instability and chemical decomposition,in addition to physical *** the presented context,establishing protocols that simulate processing and storage conditions may be decisive for obtaining stable pharmaceutical dosage forms using three-dimensional printing technology.

关键词： Three-dimensional printing Preformulation Hot-melt extrusion Thermal analysis Drug-polymer compatibility

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin li Makiko Ohshima Marianne Schultzberg Xiaofei li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

Adaptive Partial Task Offloading and Virtual Resource Placement in SDN/NFV-Based Network Softwarization

在线全文

学校读者我要写书评

暂无评论

Computer Systems Science & Engineering 2023年第5期45卷 2141-2154页

作者： Prohim Tam sa Math Seokhoon Kim Department of Software Convergence Soonchunhyang UniversityAsan31538Korea Department of Computer Software Engineering Soonchunhyang UniversityAsan31538Korea

Edge intelligence brings the deployment of applied deep learning(Dl)models in edge computing systems to alleviate the core backbone network *** setup of programmable software-defined networking(SDN)control and elastic virtual computing resources within network functions virtualization(NFV)are cooperative for enhancing the applicability of intelligent edge *** offer advancement for multi-dimensional model task offloading in edge networks with SDN/NFV-based control softwarization,this study proposes a Dl mechanism to recommend the optimal edge node selection with primary features of congestion windows,link delays,and allocatable bandwidth *** partial task offloading policy considered the Dl-based recommendation to modify efficient virtual resource placement for minimizing the completion time and termination drop *** optimization problem of resource placement is tackled by a deep reinforcement learning(DRl)-based policy following the Markov decision process(MDP).The agent observes the state spaces and applies value-maximized action of available computation resources and adjustable resource allocation *** reward formulation primarily considers taskrequired computing resources and action-applied allocation *** defined policies of resource determination,the orchestration procedure is configured within each virtual network function(VNF)descriptor using topology and orchestration specification for cloud applications(TOSCA)by specifying the allocated *** simulation for the control rule installation is conducted using Mininet and Ryu SDN *** delay and task delivery/drop ratios are used as the key performance metrics.

关键词： Deep learning partial task offloading software-defined networking virtual machine virtual network functions

Tuning the Molecular Structure and Transport Property of[bmim][Tf_(2)N]Using Electric Field

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2022年第4期31卷 1076-1083页

作者： WANG Tao lIU Xiangyang XUE sa lIU Hui HE Maogang Key laboratory of Thermal Fluid Science and Engineeringof MOE School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049China

In this work,the effects of electric field on the microstructure and transport property of[bmim][Tf_(2)N]were simulated by molecular dynamics method to provide regulating strategy of required ionic *** simulation results showed that[bmim]^(+) and [Tf_(2)N]^(–)move slowly along the positive and negative direction of the electric field,respectively,and anions and cations are still arranging alternatively under weak electric field which has slight influence on the electrostatic force in[bmim][Tf_(2)N].When the electric field is strong,it has significant influence on the electrostatic force of[bmim][Tf_(2)N],which results the aggregation of[bmim]^(+) and [Tf_(2)N]^(–) and the appearance of large hole inside[bmim][Tf_(2)N].In addition,with the increase of electric field intensity,the density of[bmim][Tf_(2)N] increases,which means the free volume inside[bmim][Tf_(2)N]become ***,the thermal conductivity and viscosity exhibit anisotropy.

关键词： ionic liquid molecular structure transport property electric field

Global research trends on diet and nutrition in Crohn’s disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第20期29卷 3203-3215页

作者： Muna Shakhshir sa'ed H Zyoud Department of Nutrition An-Najah National University HospitalNablus 44839Palestine Department of Clinical and Community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Poison Control and Drug Information Center(PCDIC) College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research Centre An-Najah National University HospitalNablus 44839Palestine

BACKGROUND Crohn’s disease represents a challenge for patients concerned with the modified diet regimen as well as practitioners who seek the best nutritional ***’s disease can alter the body’s ability to digest food and to absorb nutrients,resulting in severe vitamin deficiencies,malnutrition and sometimes lifethreatening ***,a comprehensive bibliometric analysis is lacking to map the current links between nutrition and Crohn’s disease in terms of the number of citations,geographic distribution and growth trends of *** To introduce the current state of research as well as hotspots in the field of nutrition and Crohn’s disease from a bibliometric *** We searched the Scopus database and selected the relevant literature on nutrition and Crohn’s disease that met the inclusion *** analyzed the publication trends and research hotspots by using video object segmentation viewer *** We included 1237 *** number of documents published each year has increased *** United States and the University of Otago,Christchurch,have had the highest productivity,with 208(16.81%)and 29(2.34%)documents,***“role of exclusive enteral nutrition for complicated Crohn’s disease”and“manipulation of the gut microbiota as a key target for Crohn’s disease”were the major research areas in 2016-2021,and they could be extensively investigated in the ***,research on“malnutrition in patients with Crohn’s disease”appeared to be an area that attracted more research attention before *** This is the first bibliometric analysis to map the knowledge structure and trends regarding nutrition in Crohn’s disease research over the past two *** results provide a comprehensive summary and identification of the frontiers of nutrition and Crohn’s disease-related research,which may be used as a resource by researchers in the field.

关键词： Nutrition Diet Crohn’s disease Bibliometric Microbiota Malnutrition