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Entrepreneurial finance : finance for small business / 2nd ed.

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Gastric amyloidoma in patient after remission of Non-Hodgkin's Lymphoma

2001年

作者： Adelman philip j.

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World journal of Gastrointestinal Oncology 2009年第1期1卷 93-96页

作者： Charles philip Koczka Adam j Goodman Department of Medicine SUNY Downstate Medical Center

Amyloidosis is commonly systemic,occasionally organlimited,and rarely a solitary localized *** latter,commonly referred to as tumoral amyloidosis,is described as occurring in nearly every organ/*** a few reports of gastric amyloidosis exist *** describe a 72 year-old black male from Barbados presenting with 3 d of diffuse abdominal *** medical history included Non-Hodgkin's Lymphoma diagnosed five years ago,status-post six rounds of cyclophosphamide,adriamycin,vincristine,prednisone chemotherapy,and currently was in *** computed tomography scan of the abdomen,thickening and calcification of the gastric wall was noted along with *** esophagogastroduodenoscopy,a large circumferential friable mass was seen from the gastroesophageal junction to the body.A large nonbleeding 3 cm polyp was also seen in post bulbar area of *** were stained with Congo red and gave green birefringence under polarized light,consistent with tumoral *** emission tomography scan revealed diffuse gastric mucosa uptake compatible with gastric malignancy without metastatic *** for gastric amyloidomas has presently been one of observation or,at most,resection of the amyloid *** is not known if our patient required the same approach or if this warranted the re-institutionof chemotherapy for Non-Hodgkin's *** more reports of tumoral amyloidosis are made known,treatment as well as prognosis remain uncertain.

关键词： Amyloidoma Non-Hodgkin Lymphoma Stomach Duodenum

Prevalence and predictors of nonalcoholic fatty liver disease in South Asian women with polycystic ovary syndrome

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World journal of Gastroenterology 2020年第44期26卷 7046-7060页

作者： Mohamed Shengir Srinivasan Krishnamurthy Peter Ghali Marc Deschenes philip Wong Tianyan Chen Giada Sebastiani Department of Experimental Medicine McGill UniversityMontreal H4A3J1Canada Department of Obstetrics and Gynecology McGill University Health CentreMontreal H4A3J1Canada Department of Medicine McGill University Health CentreMontreal H4A3J1Canada

BACKGROUND Polycystic ovary disease(PCOS)may be a risk factor for nonalcoholic fatty liver disease(NAFLD)due to common pathogenetic pathways,including insulin resistance and *** PCOS and NAFLD are more severe in South Asian *** on NAFLD in South Asian women with PCOS are *** To investigate prevalence and predictors of NAFLD and liver fibrosis in PCOS patients from South *** We conducted an observational routine screening program by means of transient elastography(TE)with associated controlled attenuation parameter(CAP).NAFLD was defined as CAP≥288 decibels per *** liver fibrosis(stage 2 and higher out of 4)was defined as TE measurement≥8.0 *** alanine aminotransferase(ALT)was defined as ALT>24 IU/L,as per upper limit of normal reported in South Asian *** hyperandrogenism was defined as free androgen index>*** of NAFLD were determined by logistic regression *** 101 PCOS patients(mean age 36.3 years)with no significant alcohol intake or viral hepatitis were *** of NAFLD and significant liver fibrosis was 39.6% and 6.9%,*** ALT was observed in 40%and 11.5%of patients with and without NAFLD,*** adjusting for duration of PCOS and insulin resistance measured by homeostasis model for assessment of insulin resistance,independent predictors of NAFLD were higher body mass index[adjusted odds ratio(aOR)1.30,95% confidence interval(CI):1.13-1.52],hyperandrogenism(aOR:5.32,95%CI:1.56-18.17)and elevated ALT(aOR:3.54,95%CI:1.10-11.47).Lifetime cardiovascular risk was higher in patients with NAFLD compared to those without NAFLD(0.31±0.11 vs 0.26±0.13).CONCLUSION Despite their young age,NAFLD diagnosed by TE with CAP is a frequent comorbidity in South Asian women with PCOS and is strongly associated with higher body mass index and ***-invasive screening strategies could help early diagnosis and initiation of interventi

关键词： Body mass index Transient elastography Controlled attenuation parameter Hyperadrogenism Alanine aminotransferase Lifetime cardiovascular risk

A cluster-randomized trial comparing two SWITCH implementation support strategies for school wellness intervention effectiveness

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journal of Sport and Health Science 2023年第1期12卷 87-96页

作者： Richard R.Rosenkranz philip M.Dixon David A.Dzewaltowski Gabriella M.McLoughlin joey A.Lee Senlin Chen Spyridoula Vazou Lorraine M.Lanningham-Foster Doug A.Gentile Gregory j.Welk Department of Food NutritionDietetics&HealthKansas State UniversityManhattanKS 66506USA Department of Statistics Snedecor HallIowa State UniversityAmesIA 50011-1210USA Department of Health Promotion University of NebraskaOmahaNE 68198-4365USA Implementation Science Center for Cancer Control and Prevention Research Center Brown SchoolWashington University in St.LouisSt.LouisMO 63130USA Division of Public Health Sciences(Department of Surgery) Washington University School of MedicineWashington University in St.LouisSt.LouisMO 63130USA Department of Health Sciences University of Colorado Colorado SpringsColorado SpringsCO 80918USA Department of Kinesiology Iowa State UniversityAmesIA 50011-4008USA Department of Food Science&Human Nutrition Iowa State UniversityAmesIA 50011USA Department of Psychology Iowa State UniversityAmesIA 50011-1041USA

Background:The School Wellness Integration Targeting Child Health(SWITCH)intervention has demonstrated feasibility as an implementation approach to help schools facilitate changes in students’physical activity(PA),sedentary screen time(SST),and dietary intake(DI).This study evaluated the comparative effectiveness of enhanced(individualized)implementation and standard(group-based)***:Twenty-two Iowa elementary schools participated,with each receiving standardized training(wellness conference and webinars).Schools were matched within region and randomized to receive either individualized or group implementation *** PA,SST,and DI outcomes of 1097 students were assessed at pre-and post-intervention periods using the Youth Activity *** mixed models evaluated differential change in outcomes by condition,for comparative effectiveness,and by ***:Both implementation conditions led to significant improvements in PA and SST over time(p<0.01),but DI did not improve commensurately(p value range:0.02‒0.05).There were no differential changes between the group and individualized conditions for PA(p=0.51),SST(p=0.19),or DI(p=0.73).There were no differential effects by gender(i.e.,non-significant condition-by-gender interactions)for PA(p_(for interaction)=0.86),SST(p_(for interaction)=0.46),or DI(p_(for interaction)=0.15).Effect sizes for both conditions equated to approximately 6 min more PA per day and approximately 3 min less sedentary ***:The observed lack of difference in outcomes suggests that group implementation of SWITCH is equally effective as individualized implementation for building capacity in school wellness ***,the lack of interaction by gender suggests that SWITCH can be beneficial for both boys and *** research is needed to understand the school-level factors that influence implementation(and outcomes)of SWITCH.

关键词： Children Implementation science Obesity prevention Physical activity School health

Impaired CTLA-4 responses in COPD are associated with systemic inflammation

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Cellular & Molecular Immunology 2014年第6期11卷 606-608页

作者： Dino BA Tan Sonia Fernandez PatriciaPrice Martyn A French philip j Thompson Yuben P Moodley Centre for Asthma Allergy and Respiratory Research Lung Institute of Western Australia Nedlands Australia School of Medicine and Pharmacology Nedlands Australia School of Pathology and Laboratory Medicine University of Western Australia Nedlands Australia Department of Clinical Immunology Perth Australia Department of Respiratory and Sleep Medicine Royal Perth Hospital Perth Australia

Systemic inflammation is a feature of chronic obstructive pulmo- nary disease （COPD）. Defects in T cell-mediated anti-inflamma- tory pathways such as cytotoxic T lymphocyte antigen-4 （CTLA- 4） may promote damaging inflammation. This study provides novel data implicating the impaired induction of an anti-inflam- matory molecule, CTLA-4 in the elevated inflammation observed in COPD patients. Low induction of CTLA-4 in COPD patients paralleled increased markers of systemic inflammation ex vivo and increased T-cell responses to a bacterial superantigen, staphylo- coccal enterotoxin-B （SEB） in vitro. This mechanism may explain the increased inflammation in COPD patients.

关键词： T淋巴细胞肠毒素类肺疾病慢性阻塞性抗原分化炎症胰岛素体外研究

Intraspecific variation in precipitation responses of a widespread C_(4) grass depends on site water limitation

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journal of Plant Ecology 2017年第2期10卷 310-321页

作者： Michael j.Aspinwall philip A.Fay Christine V.Hawkes David B.Lowry Albina Khasanova jason Bonnette Briana K.Whitaker Nicholas johnson Thomas E.juenger Hawkesbury Institute for the Environment Western Sydney UniversityHawkesbury CampusLocked Bag 1797PenrithNew South Wales 2751Australia USDA-ARS Grassland Soil and Water Research Laboratory 808 East Blackland RdTempleTX 76502USA Department of Integrative Biology University of Texas at Austin1 University StationAustinTX 78712USA Department of Plant Biology Michigan State University612 Wilson RoadEast LansingMI 48824USA

Aims Variation in precipitation strongly influences plant growth,species distributions and genetic *** variation in pheno-typic plasticity,the ability of a genotype to alter its growth,morphol-ogy or physiology in response to the environment,could influence species responses to changing precipitation and climate *** this,the patterns and mechanisms of intraspecific varia-tion in plasticity to variable precipitation,and the degree to which genotype responses to precipitation are influenced by variation in edaphic conditions,remain poorly ***,we determined whether genotypes of a widespread C_(4) grass(Panicum virgatum L.,switchgrass)varied in aboveground productivity in response to changes in precipitation,and if site edaphic conditions modified genotype aboveground productivity responses to *** also determined if genotype productivity responses to precipitation are related to plasticity in underlying growth and phenological *** Nine *** genotypes originating from an aridity gradient were grown under four treatments spanning the 10th to the 90th percentiles of annual precipitation at two sites in central Texas:one site with deep,fine-textured soils and another site with shallow,coarse-textured *** measured volumetric soil water content(VWC),aboveground net primary productivity(ANPP),tiller pro-duction(tiller number),average tiller mass,canopy height,leaf area index(LAi)and flowering time on all plants at both sites and examined genotype responses to changes in *** Findings Across precipitation treatments,VWC was 39%lower and more variable at the site with shallow,coarse-textured soils compared to the site with deep,fine-textured *** averaged across genotypes and precipita-tion treatments was also 103%higher at the site with deep,fine-textured soils relative to the site with shallow,coarse-textured soils,indicating substantial differences in site water limitation.W

关键词： climate change Panicum virgatum phenology phenotypic plasticity precipitation

Coastal Accessibility and Availability for Physical Activity: A Cross-Sectional Assessment in New Zealand Adults

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Open journal of Preventive Medicine 2016年第12期6卷 273-286页

作者： Nick Garrett Melody Smith philip j. Schluter Barbara Bollard-Breen Department of Epidemiology and Biostatistics Auckland University of Technology Auckland New Zealand School of Nursing The University of Auckland Auckland New Zealand School of Health Sciences University of Canterbury—Te Whare Wānanga o Waitaha Christchurch New Zealand School of Nursing Midwifery and Social Work The University of Queensland Brisbane Australia School of Applied Sciences Auckland University of Technology Auckland New Zealand

Background: This study aimed to examine cross-sectional relationships between objective measures of the built environment (neighborhood walkability and access to and availability of public open spaces including the coast) with self-reported physical activity in adults residing in Auckland, New Zealand. Methods: A telephone survey captured self-reported physical activity and socio-demographic information from adult residents from randomly selected households. Robust approaches were employed to deriving and “ground-truthing” objective built environment measures around individual addresses. Multivariable binary logistic regression models were used to examine the associations between environmental factors and being classified as accumulating sufficient physical activity or otherwise. Results: A total of 1986 participants agreed to participate. Compared with those with no coastal access points within an 800 m street network buffer of their residence, those with 1 - 2 access points were 1.45 times more likely to be classified as sufficiently active (95% CI 1.08, 1.94, p = 0.05). Compared with individuals with no coastal settings within their neighborhood buffer, those with at least two coastal settings in their neighborhood were significantly more likely to be sufficiently active (p = 0.03). Conclusion: Access to, and availability of, coastal places were important associates of accumulating sufficient activity for health in this population.

关键词： Built Environment Environment Health Behaviour

The double helium-white dwarf channel for the formation of AM CVn binaries

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Research in Astronomy and Astrophysics 2018年第1期18卷 101-112页

作者： Xian-Fei Zhang jin-Zhong Liu C.Simon jeffery philip D.Hall Shao-Lan Bi Department of Astronomy Beijing Normal University Xinjiang Astronomical Observatory Chinese Academy of Sciences Armagh Observatory and Planetarium College Hill School of Physics Trinity College Dublin

Most close double helium white dwarfs will merge within a Hubble time due to orbital decay by gravitational wave ***,a significant fraction with low mass ratios will survive for a long time as a consequence of stable mass *** stable mass transfer between two helium white dwarfs（He WDs） provides one channel for the production of AM CVn binary *** previous calculations of double He WD progenitors,the accreting He WD was treated as a point *** have computed the evolution of 16 double He WD models in order to investigate the consequences of treating the evolution of both components in *** find that the boundary between binaries having stable and unstable mass transfer is slightly modified by this *** comparing with observed periods and mass ratios,we redetermine masses of eight known AM CVn stars by our double He WDs channel,*** Cnc,AM CVn,V406 Hya,j0926,j1240,GP Com,Gaia14 aae and V396 *** propose that central spikes in the triple-peaked emission spectra of j1240,GP Com and V396 Hya and the surface abundance ratios of N/C/O in GP Com can be explained by the stable double He WD *** mass estimates derived from our calculations are used to discuss the predicted gravitational wave signal in the context of the Laser Interferometer Space Antenna（LISA） project.

关键词： stars:peculiar(helium) stars:white dwarfs binaries:close gravitational waves

Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial

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Stroke & Vascular Neurology 2021年第2期6卷 180-186页

作者： Lucy Beishon Lisa j Woodhouse Daniel Bereczki Hanne K Christensen Ronan Collins john Gommans Christina Kruuse George Ntaios Serefnur Ozturk Stephen Phillips Stuart Pocock Szabolcs Szatmari joanna Wardlaw Nikola Sprigg philip M Bath Stroke Trials Unit Division of Clinical NeuroscienceUniversity of NottinghamNottinghamUK Department of Neurology Semmelweis UniversityBudapestHungary Bispebjerg Hospital and University of Copenhagen University of CopenhagenCopenhagenDenmark Department of Geriatric and Stroke Medicine Adelaide and Meath HospitalDublinIreland Department of Medicine Hawke's Bay HospitalCamberleyNew Zealand Department of Neurology Herlev Gentofte HospitalUniversity of CopenhagenCopenhagenDenmark Department of Medicine Larissa University HospitalUniversity of ThessalyVolosGreece Department of Neurology Selcuk University Medical FacultyKonyaTurkey Department of Neurology Queen Elizabeth II Health Sciences CentreHalifaxNova ScotiaCanada Medical Statistics Unit London School of Hygiene&Tropical MedicineLondonUK Department of Neurology George Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureșTargu MuresRomania Centre for Clinical Brain Sciences University of EdinburghEdinburghUK Stroke Nottingham University Hospitals NHS TrustNottinghamUK

Introduction Nitrate-induced headache is common and may signify responsive cerebral *** assessed the relationship between nitrate headache and outcome in patients with acute *** and methods Patients were those randomised to glyceryl trinitrate(GTN)versus no GTN in the efficacy of nitric oxide in stroke *** of headache by end of treatment(day 7),and functional outcome(modified Rankin Scale,primary outcome)at day 90,were *** are adjusted for baseline prognostic factors and give OR and mean difference(MD)with 95%*** In 4011 patients,headache was more common in GTN than control(360,18.0% vs 170,8.5%;p<0.001).Nitrate-related headache was associated with:younger age,female sex,higher diastolic blood pressure,non-total anterior circulation syndrome,milder stroke and absence of dysphasia(p<0.05).Nitrate headache was not associated with improved functional outcome(OR 0.90,95% CI 0.73 to 1.10,p=0.30)or death(day 90)(HR 0.64,95% CI 0.40 to 1.02,p=0.062),but reduced death or deterioration(day 7)(OR 0.45,95% CI 0.25 to 0.82),death in hospital(OR 0.44,95% CI 0.22 to 0.88)and improved activities of daily living(Barthel index,MD 3.7,95% CI 0.3 to 7.1)and cognition(telephone interview cognitive screen,MD 2.0,95% CI 0.7 to 3.3)(day 90).Non-nitrate headache was not associated with death,disability or *** and conclusion Development of a nitrate headache by day 7 after stroke may be associated with improved activities of daily living and cognitive impairment at day 90,which was not seen with non-nitrate headache.

关键词： headache patients nitrate