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Listening plus : authentic recordings with tasks to develop listening skills and learner training (student's book) / john mcdowell,CHRISTOPHER HART.

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1987年

作者： john mcdowell CHRISTOPHER HART.

来源：畅想之星图书光盘版（南... 评论

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Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang Liu Junya Fujimoto Lingzhi Hong Alexandre Reuben Susan Varghese Carmen Behrens Tina mcdowell Luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning Le Natalie I Vokes Chao Cheng john V.Heymach Don L.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSCLC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

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Listen and speak for First Certificate /

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1000年

作者： mcdowell john.

来源：畅想之星图书光盘版（南... 评论

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PRISMS-Fatigue computational framework for fatigue analysis in polycrystalline metals and alloys

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npj Computational Materials 2021年第1期7卷 349-360页

作者： Mohammadreza Yaghoobi Krzysztof S.Stopka Aaditya Lakshmanan Veera Sundararaghavan john E.Allison David L.mcdowell Materials Science and Engineering University of MichiganAnn ArborMIUSA Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGAUSA Aerospace Engineering University of MichiganAnn ArborMIUSA School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGAUSA

The PRISMS-Fatigue open-source framework for simulation-based analysis of microstructural influences on fatigue resistance for polycrystalline metals and alloys is presented *** framework uses the crystal plasticity finite element method as its microstructure analysis tool and provides a highly efficient,scalable,flexible,and easy-to-use ICME community *** PRISMS-Fatigue framework is linked to different open-source software to instantiate microstructures,compute the material response,and assess fatigue indicator *** performance of PRISMS-Fatigue is benchmarked against a similar framework implemented using *** indicate that the multilevel parallelism scheme of PRISMS-Fatigue is more efficient and scalable than ABAQUS for large-scale fatigue *** performance and flexibility of this framework is demonstrated with various examples that assess the driving force for fatigue crack formation of microstructures with different crystallographic textures,grain morphologies,and grain numbers,and under different multiaxial strain states,strain magnitudes,and boundary conditions.

关键词： fatigue alloys grain

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Casting: Pearls and pitfalls learned while caring for children's fractures

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World Journal of Orthopedics 2016年第9期7卷 539-545页

作者： Shawn Nguyen Mitchell mcdowell john Schlechter Department of Orthopaedic Surgery Riverside University Health Sciences Department of Orthopaedic Surgery Kaiser Permanente - Moreno Valley

Casting is a routine procedure used for fracture care in the pediatric population. The purpose of this review is to provide pearls and pitfalls that our institution has learned from previous literature. When applying the cast, we recommend using cotton padding for the liner and fiberglass or plaster depending on how much swelling is expected. A well-molded cast must be applied in order to prevent further fracture *** valving is a valuable technique that allows a decrease in pressure which prevents discomfort and complications like compartment syndrome. Preventing thermal injuries, skin complications, and a wet cast are other important considerations when caring for *** use of a cast saw, avoiding pressure spots,and properly covering the cast are ways to respectively prevent those complications. Lastly, patient education remains one of the most valuable tools in ensuring proper cast maintenance.

关键词： Cast care Fracture cast Pediatric casting Pediatric fractures Casting Cast complications

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